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慢性リンパ性白血病:KOL (キーオピニオンリーダー) による分析

Chronic Lymphocytic Leukaemia: KOL Insight

発行 FirstWord 商品コード 304343
出版日 ページ情報 英文
納期: 即日から翌営業日
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慢性リンパ性白血病:KOL (キーオピニオンリーダー) による分析 Chronic Lymphocytic Leukaemia: KOL Insight
出版日: 2016年08月01日 ページ情報: 英文
概要

当レポートでは、慢性リンパ性白血病 (CLL) の上市済み薬剤6種および開発後期の薬剤7種を取り上げ、北米および欧州の12名のキーオピニオンリーダー(KOL) による各種見解をまとめています。

調査対象薬剤の例

  • Venclexta (ベネトクラックス:AbbVie/Roche)
  • Imbruvica (イブルチニブ:AbbVie/Johnson & Johnson)
  • アカラブルチニブ (Acerta Pharmaceuticals/AstraZeneca)
  • TGR-1202 (TG Therapeutics)、など

主な論点

  • 抗CD20モノクローナル抗体薬・化学療法薬:一次治療として現在のところ主流
    • 化学療法薬による一次治療に変わる選択肢
    • 有望を考えられる薬剤とその理由
  • Imbruvica:有効性で高い評価を得ているが、治療スケジュールの不定性が欠点に
    • 将来の治療薬としてKOLが模索するもの
    • 新たな臨床研究がその考察にどのように影響する可能性があるか
  • KOL:併用療法へのより一層の研究を要望
    • 併用薬が既存の治療パラダイムにもたらす影響について専門家はどう考えるか
  • CLL治療薬の毒性についての専門家の懸念
  • CLL治療薬としてのリツキシマブバイオシミラーの利用へのKOLの見解
  • 今日までに報告されているアカラブルチニブの有効性は素晴らしいものと専門家は賛同
  • CLLの「ゲームチェンジャー」としてのVenclexta
    • Venclextaの評価が非常に高い中でKOLは他のパイプライン薬をどう考えるか?
  • RevlimidおよびCDK阻害剤は新しい作用機序を提供と専門家は指摘、など

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次
Product Code: 596200636

How will established and emerging agents reshape the CLL treatment landscape?

How do key opinion leaders (KOLs) see the future treatment paradigm for chronic lymphocytic leukaemia (CLL) shaping up? Will Gazyva's/Gazyvaro's superior efficacy compared to Rituxan/MabThera influence prescribing decisions? How will familiarity, convenience and tolerability influence Imbruvica's continued uptake? What pipeline therapies do KOLs have their eyes on? Do KOLs predict a significant change in the CLL treatment paradigm in the future?

Covering 6 marketed drugs and 7 late-stage pipeline therapies, this report reveals candid insights about the CLL landscape from 12 KOLs in North America and Europe. You'll learn which treatments KOLs consistently choose (and why!), what influences their prescribing of other treatment options, and which pipeline drugs they're most excited about.

“Everything will change. How we will be treating our patients in one year to 18 months will be completely different. Venclexta is coming. Maybe we will be treating all patients in first-line with the BTK inhibitors, and we will be treating all patients in the relapsed/refractory setting with Venclexta.” US KOL.

Take a tour of the report now:

  • The table of contents
  • The key questions answered
  • The key KOL quotes
  • See the 13 therapies covered
  • Find out who the 12 EU & US KOLs are
  • Review an extract from the report - 1 drug profile

Sample of brands covered:

  • Venclexta (venetoclax, AbbVie/Roche)
  • Imbruvica (ibrutinib, AbbVie/Johnson & Johnson)
  • Acalabrutinib (Acerta Pharmaceuticals/AstraZeneca)
  • TGR-1202 (TG Therapeutics)
  • Plus 9 more

Sample of KOLS interviewed

  • Michael J. Keating. Professor of Medicine and Internist, University of Texas MD Anderson Cancer Center, TX.
  • Daniel Catovsky. Emeritus Professor and Fellow, Institute of Cancer Research, London, UK.
  • Emili Montserrat. Professor of Medicine and Director of the Institute of Haematology and Oncology, Hospital Clinic of Barcelona, Spain.
  • Anthony R. Mato. Assistant Professor of Medicine, Hospital of the University of Pennsylvania, PA.
  • Plus 8 more - download the full list now

Top Takeaways

  • Anti-CD20 mAb therapy and chemotherapy dominate at first line - for now. KOLs want to see chemotherapies in first-line replaced by other options. Which agents do they find particularly exciting, and why?
  • While Imbruvica gets high marks for efficacy, its indeterminate treatment schedule is a drawback. What else are KOLs looking for in future treatments? And how could new clinical studies influence thinking?
  • KOLs would like to see more investigation into combination therapy regimens. Find out how experts think combinations could challenge established treatment paradigms.
  • Experts are concerned about the toxicity of CLL treatments. Have FDA safety alerts relegated Zydelig to last-resort status? Will unanswered questions affect the uptake of emerging treatment choices?
  • KOLs provide their views on the use of rituximab biosimilars as treatments for CLL. Should a rituximab biosimilar be approved as a treatment for CLL via indication extrapolation, will it be used? Will cost be the key driver of uptake? Or will Gazyva's/Gazyvaro's superior efficacy limit adoption of rituximab biosimilars altogether?
  • Experts concur that the efficacy reported with acalabrutinib to date is impressive. But do they think it could completely replace Imbruvica in CLL? If not, why not?
  • Venclexta is a ‘game-changer' in CLL. In the context of high enthusiasm for Venclexta, how do KOLs perceive other pipeline agents, in particular PI3K delta or dual inhibitors of P13K delta/gamma?
  • Experts note that Revlimid and CDK inhibitors offer novel mechanisms of action. Are they impressed, and will these options have any potential in CLL?
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