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市場調査レポート

光医学:技術および世界市場

Photomedicine: Technologies and Global Markets

発行 BCC Research 商品コード 314958
出版日 ページ情報 英文 141 Pages
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光医学:技術および世界市場 Photomedicine: Technologies and Global Markets
出版日: 2014年09月29日 ページ情報: 英文 141 Pages
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概要

世界の光医学市場は2013年に6億970万米ドル規模となりました。同市場は2014年には6億1,780万になり、2019年までの5年間はCAGR4.1%で拡大しつづけ、2019年には7億5,400万米ドルになると予測されています。

当レポートは、世界の光医学市場の概要と、2013年の市場動向と2019年までの予測、治療分野別動向、および市場に参入する主な企業の包括的プロファイルなどをまとめています。

第1章 イントロダクション

第2章 サマリー

第3章 概要

  • 光医学の歴史
  • 光医学の将来的応用と光力学的治療

第4章 世界の光医学市場

  • 光医学市場

第5章 光

  • 紫外線放射
  • 可視光線

第6章 光防護

  • 皮膚
  • 光防護

第7章 光線療法:健康状態と治療

  • UVB療法
  • PUVA療法
  • 体外フォトフェレーシス(ECP)
  • 感染症治療のための紫外線(UVC)の使用
  • 紫外線血液放射
  • 光力学的治療(PDT)
  • 低度レーザー光線治療
  • 外科用レーザー治療
  • 光線療法に用いられる薬剤
  • 光線療法に用いられる装置

第8章 光医学におけるナノテクノロジー

  • 癌の光熱療法
  • 金ナノ粒子
  • 癌画像および治療における量子ドット
  • 癌画像および治療のための多機能磁気ナノ粒子
  • 光熱療法のための金ナノマテリアル

第9章 促進因子と阻害因子

第10章 特許分析

第11章 世界の医療制度

第12章 プレスリリース

第13章 企業プロファイル

図表

目次
Product Code: HLC172A

The global market of photomedicine, including drugs and devices, was valued at $609.7 million in 2013. The market is expected to reach $616.8 million in 2014 and $754 million in 2019, a compound annual growth rate (CAGR) of 4.1% for the five-year period, 2014 to 2019.

This report provides:

  • An overview of the global markets for photomedicine, a field of medicine that comprises pathologies caused by light and therapeutic applications of light itself.
  • Analyses of global market trends, with data from 2013, estimates for 2014, and projections of CAGRs through 2019.
  • Information focused on medical equipment (such as lasers, light emitting diodes and other kinds of light technologies) which are employed to treat and diagnose a variety of diseases like skin conditions (psoriasis, vitiligo, cancer etc), seasonal and non-seasonal medical conditions, sleep disorders, and more.
  • Coverage of therapeutic areas will include dermatology, surgery, optical diagnostics, cardiology, and oncology.
  • Analysis of important market dynamics such as growth drivers, inhibitors, and opportunities.
  • Comprehensive company profiles of major players in the photomedicine industry.

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REPORT SCOPE

SCOPE OF THE REPORT

The global market of photomedicine will grow to about $754 million by 2019 at a compound annual growth rate of 4.1% from 2014 to 2019. This report provides a detailed segmentation by region, by products and type of products, by therapeutic areas and by type of treatment. Profiles of key market players are also included. Major products that generate the largest revenues, as well as the most-valuable R&D products that will come on the market up to 2019 are provided.

In-depth competitive market analysis is discussed, with examples of how new products will enter the market or how existing products will survive or perish. The report also includes descriptions of current and future technologies for drugs and devices used in photomedicine. In the future, nanotechnology will play a pivotal role in drug and discovery innovation.

ANALYST'S CREDENTIALS

Alessandro Varotto has a PhD in Chemistry with a specialty in Nanotechnology and Materials Science. Dr. Varotto has worked as a research scientist in both academic and industry environments. He is the author of about 20 peer-reviewed research articles, patents, a book and dozens of technical papers in the field of life science. His expertise includes chemistry and nanomaterials for the pharmaceutical and medical device industries.

Table of Contents

CHAPTER 1 INTRODUCTION

  • STUDY GOALS AND OBJECTIVES
  • REASON FOR DOING THE STUDY
  • SCOPE OF THE REPORT
  • INTENDED AUDIENCE
  • METHODOLOGY AND INFORMATION SOURCE
  • ANALYST'S CREDENTIALS
  • RELATED BCC RESEARCH REPORTS
  • BCC RESEARCH WEBSITE
  • DISCLAIMER

CHAPTER 2 SUMMARY

  • SUMMARY TABLE GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, THROUGH 2019 ($ MILLIONS)
  • SUMMARY FIGURE GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, 2013-2019 ($ MILLIONS)

CHAPTER 3 OVERVIEW

  • TABLE 1 EXAMPLES OF DRUGS AND MEDICAL DEVICES MARKETED AS A COMBO IN PHOTOMEDICINE
  • HISTORY OF PHOTOMEDICINE
    • EARLY HISTORY OF PHOTOMEDICINE
    • DISCOVERY OF INVOLVEMENT OF LIGHT IN HUMAN DISEASES
    • DEVELOPMENT OF PHOTOTHERAPY (HELIOTHERAPY) IN CLINICAL APPLICATIONS
    • DISCOVERY OF PHOTODYNAMIC THERAPY
    • DEVELOPMENT OF LASER BASED THERAPIES
    • DEVELOPMENT OF ULTRA-VIOLET LIGHT THERAPIES
    • PRESENT STATUS OF PHOTOMEDICINE
  • NEW AND FUTURE APPLICATIONS OF PHOTOMEDICINE AND PHOTODYNAMIC THERAPY
    • DEVELOPMENT OF IMPROVED PHOTOSENSITIZERS
    • IMPROVING LIGHT EXCITATION PROCEDURES
      • Applications in Oncology
      • Advances in Antibacterial Applications
      • Other General Applications

CHAPTER 4 GLOBAL PHOTOMEDICINE MARKET

  • MARKET FOR PHOTOMEDICINE
  • TABLE 2 GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 3 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY REGION, 2013-2019 (%)
  • FIGURE 1 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY REGION, 2014 (%)
    • MARKET FOR DRUGS IN PHOTOMEDICINE
    • TABLE 4 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE, THROUGH 2019 ($ MILLIONS)
    • TABLE 5 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE BY REGION, THROUGH 2019 ($ MILLIONS)
    • TABLE 6 GLOBAL MARKET SHARE FOR DRUGS IN PHOTOMEDICINE BY THERAPEUTIC AREA, 2014 AND 2019 (%)
    • FIGURE 2 GLOBAL MARKET SHARE FOR DRUGS IN PHOTOMEDICINE BY THERAPEUTIC AREA, 2014 AND 2019 (%)
    • TABLE 7 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE BY CHEMICAL SPECIALTY, THROUGH 2019 ($ MILLIONS)
    • TREATMENT MARKET IN PHOTOMEDICINE
    • TABLE 8 GLOBAL MARKET FOR PHOTOMEDICINE, BY TREATMENT, THROUGH 2019 ($ MILLIONS)
    • TABLE 9 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY TREATMENT, 2013-2019 (%)
    • FIGURE 3 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY TREATMENT, 2014 (%)
    • TABLE 10 GLOBAL MARKET FOR PUVA THERAPY BY REGION, THROUGH 2019 ($ MILLIONS)
    • TABLE 11 GLOBAL MARKET FOR UVB THERAPY BY REGION, THROUGH 2019 ($ MILLIONS)
    • TABLE 12 GLOBAL MARKET FOR LLLT IN PHOTOMEDICINE BY REGION, THROUGH 2019 ($ MILLIONS)
    • TABLE 13 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY, THROUGH 2019 ($ MILLIONS)
    • TABLE 14 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY BY REGION, THROUGH 2019 ($ MILLIONS)
    • TABLE 15 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY LASERS FOR CANCER BY REGION, THROUGH 2019 ($ MILLIONS)

CHAPTER 5 LIGHT

  • ULTRAVIOLET RADIATION
    • ARTIFICIAL SOURCES OF UV LIGHT
      • Black lights
      • Short-wave UV Lamps
      • Gas-discharge Lamps
      • Ultraviolet Light-emitting Diodes (LEDs)
      • Ultraviolet Lasers
      • TABLE 16 ULTRAVIOLET RADIATION CLASSIFICATION BY NAME, WAVELENGTH AND ENERGY
  • VISIBLE LIGHT
  • TABLE 17 VISIBLE SPECTRUM BY COLOR, WAVELENGTH AND ENERGY

CHAPTER 6 PHOTOPROTECTION

  • SKIN
  • UV RADIATION EFFECTS ON SKIN
  • TABLE 18 DISEASES SOMETIMES AGGRAVATED BY UV IRRADIATION
  • PHOTOPROTECTION
    • UV FILTERS
    • TABLE 19 UV FILTER BY TYPE
      • Organic UV Absorbers
        • UVB Filters
        • UVA Filters
        • Broad-Spectrum UVB and UVA Filters
      • Organic Particulates
      • Inorganic Particulates
      • TABLE 20 CHEMICAL COMPOUNDS USED AS PHOTOPROTECTOR

CHAPTER 7 PHOTOTHERAPY: HEALTH CONDITIONS AND TREATMENTS

  • UVB THERAPY
    • MANAGEMENT OF PSORIASIS USING UVB
    • PRINCIPLES INVOLVED IN THE MANAGEMENT OF PSORIASIS USING UVB
    • LASER THERAPY
    • ADDITIONAL TREATMENT OPTIONS
    • THE USE OF UVB THERAPY FOR THE TREATMENT OF OTHER DISORDERS
  • PUVA THERAPY
    • MECHANISM OF ACTION OF PUVA
    • THERAPEUTIC RESULTS
    • REPUVA
  • EXTRACORPOREAL PHOTOPHERESIS (ECP)
  • USE OF ULTRAVIOLET C (UVC) FOR THE TREATMENT OF INFECTIONS
    • MECHANISM OF ACTION OF UVC
  • ULTRAVIOLET BLOOD IRRADIATION
  • TABLE 21 ADVANTAGES OF USING UBI THERAPY
  • PHOTODYNAMIC THERAPY (PDT)
    • INTRODUCTION
    • TABLE 22 PHOTODYNAMIC THERAPY PROS AND CONS
    • USE OF CLINICAL PDT IN CHINA
      • ALA
      • Hemoporfin
      • Deuteporfin
      • Suftalan Zinc
      • Radion
      • Sources of Light
    • PDT IN RUSSIA
    • TABLE 23 PHOTOSENSITIZERS FOR PDT DEVELOPED IN RUSSIA
  • LOW-LEVEL LASER LIGHT THERAPY (LLLT)
    • BIOCHEMICAL MECHANISMS
    • ACTION SPECTRA
    • WOUND HEALING
    • WAVELENGTH
    • LASER VS. NON-COHERENT LIGHT
    • PULSED OR CW
    • POLARIZATION STATUS
    • SYSTEMIC EFFECTS
  • SURGICAL LASER THERAPY
    • INTRODUCTION
    • HAIR REMOVAL
    • WRINKLE TREATMENT
    • DENTAL TREATMENTS
    • EYE SURGERY
    • OTHER MEDICAL USES
    • PRACTITIONERS
    • BIOSTIMULATION LASERS
    • LASER RADIATION SAFETY
  • DRUGS USED IN PHOTOTHERAPY
  • TABLE 24 DRUGS USED IN PHOTOTHERAPY BY TYPE OF CHEMICAL COMPOUND
    • APTOCINE
    • FOSCAN
    • PHOTOCHLORIN
    • PHOTOFRIN
    • VISUDYNE
    • ALLUMERA
    • HEXVIX
    • LEVULAN
    • METVIXIA
    • PSORALEN
    • ANTHRALIN
    • VISONAC
    • LUMACAN
    • CALCIPOTRIENE
  • DEVICES USED IN PHOTOTHERAPY
    • XTRACT
    • LEVIA
    • UVA LAMPS
  • TABLE 25 EXAMPLE OF DRUGS AND MEDICAL DEVICES MARKETED AS A COMBO IN PHOTOMEDICINE
  • TABLE 26 KEY MARKET PLAYERS IN PHOTOTHERAPY BY COMPANY AND PRODUCT
  • TABLE 27 KEY MARKET PLAYERS IN PHOTOTHERAPY, PRODUCTS PIPELINE
  • PSORIASIS
  • TABLE 28 PSORIASIS INCIDENCE BY COUNTRY IN 2011
  • TABLE 29 PSORALEN BRAND NAMES BY COMPANY AND BY COUNTRY

CHAPTER 8 NANOTECHNOLOGY IN PHOTOMEDICINE

  • CANCER PHOTOTHERMAL THERAPY
    • FULLERENE C60
    • C60 TOXICITY
    • UPTAKE AND BIODISTRIBUTION
    • PHOTODYANIMC THERAPY
  • GOLD NANOPARTICLES
    • CONTRAST ENHANCERS
    • Polymer-Based Imaging Probes for Cancer Imaging
  • QUANTUM DOTS IN CANCER IMAGING AND THERAPY
    • QUANTUM DOTS IN PHOTODYNAMIC THERAPY AND IMAGING
  • MULTIFUNCTIONAL MAGNETIC NANOPARTICLES FOR CANCER IMAGING AND THERAPY
  • GOLD NANOMATERIALS FOR PHOTOTHERMAL THERAPY

CHAPTER 9 DRIVERS AND RESTRAINTS

  • TABLE 30 BIOLOGICS APPROVED FOR PSORIASIS
  • TABLE 31 DRIVERS FOR THE PHOTOMEDICINE MARKET
  • TABLE 32 LIMITERS FOR THE PHOTOMEDICINE MARKET
  • COMPARISON BETWEEN PHOTOTHERAPY AND ORAL MEDICATIONS
  • TABLE 33 COST OF PSORIASIS FOR A TYPICAL WESTERN EUROPEAN COUNTRY

CHAPTER 10 PATENT ANALYSIS

  • TABLE 34 PATENTS IN PHOTOTHERAPY BY YEAR, 2003-2013 (NUMBER)
  • FIGURE 4 PATENTS IN PHOTOTHERAPY BY YEAR. 2003-2013 (NUMBER)
  • TABLE 35 PATENTS IN PHOTODYNAMIC THERAPY BY YEAR, 2003-2013 (NUMBER)
  • FIGURE 5 PATENTS ABOUT PHOTODYNAMIC THERAPY BY YEAR, 2003-2013 (NUMBER)

CHAPTER 11 HEALTHCARE SYSTEMS IN THE WORLD

  • EUROPE
    • BELGIUM
    • SWEDEN
  • NORTH AMERICA
  • SOUTH AMERICA
  • ASIA
    • CHINA
    • INDIA
  • AFRICA
  • TABLE 36 WORLD HEALTH ORGANIZATION HEALTHCARE RANKING, 2000
  • TABLE 37 EURO HEALTH CONSUMER INDEX HEALTHCARE RANKING IN EUROPE, 2013
  • TABLE 38 BLOOMBERG HEALTHCARE RANKING, 2013

CHAPTER 12 PRESS RELEASES

  • TABLE 39 RELEVANT PRESS RELEASES IN PHOTOMEDICINE

CHAPTER 13 PROFILES OF COMPANIES

  • ABBOTT MEDICAL OPTICS
  • ABBVIE
  • AESCULIGHT
  • AGENUS
  • AICURIS
  • ALCON
  • ALLERGAN
  • ALMIRALL
  • AMGEN
  • AMJO
  • ANACOR
  • ANGES
  • ANGIODYNAMICS
  • APEIRON
  • ASTELLAS
  • ASTION
  • ASTRAZENECA
  • ASUKA LASER SYSTEMS
  • BARRIER THERAPEUTICS
  • BASILEA
  • BELMEDPREPARATY
  • BIOLASE TECHNOLOGY
  • BIOLITEC
  • BRISTOL-MYERS SQUIBB
  • CANDELA
  • CELGENE
  • CIPHER PHARMACEUTICALS
  • COHERENT
  • CONVERGENT LASER TECHNOLOGIES
  • CYNOSURE
  • DB PHARMA
  • DEKA LASER
  • DENFOTEX LIGHT SYSTEMS
  • DORNIER MEDTECH GMBH
  • DUSA PHARMACEUTICALS
  • ELI LILLY
  • ELLEX MEDICAL LASERS
  • ERCHONIA MEDICAL
  • FRANCO-INDIAN PHARMACEUTICALS
  • GALDERMA
  • GENENTECH
  • GLAXOSMITHKLINE
  • HANALL BIOPHARMA
  • HEIDELBERG ENGINEERING
  • IMMUNE TECHNOLOGIES & MEDICINE
  • INCYTE
  • INGA LABORATORIES
  • IRIDEX
  • JANSSEN BIOTECH
  • KAKEN PHARMACEUTICALS
  • KELA 139
  • LANTIS LASER
  • LEO
  • LISA LASER PRODUCTS
  • LIGHT SCIENCES ONCOLOGY
  • LUMENIS
  • MEDA
  • NANOBIO
  • NATIONAL BIOLOGICAL
  • NAVIDEA
  • NIDEK COMPANY
  • NITRIC BIOTHERAPEUTICS
  • NOVARTIS
  • ONDINE BIOPHARMA
  • OPTOS
  • PARALLAX TECHNOLOGY
  • PFIZER
  • PHILIPS
  • PHOTOCURE
  • PHOTOMEDEX
  • PINNACLE BIOLOGICS
  • PLC SYSTEMS
  • QUANTEL MEDICAL
  • RADAPHARMA
  • REGENERON
  • SHANGHAI FUDAN-ZHANGJIAN BIO-PHARMACEUTICAL
  • SOLARC SYSTEMS
  • SOLTA MEDICAL
  • SPECTRANETICS
  • STEBA BIOTECH
  • SWITCH BIOTECH
  • THERAKOS
  • TRIA BEAUTY
  • TRIMEDYNE
  • UCLA HEALTH
  • UVBIOTEK
  • VALEANT PHARMACEUTICALS
  • VASCULAR SOLUTIONS
  • VERILUX
  • VETA GRAND
  • WORLD OF MEDICINE
  • ZEISS MEDITEC

LIST OF TABLES

  • SUMMARY TABLE GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 1 EXAMPLES OF DRUGS AND MEDICAL DEVICES MARKETED AS A COMBO IN PHOTOMEDICINE
  • TABLE 2 GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 3 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY REGION, 2013-2019 (%)
  • TABLE 4 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE, THROUGH 2019 ($ MILLIONS)
  • TABLE 5 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 6 GLOBAL MARKET SHARE FOR DRUGS IN PHOTOMEDICINE BY THERAPEUTIC AREA, 2014 AND 2019 (%)
  • TABLE 7 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE BY CHEMICAL SPECIALTY, THROUGH 2019 ($ MILLIONS)
  • TABLE 8 GLOBAL MARKET FOR PHOTOMEDICINE, BY TREATMENT, THROUGH 2019 ($ MILLIONS)
  • TABLE 9 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY TREATMENT, 2013-2019 (%)
  • TABLE 10 GLOBAL MARKET FOR PUVA THERAPY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 11 GLOBAL MARKET FOR UVB THERAPY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 12 GLOBAL MARKET FOR LLLT IN PHOTOMEDICINE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 13 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY, THROUGH 2019 ($ MILLIONS)
  • TABLE 14 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 15 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY LASERS FOR CANCER BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 16 ULTRAVIOLET RADIATION CLASSIFICATION BY NAME, WAVELENGTH AND ENERGY
  • TABLE 17 VISIBLE SPECTRUM BY COLOR, WAVELENGTH AND ENERGY
  • TABLE 18 DISEASES SOMETIMES AGGRAVATED BY UV IRRADIATION
  • TABLE 19 UV FILTER BY TYPE
  • TABLE 20 CHEMICAL COMPOUNDS USED AS PHOTOPROTECTOR
  • TABLE 21 ADVANTAGES OF USING UBI THERAPY
  • TABLE 22 PHOTODYNAMIC THERAPY PROS AND CONS
  • TABLE 23 PHOTOSENSITIZERS FOR PDT DEVELOPED IN RUSSIA
  • TABLE 24 DRUGS USED IN PHOTOTHERAPY BY TYPE OF CHEMICAL COMPOUND
  • TABLE 25 EXAMPLE OF DRUGS AND MEDICAL DEVICES MARKETED AS A COMBO IN PHOTOMEDICINE
  • TABLE 26 KEY MARKET PLAYERS IN PHOTOTHERAPY BY COMPANY AND PRODUCT
  • TABLE 27 KEY MARKET PLAYERS IN PHOTOTHERAPY, PRODUCTS PIPELINE
  • TABLE 28 PSORIASIS INCIDENCE BY COUNTRY IN 2011
  • TABLE 29 PSORALEN BRAND NAMES BY COMPANY AND BY COUNTRY
  • TABLE 30 BIOLOGICS APPROVED FOR PSORIASIS
  • TABLE 31 DRIVERS FOR THE PHOTOMEDICINE MARKET
  • TABLE 32 LIMITERS FOR THE PHOTOMEDICINE MARKET
  • TABLE 33 COST OF PSORIASIS FOR A TYPICAL WESTERN EUROPEAN COUNTRY
  • TABLE 34 PATENTS IN PHOTOTHERAPY BY YEAR, 2003-2013 (NUMBER)
  • TABLE 35 PATENTS IN PHOTODYNAMIC THERAPY BY YEAR, 2003-2013 (NUMBER)
  • TABLE 36 WORLD HEALTH ORGANIZATION HEALTHCARE RANKING, 2000
  • TABLE 37 EURO HEALTH CONSUMER INDEX HEALTHCARE RANKING IN EUROPE, 2013
  • TABLE 38 BLOOMBERG HEALTHCARE RANKING, 2013
  • TABLE 39 RELEVANT PRESS RELEASES IN PHOTOMEDICINE

LIST OF FIGURES

  • FIGURE TITLE PAGE NO.
  • SUMMARY FIGURE GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, 2013-2019 ($ MILLIONS)
  • FIGURE 1 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY REGION, 2014 (%)
  • FIGURE 2 GLOBAL MARKET SHARE FOR DRUGS IN PHOTOMEDICINE BY THERAPEUTIC AREA, 2014 AND 2019 (%)
  • FIGURE 3 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY TREATMENT, 2014 (%)
  • FIGURE 4 PATENTS IN PHOTOTHERAPY BY YEAR. 2003-2013 (NUMBER)
  • FIGURE 5 PATENTS ABOUT PHOTODYNAMIC THERAPY BY YEAR, 2003-2013 (NUMBER) 8
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