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市場調査レポート

細胞培養市場の動向

Cell Culture - Rising Demand for Biologics and Growing Visibility of Approval Pathway for Biosimilars will Create Growth Opportunities

発行 GBI Research 商品コード 254563
出版日 ページ情報 英文 75 Pages
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細胞培養市場の動向 Cell Culture - Rising Demand for Biologics and Growing Visibility of Approval Pathway for Biosimilars will Create Growth Opportunities
出版日: 2012年11月09日 ページ情報: 英文 75 Pages
概要

当レポートでは、世界の細胞培養市場について調査分析を行い、細胞培養技術、市場の促進因子、抑制因子、主な細胞培養の装置などについて考察するとともに、2004年〜2011年までの市場データ、2018年までの予測、主要企業などについてまとめ、概略下記の構成で取り上げております。

第1章 目次

第2章 細胞培養−イントロダクション

  • イントロダクション

第3章 細胞培養−概要

  • 概要
  • 細胞株
  • 細胞株の用途
  • 主な細胞株
  • トランスジェニックモデルの変換アプローチ
  • 幹細胞研究の可能性
  • 発酵法
  • 発酵槽とバイオリアクター
  • 培地
  • 血清
  • 試薬

第4章 細胞培養−現在と将来の動向

  • 細胞培養市場の予測
  • 培地市場の予測
  • 血清市場の予測
  • 試薬市場の予測
  • 細胞培養市場の促進因子と抑制因子

第5章 細胞培養−細胞培養の重要な部分である医薬品

  • 遺伝子組み換え
  • 細胞株とセルバンク
  • 生物医薬品による治療の成功により細胞培養の需要は増加している

第6章 培地、血清、試薬市場の主要企業

  • 細胞培養企業の市場シェア

第7章 付録

図表

目次
Product Code: GBIHC220MR

Summary

GBI Research, the leading business intelligence provider, has released its latest research "Cell Culture - Rising Demand for Biologics and Growing Visibility of Approval Pathway for Biosimilars will Create Growth Opportunities", which provides in-depth analysis on the processes, drivers and barriers of the cell culture market. The report analyzes the role of biopharmaceutical products that basically provide enhancement to media, sera, reagents and cell culture market. Major manufacturing technologies involved in the cell culture technology have been detailed in the report. Furthermore, the report provides competitive benchmarking for the leading players that shape the global media, sera, reagent and overall cell culture market.

This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GBI Research's team of industry experts.

Cell culture technology is used to carry out processes external to the natural environment by maintaining controlled environments which enable the growth of various cell cultures for use in medicine and research. The processes is related to methods involved in the development of tissue or organ cultures. Multicellular eukaryotic cells from animals are usually preferred for cell culture as they provide standard characteristics for growing environments. Plant cells are the second choice for culture technology, while fungi, bacteria, protists and others are also used for the developmental process.

The development of recombinant methods involves genetic manipulation and restructuring of DNA or genes. Genetic recombination usually takes place in a biological environment, while DNA recombination occurs either during a repair response or experiments using in vitro studies. This is also known as genetic engineering technology and was developed at the end of the twentieth century. This method was further developed for large-scale cell culture production and was found to be helpful in protein synthesis processes, such as insulin production.

GBI Research indicates that the cell culture market is growing continuously due to increased demand for biopharmaceutical products. The introduction of biosimilars across various geographies in the forecast period on a large scale will boost the cell culture market, rapidly. Despite concerns about low flexibility for manufacturing quantities and other factors, the higher efficacy of the end products will drive its growth in the future.

Scope

  • Analysis of various technologies involved in cell culture and the key associated manufacturing processes involved
  • Key drivers and barriers that have a significant impact on the cell culture market.
  • Major equipment, cell banks and cell lines for cell culture development have been analyzed
  • Annualized market data for the media, sera, reagents and global cell culture market from 2004 to 2011, forecast forward to 2018, have been provided in the report.
  • Major players in the cell culture market are enlisted providing their company overview and company roles in the market.

Reasons to buy

  • Align your product portfolio to the markets with high growth potential
  • Develop market-entry and market expansion strategies by identifying the leading therapeutic segments and geographic markets poised for strong growth
  • Develop strategic initiatives by understanding the key focus areas of leading companies
  • Exploit in-licensing and out-licensing opportunities by identifying products that could fill portfolio gaps

Table of Contents

1 Table of Contents 5

  • 1.1 List of Tables 7
  • 1.2 List of Figures 8

2 Cell Culture - Introduction 9

  • 2.1 Introduction 9

3 Cell Culture - Overview 10

  • 3.1 Overview 10
  • 3.2 Cell Lines 10
  • 3.3 Application of Cell Lines 10
    • 3.3.1 Characteristics of Cell Lines 10
  • 3.4 Selective Cell Lines 11
    • 3.4.1 Chinese Hamster Ovary 11
    • 3.4.2 SP2/0 and NS0 11
    • 3.4.3 HEK 293 and PER. C6 11
  • 3.5 Transformational Approach of Transgenic Model 12
    • 3.5.1 Transgenic DNA Preparation 12
    • 3.5.2 Insertion of the Transgenic DNA into Animals 12
    • 3.5.3 Clone and Integrity Verification of the Transgene 13
    • 3.5.4 DNA Purification and Establishing a Screening Method 13
    • 3.5.5 Breeding and Analysis of Transgenic Rodents 13
  • 3.6 Stem Cell Research has Enormous Potential for Cell Culture 14
    • 3.6.1 Applications of Stem Cell Research 14
    • 3.6.2 Stem Cell Research Market Analysis 15
  • 3.7 Fermentation Methods 16
    • 3.7.1 Fed-Batch Fermentation 17
    • 3.7.2 Important Factors for Regulating Cell Culture 18
  • 3.8 Fermenters and Bioreactors 19
    • 3.8.1 Bioreactor 19
    • 3.8.2 Selection of Bioreactors 19
    • 3.8.3 Batch Bioreactor 20
    • 3.8.4 Continuous Bioreactor 21
    • 3.8.5 Submerged Bioreactors - Stirred Tank 22
    • 3.8.6 Airlift Bioreactor 22
    • 3.8.7 Water-Jacketed Bioreactor 23
  • 3.9 Media 23
    • 3.9.1 Role of Media 23
    • 3.9.2 Types of Media 23
  • 3.10 Sera 24
    • 3.10.1 Sources of Sera 24
    • 3.10.2 Sera Safety and Regulations 25
    • 3.10.3 Shift to Serum Free Media 26
  • 3.11 Reagents 26
    • 3.11.1 Major Types of Biologic Reagents 26
    • 3.11.2 Reagent Safety Issues 28

4 Cell Culture - Current and Future Trends 29

  • 4.1 Cell Culture Market Forecast 29
  • 4.2 Media Market Forecast 30
  • 4.3 Sera Market Forecast 31
  • 4.4 Reagents Market Forecast 32
  • 4.5 Drivers and Restraints for Cell Culture Market 33
    • 4.5.1 Drivers for Cell Culture Market 33
    • 4.5.2 Restraints for Cell Culture Market 34

5 Cell Culture - Biopharmaceuticals an Important Part of Cell Culturing 35

  • 5.1 Genetic Modifications 35
    • 5.1.1 Cell Culture Life-Cycle Expressions 35
    • 5.1.2 Biotechnological Product Development Using Cell Culture Method 37
    • 5.1.3 Cell Banking and Seed Culture 38
    • 5.1.4 Cell Systems 39
    • 5.1.5 Advantages and Disadvantages of Cell Culture Techniques 41
  • 5.2 Cell Lines and Banks 41
    • 5.2.1 Manufacturing of Biopharmaceuticals using Cell Culture Techniques 41
    • 5.2.2 Standard Methods for Cell Culture 42
    • 5.2.3 Validation and Quality Maintenance 43
    • 5.2.4 Essential Guidelines for Maintaining Sterilization Standards 43
  • 5.3 Successful Treatments from Biopharmaceuticals is Increasing the Demand for Cell Culturing 44

6 Key Players in the Culture Media, Sera and Reagents Market 45

  • 6.1 Cell Culture Suppliers' Market Share 45
    • 6.1.1 Life Technologies Corporation 46
    • 6.1.2 Sigma-Aldrich Corporation 47
    • 6.1.3 Thermo Fisher Scientific Inc. 48
    • 6.1.4 Affymetrix, Inc. 49
    • 6.1.5 BD Biosciences 50
    • 6.1.6 EMD Millipore 51
    • 6.1.7 Advanced Biotechnologies, Inc. 52
    • 6.1.8 Amresco 53
    • 6.1.9 Analytical Biological Services Inc. 54
    • 6.1.10 Athena Biotechnologies, Inc. 55
    • 6.1.11 Biochrom AG 56
    • 6.1.12 Bioreclamation, Inc. 57
    • 6.1.13 Cell Essentials, Inc 58
    • 6.1.14 CellGenix Technologie Transfer GmbH 59
    • 6.1.15 Clontech Laboratories, Inc. 60
    • 6.1.16 Gemini Bio-Products 61
    • 6.1.17 Lonza BioSciences Singapore Pte Ltd 62
    • 6.1.18 Mediatech, Inc. 63
    • 6.1.19 MP Biomedicals, LLC 64
    • 6.1.20 PAA Laboratories GmbH 65
    • 6.1.21 Quality Biological, Inc. 66
    • 6.1.22 R&D Systems, Inc. 67
    • 6.1.23 SAFC Biosciences, Inc. 68
    • 6.1.24 Selexis SA 69
    • 6.1.25 SeraCare Life Sciences, Inc. 70
    • 6.1.26 Sera Laboratories International Ltd. 71

7 Cell Culture - Appendix 72

  • 7.1 Market Definitions 72
  • 7.2 Abbreviations 72
  • 7.3 Bibliography 73
  • 7.4 Research Methodology 74
    • 7.4.1 Coverage 74
    • 7.4.2 Secondary Research 74
    • 7.4.3 Primary Research 75
    • 7.4.4 Expert Panel Validation 75
  • 7.5 Contact Us 75
  • 7.6 Disclaimer 75

List of Tables

  • Table 1: Cell Culture, Basal-Media Components, 2011 18
  • Table 2: Cell Culture, Examples and Applications of Specialty Media, 2011 24
  • Table 3: Cell Culture, Validation Test for Sera Approval, 2011 25
  • Table 4: Cell Culture, Global, Revenue ($bn), 2004-2011 29
  • Table 5: Cell Culture, Global, Revenue ($bn), 2011-2018 29
  • Table 6: Cell Culture, Media Market Revenues, Global ($m), 2004-2011 30
  • Table 7: Cell Culture, Media Market Revenues, Global ($m), 2011-2018 30
  • Table 8: Cell Culture, Sera Market Revenues, Global ($m), 2004-2011 31
  • Table 9: Cell Culture, Sera Market Revenues, Global ($m), 2011-2018 31
  • Table 10: Cell Culture, Reagent Market Revenues, Global ($bn), 2004-2011 32
  • Table 11: Cell Culture, Reagent Market Revenues, Global ($bn), 2011-2018 32
  • Table 12: Cell Culture, Manufacturing Models, 2011 35
  • Table 13: Cell Culture, Comparison of Therapeutic Protein Production across Different Systems, 2011 35

List of Figures

  • Figure 1: Cell Culture, Transgenic Model, Process Steps, 2011 12
  • Figure 2: Cell Culture, Applications of Stem Cell Research, 2011 14
  • Figure 3: Cell Culture, Stem Cell Research, Porter's Five Force Analysis, 2011 15
  • Figure 4: Cell Culture, Fermentation Cycle, 2011 16
  • Figure 5: Cell Culture, Batch and Fed-Batch Fermentation, 2011 17
  • Figure 6: Cell Culture, Upstream Processing in Biopharmaceuticals, Tray Bioreactor, 2011 20
  • Figure 7: Cell Culture, Upstream Processing in Biopharmaceuticals, Stirred Tank Bioreactor, 2011 21
  • Figure 8: Cell Culture, Global, Revenue ($bn), 2004-2018 29
  • Figure 9: Cell Culture, Media Market Revenues, Global ($m), 2004-2018 30
  • Figure 10: Cell Culture, Sera Market Revenues, Global ($m), 2004-2018 31
  • Figure 11: Cell Culture, Reagent Market Revenues, Global ($m), 2004-2018 32
  • Figure 12: Cell Culture, Market, Drivers and Restraints, 2011 33
  • Figure 13: Cell Culture, Cell Bank System, 2011 38
  • Figure 14: Cell Culture, Suppliers Market Share, Global, 2011 45
  • Figure 15: Cell Culture, Life Technologies Corporation, Business Overview, 2011 46
  • Figure 16: Cell Culture, Sigma-Aldrich Corporation, Business Overview, 2011 47
  • Figure 17: Cell Culture, Thermo Fisher Scientific Inc., Business Overview, 2011 48
  • Figure 18: Cell Culture, Affymetrix, Inc., Business Overview, 2011 49
  • Figure 19: Cell Culture, BD Biosciences, Business Overview, 2011 50
  • Figure 20: Cell Culture, EMD Millipore, Business Overview, 2011 51
  • Figure 21: Cell Culture, Advanced Biotechnologies, Inc., Business Overview, 2011 52
  • Figure 22: Cell Culture, Amresco Inc., Business Overview, 2011 53
  • Figure 23: Cell Culture, Analytical Biological Services Inc., Business Overview, 2011 54
  • Figure 24: Cell Culture, Athena Biotechnologies, Inc., Business Overview, 2011 55
  • Figure 25: Cell Culture, Biochrom AG, Business Overview, 2011 56
  • Figure 26: Cell Culture, Bioreclamation, Inc, Business Overview, 2011 57
  • Figure 27: Cell Culture, Cell Essentials, Inc., Business Overview, 2011 58
  • Figure 28: Cell Culture, CellGenix Technologie Transfer GmbH, Business Overview, 2011 59
  • Figure 29: Cell Culture, Clontech Laboratories, Inc., Business Overview, 2011 60
  • Figure 30: Cell Culture, Gemini Bio-Products, Business Overview, 2011 61
  • Figure 31: Cell Culture, Lonza BioScience Singapore Pte Ltd, Business Overview, 2011 62
  • Figure 32: Cell Culture, Mediatech, Inc., Business Overview, 2011 63
  • Figure 33: Cell Culture, MP Biomedicals, LLC, Business Overview, 2011 64
  • Figure 34: Cell Culture, PAA Laboratories GmbH, Business Overview, 2011 65
  • Figure 35: Cell Culture, Quality Biological, Inc., Business Overview, 2011 66
  • Figure 36: Cell Culture, R&D Systems, Inc., Business Overview, 2011 67
  • Figure 37: Cell Culture, SAFC Biosciences, Inc., Business Overview, 2011 68
  • Figure 38: Cell Culture, Selexis SA, Business Overview, 2011 69
  • Figure 39: Cell Culture, SeraCare Life Sciences, Business Overview, 2011 70
  • Figure 40: Cell Culture, Sera Laboratories International Ltd., Business Overview, 2011 71
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