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市場調査レポート

癌幹細胞を標的とした治療薬のパイプライン

Cancer Stem Cells Drug Pipeline Update

発行 BioSeeker Group AB 商品コード 251307
出版日 ページ情報 英文
納期: 即日から翌営業日
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本日の銀行送金レート: 1USD=102.95円で換算しております。
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癌幹細胞を標的とした治療薬のパイプライン Cancer Stem Cells Drug Pipeline Update
出版日: 2016年08月04日 ページ情報: 英文
概要

当レポートでは、癌幹細胞および各種伝達経路を標的とした医薬品の開発動向について調査分析し、世界の医薬品203社による684の開発プロジェクトに関する詳細データをまとめ、ソフトウェアアプリケーション形式にて、概略下記の構成でお届けいたします。

癌幹細胞を標的とした治療薬のパイプライン:概要

  • 治験責任医師
  • 薬剤名および異名
    • 商標名
    • 一般名
    • コードネーム
  • 開発段階
    • 上市済み
    • 登録済み
    • 登録前
    • 第3相
    • 第2相
    • 第1相
    • 前臨床
    • データなし
    • 中断
    • 中止
  • 適応症
  • 標的
    • ATPアーゼ活性
    • 細胞接着分子活性
    • シャペロン活性
    • システインタイプペプチダーゼ活性
    • サイトカイン活性
    • 細胞骨格タンパク質結合
    • DNA結合
    • DNA修復タンパク質
    • DNAトポイソメラーゼ活性
    • Gタンパク質共役受容体活性
    • 成長因子活性
    • GTPアーゼ活性
    • イソメラーゼ活性
    • キナーゼ活性
    • キナーゼ結合
    • キナーゼ調節因子活性
    • リガンド依存性核内受容体活性
    • リパーゼ活性、など
  • 標的発現プロファイル
  • 伝達経路の参照先
    • BioCarta
    • KEGG
    • NetPath
  • 機序
  • 化合物
    • 化合物のタイプ
    • 化学名
    • CAS番号
    • 分子重量

薬剤プロファイル:薬剤開発の発展動向の分析とレビュー

  • 薬剤名・異名
  • 治験担当医師およびパートナー
  • 標的および標的の分子機能
  • 標的の所在
  • 標的経路
  • 作用機序
  • 開発プロジェクト
  • 薬剤の解説
  • 化合物データ
  • 特許データ
  • 第3相開発段階のデータ
  • 第2相開発段階のデータ
  • 第1相開発段階のデータ
  • 臨床前開発段階のデータ
  • ライセンシング情報

システム要件

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次
Product Code: BSG17006

Treatments designed to target and destroy cancer stem cells may come to revolutionize how we treat cancer. This unique product covers both explicit cancer stem cell drug development and cancer drugs which are inhibitors of the Hedgehog, Notch, and WNT Pathway. These developmental pathways are frequently activated in neoplasms, and particularly in the rare subpopulation of cancer stem cells.

There are today 441 companies plus partners developing 648 cancer stem cells and developmental pathways drugs in 2272 developmental projects in cancer. In addition, there are 6 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 308 drugs. Cancer Stem Cells Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 329 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 322 out of the 324 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 58 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 441 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 648 cancer stem cells and developmental pathways drugs in development, which have a total of 2272 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 42
  • Registered# 1
  • Pre-registration# 1
  • Phase III# 57
  • Phase II# 198
  • Phase I# 241
  • Preclinical# 323
  • No Data# 16
  • Suspended# 6
  • Ceased# 308
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included cancer stem cells and developmental pathways drugs are also in development for 258 other indications, where of 164 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 322 out of the 324 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 251 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 4845 structures available today among drug targets.
  • Identified drugs are linked to more than 329 different targets, divided into 58 classifications of molecular function:
  • Antigen binding
  • ATPase activity
  • Auxiliary transport protein activity
  • Binding
  • Carboxypeptidase activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chromatin binding
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Cytoskeletal protein binding
  • Deacetylase activity
  • DNA binding
  • DNA topoisomerase activity
  • Extracellular matrix structural constituent
  • G-protein coupled receptor activity
  • Growth factor activity
  • GTPase activity
  • Heat shock protein activity
  • Hormone activity
  • Isomerase activity
  • Kinase activity
  • Kinase binding
  • Kinase regulator activity
  • Ligand-dependent nuclear receptor activity
  • Ligase activity
  • Lipase activity
  • Lipid kinase activity
  • Metallopeptidase activity
  • Molecular function unknown
  • Peptide hormone
  • Protease inhibitor activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein serine/threonine phosphatase activity
  • Protein threonine/tyrosine kinase activity
  • Protein tyrosine/serine/threonine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein serine/threonine kinase activity
  • RNA binding
  • RNA-directed DNA polymerase activity
  • Serine-type peptidase activity
  • Structural constituent of cytoskeleton
  • Structural molecule activity
  • Superoxide dismutase activity
  • T cell receptor activity
  • Transcription factor activity
  • Transcription regulator activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Ubiquitin-specific protease activity
  • Voltage-gated ion channel activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 38 different primary and alternate sub-cellular localizations:
  • Basolateral membrane
  • Cell junction
  • Cell surface
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Extracellular matrix
  • Focal adhesion
  • Golgi apparatus
  • Integral to membrane
  • Intermediate filament
  • Kinetochore
  • Late endosome
  • Lysosome
  • Membrane fraction
  • Microsome
  • Microtubule
  • Mitochondrial membrane
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleoplasm
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisome
  • Plasma membrane
  • Ribosome
  • Secreted
  • Synaptic vesicle
  • Vesicle
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 496 protein expression profiles of 303 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 250 Pathways
  • KEGG# 186 Pathways
  • NCI-Nature# 258 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

  • Search, Find and Filter Panel with Initial Result Presentation
  • With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
  • The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
  • Direct linkage from inside the application to related internet resources
  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

  • Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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