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次世代シーケンシング:新しい臨床アプリケーションおよび世界市場

Next Generation Sequencing: Emerging Clinical Applications and Global Markets

発行 BCC Research 商品コード 276316
出版日 ページ情報 英文 321 Pages
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次世代シーケンシング:新しい臨床アプリケーションおよび世界市場 Next Generation Sequencing: Emerging Clinical Applications and Global Markets
出版日: 2017年06月26日 ページ情報: 英文 321 Pages
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概要

世界の次世代シーケンシング (NGS) 市場は2016年に27億米ドルに達しました。同市場は、2017年の32億米ドルから2022年までに105億米ドルへと27%のCAGR (年間複合成長率) で拡大すると予測されています。

当レポートでは、世界の次世代シーケンシング市場とその新しい臨床アプリケーション市場について調査し、実績・推計データおよびCAGR予測を含む世界市場の動向分析、主要な市場セグメントの産業構造調査、戦略的アライアンス・買収およびシーケンシング特許の評価、主要企業の戦略の分析および主要企業のプロファイルなどをまとめ、お届けいたします。

第1章 イントロダクション

第2章 サマリー・ハイライト

第3章 概要

  • イントロダクション
  • 臨床向けNGS市場
  • 臨床向けNGSの成長促進因子
    • 技術促進因子
    • 市場促進因子
  • 臨床向けNGSのアプリケーション
  • 臨床向けNGS産業

第4章 技術背景

  • DNAの重要性
  • 遺伝的変異・分析
  • 遺伝分析技術
  • 臨床アプリケーションにおけるシーケンシング
  • シーケンシング技術
  • インフォマティクス技術
  • 臨床シーケンシング技術の課題

第5章 臨床向け次世代シーケンシング (NGS) イニシアチブ

  • 臨床向けNGSプロジェクト
    • Actionable Genome Consortium
    • BabySeq
    • Cancer Moon Shoots Program
    • China Precision Medicine Initiative
    • ClinGen
    • France Genomic Medicine Plan
    • Lung-Map
    • Matchmaker Exchange
    • MedSeq
    • Metagenomics and Metadesign of Subways and Urban Biomes (MetaSub)
    • Microbiome Coalition
    • Million Veteran Program
    • National Microbiome Initiative
    • Precision Medicine
    • Prompt

第6章 臨床向け次世代シーケンシング (NGS) アプリケーション

  • イントロダクション
  • 癌アプリケーション
  • メンデル性疾患アプリケーション
  • リプロダクティブヘルスアプリケーション
  • 微生物学・感染症アプリケーション
  • 複合疾患アプリケーション

第7章 臨床向け次世代シーケンシング (NGS) 産業

  • イントロダクション
  • NGS装置産業
  • ターゲットエンリッチメント・増幅産業
  • NGS臨床インフォマティクス産業
  • NGS検査サービス産業
  • リプロダクティブヘルス診断産業
  • 液体細胞診産業
  • 免疫シーケンシング産業
  • ヒト白血球抗原タイピング (HLAタイピング) 産業
  • 第3世代シーケンシング産業
  • DTC (Direct-to-Consumer) 遺伝子検査産業

第8章 買収・戦略的アライアンス

  • 買収
  • 戦略的アライアンス

第9章 臨床向け次世代シーケンシング (NGS) 市場

  • 成長促進因子
  • 臨床向けシーケンシング市場
  • 臨床向けNGS癌市場
  • NGS心血管診断市場
  • NGSメンデル性疾患診断市場
  • NGS代謝/免疫疾患市場
  • NGS神経診断市場
  • リプロダクティブヘルス市場
  • NGS微生物学・感染症診断市場
  • 移植市場
  • 地域市場

第10章 特許レビュー

  • 臨床向けNGS特許
  • 臨床向けNGS特許:適応症別
  • セルフリーDNA特許
  • シーケンシング関連特許の問題

第11章 企業プロファイル

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目次
Product Code: BIO126C

Report Highlights

The global clinical next-generation sequencing (NGS) market reached $2.7 billion in 2016. This market is expected to grow at a compound annual growth rate (CAGR) of 27%, from nearly $3.2 billion in 2017 to $10.5 billion by 2022.

Report Includes:

  • An overview of the global market for next-generation sequencing and its emerging clinical applications.
  • Analyses of global market trends, with data from 2016, estimates for 2017, and projections of compound annual growth rates (CAGRs) through 2022.
  • Examination of the sequencing industry structure for key market segments.
  • Discussion covering the strategies employed by the main companies in the market.
  • Comprehensive company profiles of major players in the field.

Report Scope

The scope of the report includes clinical NGS technologies, applications, industries, initiatives, patents and companies. The markets for NGS-based diagnostics are given for the years 2015, 2016, 2017 and 2022.

This report reviews the main sequencing technologies and explains why genetic variation is important in clinical testing. It then discusses some of the significant research initiatives that impact clinical NGS applications. The main market driving forces are also discussed.

The report examines the markets by test complexity, clinical indication and test purpose. Test complexity refers to the plex level (i.e., the number of genetic markers that can be analyzed within a sample) and coverage (e.g., the extent to which the genome is covered) of the test. Examining the market by test complexity provides valuable insight into which products (e.g., sample preparation, NGS instrument, informatics, etc.) will be in demand in the future.

The report provides market data and forecasts for NGS diagnostics by specific applications, including those for cancer, cardiovascular diseases, clinical microbiology and infectious diseases, Mendelian disorders, metabolic and immune disorders, neurological disorders, reproductive health, and transplant medicine.

Specific geographic markets are discussed, including North America, Europe, Asia-Pacific, and the rest of the world.

Industry sectors analyzed include sequencing instruments, target enrichment, informatics, clinical laboratory testing services, reproductive health diagnostics, liquid biopsy, immune sequencing, HLA typing, third generation sequencing, and direct to consumer.

More than 200 companies in the clinical NGS industry are profiled in this report.

BCC Research provides a summary of the main industry acquisitions and strategic alliances from 2015 through April 2017, including key alliance trends.

Analyst Credentials

John Bergin has held business development, sales and marketing positions with a Fortune 500 advanced materials company, as well as executive management positions with a nanotechnology/separations company. Bergin holds a B.S. degree in Chemistry, an M.S. degree in Biotechnology and a Master of Business Administration. John Bergin is a pseudonym of the author.

Table of Contents

Chapter 1: Introduction

  • Study Goals and Objectives
  • Reasons for Doing This Study
  • Scope of Report
  • Information Sources
  • Methodology
  • Geographic Breakdown
  • Analyst's Credentials
  • Related BCC Research Reports

Chapter 2: Summary and Highlights

Chapter 3: Overview

  • Introduction
  • Clinical NGS Markets
  • Clinical NGS Growth Driving Forces
    • Technology Drivers
    • Market Drivers
  • Clinical NGS Applications
  • Clinical NGS Industry

Chapter 4: Technology Background

  • Importance of DNA
  • Genetic Variation and Analysis
  • Genetic Analysis Technologies
  • Sequencing in Clinical Applications
  • Sequencing Technologies
    • History of DNA Sequencing
    • Sanger Sequencing Technology
    • Next-Generation Sequencing Platforms
    • Benchtop Sequencers
  • Informatics Technologies
    • Base Calling
    • Mapping to a Reference Sequence
    • Variant Analysis
  • Clinical Sequencing Technology Challenges

Chapter 5: Clinical NGS Initiatives

  • Clinical Next-Generation Sequencing Projects
    • Actionable Genome Consortium
    • BabySeq
    • Cancer Moon Shoots Program
    • China Precision Medicine Initiative
    • ClinGen
    • France Genomic Medicine Plan
    • Lung-Map
    • Matchmaker Exchange
    • MedSeq
    • Metagenomics and Metadesign of Subways and Urban Biomes (MetaSub)
    • Microbiome Coalition
    • Million Veteran Program
    • National Microbiome Initiative
    • Precision Medicine
    • Prompt

Chapter 6: Clinical NGS Applications

  • Introduction
  • Cancer Applications
  • Mendelian Disorders Applications
  • Reproductive Health Applications
  • Microbiology and Infectious Disease Applications
  • Complex Disorders Applications

Chapter 7: Clinical NGS Industry

  • Introduction
  • NGS Instrument Industry
  • Target Enrichment and Amplification Industry
  • NGS Clinical Informatics Industry
  • NGS Testing Services Industry
  • Reproductive Health Diagnostics Industry
    • NonInvasive Prenatal Testing Industry
    • Fetal Cell NIPT Industry
  • Liquid Biopsy Industry
  • Immune Sequencing Industry
  • HLA Typing Industry
  • Third-Generation Sequencing Industry
    • Tier 1 Companies
    • Tier 2 Companies
    • Tier 3 Companies
  • Direct-to-Consumer Genetic Testing Industry

Chapter 8: Acquisitions and Strategic Alliances

  • Acquisitions
  • Strategic Alliances
    • 2015 Alliances
    • 2016 Alliances
    • 2017 Alliances

Chapter 9: Clinical NGS Markets

  • Growth Driving Forces
  • Clinical Sequencing Market
  • Clinical NGS Cancer Market
  • NGS Cardiology Diagnostics Markets
  • NGS Mendelian Disorders Diagnostics Markets
  • NGS Metabolic/Immune Disorder Diagnostics Markets
  • NGS Neurology Diagnostics Markets
  • Reproductive Health Markets
    • NIPT Market
    • IVF Market
    • Newborn Screening Market
    • Carrier Screening Market
  • NGS Microbiology and Infectious Disease Diagnostic Market
  • Transplant Market
  • Geographical Market

Chapter 10: Patent Review

  • Clinical NGS Patents
  • Clinical NGS Patents by Indication
  • Cell-free DNA Patents
  • Sequencing-Related Patent Issues

Chapter 11: Company Profiles

About BCC Research

  • About BCC Research
  • BCC Membership
  • BCC Custom Research

List of Tables

  • Table 1: Summary Table: Global Clinical Next-Generation Sequencing Market, by Disease Class, Through 2022 ($ Millions)
  • Table 2: Report Scope
  • Table 3: Global Next-Generation Sequencing Diagnostic Market, by Disease Type, Through 2022 ($ Millions)
  • Table 4: Key Technology Drivers for Clinical Next-Generation Sequencing
  • Table 5: Clinical Next-Generation Sequencing Market Driving Forces
  • Table 6: Clinical Next-Generation Sequencing Application Status
  • Table 7: Key Diagnostic Next-Generation Industry Participants by Sector
  • Table 8: DNA Chemical Building Blocks
  • Table 9: DNA Translation and Transcription
  • Table 10: Long-range DNA Structure
  • Table 11: Genetic Variant Types
  • Table 12: Molecular Diagnostic Technology Platforms
  • Table 13: Genetic Testing Evolution
  • Table 14: Key Near- to Mid-term Segments for Next-Generation Sequencing Diagnostics
  • Table 15: DNA Sequencing Historical Timeline
  • Table 16: Sequencing Technology Development, 1990-2020
  • Table 17: Cost to Sequence a Single Human Genome, 2001-2017 ($)
  • Table 18: Sanger Sequencing Summary
  • Table 19: Sanger Sequencing Improvements
  • Table 20: Next-Generation Sequencing Technologies
  • Table 21: Roche Next-Generation Sequencing Workflow
  • Table 22: Illumina Next-Generation Sequencing Workflow
  • Table 23: Thermo Fisher Next-Generation Sequencing Workflow
  • Table 24: Benchtop and Handheld Sequencer Platforms
  • Table 25: Next-Generation Sequencing Bioinformatics Workflow
  • Table 26: Sequence Annotation Steps
  • Table 27: Future Challenges for Implementing Clinical Next-Generation Sequencing
  • Table 28: Clinical Next-Generation Sequencing Projects
  • Table 29: Clinical Next-Generation Sequencing Near- to Mid-term Applications
  • Table 30: Cancer Applications
  • Table 31: Mendelian Disorders Applications
  • Table 32: Reproductive Health Screening Applications
  • Table 33: Ethical Issues Associated with Prenatal and Newborn Screening
  • Table 34: Microbiology and Infectious Disease Applications
  • Table 35: Complex Disorder Applications
  • Table 36: Key Segments within the Next-Generation Sequencing Clinical Industry
  • Table 37: Next-Generation Sequencing Instrument Company Summary
  • Table 38: Target Enrichment Industry
  • Table 39: Next-Generation Sequencing Clinical Informatics Company Positioning
  • Table 40: Selected NGS Clinical Testing Laboratories
  • Table 41: NGS NIPT Industry
  • Table 42: Number of Tests and Market for NIPT, by Region and Company, 2015 (Number of Tests Performed)
  • Table 43: Germany NGS-based Non-invasive Prenatal Diagnostic Companies
  • Table 44: Fetal Cell NIPT Industry
  • Table 45: Liquid Biopsy Company Focus
  • Table 46: Example of NGS-based Liquid Biopsy Market Differentiation
  • Table 47: Immune System Profiling Industry
  • Table 48: NGS-based HLA Typing Industry Competitors
  • Table 49: Third-Generation Sequencing Industry
  • Table 50: Key Competitors in the Direct-to-Consumer Genetic Testing Industry
  • Table 51: Clinical Next-Generation Sequencing Industry Acquisitions, January 2015- April 2017
  • Table 52: Clinical Next-Generation Sequencing Strategic Alliances, January 2015- April 2017
  • Table 53: Clinical Next-Generation Sequencing Key Market Growth Driving Forces
  • Table 54: Global Clinical Sequencing Market, by Indication, Through 2022 ($ Millions)
  • Table 55: Global Clinical NGS Market, by Test Complexity, Through 2022 ($ Millions)
  • Table 56: Global Clinical NGS Market, by Test Purpose, Through 2022 ($ Millions)
  • Table 57: NGS-based Preventive Genetic Screening Tests
  • Table 58: Global Clinical NGS Cancer Market, by Indication, Through 2022 ($ Millions)
  • Table 59: Global Clinical NGS Cancer Market, by Test Purpose, Through 2022 ($ Millions)
  • Table 60: Early Cancer Detection
  • Table 61: NGS Instrument Company Companion Diagnostics Status
  • Table 62: Global Clinical NGS Cancer Market, by Test Complexity, Through 2022 ($ Millions)
  • Table 63: Global Clinical NGS Cardiology Diagnostic Market, by Test Purpose, Through 2022 ($ Millions)
  • Table 64: Dilated Cardiomyopathy Test Providers
  • Table 65: Global Clinical NGS Cardiology Diagnostic Market, by Test Complexity, Through 2022 ($ Millions)
  • Table 66: Global Clinical NGS Mendelian Disorder Diagnostic Market, by Test Purpose, Through 2022 ($ Millions)
  • Table 67: Global Clinical NGS Mendelian Disorder Diagnostic Market, by Test Complexity, Through 2022 ($ Millions)
  • Table 68: Global Clinical NGS Metabolic and Immune Disorder Diagnostic Market, by Test Purpose, Through 2022 ($ Millions)
  • Table 69: Multiple Sclerosis Diagnostic Technologies
  • Table 70: Global Clinical NGS Metabolic and Immune Disorder Diagnostic Market, by Test Complexity, Through 2022 ($ Millions)
  • Table 71: Global Clinical NGS Neurology Diagnostic Market, by Test Purpose, Through 2022 ($ Millions)
  • Table 72: Global Clinical NGS Neurology Diagnostic Market, by Test Complexity, Through 2022 ($ Millions)
  • Table 73: Global Reproductive Health Market, by Application, Through 2022 ($ Millions)
  • Table 74: Global NIPT Market, by Risk Type, Through 2022 ($ Millions)
  • Table 75: Global Clinical NGS Reproductive Health Market, by Test Complexity, Through 2022 ($ Millions)
  • Table 76: NGS-based Infectious Disease Landscape
  • Table 77: Global Clinical NGS Microbiology and Infectious Disease Diagnostic Market, by Test Purpose, Through 2022 ($ Millions)
  • Table 78: Global Clinical NGS Microbiology and Infectious Disease Diagnostic Market, by Test Complexity, Through 2022 ($ Millions)
  • Table 79: NGS in Infectious Disease Diagnostics
  • Table 80: Global Clinical NGS Transplant Market, by Analysis Purpose, Through 2022 ($ Millions)
  • Table 81: Global Clinical NGS Transplant Market, by Test Complexity, Through 2022 ($ Millions)
  • Table 82: Global Clinical NGS Transplant Monitoring Market, by Organ Type, Through 2022 ($ Millions)
  • Table 83: Transplant Procedures Performed in the United States, 2015 and 2016
  • Table 84: Global Clinical NGS Market, by Region, Through 2022 ($ Millions)
  • Table 85: Global Clinical NGS Cancer Market, by Region, Through 2022 ($ Millions)
  • Table 86: Global Reproductive Health Market, by Region, Through 2022 ($ Millions)
  • Table 87: Global Transplant Market, by Region, Through 2022 ($ Millions)
  • Table 88: Clinical Next-Generation Sequencing Patents, 2005-2015
  • Table 89: Clinical Next-Generation Sequencing Patents by Indication, 2005-2015
  • Table 90: Cell-free DNA Patents, 2005-2015
  • Table 91: Status of Sequencing-Related Patent Disputes
  • Table 92: Data Needs
  • Table 93: Companies in the Epigenetic Sequencing Industry
  • Table 94: Molecular Thyroid Nodule Classifier Test Company Positioning
  • Table 95: Sensitivity to Detect Drug Resistant Mutations in Viruses (%)
  • Table 96: WaferGen Strategic Alliances

List of Figures

  • Figure 1: Summary Figure: Global Clinical Next-Generation Sequencing Market, by Disease Class, 2015- 2022 ($ Millions)
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