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がん治療用ミトコンドリア薬のパイプライン:最新動向

Mitochondrial Drugs in Oncology Drug Pipeline Update

発行 BioSeeker Group AB 商品コード 279113
出版日 ページ情報 英文
納期: 即日から翌営業日
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がん治療用ミトコンドリア薬のパイプライン:最新動向 Mitochondrial Drugs in Oncology Drug Pipeline Update
出版日: 2016年08月04日 ページ情報: 英文
概要

近年、がん治療におけるミトコンドリアの役割に大きな関心が集まっています。良性・悪性腫瘍の内部におけるミトコンドリアの活動に違いがあることが判明し、選択的な抗がん治療の鍵となる可能性が出てきました。ミトコンドリアの機能に直接作用する化合物は、化学療法に耐性のある癌に対する有望な代替的治療手段となっています。

当レポートでは、治験パイプライン上にある癌治療用のミトコンドリア薬の開発状況を調査し、開発事業者とそのパートナー、各薬剤の治験進行状況、標的の種類とその分子機能、標的の位置特定、発現プロファイル、関連する適応症などといった内容を取りまとめて、概略以下の構成でお届けします。

薬剤パイプラインの現状:概要

  • 研究開発企業・機関(全230社およびそのパートナー)
  • 薬剤の名称と別名
  • 創薬の段階(241種類の薬剤と848件の創薬プロジェクト)
    • パイプラインの各段階にある医薬品の件数
      • 上市済み:28件
      • 登録前:2件
      • 第III相:26件
      • 第II相:81件
      • 第I相:88件
      • 前臨床:130件
      • データ無し:1件
      • 中断:5件
      • 中止:131件
  • 適応症
  • 標的
    • 突然変異
    • 分子構造
    • 177件の標的(50種類)
    • 細胞内局在(32種類)
  • 標的の発現プロファイル
    • 正常組織(48種類)
    • がん(20種類)
    • 細胞株(47種類)
    • 一次血球(12サンプル)
  • 参照の経路
  • メカニズム
  • 化合物

薬剤プロファイル

  • 開発事業者とパートナー
  • 標的とその分子機能
  • 標的の位置確認
  • 突然変異
  • 目標経路
  • 薬剤のメカニズム
  • 薬剤開発プロジェクト
  • 薬剤の開設
  • 化合物データ
  • 特許データ
  • 登録・認証
  • 第IV相データ
  • 第III相データ
  • 第II相データ
  • 第I相データ
  • 第0相データ
  • 全臨床データ
  • 創薬データ

アプリケーションの特徴

  • 動的レポート作成機能
  • システム要件
    • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
    • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
    • Internet access (to access related internet resources)

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次
Product Code: BSG18098

Focusing on mitochondria has recently become an intriguing target for cancer therapy. It is well known that mitochondrial activity in tumor cells is suppressed and exploiting the differences in mitochondrial functions between tumor and normal cells can be the key to design selective anti-cancer therapies. Compounds that directly affect mitochondrial functions are considered to present a promising alternative approach to eradicate chemotherapy-resistant cancers, as this would for an example bypass any upstream oncogenic blockade of cell death pathways.

The present drug pipeline update is focused on the different therapeutic cancer strategies addressed to target metabolic pathways or mediators of apoptosis. The first group includes drugs that act on glycolysis, β-oxidation, electron transport chain, mitochondrial permeability and the Bcl-2/IAP family protein, the second one consists of those drugs that cause cell death through the intrinsic apoptosis pathway by promoting ROS generation or by modulating mitochondrial protein involved in apoptosis induction.

There are today 341 companies plus partners developing 373 mitochondrial drugs in oncology drugs in 1212 developmental projects in cancer. In addition, there are 5 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 156 drugs. Mitochondrial Drugs In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 223 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 220 out of the 221 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 59 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 341 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 373 mitochondrial drugs in oncology drugs in development, which have a total of 1212 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 33
  • Pre-registration# 1
  • Phase III# 32
  • Phase II# 102
  • Phase I# 116
  • Preclinical# 178
  • No Data# 17
  • Suspended# 5
  • Ceased# 156
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included mitochondrial drugs in oncology drugs are also in development for 207 other indications, where of 143 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 220 out of the 221 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 172 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 3612 structures available today among drug targets.
  • Identified drugs are linked to more than 223 different targets, divided into 59 classifications of molecular function:
  • Acid phosphatase activity
  • Aminopeptidase activity
  • ATPase activity
  • Auxiliary transport protein activity
  • Carboxypeptidase activity
  • Caspase activator activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Cytoskeletal protein binding
  • Deacetylase activity
  • DNA binding
  • DNA repair protein
  • DNA topoisomerase activity
  • GTPase activity
  • Guanyl-nucleotide exchange factor activity
  • Heat shock protein activity
  • Hydrolase activity
  • Ion channel activity
  • Isomerase activity
  • Kinase activity
  • Kinase binding
  • Kinase regulator activity
  • Ligand-dependent nuclear receptor activity
  • Ligase activity
  • Lipid kinase activity
  • Lipid phosphatase activity
  • Metallopeptidase activity
  • Molecular function unknown
  • Oxidoreductase activity
  • Phosphorylase activity
  • Protease inhibitor activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein serine/threonine phosphatase activity
  • Protein threonine/tyrosine kinase activity
  • Protein tyrosine/serine/threonine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein serine/threonine kinase activity
  • Receptor signaling protein tyrosine phosphatase activity
  • RNA binding
  • RNA-directed DNA polymerase activity
  • Serine-type peptidase activity
  • Structural constituent of cytoskeleton
  • Superoxide dismutase activity
  • T cell receptor activity
  • Transcription factor activity
  • Transcription regulator activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Ubiquitin-specific protease activity
  • Voltage-gated ion channel activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 39 different primary and alternate sub-cellular localizations:
  • Cell junction
  • Cell surface
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Extracellular matrix
  • Golgi apparatus
  • Immunological synapse
  • Intermediate filament
  • Kinetochore
  • Late endosome
  • Lysosome
  • Membrane fraction
  • Microsome
  • Microtubule
  • Mitochondrial intermembrane space
  • Mitochondrial matrix
  • Mitochondrial membrane
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleoplasm
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisomal matrix
  • Peroxisome
  • Plasma membrane
  • Ribosome
  • Sarcoplasmic reticulum
  • Secretory granule
  • Vesicle
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 373 protein expression profiles of 211 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 241 Pathways
  • KEGG# 197 Pathways
  • NCI-Nature# 240 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

  • Search, Find and Filter Panel with Initial Result Presentation
  • With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
  • The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
  • Direct linkage from inside the application to related internet resources
  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

  • Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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