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癌治療薬パイプラインにおけるHIF-1シグナル伝達経路

HIF-1 Signaling Pathway in Cancer Drug Pipeline Update

発行 BioSeeker Group AB 商品コード 263237
出版日 ページ情報 英文
納期: 即日から翌営業日
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癌治療薬パイプラインにおけるHIF-1シグナル伝達経路 HIF-1 Signaling Pathway in Cancer Drug Pipeline Update
出版日: 2016年08月04日 ページ情報: 英文
概要

当レポートでは、HIF-1シグナル伝達経路を標的とした癌治療薬の開発状況を個別に調査分析し、開発事業者および提携事業者、開発ステージ別の分類、標的の種類と分子機能、標的の位置特定、発現プロファイル、その他の適応症などをまとめ、概略下記の構成でお届けいたします。

調査内容

  • 開発事業者(301社)・提携事業者
  • 薬剤名および異名
    • 商標名
    • ジェネリック薬
    • コードネーム
  • 開発ステージの分類:開発中のHIF-1経路標的薬剤401種・計1457件の開発プロジェクト
    • 上市済み
    • 登録前
    • 第3相
    • 第2相
    • 第1相
    • 前臨床
    • データなし
    • 中断
    • 中止
  • 適応症
  • 標的:163種の標的・45の分子機能分類
    • 抗原結合
    • 補助輸送タンパク質活性
    • カルボキシラーゼ活性
    • 触媒活性
    • 細胞接着分子活性
    • シャペロン活性
    • クロマチン結合
    • システインペプチダーゼ活性
    • サイトカイン活性
    • DNA修復タンパク質
    • DNAトポイソメラーゼ活性
    • Gタンパク質共役受容体活性
    • 成長因子活性
    • ホルモン活性
    • ヒドロラーゼ活性
    • イソメラーゼ活性
    • キナーゼ活性
    • キナーゼ結合
    • キナーゼ調節因子活性
    • 脂質キナーゼ活性
    • 脂質ホスファターゼ活性
    • 運動活性
    • オキシドレダクターゼ活性
    • ペルオキシダーゼ活性
    • プロテアーゼ阻害活性
    • タンパク質結合
    • プロテインセリン/スレオニンキナーゼ活性
    • プロテインスレオニン/チロシンキナーゼ活性
    • プロテインチロシン/セリン/スレオニンホスファターゼ活性
    • プロテインチロシンキナーゼ活性
    • 受容体活性
    • 受容体結合
    • RNA依存性DNAポリメラーゼ活性
    • 細胞骨格構成成分
    • 糖ホスファターゼ活性
    • 転写因子活性
    • 転写調節因子活性
    • 翻訳調節因子活性
    • 膜貫通受容体活性
    • 膜貫通受容体プロテインチロシンキナーゼ活性
    • トランスポーター活性
    • ユビキチン特異的プロテアーゼ、など
  • 特定標的の細胞下のロケーション:25ヵ所
    • 中心体
    • 染色体
    • クラスリン被覆小胞
    • 細胞質
    • 細胞質小胞
    • 細胞骨格
    • サイトゾル
    • 小胞体
    • エンドソーム
    • 細胞外
    • ゴルジ装置
    • ゴルジ膜
    • リソソーム
    • ミトコンドリア膜
    • ミトコンドリア
    • 核膜
    • 核小体
    • 核周囲領域
    • 核周囲小胞
    • 原形質膜
    • リボソーム
    • 筋小胞体
    • 分泌
    • 小胞

標的の発現プロファイル

  • 48種の正常組織
  • 20種の癌
  • 47種の細胞株
  • 一次血球の12サンプル

経路の照会

機序

化合物

薬剤プロファイル

  • 薬剤名
  • 治験担当医師およびパートナー
  • 標的および標的の分子機能
  • 標的の部位
  • 標的経路
  • 機序
  • 開発プロジェクト
  • 薬剤解説
  • 化合物データ
  • 特許データ
  • 分析
  • 第3相データ
  • 第2相データ
  • 第1相データ
  • 臨床前データ
  • ライセンシング情報

Drug Pipeline Updateソフトウェア・アプリケーションについて

システム要件

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次
Product Code: BSG17705

Cancer cells are characterized by rapid proliferation and require adaptive metabolic responses to allow continued biosynthesis and cell growth in the setting of decreased oxygen (O(2)) and nutrient availability. The hypoxia-inducible factors (HIFs) are a common link between adaptation to low O(2), changes in cancer metabolism, and malignant progression. This report focusses around the cancer drugs targeting the hypoxia-inducible factor 1 (HIF-1) pathway as a master regulator of oxygen homeostasis.

There are today 478 companies plus partners developing 658 HIF-1 signaling pathway targeting drugs in 2402 developmental projects in cancer. In addition, there are 4 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 246 drugs. Hif-1 Signaling Pathway In Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 236 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 231 out of the 234 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 48 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 478 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 658 HIF-1 signaling pathway targeting drugs in development, which have a total of 2402 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 48
  • Pre-registration# 6
  • Phase III# 74
  • Phase II# 182
  • Phase I# 246
  • Preclinical# 323
  • No Data# 22
  • Suspended# 4
  • Ceased# 246
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included HIF-1 signaling pathway targeting drugs are also in development for 240 other indications, where of 167 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 231 out of the 234 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 197 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 3889 structures available today among drug targets.
  • Identified drugs are linked to more than 236 different targets, divided into 48 classifications of molecular function:
  • Antigen binding
  • Auxiliary transport protein activity
  • Carboxy-lyase activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chemokine activity
  • Chromatin binding
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Deacetylase activity
  • DNA topoisomerase activity
  • G-protein coupled receptor activity
  • Growth factor activity
  • GTPase activity
  • Hormone activity
  • Hydrolase activity
  • Isomerase activity
  • Kinase activity
  • Kinase binding
  • Kinase regulator activity
  • Lipid kinase activity
  • Lipid phosphatase activity
  • Molecular function unknown
  • Motor activity
  • Oxidoreductase activity
  • Peroxidase activity
  • Protease inhibitor activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein threonine/tyrosine kinase activity
  • Protein tyrosine/serine/threonine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • RNA-directed DNA polymerase activity
  • Structural constituent of cytoskeleton
  • Sugar-phosphatase activity
  • Superoxide dismutase activity
  • T cell receptor binding
  • Transcription factor activity
  • Transcription regulator activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Ubiquitin-specific protease activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 32 different primary and alternate sub-cellular localizations:
  • Basolateral membrane
  • Cell junction
  • Cell surface
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Golgi apparatus
  • Golgi membrane
  • Integral to membrane
  • Kinetochore
  • Lysosome
  • Microtubule
  • Mitochondrial membrane
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisome
  • Plasma membrane
  • Ribosome
  • Sarcoplasmic reticulum
  • Secreted
  • Vesicle
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 359 protein expression profiles of 219 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 243 Pathways
  • KEGG# 183 Pathways
  • NCI-Nature# 242 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

  • Search, Find and Filter Panel with Initial Result Presentation
  • With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
  • The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
  • Direct linkage from inside the application to related internet resources
  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

  • Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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