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3D細胞培養:技術と世界の市場

3D Cell Cultures: Technologies and Global Markets

発行 BCC Research 商品コード 320803
出版日 ページ情報 英文 290 Pages
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3D細胞培養:技術と世界の市場 3D Cell Cultures: Technologies and Global Markets
出版日: 2017年05月30日 ページ情報: 英文 290 Pages
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概要

2016年、3D細胞培養の市場は10億ドルの規模を記録しました。2016年から2021年にかけては42.6%のCAGRで推移し、2021年には39億ドルの規模に成長すると予測されています。

当レポートでは、3D細胞培養の技術および市場について調査し、組織培養・細胞培養の概要、3D技術の種類と概要、バリューチェーンの分析、市場規模の推移と予測、用途別の詳細、市場影響因子および市場機会の分析、特許動向、主要企業のプロファイルなどをまとめています。

第1章 イントロダクション

第2章 サマリーおよびハイライト

第3章 市場および技術背景

  • 組織および細胞培養
  • 組織
  • 細胞
  • 組織培養・細胞培養の定義
  • 細胞培養の獲得
  • 細胞タイプ:形態ベース
  • 細胞タイプ:ハイブリドーマベース
  • 細胞培養:基礎要件
  • 基本的な細胞培養システム
  • 過去の経緯・初期の利用

第4章 組織・細胞培養システムの環境

  • 生物薬剤およびワクチンの大規模製造
  • 体細胞、幹細胞および細胞生成用小規模細菌
  • 技術概要:細胞培養タイプ別
  • 付着アプローチ
  • 3Dバイオリアクター
  • 再生医療における利用
  • 細胞培養:初期3Dの先駆者
  • 収益推計

第5章 研究環境と3D細胞培養で利用される消耗品

  • マイクロプレート
  • セロミクスの概要
  • 2D培養 vs 3D培養
  • 主要サプライヤー
  • ハイスループットスクリーニング(HTS)用途
  • 3D細胞培養技術アッセイの オープン・イノベーション・プラットフォーム.

第6章 3D技術と基本的製品

  • マイクロタイタープレートによるプラットフォームの提供
  • 3D細胞培養技術
  • 2Dおよび3Dシステムの重要性
  • 基本的な3D細胞培養の可変因子
  • 3D技術と製品
  • 器官および原形質類器官
  • 再生医療における組織工学
  • 代用皮膚産業
  • バイオプリント製品に対する米国の規制状況
  • 器官移植
  • 買収および戦略的提携
  • 収益サマリー
  • 市場推計

第7章 癌の3Dモデル

  • 癌:細胞レベルの概要
  • 最新のアプローチ
  • インビボ(動物)検査基準
  • 3Dの要件
  • 癌研究における3Dのメリット
  • 3D培養の推進因子としての乳癌
  • 3D培養の推進因子としての黒色腫
  • 癌研究における3Dシステム
  • 3D培養スキャフォールド
  • 薬剤感受性および薬剤耐性からの学び
  • 細胞情報
  • 薬剤スクリーニング
  • 癌の代謝性
  • 将来性
  • 患者由来の細胞
  • PDCプラットフォームの進化
  • インビボモデル
  • エクスビボとNGSの組み合わせ
  • 収益予測

第8章 毒性・医薬品安全性検査の環境

  • 毒物学の背景
  • 化粧品および薬用化粧品の有効性
  • バイオプリンティング
  • 慢性毒性・反復投与毒性試験
  • 発癌性および遺伝毒性
  • 生殖・発生毒性試験
  • 内分泌かく乱物質スクリーニング
  • トキシコキネティクスとADME
  • インビトロの発展
  • 器官型モデル
  • 吸収障壁モデル
  • 腎臓毒性
  • 肝臓の固有性と複雑性
  • 3Dの革新の主要推進因子としての肝臓
  • インビトロ肝臓用途
  • インビボ肝臓機能と構造
  • 肝臓の代謝
  • 肝臓インビトロモデル
  • 肝細胞とマクロファージの混合培養
  • 3D肝臓モデル
  • 肝組織のバイオプリント、など

第9章 幹細胞における3D培養の役割

  • イントロダクション
  • 初期の学び
  • 胚形成
  • 3D幹細胞培養システム
  • 胚様体形成の制御
  • 用途
  • 状況および促進因子
  • 富士フィルム(Cellular Dynamics Inc.)
  • 肝細胞研究から得られた飛躍的進歩
  • 収益推計

第10章 3Dの次世代の展望

  • 概要
  • 予測的毒物学
  • 神経科学の発見と発展のための幹細胞
  • 心血管上の発見のための幹細胞
  • 再生医療の発展のための幹細胞
  • 収益推計
  • 付録:肝臓

第11章 企業プロファイル

付録:特許分析

BCC Research について

図表

目次
Product Code: BIO140B

The three-dimensional cell culture market reached $1.0 billion in 2016 and should reach $3.9 billion in 2021, with a compound annual growth rate (CAGR) of 42.6% from 2016 to 2021.

Report Includes

  • An overview of the global markets and technologies for 3D cell cultures.
  • Analyses of global market trends, with data from 2015, estimates for 2016, and projections of compound annual growth rates (CAGRs) through 2021.
  • Information on 3D technologies, with a focus on representative platforms, including cube, spherical droplet, stacked plate, magnetic bead, and other platforms.
  • Value-chain analysis at the following levels: key innovation or founding intellectual property, prototyping, beta testing, and research collaborations or relationship building.
  • Analysis of the market's dynamics, specifically growth drivers, restraints, and opportunities.
  • Relevant patent analysis, including recent activity and a list of key patents.
  • Profiles of major players in the industry.

Report Scope

The scope of the report encompasses the major types of 3D cell culture that have been used, as well as the major applications being developed by industry, academic researchers and their commercialization offices, and government agencies. It analyzes current market status, examines future market drivers and presents forecasts of growth over the next five years. Technology developments, including the latest trends, are discussed. Other influential factors such as screening strategies for pharmaceuticals have also been included.

Analyst Credentials

Robert G. Hunter is a senior management consultant, commercialization consultant and technology and market analyst with over 20 years of experience in life sciences and healthcare. Recent consulting includes market/technology analysis and forecasting of customer adoption and revenue for a high content screening (HCS) technology leader. He is an early investor in a company using stem cells for predictive drug safety testing in vitro. He has a B.S. in Mechanical Engineering from Clemson University and Master of Business Administration from The Tuck School of Business at Dartmouth.

Table of Contents

Chapter 1: Introduction

  • Study Goals and Objectives.
  • Reasons for Doing the Study
  • Scope of Report
  • Intended Audience
  • Methodology and Information Sources
  • Analyst's Credentials
  • Related BCC Research Reports

Chapter 2: Summary and Highlights

  • New Applications Identified Since 2015 Report
  • Changes from 2015 Report

Chapter 3: Market and Technology Background

  • Tissue and Cell Culture
  • Tissue
  • Cells
    • Cell Types
  • Tissue Culture and Cell Culture Definitions
  • Obtaining Cell Cultures
    • Isolating Cells from Tissues
    • Maintaining Cells in Culture
    • Plating Density and Sub-culturing
    • Cryogenic Storage.
    • Obtaining Cells from Other Sources: Issue of Cross-contamination
  • Cell Types Based on Morphology
  • Cell Types Based on Hybridomas
  • Cell Culture: Basic Requirements
    • Avoiding Contamination
    • Important Indicators of Cell Culture Health
    • Maintaining Optimal Cell Culture Conditions
  • Basic Cell Culture Systems
    • Adherent Cells Requiring Attachment Substrate
    • Suspension Cell Cultures
  • History and Early Applications
    • Invention of Tissue Culture
    • Development of Sustained Cell Lines
    • First Cell Culture Flask and Rigorous Techniques
    • Lindbergh: The Cell Culture Equipment Pioneer
    • Establishing Continuous Cell Lines
    • Key Developments in Equipment
    • Vaccine Development as Catalyst
    • Cell Strains and Cell Lines
    • Vaccines Developed Using Human Cell Strains
    • Continued Catalyst

Chapter 4: Tissue and Cell Culture Systems Landscape

  • Large-Scale Manufacture of Biopharmaceuticals and Vaccines
    • Suspension Proteins and Monoclonal Antibodies
    • Adherent-Cell-based Therapies and Vaccines
  • Small-Scale Adherent to Make Somatic Cells, Stem Cells and Tissues
  • Technology Overview by Cell Culture Type
    • Suspension Approaches
    • Innovation and Challenges
    • Single-Use Technology
    • Mini- and MicroBioreactors: Clone Selection and Development
  • Adherent Approaches
    • Traditional Roller Bottles
    • Other Systems
    • New Understanding of Cell Attachment and Detachment
  • Three-dimensional Bioreactors
  • Applications in Regenerative Medicine
  • Tissue Culture - Early 3D Pioneers
  • Revenue Estimate

Chapter 5: Research Landscape and Products Used in Three-dimensional Cell Culture

  • Microplates
    • Standards Setting
    • Continuous Innovation
    • Microplate Readers
    • Liquid-Handling Equipment
  • Cellomics Overview
    • Fluorescence as Driver of Screening
    • High Content Screening
    • Imaging Advances
    • Flow Cytometry
    • Future Vision for High-content Screening
    • Label-Free Platforms
    • Electrophysiology
    • Assays and Assay Kits
    • Cell-Based Assays: Overview and Newer Developments
    • Cells Used in Cell-Based Assays
  • Two-dimensional Cultures vs. Three-dimensional Cultures
  • Key Suppliers
  • Basic 3D Cell Culture Variables
    • Cell Adhesion
    • Cell Migration
    • Cell Invasion.
    • Viability and Cytotoxicity
    • Cell Signaling and Communication
    • Enhanced Functionality and Confirming Assays
    • Cytotoxicity: A Major Category
    • Permeability Assays for Cell Viability and Survival
    • Metabolic Assays for Cell Viability and Survival
    • Cell Death Assays
    • Cytostatic or Long-Term Impact Assays
    • Multiplex Assays
    • Composite Screening Strategies
  • High Throughput Screening (HTS) Applications
    • Three-dimensional Cytotoxicity Applications.
    • Correlation with Gene-Expression Data
    • 1,536-Well Formats
    • Kinetic Metabolism Assays
  • 3D Assay Open Innovation Platform

Chapter 6: Three-dimensional Technologies and Basic Products

  • Microtiter Plates Provide Platform
    • Supportive Standards
    • Microplate Well Inserts
  • Three-dimensional Cell Culture Technologies
    • Three-dimensional Adoption Status
  • Importance of 2D vs. 3D Systems
    • Paracrine vs. Autocrine Signaling
  • Basic 3D Cell Culture Variables
    • Cell Adhesion
    • Cell Migration
    • Cell Invasion.
    • Basic Assay Types
  • Three-dimensional Technology and Products
    • Three-dimensional Matrices to Replicate the Extracellular Matrix
    • Foundational Tools: Gels and Basement Membranes
    • Scaffolds
    • Examples of Innovation
    • Scaffold-Free Formats
    • Applications Overview
    • Analytical Methods
    • Imaging
    • Liquid Handling
    • High-throughput Screening Capability
    • Continued Spheroid Adoption
    • Organotypic Models
    • Directional Culture
    • Microfluidics
    • Glass/Silicon-Based Platforms
    • Polymer-based Platforms
    • Chip Technology
    • Organ/Tissue-On-Chip Industry
    • Bioprinting
    • Current Dominant Technologies
    • Bioprint Instrument Industry
    • Bioink Technologies
    • Bioink Industry
    • Applications
    • Toxicology Testing in Cosmetics
  • Organs and Organoids
    • Organoids
  • Tissue Engineering in Regenerative Medicine
  • Skin Substitutes Industry
    • Recent Example: Skin and Hair
    • U.S. Regulatory Status of Bioprinted Products
  • Organ Transplants
  • Acquisitions and Strategic Alliances
  • Regenerative Medicine
    • Future Challenges
    • Increasing Integration and Evolution
  • Revenue Summary
  • Market Estimate

Chapter 7: Three-dimensional Models for Cancer

  • Cancer at the Cellular Level Overview
  • Approaches to Date
  • In Vivo (Animal) Testing Standard
    • Xenografts
    • Two-dimensional Learnings and Drawbacks
  • Three-dimensional Requirements
    • Cell Number and Viability
    • Migration and Invasion
    • Unmet Needs: Angiogenesis and Immune System Evasion
  • Three-dimensional Benefits to Cancer Research
    • Greater Distinction in Cell Morphology and Proliferation
    • Greater Gene Expression and Cell Behavior
    • Better Models of Cell Migration and Invasion
    • Cell Heterogeneity
  • Breast Cancer as a Driver of Three-dimensional Cultures
    • Structure, Polarity and Apoptosis
  • Melanoma as a Driver of Three-dimensional Cultures
    • Moving to Spheroid Configurations
  • Three-dimensional Systems in Cancer Research
    • Multicellular Tumor Spheroids
    • Multilayered Cell Cultures
  • Three-dimensional Engineered Scaffolds
    • Natural Materials
    • Synthetic Materials
  • Learnings from Drug Sensitivity and Resistance
    • Altered Signaling and Sensitivity
    • Drug Resistance
  • Cellular Signaling
    • Cellular Signaling Mediated by Integrins
  • Drug Screening
    • Approaches and Endpoints
    • Spheroids Applications
    • Metastasis via Three-dimensional Cell Migration Model
    • Metastasis via Lung-on-Chip
  • Cancer Metabolism
  • Future Horizons
    • Metastases
    • Co-culture
    • Vascularization
    • Cancer-associated Fibroblasts
    • Cancer Stem Cells
    • Combination Therapies
    • Biologics Development
    • Tumor Recurrence
  • Patient-derived Cells
    • Patient-derived Tumor Xenografts
  • Evolution of PDX Platforms
  • Ex Vivo Models
    • Ex Vivo Applications
    • Ex Vivo Shortcomings
    • Ex Vivo PDX in 3D Cell Culture
  • Combining Ex Vivo with NGS
    • Preserving Heterogeneity in Cancer Models
    • High-Throughput Drug Screening
  • Revenue Forecast

Chapter 8: Landscape for Toxicology and Drug Safety Testing

  • Toxicology Background
    • Testing for Adverse Effects on the Skin
    • Toxicology Testing in Cosmetics
    • Updated Regulatory Requirements
  • Efficacy of Cosmetics and Cosmeceuticals
  • Bioprinting
    • Skin Irritation
    • Skin Corrosion
    • Phototoxicity
    • Skin Sensitization
    • Eye Irritation
    • Acute Systemic Toxicity
    • Acute Toxicity Testing
    • Cytotoxicity Assays for Acute Toxicity Testing
  • Chronic and Repeated Dose Toxicity
    • Chronic and Repeated Dose Toxicity Study Goals
    • Development of Repeated Dose Toxicity Testing In Vitro
  • Carcinogenicity and Genotoxicity
    • Overview
    • In Vitro Methods: Background and Recent Developments
    • Regulatory vs. Drug Development Applications
    • Efforts to Reduce False Positives
    • Recent Innovations for Screening
    • Future Challenge: Non-Genotoxic Carcinogens
  • Reproductive and Developmental Toxicity
    • Background
    • Following the Reproductive Cycle
    • Development and Reproductive Tox Testing Types
    • Zebrafish Model for Developmental Toxicity Screening
    • Combinations of Zebrafish and Stem Cells
    • Biomedical Frontiers: Male Testis
  • Endocrine Disruptor Screening
    • Background
    • Environmental Toxicology Impacts In Vitro Methods
    • High-Production Volume Chemicals
    • ToxCast and Tox 21 Initiatives
    • Future Challenge: Thyroid Disruption
    • BG1 Assay
  • Toxicokinetics and ADME
  • In Vitro Developments
    • Metabolism
    • Pharmacokinetics of Low Turnover Compounds
  • Organotypic Models
    • Three-dimensional Models for Skin
    • Three-dimensional Corneal System
  • Absorption Barrier Models
    • Gastrointestinal
    • Lung
    • Blood-Brain Barrier
    • Blood-Brain Barrier on a Chip
    • Real Architecture for Three-dimensional Tissue Barriers and Extracellular Matrix
  • Liver Toxicity
  • Uniqueness and Complexity of Liver.
  • Liver as a Key Driver for Three-dimensional Innovation
  • In Vitro Liver Applications
    • Liver Toxicity Testing
    • Primary Hepatocyte Use
    • Learnings From Monolayer Cultures
    • Learnings from Co-Cultures Contribution to the Development of Cytotoxicity and Three-dimensional
    • Assays
  • In Vivo Liver Function and Structure
    • Hepatocytes or Parenchymal Cells
    • Specialized Liver Endothelial Cells
    • Endothelial Cells Surround Hepatocyte Core
    • Non-Parenchymal Stellate and Kupffer Cells
  • Liver Metabolism
    • Sub-Cellular Liver Enzyme Fractions
    • Extracellular Matrix as a Driver of Differentiation
    • Toxicity Studies and Non-Parenchymal Cells Drive In Vitro Development
    • Challenges
  • Liver In Vitro Models
    • Isolated Perfused Rat Liver
    • Precision-Cut Liver Slices
    • Human Hepatocyte Isolation
    • Isolated Hepatocyte Shipping
  • Co-Cultures of Hepatocytes and Macrophages
    • Two-Chamber Systems
    • Micropatterning
  • Three-dimensional Liver Models
    • Two-dimensional Sandwich
    • Sandwich-Culture Model
    • Hydrogel Three-dimensional Scaffolds
    • Synthetic Scaffolds
    • Self-Assembled Hepatospheres
    • Hepatospheres-Derived from Cell lines vs. Primary Cells
  • Bioprinted Liver Tissue
  • Detected Hepatosphere Structures and Functionality
    • Extracellular Matrix
    • Cell-cell Contacts: Learnings from In Vitro Tox
    • Oxygen Supply
    • Co-culture with Non-parenchymal Cells In Three-dimensional Spheroids
    • Refinements to Co-culture
  • Ideal Criteria
  • Drug Resistance
  • Transporter Studies
  • Achieving Heterotypic Cell-cell Contacts
  • Summary Learnings
  • Unmet Needs and Future Drivers of Innovation
    • Regeneration
    • Achievement of Hepatocyte Expansion Still Elusive
    • Inflammation Models
    • Immune-mediated Drug-induced Liver Injury
    • High-content Imaging and Analysis
    • Stem Cell-Derived Hepatocyte Potential
  • Morphogen Signaling
  • Microfluidics Applications
    • Dielectrophoretic Forces
    • Learnings from Microfluidics
    • Self-organizing Systems
  • Multi-Donor Liver Cells
  • Kidney Toxicity Applications
  • Future Challenge: Stem-Cell Derived Kidney Cells
    • Bioprinted Kidney Tissue
  • Pancreatic Toxicology Applications
  • Cardiovascular Safety Testing of New Drug Candidates
    • Commercial Avenue
    • Collaboration with Regulators
    • In Silico: Model-Based Drug Development
    • Microelectrode Arrays Based on Impedance
    • Surrogate for Aortic Ring Assay via Bioprinted Magnetics
    • Vasodilator Activity
    • Three-dimensional Engineered Heart Tissues
  • Revenue Estimate

Chapter 9: 3D Culture Role in Stem Cells

  • Introduction
  • Early Learnings
  • Embryogenesis
    • Growth, Structure and Morphology
    • Differentiation
    • Differentiation vs. Proliferation
    • Extracellular Matrix
    • Soluble Factors
    • Mechanical Forces
    • MicroRNAs
  • Three-dimensional Stem Cell Culture Systems
    • Plate or Culture Dish
    • Spinner Flask and Rotating Wall Vessel
    • Perfusion Bioreactor and Microcarrier Systems
    • Shortcomings
  • Controlling Embryoid Body Formation
    • Forced Aggregation Cultures
    • Hanging-Drop Approach
  • Applications
    • Stem Cell Microenvironments
    • Stem Cell Markers for High-throughput Screening
    • Teratomas and the Teratoma Assay.
  • Status and Drivers
  • Fujifilm (Cellular Dynamics Inc.)
  • Breakthroughs Resulting from Stem Cells Research
  • Revenue Estimate

Chapter 10: Three-dimensional Next-Generation Outlook

  • Overview
  • Cancer
    • CDx Based on Ex Vivo 3D
    • Immuno-Oncology
  • Predictive Toxicology
    • Neuro Safety
  • Stem Cells for Neuroscience Discovery and Development
    • Example: Alzheimer's Research
    • Background: B-Amyloid Cascade Hypothesis
    • Human iPSC-derived Models
    • New 3D Model
    • Other 3D Advantages
    • Envisioned Applications
    • Other 3D Neuro Applications
  • Stem Cells for Cardiovascular Discovery
  • Stem Cells for Development of Regenerative Medicine
    • Background: Allogenic vs. Autologous
    • Induced Pluripotent Stem Cells (IPS)
  • Revenue Estimate
  • Chapter Appendix: Liver
    • Integration with "-Omics"

Chapter 11: Company Profiles

Appendix: Patent Analysis

About BCC Research

  • About BCC Research
  • BCC Library Access
  • BCC Custom Research

List of Tables

  • Summary Table Global Three-dimensional Cell Culture Market, Through 2021 ($ Millions)
  • Table 1 Tissue Types
  • Table 2 Cell Types
  • Table 3 Cell Culture Applications
  • Table 4 Leading Bioreactor Suppliers, 2017
  • Table 5 Leading Tissue Products and Suppliers, October 2016
  • Table 6 Global Market for Three-dimensional Bioreactors and Microcarriers, Through 2021 ($ Millions)
  • Table 7 High-Content Screening Suppliers and Key Attributes, January 2017
  • Table 8 Label-Free Technologies and Suppliers, January 2017
  • Table 9 Automated Patch Clamping Companies and Technologies, January 2017
  • Table 10 Leading Cell Line Suppliers, January 2017
  • Table 11 Leading Primary Cell Suppliers, January 2017
  • Table 12 Leading Stem Cell Suppliers, January 2017
  • Table 13 Typical Assay Endpoints and Tests
  • Table 14 Organ-On-Chip Industry
  • Table 15 Bioprinting Instrument Technologies
  • Table 16 Maintaining Cell Viability During Printing
  • Table 17 Bioprinting Instrument Industry
  • Table 18 Bioink Components
  • Table 19 Bioink Types
  • Table 20 Matrix Bioink Hydrogel Classes
  • Table 21 Matrix Bioink Selection Criteria
  • Table 22 Selected Bioink Companies
  • Table 23 In Vitro Testing in Cosmetics
  • Table 24 Bioprinting Industry Alliances in Cosmetics, 2015
  • Table 25 Printed Tissue and Organs: Commercialization Timeframe
  • Table 26 Tissue/Organ Complexity
  • Table 27 Skin Substitute Products and Market Focus
  • Table 28 U.S. Regulatory Considerations
  • Table 29 Number of United States Organ Transplants, January-June 2016
  • Table 30 Bioprinting Industry Acquisitions and Strategic Alliances, January 2014-February 2016
  • Table 31 Leading Reagent, Media and Microplate Suppliers, January 2017
  • Table 32 Three-dimensional Technology Product Market, Through 2021 ($ Millions)
  • Table 33 Common Three-dimensional Assays
  • Table 34 Three-dimensional Tumor Models Developed for Drug Discovery, June 2017
  • Table 35 Summary of EV3D Benefits/Advantages
  • Table 36 Global Market for Three-dimensional Culture Used in Cancer Drug Development, Through 2021 ($ Millions)
  • Table 37 In Vitro Testing in Cosmetics
  • Table 38 Alliances Between Bioprinting and Cosmetics Companies, 2015
  • Table 39 In Vitro and In Vivo Assays in the Tier 1 Screening Battery, January 2014
  • Table 40 Global Market for Three-dimensional Cultures Used in Predictive Tox Applications, Through 2021 ($ Millions)
  • Table 41 Global Market for Three-dimensional Cultures Used in Stem Cell Research Applications, Through 2021 ($ Millions)
  • Table 42 New Applications That Have Emerged Since the 2015 Report
  • Table 43 Global Market for Next-Generation 3D Applications, Through 2021 ($ Millions)
  • Table 44 Patents Assigned in 3D Cell Culture, 2009-2017

List of Figures

  • Summary Figure Global Three-dimensional Cell Culture Market, 2015-2021 ($ Millions)
  • Figure 1 Technology Maturity
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