市場調査レポート
商品コード
1118529
全身型重症筋無力症(gMG)市場 - 市場考察、疫学、市場予測(2032年)Generalized Myasthenia Gravis (gMG) - Market Insight, Epidemiology And Market Forecast - 2032 |
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全身型重症筋無力症(gMG)市場 - 市場考察、疫学、市場予測(2032年) |
出版日: 2022年08月01日
発行: DelveInsight
ページ情報: 英文 182 Pages
納期: 1~3営業日
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主要7市場(米国・ドイツ・フランス・イタリア・スペイン・英国・日本)の全身型重症筋無力症(gMG)の市場規模は、2021年に26億9,000万米ドルでした。
当レポートでは、世界の全身型重症筋無力症(gMG)市場について調査分析し、市場の考察、疫学、地域分析などを提供しています。
DelveInsight's, 'Generalized Myasthenia Gravis (gMG)-Market Insights, Epidemiology, and Market Forecast-2032' report delivers an in-depth understanding of the Generalized Myasthenia Gravis (gMG), historical and forecasted epidemiology as well as the market trends in the United States, EU-5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.
The Generalized Myasthenia Gravis (gMG) market report provides current treatment practices, emerging drugs, and their market share of the individual therapies, current and forecasted Generalized Myasthenia Gravis (gMG) symptoms market size from 2019 to 2032 segmented by the seven major markets. The report also covers current Generalized Myasthenia Gravis (gMG) symptoms, diagnostic and treatment practice guidelines/algorithm and unmet medical needs to curate the best opportunities. It assesses the underlying potential of the market.
Study Period: 2019-2032
Generalized Myasthenia Gravis (gMG) Disease Background and Treatment Algorithm
Generalized Myasthenia Gravis (gMG) Overview
Myasthenia gravis (MG) is an autoimmune disease that occurs when the immune system attacks the body's own tissues. In MG, that attack interrupts the connection between nerve and muscle-the neuromuscular junction. MG is characterized mostly by autoantibodies against the acetylcholine receptor (AChR-Ab) or against a receptor-associated protein called muscle-specific tyrosine kinase (MuSK-Ab).
Generalized Myasthenia Gravis (gMG) Diagnosis and Treatment
This section covers the details of conventional and current medical therapies and diagnosis available in the Generalized Myasthenia Gravis (gMG) market to treat the condition. It also provides the country-wise treatment guidelines and algorithms across the United States, Europe, and Japan.
DelveInsight's, 'Generalized Myasthenia Gravis (gMG) market report' thoroughly understands Generalized Myasthenia Gravis (gMG) symptoms by including disease definition, symptoms, causes, physiology, and diagnosis. It also provides Generalized Myasthenia Gravis (gMG) treatment algorithms and treatment guidelines for Generalized Myasthenia Gravis (gMG) symptoms in the US, Europe, and Japan.
At present, the therapeutic market size of Myasthenia Gravis is mainly accounted by symptomatic treatments, including acetylcholinesterase inhibitors (Pyridostigmine), short-term immunosuppressants (corticosteroids), long-term immunosuppressant (azathioprine, cyclosporine, cyclophosphamide, methotrexate, mycophenolate mofetil, rituximab, tacrolimus), rapid-acting short- term immunomodulators (intravenous immunoglobulin, plasma exchange), and long-term immunomodulatory procedures (thymectomy).
Few major unmet needs in the market include therapeutic and diagnostic challenges, economic and humanistic burden, role of thymus and thymectomy warrants further research, and incidence of meningococcal infection in people treated with Soliris (eculizumab).
The Generalized Myasthenia Gravis (gMG) symptoms epidemiology division provides insights into the historical and current patient pool and the forecasted trend for every seven major countries. It helps recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the DelveInsight report also provides the diagnosed patient pool and their trends and assumptions.
Key Findings
The total diagnosed prevalent cases of Generalized Myasthenia Gravis (gMG) patients in the 7MM are increasing during the study period, i.e., 2019-2032.
The disease epidemiology covered in the report provides historical as well as forecasted Generalized Myasthenia Gravis (gMG) epidemiology segmented as the total diagnosed prevalent cases of Generalized Myasthenia Gravis (gMG), gender-specific cases of Generalized Myasthenia Gravis (gMG), and antibodies-specific cases of Generalized Myasthenia Gravis (gMG). The report includes the diagnosed prevalent cases scenario of Generalized Myasthenia Gravis (gMG) in the 7MM covering the United States, EU-5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2019 to 2032.
The epidemiology segment also provides the Generalized Myasthenia Gravis (gMG) epidemiology data and findings across the United States, EU-5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
The total number of diagnosed prevalent cases of Generalized Myasthenia Gravis (gMG) associated in the 7MM countries was approximately 116,100 in 2021.
The Generalized Myasthenia Gravis (gMG) report's drug chapter segment encloses the detailed analysis of Generalized Myasthenia Gravis (gMG) early-stage (Phase I, II, and III) pipeline drugs. It also helps understand the Generalized Myasthenia Gravis (gMG) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.
Generalized Myasthenia Gravis (gMG) Emerging Drugs
Rozanolixizumab: UCB Biopharma
Rozanolixizumab is a subcutaneously administered, humanized monoclonal antibody that specifically binds, with high affinity, to the human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and Immunoglobulin G (IgG), accelerating antibodies' catabolism and reducing pathogenic IgG autoantibodies' concentration. Rozanolixizumab is under clinical development to improve the lives of people with pathogenic IgG-autoantibody-driven autoimmune diseases, including gMG, primary immune thrombocytopenia (ITP), myelin oligodendrocyte glycoprotein antibody-associated disease (MOG-AD) and autoimmune encephalitis (AIE) by driving removal of pathogenic IgG autoantibodies.
The drug is currently being evaluated in Phase III of its clinical trials for the treatment of generalized myasthenia gravis.
Subcutaneous Efgartigimod: Argenx-Halozyme Therapeutics
Subcutaeous Efgartigimod is a novel formulation of the drug VYVGART (efgartigimod alfa-fcab). VYVGART is the first and only approved FcRn blocker. It is a human IgG1 antibody fragment that binds to the neonatal Fc receptor (FcRn), resulting in the reduction of circulating immunoglobulin G (IgG) autoantibodies Subcutaneous Efgartigimod is co-formulated with recombinant human hyaluronidase PH20 (rHuPH20). Halozyme's ENHANZE drug delivery technology allows for subcutaneous delivery of biologics that are typically administered via infusion. This new formulation aims to provide subcutaneous administration options for patients based on individual preferences. SC Efgratigimod completed its Phase III clinical trials and positive results of pivotal studies were released in March 2022.
Other Products detailed in the report…
The report's Generalized Myasthenia Gravis (gMG) market outlook helps to better understand the historic, current, and forecasted Generalized Myasthenia Gravis (gMG) market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers, and demand for better technology.
This segment gives a thorough detail of Generalized Myasthenia Gravis (gMG) market trend of each marketed drug and early-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to view the market at first sight.
According to DelveInsight, the Generalized Myasthenia Gravis (gMG) market in the 7MM is expected to grow steadily during the study period 2019-2032.
The mainstay of treatment in MG involves cholinesterase enzyme inhibitors and immunosuppressive agents. Symptoms resistant to primary treatment modalities or those requiring rapid resolution of symptoms (myasthenic crisis), plasmapheresis, or intravenous immunoglobulins can be used.
The major market players in Generalized Myasthenia Gravis (gMG) therapeutic market are UCB Biopharma, Argenx-Halozyme Therapeutics, Horizon Therapeutics, among others.
Key Findings
This section includes a glimpse of the Generalized Myasthenia Gravis (gMG) market in 7MM. Generalized Myasthenia Gravis (gMG) market size in the seven major markets was USD 2,690 million in 2021.
This section provides the total Generalized Myasthenia Gravis (gMG) market size and market size by therapies in the United States.
The United States accounts for the largest market size of Generalized Myasthenia Gravis (gMG) compared to the EU-5 (the United Kingdom, Germany, Italy, France, and Spain) and Japan.
The total Generalized Myasthenia Gravis (gMG) market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.
The total Generalized Myasthenia Gravis (gMG) market size and market size by therapies in Japan are also mentioned.
This section focuses on the uptake of the potential drugs recently launched or expected to get launched in the market during the study period 2019-2032. The analysis covers the Generalized Myasthenia Gravis (gMG) market uptake by drugs, patient uptake by therapies, and sales of each drug.
This helps understand the drugs with the most rapid uptake, reasons behind the maximal use of new drugs, and the comparison of the drugs based on market share and size, which will again be useful in investigating factors important in the market uptake and in making financial and regulatory decisions.
Generalized Myasthenia Gravis (gMG) Pipeline Development Activities
The report provides insights into the therapeutic candidate in Phase I, II, and III stages. It also analyses Generalized Myasthenia Gravis (gMG) key players involved in developing targeted therapeutics.
Major market players includes UCB Biopharma, Argenx-Halozyme Therapeutics, Horizon Therapeutics, among others.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition, and merger, licensing, and patent details for Generalized Myasthenia Gravis (gMG) emerging therapies.
In April 2020, UCB Biopharma announced that the European Commission had granted Orphan Drug Designation to Rozanolixizumab to treat myasthenia gravis.
Reimbursement Scenario in Generalized Myasthenia Gravis (gMG)
Proactively approaching reimbursement can induce a positive impact both during the early stages of product development and well after product launch. The report considers reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with better market access can be a critical business and price strategy.
Medical treatment is based on cholinesterase inhibitors, corticosteroids, and immunosuppressants. Long-term maintenance therapy poses some caveats. Many patients need high doses of prednisone to do well, but the potential side effects of corticosteroids make the clinicians substitute prednisone for immunosuppressive drugs, including azathioprine, cyclosporine, tacrolimus, mycophenolate, and Rituximab. Plasma exchange/Plasmapheresis (PE/PP) is also effective against anti-AChR antibody-negative MG.
The My VYVGART Path by Argnex offers multiple resources to patients, including insurance and reimbursement support. Similarly, Alexion OneSource CoPay Program helps patients have commercial or private insurance and unapproved prescription coverage. The program pays for eligible out-of-pocket medication and infusion costs associated with Soliris (eculizumab) up to USD 15,000 US dollars per calendar year.
In an economic evaluation, the mean per-patient annual direct medical cost of illness was estimated at between USD 760 in Japan and USD 28,780 in the US, and the cost per hospitalization between USD 2,550 and USD 164,730. The indirect cost of illness was estimated at USD 80 and USD 3,550.
KOL Views
To keep up with current market trends, we take KOLs and SMEs' opinions working in the Generalized Myasthenia Gravis (gMG) domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps understand and validate current and emerging therapies treatment patterns or Generalized Myasthenia Gravis (gMG) market trends. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the market and the unmet needs.
Competitive Intelligence Analysis
We perform a Competitive and Market Intelligence analysis of the Generalized Myasthenia Gravis (gMG) Market by using various Competitive Intelligence tools: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.
Key Questions
Market Insights:
Epidemiology Insights:
Current Treatment Scenario, Marketed Drugs, and Emerging Therapies: