表紙:バイオロジカルマルチプレックスアッセイの世界市場(2021年~2028年)
市場調査レポート
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1033682

バイオロジカルマルチプレックスアッセイの世界市場(2021年~2028年)

Global Biological Multiplex Assays Market - 2021-2028

出版日: | 発行: DataM Intelligence | ページ情報: 英文 180 Pages | 納期: 約2営業日

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バイオロジカルマルチプレックスアッセイの世界市場(2021年~2028年)
出版日: 2021年10月24日
発行: DataM Intelligence
ページ情報: 英文 180 Pages
納期: 約2営業日
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概要

バイオロジカルマルチプレックスアッセイ市場の成長を促進する要因には、製薬業界における研究開発活動の活発化、技術の進歩などが挙げられます。バイオロジカルマルチプレックスアッセイには多くの利点がありますが、その一方で、良好な抗体ペアの入手、マトリックスの干渉、アッセイ間のクロストーク、アッセイ試薬のロット間のばらつきなどによる制限等の欠点があり、市場成長の妨げとなる恐れがあります。

地域別の市場では、北米地域が中心となっています。同地域では、政府機関からの資金提供が増加しており、新薬やバイオマーカーの開発に注力していることから、バイオロジカルマルチプレックスアッセイの世界市場で最大のシェアを占めると予想されます。

当レポートは、世界のバイオロジカルマルチプレックスアッセイ市場について調査しており、市場規模、機会や影響、促進および抑制要因、COVID-19による影響、タイプ・テクノロジー・アプリケーション・地域別の市場分析、競合情勢、主要企業のプロファイルなどの情報を提供しています。

目次

第1章 世界のバイオロジカルマルチプレックスアッセイ市場-調査手法と範囲

  • 調査手法
  • 調査の目的と調査範囲

第2章 世界のバイオロジカルマルチプレックスアッセイ市場-市場の定義と概要

第3章 世界のバイオロジカルマルチプレックスアッセイ市場-エグゼクティブサマリー

  • タイプ別の市場内訳
  • テクノロジー別市場内訳
  • アプリケーション別の市場内訳
  • 地域別の市場内訳

第4章 バイオロジカルマルチプレックスアッセイ市場-市場力学

  • 市場に影響を与える要因
    • 促進要因
    • 抑制要因
    • 市場機会
    • 影響分析

第5章 世界のバイオロジカルマルチプレックスアッセイ市場-業界分析

  • ポーターのファイブフォース分析
  • 疫学分析
  • サプライチェーン分析
  • 価格分析
  • 規制分析
  • 償還分析
  • アンメットニーズ

第6章 世界のバイオロジカルマルチプレックスアッセイ市場-COVID-19分析

  • 市場でのCOVID-19の分析
    • COVID-19以前の市場シナリオ
    • 現在のCOVID-19市場シナリオ
    • COVID-19以後または今後のシナリオ
  • COVID-19における価格動向
  • 需要と供給のスペクトル
  • パンデミック時の市場に関連する政府のイニシアチブ
  • メーカーの戦略的イニシアチブ
  • 結論

第7章 世界のバイオロジカルマルチプレックスアッセイ市場-タイプ別

  • イントロダクション
    • 市場規模分析および前年比成長分析
    • 市場魅力指数
  • タンパク質ベースのマルチプレックスアッセイ
  • 核酸ベースのマルチプレックスアッセイ
  • その他

第8章 世界のバイオロジカルマルチプレックスアッセイ市場-テクノロジー別

  • イントロダクション
    • 市場規模分析および前年比成長分析
    • 市場魅力指数
  • マルチプレックスPCR
  • マルチプレックスタンパク質マイクロアレイ

第9章 世界のバイオロジカルマルチプレックスアッセイ市場-アプリケーション別

  • イントロダクション
    • 市場規模分析および前年比成長分析
    • 市場魅力指数
  • 臨床診断
  • 研究開発
  • その他

第10章 世界のバイオロジカルマルチプレックスアッセイ市場-地域別

  • イントロダクション
    • 市場規模分析および前年比成長分析
    • 市場魅力指数
  • 北米
  • 欧州
  • 南米
  • アジア太平洋
  • 中東とアフリカ

第11章 世界のバイオロジカルマルチプレックスアッセイ市場-競合情勢

  • 主な発展と戦略
  • 企業シェア分析
  • 製品のベンチマーク

第12章 世界のバイオロジカルマルチプレックスアッセイ市場-企業プロファイル

  • Thermo Fisher Scientific Inc.
    • 企業概要
    • 製品ポートフォリオ・概要
    • 要点
    • 財務概要
  • Luminex Corporation
  • Illumina Inc.
  • Bio-Rad Laboratories Inc.
  • Qiagen N.V.
  • Becton, Dickinson and Company
  • Abcam PLC
  • Tianjin JingMing New Tech. Devp. Co., Ltd
  • Hanson Meditec Co., Ltd.
  • Huaian Meide Medical Instrument Co., Ltd(LIST NOT EXHAUSTIVE)

第13章 世界のバイオロジカルマルチプレックスアッセイ市場-DataM

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目次
Product Code: DMPH4196

Market Overview

The global biological multiplex assays market size was valued at US$ XX million in 2020 and is estimated to reach US$ XX billion by 2028, growing at CAGR of XX % during the forecast period (2021-2028).

In the biological science, biological multiplex assay is a type of immunoassay that uses magnetic beads to measure multiple analytes simultaneously. This assay is a derivative of an ELISA using beads for binding the capture antibody.

Market Dynamics

Some of the factors driving the growth of the biological multiplex assays market include increasing research and development activities in the pharmaceutical sector, technological advancements, among others.

Increasing research and development activities in the pharmaceutical sector are expected to drive the growth of biological multiplex assays market

The pharmaceutical industry has generated many novel therapeutics that are typically protein-based molecules derived from biological sources. However, therapeutic protein products often initiate immune responses against the therapeutic protein that can potentially lead to adverse clinical events in patients. For above 50 years, immunoassays have allowed sensitive and increased specific detection of analytes of interest in biological samples for use in both clinical diagnostics and life science research. Traditional enzyme-linked immunosorbent assays (ELISA assays) measure and detect a single analyte per plate. Latest bead-based immunoassays like the ones based on Luminex xMAP technology, utilize the same principle and apply it to uniquely identifiable beads. These beads allow simultaneous detection of multiple analytes in a single reaction or well. Multiplex immunoassays yield a wealth of information on the roles of multiple proteins and other biomolecules in diverse biological processes, thereby providing clinicians with insight into identifying and assessing disease progression.

The Bio-Plex array system utilizes Multi-Analyte Profiling (MAP) technology developed by the Luminex Corporation (Austin, TX). It comprises a fully integrated system combining hardware and Bio-Plex Manager Software. The Bio-Plex includes enhancements designed by Bio-Rad to increase the dynamic range of the basic Luminex instrument. "Bio-Plex xMAP technology permits the multiplexing of up to 100 different assays within a single sample. The system utilizes a liquid suspension array of 100 sets of 5.5-micron beads, internally each dyed with ratios different of two spectrally distinct fluorophores to assign a unique spectral address.

Technological advancements are expected to drive the biological multiplex assays market in the forecast period

From a single sample the simultaneous measurement of different substances is an emerging area for achieving high-throughput and efficient detection in several applications. Although immunoanalytical techniques are advantageous and established over alternative screening analytical platforms, one of the challenges for immunoassays is multiplexing. While ELISA is still commonly used to characterize a single analyte, laboratories and organizations use multiplex immunoassays. In a single sample the validation of novel biomarkers and their mix into multiplex immunoassays confers the prospects of measurement of simultaneous multiple analytes, thereby time, minimising cost and sample. Therefore, in clinical sciences the technological advancement is helpful in the identification of biomarkers or analytes in test samples. The analytical bioanalysers are capable of detecting small analytes type. The simultaneous measurement of different substances from a single sample called multiplexing has become increasingly important for quantifying toxicological or pathological samples.

Drawbacks related to the biological multiplex assays is estimated to hamper the biological multiplex assays market

For basic research and biomarker discovery multiplex immunoassays confer many advantages over the widely adopted singleplex immunoassays, but successful assays depend on careful, thorough validation and development. Assay development is often limited by the availability of good antibody pairs, matrix interference, cross-talk between assays, and lot-to-lot variability in assay reagents. The quality of a finished multiplex immunoassay critically depends on the pairing of high-quality detection and capture antibodies. Antibodies validated for singleplex immunoassays on one platform don't always display the same quality in a multiplex setting. In addition, a positive western blot result does not always translate to equal performance in a suspension format. Thus, careful validation of antibody pairs must be carried out on the same platform used for the final assay to ensure optimum performance.

Multiplex immunoassays are used extensively in both diagnostics and research and their continued success relies on careful validation processes. The selection of the appropriate biomarkers and the associated reagents to develop multiplex assays should start with open communications between the end-user and the assay vendor and between the assay vendor and suppliers of the raw materials. This ensures the assays are manufactured according to validation methods that apply to a wide range of academic and clinical research settings.

COVID-19 Impact Analysis

The multiplex assay can detect patient responses to five SARS-CoV-2 proteins simultaneously the full spike protein, three individual spike protein domains (S1, S2, and receptor binding domain), and the nucleocapsid protein. Antibodies to the mentioned proteins are SARS-CoV-2 specific, as antibodies to four common coronaviruses do not cross-react. This new assay provides a novel tool for investigating the spectrum of immune responses to SAR-CoV-2 and is specifically designed for use in the transplant setting. Hence, covid is estimated to have a positive impact on the biological multiplex assays market.

Segment Analysis

The protein-based assay segment is estimated to dominate the biological multiplex assays market

For detecting protein-specific functional groups protein assays differ in their chemical basis. Some assay methods detect peptide bonds. Each protein assay instead detects one or several amino acids with greater sensitivity than others. Proteins with different amino acid compositions consequently produce color at different rates or intensities in any protein assay. The Bradford protein assay use a blue dye that binds to specific amino acids. The resulting intensity of the blue color can be measured with a spectrophotometer. The resulting absorbance is compared to a standard to determine the concentration of protein in the sample. This method is called the Coomassie dye protein assay because the dye used is called a Coomassie dye.

The protein assay aims to determine the concentration or amount of a specific protein or an array of proteins in different sample. Detecting and isolating protein is used for many clinical and research processes. This can be a primary step before further manipulation in a research and development process, an initial protein capture before structural analysis or a final detection step in a clinical laboratory as part of a disease diagnosis.

Multiplex PCR segment is expected to dominate the biological multiplex assays market

Multiplex PCR is a two-amplicon system or amplify 13 or more separate regions of DNA. It can be the end point of the analysis, or it may be preliminary to further analysis such as sequencing and hybridisation. Producing multiplex PCR systems can be simple as combining two sets of primers for which reaction have been separately determined. However, for the regions to be amplified multiplex PCRs should be developed with careful consideration, the sizes of relative fragments, the dynamics of the primers and the optimisation of PCR technique to accommodate multiple fragments. The expense of reagents and time of preparation are less in multiplex PCR than in other systems. Multiplex PCR assays can be time-consuming, tedious and lengthy procedures for optimisation such as adjusting primers concentration, concentration of Mg2 + and amount of enzyme are often necessary. Novel developments in reaction chemistry have made multiplex PCR more straightforward. Multiplex PCR methods exhibit great flexibility in overcoming limiting primer kinetics and in experimental design and fragment competition.

A molecular technique multiplex PCR is used for the diagnosis of important foodborne microorganisms. In the same reaction this technique uses more than one primer pair, thus permitting the simultaneous amplification of different DNA sequences. It can be used to simultaneously amplify target sequences of different pathogenic microorganisms in a single reaction, with potential application in routine laboratories.

The clinical diagnostics segment is expected to dominate the market

Multiplex assay techniques are highly sensitive yet versatile, they are well suited to clinical applications such as immunology, cancer diagnosis and immuno-oncology. They are particularly useful for biomarker discovery. A panel of analytes is measured together as an indicator for a specific disease, a response to medical treatment, or stratifying treatments at the patient level.

Than single assay testing they require samples in far smaller quantities, and are particularly valuable where sample volumes are limited. This includes research that uses mice models, research and clinical treatment of neonates and analysis of tumor biopsy samples. The applications for immunoassays were limited to basic research once, but have expanded into diagnostic- and clinical-research spaces. With the invention of multiplex immunoassays, researchers have gained the opportunity for more information about a protein or series of proteins within a single reaction of an experiment. These enable users to gather more information in less time and help researchers conserve very small volume samples. Increasing number of tools are being used by researchers available for multiplex immunoassays to investigate cellular regulatory events involved in cancer. For instance, pharmaceutical companies are using multiplex immunoassays to increase their testing power.

Geographical Analysis

North America region dominated the biological multiplex assays market

Increasing funding from government agencies and rise in focus to develop novel drugs and biomarkers in this region is expected to account for largest market share in global biological multiplex assays market.

The ideal government upholds adding to the market development. North America held a generous offer attributable to the most elevated number of preliminaries embraced and reevaluated in the locale. Moreover, developing government uphold for R&D exercises through awards and assets to explore establishments and organizations has driven this local market. The Canada and USA play a leading role in the increasing globalisation of science and research. In the world North America and especially the USA continues to be the most competitive research region. More than a quarter of the global funds spent on research and development are invested herGlobal Biological Multiplex Assays Market

Competitive Landscape

The biological multiplex assays market is highly competitive with increasing demand of assays in pharmaceutical research and development and new drug launches.

Some of the major key players in the global biological multiplex assays market are Luminex Corporation, Thermo Fisher Scientific Inc., Illumina Inc., Bio-Rad Laboratories Inc., QIAGEN N.V., Becton, Dickinson and Company, Abcam PLC, Seegene Inc., Meso Scale Diagnostics LLC, and Randox Laboratories Ltd.

Thermo Fisher Scientific Inc.

Overview: Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of more than $24 billion and approximately 70,000 employees globally. It is a company based in the United States that sells scientific instruments, reagents and consumables, and software services. Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, and Patheon are just a few of their industry-leading brands.

Product Portfolio: The company comprises analytical instruments, laboratory supply chain programs and ecommerce, laboratory equipment, lab services, specialty diagnostics, life sciences, pharma services, and CDMO.

Key Development: On 16th April 2021, Thermo Fisher Scientific acquired PPD, Inc., a leading clinical research organization to further expand service offering to pharma and biotech customers.

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Target Audience

Service Providers/ Buyers

Industry Investors/Investment Bankers

Education & Research Institutes

Research Professionals

Emerging Companies

Manufacturers

Market Segmentation

Global Biological Multiplex Assays Market - By Type

Protein-based Multiplex Assays

Nucleic Acid-based Multiplex Assays

Others

Global Biological Multiplex Assays Market - By Technology

Multiplex PCR

Multiplex Protein Microarray

Global Biological Multiplex Assays Market - By Application

Clinical Diagnostics

Research & Development

Others

Global Biological Multiplex Assays Market - By Region

North America

Europe

South America

Asia Pacific

Middle East and Africa

Table of Contents

1. Global Biological Multiplex Assays Market - Methodology and Scope

  • 1.1. Research Methodology
  • 1.2. Research Objective and Scope of the Report

2. Global Biological Multiplex Assays Market - Market Definition and Overview

3. Global Biological Multiplex Assays Market - Executive Summary

  • 3.1. Market Snippet by Type
  • 3.2. Market Snippet by Technology
  • 3.3. Market Snippet by Application
  • 3.4. Market Snippet by Region

4. Biological Multiplex Assays Market - Market Dynamics

  • 4.1. Market Impacting Factors
    • 4.1.1. Drivers
      • 4.1.1.1. Increasing R&D activities in the pharmaceutical sector
      • 4.1.1.2. Technological advancements in products
    • 4.1.2. Restraints:
      • 4.1.2.1. Drawbacks related to the biological multiplex assays is likely to hamper the biological multiplex assays market
    • 4.1.3. Opportunity
    • 4.1.4. Impact Analysis

5. Global Biological Multiplex Assays Market - Industry Analysis

  • 5.1. Porter's Five Forces Analysis
  • 5.2. Epidemiology Analysis
  • 5.3. Supply Chain Analysis
  • 5.4. Pricing Analysis
  • 5.5. Regulatory Analysis
  • 5.6. Reimbursement Analysis
  • 5.7. Unmet Needs

6. Global Biological Multiplex Assays Market - COVID-19 Analysis

  • 6.1. Analysis of Covid-19 on the Market
    • 6.1.1. Before COVID-19 Market Scenario
    • 6.1.2. Present COVID-19 Market Scenario
    • 6.1.3. After COVID-19 or Future Scenario
  • 6.2. Pricing Dynamics Amid Covid-19
  • 6.3. Demand-Supply Spectrum
  • 6.4. Government Initiatives Related to the Market During Pandemic
  • 6.5. Manufacturers Strategic Initiatives
  • 6.6. Conclusion

7. Global Biological Multiplex Assays Market - By Type

  • 7.1. Introduction
    • 7.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type Segment
    • 7.1.2. Market Attractiveness Index, By Type Segment
  • 7.2. Protein-based Multiplex Assays*
    • 7.2.1. Introduction
    • 7.2.2. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 7.3. Nucleic Acid-based Multiplex Assays
  • 7.4. Others

8. Global Biological Multiplex Assays Market - By Technology

  • 8.1. Introduction
    • 8.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Technology
    • 8.1.2. Market Attractiveness Index, By Technology
  • 8.2. Multiplex PCR*
    • 8.2.1. Introduction
    • 8.2.2. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 8.3. Multiplex Protein Microarray

9. Global Biological Multiplex Assays Market - By Application

  • 9.1. Introduction
    • 9.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application Segment
    • 9.1.2. Market Attractiveness Index, By Application Segment
  • 9.2. Clinical Diagnostics*
    • 9.2.1. Introduction
    • 9.2.2. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 9.3. Research & Development
  • 9.4. Others

10. Global Biological Multiplex Assays Market - By Region

  • 10.1. Introduction
    • 10.1.1. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028, By Region
    • 10.1.2. Market Attractiveness Index, By Region
  • 10.2. North America
    • 10.2.1. Introduction
    • 10.2.2. Key Region-Specific Dynamics
    • 10.2.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type
    • 10.2.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Technology
    • 10.2.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.2.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.2.6.1. U.S.
      • 10.2.6.2. Canada
      • 10.2.6.3. Mexico
  • 10.3. Europe
    • 10.3.1. Introduction
    • 10.3.2. Key Region-Specific Dynamics
    • 10.3.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type
    • 10.3.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Technology
    • 10.3.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.3.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.3.6.1. Germany
      • 10.3.6.2. U.K.
      • 10.3.6.3. France
      • 10.3.6.4. Italy
      • 10.3.6.5. Spain
      • 10.3.6.6. Rest of Europe
  • 10.4. South America
    • 10.4.1. Introduction
    • 10.4.2. Key Region-Specific Dynamics
    • 10.4.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type
    • 10.4.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Technology
    • 10.4.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.4.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.4.6.1. Brazil
      • 10.4.6.2. Argentina
      • 10.4.6.3. Rest of South America
  • 10.5. Asia Pacific
    • 10.5.1. Introduction
    • 10.5.2. Key Region-Specific Dynamics
    • 10.5.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type
    • 10.5.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Technology
    • 10.5.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.5.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.5.6.1. China
      • 10.5.6.2. India
      • 10.5.6.3. Japan
      • 10.5.6.4. Australia
      • 10.5.6.5. Rest of Asia Pacific
  • 10.6. Middle East and Africa
    • 10.6.1. Introduction
    • 10.6.2. Key Region-Specific Dynamics
    • 10.6.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type
    • 10.6.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Technology
    • 10.6.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application

11. Global Biological Multiplex Assays Market - Competitive Landscape

  • 11.1. Key Developments and Strategies
  • 11.2. Company Share Analysis
  • 11.3. Product Benchmarking

12. Global Biological Multiplex Assays Market - Company Profiles

  • 12.1. Thermo Fisher Scientific Inc.*
    • 12.1.1. Company Overview
    • 12.1.2. Product Portfolio and Description
    • 12.1.3. Key Highlights
    • 12.1.4. Financial Overview
  • 12.2. Luminex Corporation
  • 12.3. Illumina Inc.
  • 12.4. Bio-Rad Laboratories Inc.
  • 12.5. Qiagen N.V.
  • 12.6. Becton, Dickinson and Company
  • 12.7. Abcam PLC
  • 12.8. Tianjin JingMing New Tech. Devp. Co., Ltd
  • 12.9. Hanson Meditec Co., Ltd.
  • 12.10. Huaian Meide Medical Instrument Co., Ltd (*LIST NOT EXHAUSTIVE)

13. Global Biological Multiplex Assays Market - DataM

  • 13.1. Appendix
  • 13.2. About Us and Services
  • 13.3. Contact Us