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癌の免疫療法:薬剤パイプライン

Immunotherapy in Oncology Drug Pipeline Update

発行 BioSeeker Group AB 商品コード 171759
出版日 ページ情報 英文
納期: 即日から翌営業日
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本日の銀行送金レート: 1USD=101.51円で換算しております。
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癌の免疫療法:薬剤パイプライン Immunotherapy in Oncology Drug Pipeline Update
出版日: 2016年08月04日 ページ情報: 英文
概要

当データベースでは、癌の免疫療法における薬剤の開発段階、開発プロジェクト、その標的、薬剤プロファイルなどについて、概略以下の構成でお届けいたします。

治験担当医師および協力者

  • 473名以上

薬剤名(異名)

  • 商標名、ジェネリック医薬品名、コード名を掲載

開発ステージ

  • 978の免疫治療薬に関する1959の開発プロジェクト
    • 上市薬剤
    • 登録薬剤
    • 登録前の薬剤
    • 第III相プロジェクト
    • 第II相プロジェクト
    • 第I相プロジェクト
    • 臨床前
    • データなし
    • 中断
    • 中止

適応

標的

  • 336以上の標的を56の分子機能に分類
  • 標的を27のローカリゼーションにて分類

標的発現プロファイル

標的シグナリング経路

メカニズム

化合物

薬剤プロファイル

  • 薬剤名
  • 治験担当医師およびパートナー
  • 標的および標的の分子機能
  • 標的の部位
  • 標的発現プロファイル
  • 標的シグナリング経路
  • メカニズム
  • 開発プロジェクト
  • 薬剤解説
  • 化合物データ
  • 特許データ
  • ビジネスおよび市場
  • 第III相データ
  • 第II相データ
  • 第I相データ
  • 臨床前データ
  • ライセンシング情報

応用特性

  • 13のパラメータ
  • 関連インターネットリソースへの応用
  • 情報の提供と分担

システム要件

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次
Product Code: BSG0606301

Cancer immunotherapy offers an attractive therapeutic addition, delivering treatment of high specificity, low toxicity and prolonged activity. In this Drug Pipeline Update BioSeeker brings together the fields of antibodies, vaccines, and immunostimulators in oncology drug development into one source.

There are today 830 companies plus partners developing 1578 cancer immunotherapy drugs in 4062 developmental projects in cancer. In addition, there are 19 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 624 drugs. Immunotherapy In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 535 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 485 out of the 491 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 77 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 830 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 1578 cancer immunotherapy drugs in development, which have a total of 4062 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 90
  • Registered# 1
  • Pre-registration# 11
  • Phase III# 113
  • Phase II# 408
  • Phase I# 455
  • Preclinical# 672
  • No Data# 33
  • Suspended# 19
  • Ceased# 624
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included cancer immunotherapy drugs are also in development for 358 other indications, where of 201 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 485 out of the 491 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 332 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 4092 structures available today among drug targets.
  • Identified drugs are linked to more than 535 different targets, divided into 77 classifications of molecular function:
  • Acid phosphatase activity
  • Antigen binding
  • ATPase activity
  • Auxiliary transport protein activity
  • B cell receptor activity
  • Calcium ion binding
  • Carboxy-lyase activity
  • Carboxypeptidase activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chemokine activity
  • Cofactor binding
  • Complement activity
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Cytoskeletal protein binding
  • Deaminase activity
  • Defense/immunity protein activity
  • DNA binding
  • DNA topoisomerase activity
  • DNA-directed DNA polymerase activity
  • Extracellular ligand-gated ion channel activity
  • Extracellular matrix structural constituent
  • G-protein coupled receptor activity
  • Glutathione transferase activity
  • Growth factor activity
  • GTPase activity
  • Guanyl-nucleotide exchange factor activity
  • Heat shock protein activity
  • Helicase activity
  • Hormone activity
  • Hydrolase activity
  • Intracellular ligand-gated ion channel activity
  • Isomerase activity
  • Kinase activity
  • Kinase binding
  • Kinase regulator activity
  • Ligand-dependent nuclear receptor activity
  • Ligase activity
  • Lipid phosphatase activity
  • Metallopeptidase activity
  • MHC class I receptor activity
  • Molecular function unknown
  • Motor activity
  • Oxidoreductase activity
  • Peptidase activity
  • Peptide hormone
  • Phosphoric diester hydrolase activity
  • Phosphorylase activity
  • Protease inhibitor activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein threonine/tyrosine kinase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein serine/threonine kinase activity
  • Receptor signaling protein tyrosine phosphatase activity
  • RNA binding
  • RNA-directed DNA polymerase activity
  • Serine-type peptidase activity
  • Signal transducer activity
  • Structural constituent of cytoskeleton
  • Structural molecule activity
  • T cell receptor activity
  • T cell receptor binding
  • Transcription factor activity
  • Transcription regulator activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Ubiquitin-specific protease activity
  • Unclassified
  • Voltage-gated ion channel activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 36 different primary and alternate sub-cellular localizations:
  • Apical membrane
  • Cell junction
  • Cell surface
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Extracellular matrix
  • Golgi apparatus
  • Immunological synapse
  • Integral to membrane
  • Kinetochore
  • Lysosome
  • Membrane fraction
  • Microtubule
  • Mitochondrial matrix
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisomal matrix
  • Plasma membrane
  • Sarcoplasmic reticulum
  • Secreted
  • Secretory granule
  • Soluble fraction
  • Vesicle
  • Zymogen granule
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 679 protein expression profiles of 441 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 230 Pathways
  • KEGG# 192 Pathways
  • NCI-Nature# 237 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

  • Search, Find and Filter Panel with Initial Result Presentation
  • With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
  • The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
  • Direct linkage from inside the application to related internet resources
  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

  • Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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