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市場調査レポート
商品コード
1020361
視神経脊髄炎(デビック症候群)の世界市場(2021年~2028年)Global Neuromyelitis Optica (Devic's Syndrome) Market - 2021-2028 |
視神経脊髄炎(デビック症候群)の世界市場(2021年~2028年) |
出版日: 2021年07月28日
発行: DataM Intelligence
ページ情報: 英文 180 Pages
納期: 約2営業日
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デビック病として知られる視神経脊髄炎スペクトラム障害(NMOSD)は、視神経の炎症(視神経炎)と脊髄の炎症(脊髄炎)を主症状とする脳と脊髄の慢性疾患です。
当レポートは、世界の視神経脊髄炎(デビック症候群)市場について調査しており、市場規模、機会や影響、成長および抑制要因、COVID-19による影響、製品タイプ・用途・地域別の市場分析、競合情勢、主要企業のプロファイルなどの情報を提供しています。
Neuromyelitis Optica (Devic's Syndrome) Market. Overview
The Neuromyelitis Optica (Devic's Syndrome) Market. The size was valued at US$ XX billion in 2020 and is estimated to reach US$ XX billion by 2028, growing at a CAGR of XX % during the forecast period (2021-2028).
Neuromyelitis optica spectrum disorder (NMOSD) ,known as Devic disease, is a chronic disorder of the brain and spinal cord which is dominated by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis).
Neuromyelitis Optica (Devic's Syndrome) Market. Dynamics
An increase in neuromyelitis optica (Devic's syndrome ) incidence will drive the market. Morever increase in research and development by key players will see a rise in its market.
An increase in neuromyelitis optica (Devic's syndrome ) incidence will drive the market
Neuromyelitis optica or NMO is also called devic's disease , is an immunological disorder. It is often characterized by immune attacks on the optic nerves (which transmit what you see to your brain) and the spinal cord. The FDA recently approved two drugs to treat it. Eculizumab (Soliris), inebilizumab-cdon (Uplizna), and satralizumab-mwge (Enspryng) they work by targeting the defective antibodies that attack the healthy cells in your body, triggering NMO. A doctor may prescribe other drugs to suppress the immune system.
NMOSD occurs in individuals of all races. Its prevalence is approximately 1-10 per 100,000 individuals. Though somewhat higher rates have been reported in countries with a higher proportion of individuals of African ancestry, it seems to be similar worldwide.
An increase in research and development will increase the market in the forecast period
In recent years, scientists and clinical neurologists have gained enormous interest in the condition, fuelled by detecting a specific serum immunoglobulin (Ig)G reactivity (NMO-IgG) in up to 80% of patients with NMO. These autoantibodies were later shown to target aquaporin-4 (AQP4), the most abundant water channel in the central nervous system (CNS).
The U.S. FDA has approved Soliris (eculizumab) injection in the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive for intravenous use. NMOSD is an autoimmune disease of the CNS that affects the optic nerves and spinal cord. Soliris provided the first FDA-approved treatment for neuromyelitis optica spectrum disorder, a debilitating disease.
Genentech Inc. for Enspryng (satralizumab-mwge) is approved as a treatment for the rare autoimmune condition neuromyelitis optica spectrum disorder (NMOSD) by the U.S. Drug and Food Administration.
Unavailability of disease specific treatment will hamper the market
Neuromyelitis Optica (Devic's Syndrome) is a relatively rare disease, there are have been no large-scale studies of treatment for this disease. Treatment for an acute attack of Devic's begins with intravenous steroids and is then followed by oral steroids. Incase the steroids are not effective, a treatment known as plasmapheresis is generally used. This therapy cleans the antibodies from the blood by circulating them through a machine, similar to how dialysis works. This disease does not appear to respond to standard medications for multiple sclerosis. There is no cure, but their medicines and treatments may inhibit future disease flares.Patients with neuromyelitis optica (NMO) patients have a 91% to 98% five-year survival rate. Current research indicates that neuromyelitis optica (NMO) patients have a 91% to 98% five-year survival rate.
COVID-19 Impact Analysis
COVID-19 has impacted the healthcare sector and also has a notable impact on the neuromyelitis optica (Devic's Syndrome) market. The admissions due to neuromyelitis optica (Devic's Syndrome) have gone down with increasing demand for COVID-19 treatment in hospitals, and even pharmaceutical companies' interest was more in the development of vaccines for COVID-19. Hence the market was affected by COVID-19.
Neuromyelitis Optica (Devic's Syndrome) Market. Segment Analysis
Eculizumab will dominate this segment of the market
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease of the CNS distinct from multiple sclerosis and typically presents with a relapsing course of optic neuritis, myelitis and midline brain inflammatory lesions. In at least two-thirds of cases, antibodies against the water channel AQP4 can be found, leading to an antibody-mediated activation of the complement system with consecutive damage to neuronal structures. Eculizumab, a humanized monoclonal antibody against the terminal complement component 5, was shown to significantly reduce the risk of NMOSD relapse in Phase III placebo-controlled trial. Based on this, eculizumab (Soliris®) was the first drug to be formally approved to treat anti-AQP4antibody-positive NMOSD in 2019.
The U.S. FDA has approved Soliris (eculizumab) injection for intravenous use in the treatment of neuromyelitis optica spectrum disorder (NMOSD) in patients with anti-aquaporin-4 (AQP4) antibody positive.
The hospital segment will dominate the market
Treatment for NMO generally consists of two parts: addressing current attack and preventing the future attacks. During the initial attack, healthcare team will try to get the condition and its symptoms under control. Treatment at this stage is often intravenous corticosteroids and plasma exchange (PLEX).
More than 90% of patients with NMO experience more than one attack, with the attacks being usually severe. Doctors typically recommend ongoing treatment to help prevent future attacks and disease progression. This usually involves immunotherapy, which is a type of treatment that modulates the immune system. The patient should be assisted by doctors during this treatment, and hospitals provide a better facility for the treatment.
Neuromyelitis Optica (Devic's Syndrome) Market. Geographical Analysis
North America will dominate neuromyelitis optica (Devic's Syndrome) market in the forecast period
Increased incidence of neuromyelitis optica (Devic's Syndrome) and major key players in this region will drive the market.
There are approximately 1,000 to 3,000 Canadians living with NMOSD, with the disease being most commonly diagnosed among non-Caucasian women in their 20s to 40s. People with NMOSD experience unpredictable, severe relapses causing cumulative, permanent neurological damage and disability.
The U.S. Drug and Food Administration has approved Genentech Inc. for Enspryng (satralizumab-mwge). AR 50% of patients with NMOSD have permanent visual impairment and paralysis. In the U.S, it is thought to affect approximately 4,000-8,000 Americans.
Neuromyelitis Optica (Devic's Syndrome) Market. Competitive Landscape
Some prominent key players in this market are Alexion Pharmaceuticals, Inc., Hoffmann-La Roche Ltd, Viela Bio, Genentech, Inc., AstraZeneca, Shanghai Pharmaceutical Group Co., Ltd., China Resources Pharmaceutical GroupCo., Ltd. and Guangzhou Baiyunshan Pharmaceutical Group Co., Ltd. SAGENT PHARMACEUTICALS, INC. and ZYDUS PHARMACEUTICALS, INC.
Neuromyelitis Optica (Devic's Syndrome) Market. Key Companies to Watch
Alexion Pharmaceuticals, Inc
Overview: Alexion Pharmaceuticals Inc best known for its development of Soliris, is an American pharmaceutical company which developed a drug used to treat the rare disorders atypical hemolytic uremic syndrome and paroxysmal nocturnal hemoglobinuria. It is also involved in immune system research related to autoimmune diseases.
Product Portfolio: The company's mission is to transform the lives of people living with rare diseases,devastating conditions through the development , delivery of innovative medicine, supportive technologies, and healthcare services.
Key Development: On Jun. 27, 2019, Alexion Pharmaceuticals, Inc. (NASDAQ: ALXN) announced that the U.S. FDA has approved SOLIRIS® (eculizumab) for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients with anti-aquaporin-4 (AQP4) antibody positive.1 Approximately three-quarters (73%) of all patients with NMOSD test positive for anti-AQP4 auto-antibodies.2 The FDA approved SOLIRIS following an expedited six-month priority review.
The neuromyelitis optica (Devic's Syndrome) market. report would provide an access to an approx. 52 market data table, 43 figures and 200 pages.
Neuromyelitis Optica (Devic's Syndrome) Market. - By Product Type
Neuromyelitis Optica (Devic's Syndrome) Market. - By Application
Neuromyelitis Optica (Devic's Syndrome) Market. - By Region
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