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腎癌治療薬パイプライン

Renal Cancer Drug Pipeline Update

発行 BioSeeker Group AB 商品コード 171789
出版日 ページ情報 英文
納期: 即日から翌営業日
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腎癌治療薬パイプライン Renal Cancer Drug Pipeline Update
出版日: 2016年08月04日 ページ情報: 英文
概要

当レポートでは、腎癌治療薬開発に焦点を当て、その開発進捗動向や様々な標的などについてまとめ、概略下記の内容でお届けします。

治験責任医師

薬剤名および異名

  • 商標名
  • ジェネリック薬
  • コードネーム

開発段階

  • 開発中の194の薬剤最新動向
  • 上市済み
  • 登録済み
  • 登録前
  • 第3相
  • 第2相
  • 第1相
  • 前臨床
  • データなし
  • 中断
  • 中止

適応

標的

  • 168の標的を45に分類

標的発現プロファイル

経路

メカニズム

化合物

薬剤プロファイル

  • 薬剤名
  • 治験担当医師およびパートナー
  • 標的および標的の分子機能
  • 標的の部位
  • 標的発現プロファイル
  • 標的シグナリング経路
  • メカニズム
  • 開発プロジェクト
  • 薬剤解説
  • 化合物データ
  • 特許データ
  • ビジネスおよび市場
  • 第3相データ
  • 第2相データ
  • 第1相データ
  • 臨床前データ
  • ライセンシング情報

応用特性

システム要件

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次
Product Code: BSG0705102

The high existing unmet need in the treatment of renal cancer is reflected by the poor prognosis of patients with advanced stage disease, five- year survival rates with existing cytokine therapy being less than 20% (RCC) in this patient cohort.The identification of biomarkers is set to revolutionize patient staging and prognosis by individualizing patient treatments and creating novel drug targets.

There are today 243 companies plus partners developing 270 drugs targeting renal cancer in development. In addition, there are 3 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 95 drugs. Renal Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 233 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 226 out of the 228 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 55 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 243 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 270 drugs in development for the treatment of renal cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 32
  • Registered# 1
  • Pre-registration# 2
  • Phase III# 16
  • Phase II# 90
  • Phase I# 78
  • Preclinical# 50
  • No Data# 1
  • Suspended# 3
  • Ceased# 95
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included renal cancer drugs are also in development for 282 other indications, where of 171 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 226 out of the 228 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 187 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 3508 structures available today among drug targets.
  • Identified drugs are linked to more than 233 different targets, divided into 55 classifications of molecular function:
  • Aminopeptidase activity
  • Antigen binding
  • Auxiliary transport protein activity
  • Calcium ion binding
  • Carboxy-lyase activity
  • Carboxypeptidase activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chemokine activity
  • Complement activity
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Deacetylase activity
  • DNA binding
  • DNA topoisomerase activity
  • DNA-directed DNA polymerase activity
  • DNA-methyltransferase activity
  • Extracellular matrix structural constituent
  • G-protein coupled receptor activity
  • Glutathione transferase activity
  • Growth factor activity
  • Hydrolase activity
  • Isomerase activity
  • Kinase activity
  • Kinase regulator activity
  • Ligase activity
  • Lipid kinase activity
  • Lipid phosphatase activity
  • Metallopeptidase activity
  • Molecular function unknown
  • Motor activity
  • Oxidoreductase activity
  • Peptide hormone
  • Phosphoric diester hydrolase activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein threonine/tyrosine kinase activity
  • Protein tyrosine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • RNA binding
  • RNA-directed DNA polymerase activity
  • Serine-type peptidase activity
  • Structural constituent of cytoskeleton
  • Superoxide dismutase activity
  • T cell receptor activity
  • Transcription factor activity
  • Transcription regulator activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 27 different primary and alternate sub-cellular localizations:
  • Cell surface
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Golgi apparatus
  • Integral to membrane
  • Kinetochore
  • Lysosome
  • Membrane fraction
  • Microtubule
  • Mitochondrion
  • Nucleolus
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Plasma membrane
  • Sarcoplasmic reticulum
  • Secretory granule
  • Secretory vesicle
  • Zymogen granule
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 331 protein expression profiles of 210 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 225 Pathways
  • KEGG# 188 Pathways
  • NCI-Nature# 240 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

  • Search, Find and Filter Panel with Initial Result Presentation
  • With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
  • The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
  • Direct linkage from inside the application to related internet resources
  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

  • Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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