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複合型がん治療薬のパイプライン:最新動向

Conjugated Drugs in Oncology Drug Pipeline Update

発行 BioSeeker Group AB 商品コード 279112
出版日 ページ情報 英文
納期: 即日から翌営業日
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複合型がん治療薬のパイプライン:最新動向 Conjugated Drugs in Oncology Drug Pipeline Update
出版日: 2016年08月04日 ページ情報: 英文
概要

複合型がん治療薬のうち、特に抗体薬複合体(ADC)には近年大きな関心が寄せられています。研究開発や効能改善も進み、抗体薬複合体の治験・認証も急速に進められています。しかし、抗体だけが分子を接合させた化合物ではなく、がん治療に適した唯一の医薬品という訳でもありません。

当レポートでは、治験パイプライン上にある複合型の癌治療薬(抗体薬複合体(ADC)など)の開発状況を調査し、開発事業者とそのパートナー、各薬剤の治験進行状況、標的の種類とその分子機能、標的の位置特定、発現プロファイル、関連する適応症などといった内容を取りまとめて、概略以下の構成でお届けします。

薬剤パイプラインの現状:概要

  • 研究開発企業・機関(全200社およびそのパートナー)
  • 薬剤の名称と別名
  • 創薬の段階(258種類の薬剤と599件の創薬プロジェクト)
    • パイプラインの各段階にある医薬品の件数
      • 上市済み:11件
      • 登録前:1件
      • 第III相:21件
      • 第II相:64件
      • 第I相:81件
      • 前臨床:155件
      • データ無し:1件
      • 中断:2件
      • 中止:116件
  • 適応症
  • 標的
    • 突然変異
    • 分子構造
    • 116件の標的(48種類)
    • 細胞内局在(21種類)
  • 標的の発現プロファイル
    • 正常組織(48種類)
    • がん(20種類)
    • 細胞株(47種類)
    • 一次血球(12サンプル)
  • 参照の経路
  • メカニズム
  • 化合物

薬剤プロファイル

  • 開発事業者とパートナー
  • 標的とその分子機能
  • 標的の位置確認
  • 突然変異
  • 目標経路
  • 薬剤のメカニズム
  • 薬剤開発プロジェクト
  • 薬剤の開設
  • 化合物データ
  • 特許データ
  • 分析
  • 第IV相データ
  • 第III相データ
  • 第II相データ
  • 第I相データ
  • 第0相データ
  • 全臨床データ
  • 創薬データ

アプリケーションの特徴

  • 動的レポート作成機能

システム要件

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次
Product Code: BSG17904

Among conjugated drugs in oncology, antibody-drug conjugates (ADCs) are by far getting the most attention as a new drug class. Owing to improved technology and appropriate targeting, the clinical application of ADCs is accelerating rapidly. But antibodies are not the only kind of compound one could conjugate small molecules to, nor the only class of compounds which one can yield targeted therapy from. This drug pipeline update gives a 360 degree account on what conjugated drugs in oncology entails, from antibody-drug conjugates to conjugated siRNAs and fusion proteins. Meet drugs which linker technology is responsive to various factors in the tumor microenvironment or 2-part drug targeting technology which concentrates the therapeutic agent from a low and harmless dose in the blood to a high therapeutic dose specifically in the target tissue. The degree of innovation among conjugated drugs in oncology is truly amazing and inspiring for any stakeholder in cancer drug development.

There are today 295 companies plus partners developing 451 conjugated drugs in oncology drugs in 1015 developmental projects in cancer. In addition, there are 2 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 145 drugs. Conjugated Drugs In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 238 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 222 out of the 225 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 51 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 295 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 451 conjugated drugs in oncology drugs in development, which have a total of 1015 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 12
  • Pre-registration# 1
  • Phase III# 25
  • Phase II# 98
  • Phase I# 118
  • Preclinical# 248
  • No Data# 8
  • Suspended# 2
  • Ceased# 145
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included conjugated drugs in oncology drugs are also in development for 186 other indications, where of 132 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 222 out of the 225 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 155 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 2336 structures available today among drug targets.
  • Identified drugs are linked to more than 238 different targets, divided into 51 classifications of molecular function:
  • ATPase activity
  • Auxiliary transport protein activity
  • B cell receptor activity
  • Carboxypeptidase activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chemokine activity
  • Cofactor binding
  • Cytokine activity
  • Deaminase activity
  • DNA binding
  • DNA topoisomerase activity
  • DNA-directed DNA polymerase activity
  • DNA-directed RNA polymerase activity
  • Extracellular matrix structural constituent
  • G-protein coupled receptor activity
  • Growth factor activity
  • Guanylate cyclase activity
  • Heat shock protein activity
  • Hormone activity
  • Hydrolase activity
  • Kinase activity
  • Kinase regulator activity
  • Ligand-dependent nuclear receptor activity
  • Ligase activity
  • Lipid kinase activity
  • Metallopeptidase activity
  • MHC class I receptor activity
  • Molecular function unknown
  • Oxidoreductase activity
  • Peptide hormone
  • Phosphoric diester hydrolase activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein serine/threonine kinase activity
  • Receptor signaling protein tyrosine phosphatase activity
  • RNA binding
  • Serine-type peptidase activity
  • Structural constituent of cytoskeleton
  • Transcription factor activity
  • Transcription regulator activity
  • Transferase activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 26 different primary and alternate sub-cellular localizations:
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Extracellular matrix
  • Golgi apparatus
  • Integral to membrane
  • Kinetochore
  • Late endosome
  • Lysosome
  • Membrane fraction
  • Mitochondrial matrix
  • Mitochondrion
  • Nucleolus
  • Nucleus
  • Perinuclear vesicle
  • Peroxisomal matrix
  • Peroxisome
  • Plasma membrane
  • Sarcoplasmic reticulum
  • Secreted
  • Secretory granule
  • Zymogen granule
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 313 protein expression profiles of 205 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 182 Pathways
  • KEGG# 165 Pathways
  • NCI-Nature# 211 Pathways
  • NetPath# 28 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

  • Search, Find and Filter Panel with Initial Result Presentation
  • With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
  • The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
  • Direct linkage from inside the application to related internet resources
  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

  • Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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