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医薬品分析:Menactra

Menactra

発行 Datamonitor Healthcare 商品コード 912150
出版日 ページ情報 英文 12 Pages
納期: 即日から翌営業日
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本日の銀行送金レート: 1USD=111.33円で換算しております。
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医薬品分析:Menactra Menactra
出版日: 2019年09月03日 ページ情報: 英文 12 Pages
概要

Sanofi社のMenactraは、4価多糖体ジフテリアトキソイド結合ワクチンで、髄膜炎菌 (血清型A、C、Y、W-135) による侵襲性髄膜炎菌感染症 (IMD) の予防を目的としています。

当レポートでは、Menactraについて調査分析し、医薬品の概要、製品プロファイルなどについて、体系的な情報を提供しています。

概要

  • 医薬品の概要
  • 製品プロファイル
  • Menactra:髄膜炎菌ワクチン
目次
Product Code: DMKC0157428

Drug Overview

Menactra (Sanofi) is a quadrivalent polysaccharide diphtheria toxoid conjugate vaccine indicated for active immunization to prevent invasive meningococcal disease (IMD) caused by Neisseria meningitidis (N. meningitidis) serogroups A, C, Y, and W-135 in individuals aged nine months through to 55 years in the US. It contains N. meningitidis capsular polysaccharide antigens individually conjugated to diphtheria toxoid protein. The presence of bactericidal anti-capsular meningococcal antibodies has been associated with protection from IMD, and Menactra induces production of these antibodies specifically for the aforementioned serogroups.

Despite a large patient population, broad serotype coverage, and first-to-market status for meningococcal conjugate vaccines, Menactra's dominant position in the US market has been weakened by Menveo (quadrivalent oligosaccharide diphtheria CRM-197 conjugate vaccine; GlaxoSmithKline), a vaccine that covers the same serotypes and is recommended for the same risk groups as Menactra. In addition, Menveo is the only approved quadrivalent meningococcal conjugate vaccine for high-risk children aged below nine months.

The lack of clinical differentiation between the two vaccines means that competition is driven primarily by price, and Menveo possesses a competitive advantage in this regard. Menactra's US price increased slightly from $89.16 per dose in 2016 to $91.81 in 2019 for the pediatric population, whereas Menveo's price decreased from $85.22 to $73.83 per dose in the same period. This competitive pricing seems to have incentivized some prescribers to preferentially procure Menveo over Menactra, as reflected by Menveo's increasing US sales from $157.3m in 2016 to $226.2m in 2018, and Menactra's declining sales from $563.6m in 2016 to $465.2m in 2018. Sanofi is developing a successor vaccine, MenQuadfi (quadrivalent polysaccharide tetanus toxoid conjugate vaccine; Sanofi), which could cannibalize some of Menactra's market share, but it is unlikely to gain significant uptake without a discounted price, due to limited available trial data suggesting only non-inferiority to Menactra. In the long term, both of Sanofi's vaccines face a significant threat from GlaxoSmithKline's MenABCW-135Y (pentavalent meningococcal conjugate vaccine), which is being positioned to replace standalone meningococcal ACWY (MenACWY) and meningococcal B (MenB) vaccinations in persons aged ≥10 years.

TABLE OF CONTENTS

OVERVIEW

  • Drug Overview
  • Product Profiles
  • Menactra : Meningococcal vaccines

LIST OF TABLES

  • Table 1: Menactra drug profile
  • Table 2: Approval history of Menactra for meningococcal vaccination in the US and Japan
  • Table 3: Late-phase trials of Menactra for meningococcal vaccination
  • Table 4: Menactra for meningococcal disease - SWOT analysis
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