VRAYLAR：新薬の考察と市場予測 (2032年)

VRAYLARはカリプラジンとも呼ばれる経口非定型の抗精神病薬です。本剤は、強力な中枢性ドパミンD3およびD2受容体の部分作動薬であり、D3受容体に優先的に結合します。また、セロトニン5-HT1A受容体に対しては部分作動薬として、セロトニン5-HT2A受容体に対しては拮抗薬として作用します。カリプラジンの薬力学的研究により、ドパミンD3、ドパミンD2およびセロトニン5-HT1A受容体に高い結合親和性を有する部分作動薬として作用することが示されています。カリプラジンは、ドパミンD3受容体とD2受容体に対して、in vitroで最大8倍の親和性を示しました。また、セロトニン5-HT2Bおよび5-HT2A受容体に対しては、それぞれ高・中程度の結合親和性で拮抗薬として作用し、ヒスタミンH1受容体に対しても結合します。セロトニン5-HT2Cおよびα1Aアドレナリン受容体には低い結合親和性を示し、コリン作動性ムスカリン受容体には顕著な親和性を示しません。

当レポートでは、治療抵抗性うつ病の治療薬の一種であるVRAYLARの市場構造・動向について分析し、製品の概要 (用法・容量、作用機序など) や関連規制、製品開発・治験の進行状況、主要7ヶ国 (米国、欧州5ヶ国 (ドイツ、フランス、イタリア、スペイン、英国)、日本) の市場規模の動向見通し (2023～2032年)、市場の競争状態・SWOT分析、他の治療薬との競合状態、今後の市場成長の可能性などを調査・考察しております。

目次

第1章 分析概要

第2章 治療抵抗性うつ病向けVRAYLAR：概要

• 製品の詳細
• 臨床開発
  • 臨床研究
  • 治験情報
  • 安全性と有効性
• その他の開発活動
• 製品プロファイル

第3章 競合情勢 (後期段階の新興治療薬)

第4章 VRAYLARの市場評価

• 治療抵抗性うつ病向けVRAYLAR：市場展望
• 主要7ヶ国の市場分析
  • 治療抵抗性うつ病向けVRAYLAR：主要7ヶ国の市場規模
• 国別の市場分析
  • 米国
  • ドイツ
  • 英国

第5章 SWOT分析

第6章 アナリストの見解

第7章 付録

第8章 DelveInsightのサービス内容

第9章 免責事項

第10章 DelveInsightについて

第11章 レポート購入オプション

List of Tables

• Table 1: VRAYLAR, Clinical Trial Description, 2022
• Table 2: VRAYLAR, General Description, 2022
• Table 3: Competitive Landscape (Emerging Therapies)
• Table 4: VRAYLAR Market Size in the 7MM, in USD million (2019-2032)
• Table 5: VRAYLAR Market Size in the US, in USD million (2019-2032)
• Table 6: VRAYLAR Market Size in Germany, in USD million (2019-2032)
• Table 7: VRAYLAR Market Size in France, in USD million (2019-2032)
• Table 8: VRAYLAR Market Size in Italy, in USD million (2019-2032)
• Table 9: VRAYLAR Market Size in Spain, in USD million (2019-2032)
• Table 10: VRAYLAR Market Size in the UK, in USD million (2019-2032)
• Table 11: VRAYLAR Market Size in Japan, in USD million (2019-2032)

List of Figures

• Figure 1: VRAYLAR Market Size in the 7MM, USD million (2019-2032)
• Figure 2: VRAYLAR Market Size in the United States, USD million (2019-2032)
• Figure 3: VRAYLAR Market Size in Germany, USD million (2019-2032)
• Figure 4: VRAYLAR Market Size in France, USD million (2019-2032)
• Figure 5: VRAYLAR Market Size in Italy, USD million (2019-2032)
• Figure 6: VRAYLAR Market Size in Spain, USD million (2019-2032)
• Figure 7: VRAYLAR Market Size in the United Kingdom, USD million (2019-2032)
• Figure 8: VRAYLAR Market Size in Japan, USD million (2019-2032)

"VRAYLAR, Emerging Drug Insight and Market Forecast - 2032" report provides comprehensive insights about VRAYLAR for Treatment Resistant Depression in seven major markets. A detailed picture of the VRAYLAR for Treatment Resistant Depression in 7MM, i.e., United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan, for the study period 2019 -2032 is provided in this report along with a detailed description of the VRAYLAR for Treatment Resistant Depression. The report provides insights about mechanism of action, dosage and administration, as well as research and development including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the VRAYLAR market forecast analysis for Treatment Resistant Depression in 7MM, SWOT, analyst views, comprehensive overview of market competitors, and brief about other emerging therapies in Treatment Resistant Depression.

Drug Summary:

VRAYLAR also known as Cariprazine is an oral, once-daily atypical antipsychotic. It is a potent central dopamine D3 and D2 receptor partial agonist, which preferentially binds to the D3 receptor. It also has partial agonist activity at serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. Pharmacodynamic studies with cariprazine have shown that it acts as a partial agonist with a high binding affinity at dopamine D3, dopamine D2, and serotonin 5-HT1A receptors. Cariprazine demonstrated up to eightfold greater in vitro affinity for dopamine D3 vs. D2 receptors. Cariprazine also acts as an antagonist at serotonin 5-HT2B and 5-HT2A receptors with high and moderate binding affinity, respectively, as well as it binds to the histamine H1 receptors. It shows a lower binding affinity to the serotonin 5-HT2C and α1A-adrenergic receptors and has no appreciable affinity for cholinergic muscarinic receptors.

It was discovered and co-developed by Gedeon Richter and is licensed to Actavis, now Allergan, in the US and Canada. For more than a decade, both companies have conducted over 20 clinical trials enrolling thousands of patients worldwide to evaluate the efficacy and safety of cariprazine for patients suffering from a broad range of mental health illnesses.

Scope of the Report:

The report provides insights into:

• A comprehensive product overview including the VRAYLAR description, mechanism of action, dosage and administration, research and development activities in Treatment Resistant Depression.
• Elaborated details on VRAYLAR regulatory milestones and other development activities have been provided in this report.
• The report also highlights the VRAYLAR research and development activities in Treatment Resistant Depression across the United States, Europe and Japan.
• The report also covers the patents information with expiry timeline around VRAYLAR.
• The report contains forecasted sales of VRAYLAR for Treatment Resistant Depression till 2032.
• Comprehensive coverage of the late-stage emerging therapies for Treatment Resistant Depression.
• The report also features the SWOT analysis with analyst views for VRAYLAR in Treatment Resistant Depression.

Methodology:

The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by DelveInsight's team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.

VRAYLAR Analytical Perspective by DelveInsight

• In-depth VRAYLAR Market Assessment

This report provides a detailed market assessment of VRAYLAR for Treatment Resistant Depression in seven major markets, i.e., United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. This segment of the report provides forecasted sales data from 2023 to 2032.

• VRAYLAR Clinical Assessment

The report provides the clinical trials information of VRAYLAR for Treatment Resistant Depression covering trial interventions, trial conditions, trial status, start and completion dates.

Report Highlights:

• In the coming years, the market scenario for Treatment Resistant Depression is set to change due to the extensive research and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
• The companies are developing therapies that focus on novel approaches to treat/improve the disease condition, assess challenges, and seek opportunities that could influence VRAYLAR dominance.
• Other emerging products for Treatment Resistant Depression are expected to give tough market competition to VRAYLAR and launch of late-stage emerging therapies in the near future will significantly impact the market.
• A detailed description of regulatory milestones, and developmental activities, provide the current development scenario of VRAYLAR in Treatment Resistant Depression.
• Our in-depth analysis of the forecasted sales data of VRAYLAR from 2023 to 2032 will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the VRAYLAR in Treatment Resistant Depression.

Key Questions

• What is the product type, route of administration and mechanism of action of VRAYLAR?
• What is the clinical trial status of the study related to VRAYLAR in Treatment Resistant Depression and study completion date?
• What are the key collaborations, mergers and acquisitions, licensing and other activities related to the VRAYLAR development?
• What are the key designations that have been granted to VRAYLAR for Treatment Resistant Depression?
• What is the forecasted market scenario of VRAYLAR for Treatment Resistant Depression?
• What are the forecasted sales of VRAYLAR in the seven major countries, including the United States, Europe (Germany, France, Italy, Spain, and the United Kingdom), and Japan?
• What are the other emerging products available and how are these giving competition to VRAYLAR for Treatment Resistant Depression?
• Which are the late-stage emerging therapies under development for the treatment of Treatment Resistant Depression?

Table of Contents

1. Report Introduction

2. VRAYLAR overview in Treatment Resistant Depression

• 2.1. Product Detail
• 2.2. Clinical Development
  • 2.2.1. Clinical Studies
  • 2.2.2. Clinical Trials Information
  • 2.2.3. Safety and Efficacy
• 2.3. Other Developmental Activities
• 2.4. Product Profile

3. Competitive Landscape (Late-stage Emerging Therapies)

4. VRAYLAR Market Assessment

• 4.1. Market Outlook of VRAYLAR in Treatment Resistant Depression
• 4.2. 7MM Market Analysis
  • 4.2.1. Market Size of VRAYLAR in the 7MM for Treatment Resistant Depression
• 4.3. Country-wise Market Analysis
  • 4.3.1. Market Size of VRAYLAR in the United States for Treatment Resistant Depression
  • 4.3.2. Market Size of VRAYLAR in Germany for Treatment Resistant Depression
  • 4.3.3. Market Size of VRAYLAR in France for Treatment Resistant Depression
  • 4.3.4. Market Size of VRAYLAR in Italy for Treatment Resistant Depression
  • 4.3.5. Market Size of VRAYLAR in Spain for Treatment Resistant Depression
  • 4.3.6. Market Size of VRAYLAR in the United Kingdom for Treatment Resistant Depression
  • 4.3.7. Market Size of VRAYLAR in Japan for Treatment Resistant Depression

5. SWOT Analysis

6. Analysts' Views

7. Appendix

• 7.1. Bibliography
• 7.2. Report Methodology

8. DelveInsight Capabilities

9. Disclaimer

10. About DelveInsight

11. Report Purchase Options