株式会社グローバルインフォメーション
TEL: 044-952-0102
表紙
市場調査レポート

マイクロRNA研究ツール・診断・治療の世界市場

MicroRNA Research Tools, Diagnostics and Therapeutics: Global Markets

発行 BCC Research 商品コード 254754
出版日 ページ情報 英文 273 Pages
即納可能
価格
本日の銀行送金レート: 1USD=114.81円で換算しております。
Back to Top
マイクロRNA研究ツール・診断・治療の世界市場 MicroRNA Research Tools, Diagnostics and Therapeutics: Global Markets
出版日: 2014年09月24日 ページ情報: 英文 273 Pages
担当者のコメント
BCC Research社のレポートは、Reuter、Wall Street Journal、Fortuneなどで引用されることも多く、それぞれの業界の識者の意見として重きを置かれています。同社レポートを複数冊ご購入の場合年間パッケージのご契約がお得です。詳細は右の担当者のおすすめ商品よりご覧下さい。
概要

世界のマイクロRNA(miRNA)研究ツール、サービス、診断および創薬市場は、2013年に金額ベースで4億7,880万米ドル規模となりました。同市場は2014-2019年の期間中、12.6%のCAGRで成長し、市場規模は2014年の5億7,200万米ドルから2019年には10億米ドルに達すると予測されています。

当レポートでは、世界のマイクロRNA診断・治療市場について調査し、同研究分野の商業的可能性について分析しており、世界市場の動向とデータ、CAGR予測、miRNA候補薬のポートフォリオ、RNA治療の主要市場、および主要企業のプロファイルなどをまとめ、お届けします。

第1章 イントロダクション

第2章 エグゼクティブサマリー

第3章 マイクロRNA研究のイントロダクション

  • 過去の経緯の概要
  • マイクロRNAの命名法
  • マイクロRNAの生物発生
  • マイクロRNA研究:有機体別
  • マイクロRNA研究:分野別
  • 人間の病気に関連したマイクロRNA
  • マイクロRNA研究資金
  • マイクロRNAデータベースの成長
  • マイクロRNAに関する論文審査のある科学専門誌
  • マイクロRNA関連の特許
  • マイクロRNA市場における主なコラボレーション
  • マイクロRNA研究ツールの世界市場
  • マイクロRNA研究製品の世界市場:地域別

第4章 マイクロRNA-標的療法:概要

  • RNA療法:最も重要な新興技術の第4位
  • マイクロRNA療法が対処する疾病クラス
  • マイクロRNA技術・治療法の開発企業
  • マイクロRNA療法のメリット
  • 心血管マイクロRNAの治療標的
  • マイクロRNA:標的創薬市場

第5章 マイクロRNAサービス部門:概要

  • マイクロRNAサービスプロバイダー
  • マイクロRNAサービス市場

第6章 診断におけるマイクロRNA:概要

  • 診断バイオマーカーとしてのマイクロRNAの潜在的用途
  • 診断におけるさまざまなマイクロRNA検出手法の比較
  • マイクロRNA型診断におけるROSETTA GENOMICSのリーダーシップ
  • 癌診断としてのマイクロRNA
  • マイクロRNA診断の世界市場

第7章 バイオインフォマティックス:マイクロRNA研究における用途

  • マイクロRNAターゲット予測ツール
  • 世界のバイオインフォマティックス市場

第8章 マイクロRNA技術:概要

  • マイクロRNAプロファイリング

第9章 マイクロRNA研究におけるツール・試薬のサマリー

第10章 マイクロRNA研究ツール、サービス、診断および創薬製品開発の市場サマリー

  • 主なマイクロRNA市場参入企業

第11章 主要企業のプロファイル

第12章 付録:頭字語・略語

図表リスト

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次
Product Code: BIO115B

The global market for microRNA (miRNA) research tools, services, diagnostics and drug discovery was valued at $478.8 million in 2013. This market is expected to reach $572 million in 2014 and $1 billion in 2019, at a compound annual growth rate (CAGR) of 12.6% for the period of 2014 to 2019.

This report provides:

  • An overview of the global market for microRNA diagnostics and therapeutics with an analysis of the commercial potential of this research field.
  • Analyses of global market trends, with data from 2013, estimates for 2014, and projections of CAGRs through 2019.
  • Examination of the extensive portfolio of miRNA pathway drug candidates, some already in Phase II clinical trials, showing promising clinical data in different areas of medicine, such as cancer, HCV infection, and cardiovascular diseases.
  • A focus on recent drug candidates, products, deals between different pharmaceutical companies, major participants, and new trends and developments.
  • Identification of the main markets for RNA therapeutics.

image1

REPORT SCOPE

SCOPE AND FORMAT

This BCC Research report is a business tool that is intended to help biotechnology companies evaluate emerging commercial opportunities in the microRNA reagent, diagnostic and therapeutic submarkets. The existing leading players in this market segment are provided with an opportunity to learn what the other competitors in this nascent arena have achieved to gain a stronger foothold in the sector in their quest for bringing to the market blockbuster therapeutics to treat diseases with significant unmet medical needs.

ANALYST'S CREDENTIALS

P. Natana Raj is a medical analyst and has edited 25 market research reports in the past nine years, covering pharmaceuticals, medical devices, stem cells, regenerative medicine and beverages. He is a retired college professor with 32 years of experience in teaching biochemistry, biotechnology, biochemical pharmacology, molecular biology and genetics. In addition to his Master of Science degree in Biology, he also holds diplomas in biochemistry, biochemical pharmacology, biotechnology and environmental biology.

Table of Contents

CHAPTER 1 INTRODUCTION

  • STUDY GOALS AND OBJECTIVES
  • REASONS FOR DOING THIS STUDY
  • SCOPE AND FORMAT
  • METHODOLOGY AND INFORMATION SOURCES
  • INTENDED AUDIENCE
  • ANALYST'S CREDENTIALS
  • RELATED BCC RESEARCH REPORTS
  • BCC RESEARCH WEBSITE
  • DISCLAIMER

CHAPTER 2 EXECUTIVE SUMMARY

  • SUMMARY TABLE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES, DIAGNOSTICS AND DRUG DISCOVERY, THROUGH 2019 ($ MILLIONS)
  • SUMMARY FIGURE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES, DIAGNOSTICS AND DRUG DISCOVERY, 2013-2019 ($ MILLIONS)

CHAPTER 3 INTRODUCTION TO MICRORNA RESEARCH

  • HISTORICAL OVERVIEW OF MICRORNA RESEARCH
  • TABLE 1 MICRORNA TIMELINE
    • LANDMARK DISCOVERIES IN MICRORNA
      • Discovery of lin-4 in 1993
      • Discovery of let-7 in 2000
      • Discovery of miRNA in Plants in 2002
      • Discovery of miRNA Alterations in Cancer Cells (miR15 and miR16) in 2002
      • Discovery of miRNA Genes in Cancer-Associated Genomic Regions in 2004
      • Discovery of miRNA-Target Interaction Relevant to Cancer in 2005
      • Discovery of miRNA Deregulation in Cancer Metastasis in 2007
      • Discovery of miR-373 in 2008
      • Development of Proof of Concept of miRNA Delivery as Cancer Therapy in 2009
      • Discovery of miRNA as Molecular Decoys in 2010
      • Discovery of Food-Derived Exogenous miRNAs in Serum and Plasma in 2012
  • NOMENCLATURE OF MICRORNA
  • BIOGENESIS OF MICRORNA
  • FIGURE 1 BIOGENESIS OF MICRORNA
  • MICRORNA RESEARCH BY ORGANISM
  • FIGURE 2 MICRORNA RESEARCH SHARE BY ORGANISM, 2013 (%)
  • MICRORNA RESEARCH BY AREA
  • FIGURE 3 MICRORNA RESEARCH SHARES BY AREA, 2013 (%)
  • MICRORNAS ASSOCIATED WITH HUMAN DISEASES
  • TABLE 2 MICRORNA ASSOCIATED WITH HUMAN DISEASES
    • MIR-15
    • MIR-16
    • MIR-125B
    • MIR-145
    • MIR-21
    • MIR-155
    • MIR-210
    • MIR-29B
    • MIR-122
    • MIR-150
    • MIR-223
    • MIR-34A
    • MIR-326
    • MIR-144
    • MIR-103
    • MIR-200
  • FUNDING FOR MICRORNA RESEARCH
  • TABLE 3 EXIQON MICRORNA RESEARCH GRANT PROGRAMS, 2011-2014
  • GROWTH IN MICRORNA DATABASE
  • FIGURE 4 GROWTH OF MICRORNA DATABASE, 2002-2013 (NUMBER)
  • PEER-REVIEWED SCIENTIFIC PUBLICATIONS ON MICRORNA
  • FIGURE 5 PEER-REVIEWED SCIENTIFIC PUBLICATIONS ON MICRORNA, 2003-2013 (NUMBER OF PUBLICATIONS)
  • PATENTS RELATED TO MICRORNA
    • MICRORNA PATENTS BY TECHNOLOGICAL CATEGORY
    • TABLE 4 PERCENTAGE SHARE OF MICRORNA PATENTS BY TECHNOLOGICAL CATEGORY, 2013 (%)
    • TABLE 5 U.S. PATENT APPLICATIONS RELATED TO MICRORNA, 2014
    • MICRORNA PATENTS BY DISEASE CATEGORY
    • TABLE 6 PERCENTAGE OF MICRORNA PATENTS BY DISEASE CATEGORY, 2013 (%)
  • MAJOR COLLABORATIONS WITHIN THE MICRORNA MARKET IN 2013 AND 2014
    • SANTARIS PHARMA A/S AND MIRAGEN THERAPEUTICS INC.
    • SANTARIS PHARMA A/S AND BRISTOL-MYERS SQUIBB CO.
    • SANTARIS PHARMA A/S AND PFIZER INC.
    • SANTARIS PHARMA A/S AND SHIRE PLC
    • SANTARIS PHARMA A/S AND WYETH PHARMACEUTICALS
    • SANTARIS PHARMA A/S AND GLAXOSMITHKLINE
    • MARINA BIOTECH AND MIRNA THERAPEUTICS
  • GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS
  • FIGURE 6 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, 2013-2019 ($ MILLIONS)
  • GLOBAL MARKET FOR MICRORNA RESEARCH PRODUCTS BY GEOGRAPHICAL REGION
  • FIGURE 7 GLOBAL MARKET SHARES OF MICRORNA RESEARCH PRODUCTS BY REGION, 2013 (%)

CHAPTER 4 MICRORNA-TARGETED THERAPEUTICS: AN OVERVIEW

  • RNA THERAPEUTICS: FOURTH MOST IMPORTANT EMERGING TECHNOLOGY IN 2014
  • TABLE 7 TOP 10 EMERGING TECHNOLOGIES IN 2014
  • DISEASE CLASSES ADDRESSED BY MICRORNA THERAPEUTICS
  • TABLE 8 DISEASE CLASSES ADDRESSED BY MICRORNA THERAPEUTICS
    • CURRENT STATUS OF MICRORNA-TARGETING THERAPEUTICS
    • TABLE 9 CURRENT CLINICAL APPLICATIONS TARGETING MICRORNA
      • Anti-miR-122 Therapy against Chronic Hepatitis C
      • FIGURE 8 INHIBITION OF MIR-122 BY MIRAVIRSEN
      • miR-34 Mimics as a Therapeutic against Primary and Metastatic Liver Cancer
      • Preclinical In Vivo Experiments with MicroRNA
      • TABLE 10 A SMALL SAMPLE OF PRECLINICAL IN VIVO EXPERIMENTS WITH MICRORNA
        • miR-221 as an Oncogenic miRNA
        • miR-7 in HCC Cells
        • miR-520 in HCC Cells
        • miR-375 in HCC Cells
        • miR-25 in Colon Cancer Cells
        • miR-217 in Pancreatic Cancer Cells
      • miR-208 in Cardiac Remodeling
      • miR-155 in Inflammatory Disease
      • miR-21 in Fibrosis
      • miR-92a in Neoangiogenesis
      • miR-15 Family in Cardiac Regeneration and Injury
  • COMPANIES DEVELOPING MICRORNA TECHNOLOGIES AND THERAPEUTICS
  • TABLE 11 SELECTED COMPANIES DEVELOPING MICRORNA THERAPEUTICS
    • MARINA BIOTECH
    • ROSETTA GENOMICS
    • ASURAGEN INC.
    • NEW ENTRANTS
      • miRagen Therapeutics and Santaris Pharma
      • Regulus Therapeutics
      • Mirna Therapeutics
  • ADVANTAGES OF MICRORNA THERAPEUTICS
  • THERAPEUTIC TARGETING OF CARDIOVASCULAR MICRORNAS
  • TABLE 12 THERAPEUTIC TARGETING OF CARDIOVASCULAR MICRORNA
  • MICRORNA-TARGETED DRUG DISCOVERY MARKET
  • FIGURE 9 GLOBAL MICRORNA DRUG DISCOVERY MARKET, 2013-2019 ($ MILLIONS)

CHAPTER 5 MICRORNA SERVICE SECTOR: AN OVERVIEW

  • MICRORNA SERVICE PROVIDERS
  • TABLE 13 SELECTED COMPANIES OFFERING MICRORNA PROFILING SERVICES
    • SELECTED MICRORNA SERVICE PROVIDERS
      • miRNA Services from Applied Biological Materials Inc.
      • TABLE 14 PRICES OF RNA SEQUENCING SERVICES BY ABM ($)
      • miRNA Services from Asuragen
        • Biomarker Solutions
        • Platform and Technologies
        • Next-Generation Sequencing Services
      • miRNA Services from Cogenics
        • RNA Extraction and Biobanking
        • miRNA Profiling
        • Microarray Analysis
        • qRT-PCR
        • Experimental Design, Bioinformatics and Data Analysis
      • miRNA Services from Dharmacon (GE Healthcare Life Sciences)
        • miRNA Phenotypic Screening: Functional Characterization of miRNA Biology
        • Functional Characterization of miRNAs
      • miRNA Services from Exiqon
        • Biomarker Discovery from Exiqon
        • miRNA Services from Comprehensive Biomarker Center GmbH
        • miRNA Profiling
      • miRNA Services from Genome Explorations
      • miRNA Services from LC Sciences
        • miRNA Sequencing Service
        • miRNA Microarray Service
        • miRNA qRT-PCR Service
        • Degradome Sequencing
        • Seq-Array for miRNA Discovery and Profiling
      • Services from Life Technologies
        • Total RNA Isolation from Cells or Tissues
        • miRNA Isolation from Cells, Tissues or Total RNA
        • NCode miRNA Microarray Expression Profiling
        • NCode SYBR Green miRNA qRT-PCR Analysis
        • TaqMan Service Provider Programs (Life Technologies)
        • TABLE 15 TAQMAN SERVICE PROVIDERS
        • Services from Oxford Gene Technology
        • TABLE 16 PREDESIGNED MICROARRAYS FROM OXFORD GENE TECHNOLOGY
      • Services from ServiceXS
      • TABLE 17 SERVICEXS' SOLUTIONS FOR RNA ANALYSIS
      • Services from System Biosciences Inc.
        • MicroRNA Expression Profiling Services
        • SBI's Custom Service to Profile Serum miRNAs
      • miRNA Services from Affymetrix
      • TABLE 18 AFFYMETRIX SERVICES PRICE LIST ($)
      • NGS-Specific Service Providers
      • TABLE 19 LIST OF SELECTED NGS-SPECIFIC SERVICE PROVIDERS
  • MICRORNA SERVICE MARKET
  • FIGURE 10 GLOBAL MICRORNA SERVICES MARKET, 2013-2019 ($ MILLIONS)

CHAPTER 6 MICRORNA IN DIAGNOSTICS: AN OVERVIEW

  • POTENTIAL USES OF MICRORNA AS BIOMARKERS FOR DIAGNOSIS
    • MAJOR APPLICATIONS OF MICRORNA AS BIOMARKERS
    • TABLE 20 MAJOR APPLICATIONS OF MICRORNA AS BIOMARKERS
  • COMPARISON OF VARIOUS MICRORNA DETECTION METHODS IN DIAGNOSTICS
  • TABLE 21 COMPARISON OF VARIOUS MICRORNA DETECTION METHODS
  • ROSETTA GENOMICS' LEADERSHIP IN MICRORNA-BASED DIAGNOSTICS
    • ROSETTA GENOMICS' CANCER ORIGIN TEST
    • ROSETTA GENOMICS' LUNG CANCER TEST
    • ROSETTA GENOMICS' KIDNEY CANCER TEST
    • ROSETTA GENOMICS' MESOTHELIOMA TEST
  • MICRORNA AS CANCER DIAGNOSTICS
  • TABLE 22 EXPRESSION PROFILE OF MICRORNA IN DIFFERENT TYPES OF CANCERS
    • CIRCULATING MICRORNAS AS CANCER DIAGNOSTICS
      • Prostrate Cancer
      • TABLE 23 SELECTED CIRCULATING MICRORNA REPORTED TO BE BIOMARKERS FOR PROSTRATE CANCER
      • Breast Cancer
      • TABLE 24 SELECTED CIRCULATING MICRORNAS AS BIOMARKERS FOR BREAST CANCER
      • Lung Cancer
      • TABLE 25 CIRCULATING MICRORNA AS BIOMARKERS FOR LUNG CANCER
  • GLOBAL MARKET FOR MICRORNA DIAGNOSTICS
  • FIGURE 11 GLOBAL MICRORNA DIAGNOSTICS MARKET, 2013-2019 ($ MILLIONS)

CHAPTER 7 BIOINFORMATICS: APPLICATIONS IN MICRORNA RESEARCH

  • MICRORNA TARGET PREDICTION TOOLS
    • POPULAR COMPUTATIONAL TOOLS 8
      • miRanda
      • TABLE 26 PROFILE OF MIRANDA
      • miRanda-mirSVR
      • TABLE 27 PROFILE OF MIRANDA-MIRSVR
      • TargetScan
      • TABLE 28 PROFILE OF TARGETSCAN
      • DIANA-micro T-CDS
      • TABLE 29 PROFILE OF DIANA-MICRO T-CDS
      • MirTarget2
      • TABLE 30 PROFILE OF MIRTARGET2
      • rna-22-GUI
      • TABLE 31 PROFILE OF RNA-22-GUI
      • TargetMiner
      • TABLE 32 PROFILE OF TARGETMINER
      • SVMicrO
      • TABLE 33 PROFILE OF SVMICRO
      • Probability of Interaction by Target Accessibility (PITA)
      • TABLE 34 PROFILE OF PITA
      • RNAhybrid
      • TABLE 35 PROFILE OF RNAHYBRID
    • MICRORNA DATABASES
      • miRBase Database
      • deepBase
      • microRNA.org
      • miRGen 2.0
      • miRNAMap
      • PMRD
    • MICRORNA NGS DATA ANALYSIS TOOLS
      • miRanalyzer
      • miRCat
      • miRDeep Package
      • miRExpress
  • GLOBAL BIOINFORMATICS MARKET
  • FIGURE 12 GLOBAL BIOINFORMATICS MARKET, 2013-2019 ($ BILLIONS)

CHAPTER 8 MICRORNA TECHNOLOGIES: AN OVERVIEW

  • MICRORNA PROFILING
    • MICRORNA PROFILING METHODS
    • TABLE 36 IMPORTANT MICRORNA PROFILING TECHNOLOGIES AND VENDORS
      • miRNA Profiling Technologies and Related Assays
      • TABLE 37 A SAMPLE MICRORNA PROFILING TECHNOLOGIES AND RELATED ASSAYS
    • MICRORNA PROFILING WORKFLOW
    • MICRORNA PROFILING TOOLS FROM LIFE TECHNOLOGIES
      • TaqMan miRNA ABC Purification Kit
      • miRVana miRNA Isolation Kit
      • RecoverAll Total Nucleic Acid Isolation Kit for FFPE
      • Ambion TaqMan microRNA Cells-to-CT Kit
    • MICRORNA PROFILING PRODUCTS FROM EXIQON
      • miRCURY RNA Isolation Kit
      • TABLE 38 MIRCURY RNA ISOLATION KITS OFFERED BY EXIQON
      • miRCURY LNA miRNA Arrays
      • TABLE 39 EXIQON'S MICRORNA MICROARRAY PRODUCTS
      • miRCURY LNA Universal RT miRNA PCR
    • REAGENT KITS FROM EXIQON
      • Universal cDNA Synthesis Kit II
      • TABLE 40 EXIQON'S UNIVERSAL CDNA SYNTHESIS KIT II
      • miRCURY LNA Universal RT microRNA PCR Starter Kit
      • TABLE 41 EXIQON'S MIRCURY LNA UNIVERSAL RT MICRORNA PCR STARTER KIT
      • ExiLENT SYBR Green Master Mix 2.5 mL
      • TABLE 42 EXIQON'S EXILENT SYBR GREEN MASTER MIX 2.5 ML
      • ExiLENT SYBR Green Master Mix 20 mL
      • TABLE 43 EXIQON'S EXILENT SYBR GREEN MASTER MIX 20 ML
    • PRIMER SETS AND PANELS FROM EXIQON
      • miRNA LNA PCR Primer Set
      • Reference Gene Primer Set
      • Predefined microRNA PCR Panels
      • TABLE 44 CONTENTS OF EXIQON'S HUMAN MIRNOME PANEL I AND II, V3
      • TABLE 45 CONTENTS OF EXIQON'S MOUSE, RAT MIRNOME PANEL I AND II, V3
      • TABLE 46 CONTENTS OF EXIQON'S SERUM/PLASMA FOCUS MICRORNA PCR PANEL
      • V3 105
      • TABLE 47 CONTENTS OF EXIQON'S CANCER FOCUS MICRORNA PCR PANEL, V3
      • Pick-&-Mix miRNA PCR Panel
      • TABLE 48 CONTENTS OF EXIQON'S PICK-&-MIX MICRORNA PCR PANEL
      • Exiqon's miRCURY LNA microRNA Detection Probes for Northern Blotting
    • FLUIDIGM'S NUCLEIC ACID PROFILING PRODUCTS
      • C1 Single-Cell Auto Prep IFC
      • Dynamic Array IFC
      • Digital Array IFC
      • Access Array IFC
      • Quantitative Real-Time Digital PCR IFC
    • WAFERGEN'S MICRORNA PROFILING PRODUCTS
      • SmartChip Human miRNA Panel, V3
      • SmartChip Human lncRNA 1 Panel
      • SmartChip Real-Time PCR System
    • QIAGEN'S MICRORNA PROFILING PRODUCTS
      • TABLE 49 QIAGEN'S PRODUCTS FOR MICRORNA PROFILING
    • MICRORNA PROFILING PRODUCTS FROM CBC
      • Geniom RT Analyzer from CBC
      • CBC's microRNA Biomarkers in Cancer
    • MICRORNA PROFILING TOOLS FROM AFFYMETRIX
      • GeneChip miRNA Arrays
      • TABLE 50 AFFYMETRIX' GENECHIP MICRORNA ARRAY PRODUCTS
      • Affymetrix FlashTag Biotin HSR RNA Labeling Kits
      • TABLE 51 AFFYMETRIX FLASHTAG BIOTIN HSR RNA LABELING KIT
    • MICRORNA PROFILING TOOLS FROM GENOSENSOR
    • TABLE 52 GENOSENSOR'S MICRORNA PROFILING TOOLS
    • MICRORNA PROFILING TOOLS FROM AGILENT TECHNOLOGIES
      • Human miRNA Microarrays
      • TABLE 53 AGILENT TECHNOLOGIES' HUMAN MICRORNA MICROARRAYS
    • MICRORNA PROFILING TOOLS FROM LIFE TECHNOLOGIES
      • NCode miRNA Arrays
      • TABLE 54 NCODE HUMAN RNA MICROARRAYS FROM LIFE TECHNOLOGIES
    • NCOUNTER ANALYSIS SYSTEMS FROM NANOSTRING TECHNOLOGIES
    • ONE ARRAY PRODUCTS FROM PHALANX BIOTECH
    • TABLE 55 ONE ARRAY PRODUCTS FROM PHALANX BIOTECH
    • MPARAFLO BIOCHIP ARRAY FROM LC BIOSCIENCES
    • TABLE 56 PARAFLO BIOCHIP ARRAY SERVICES FROM LC BIOSCIENCES
    • SOLID SYSTEM FROM LIFE TECHNOLOGIES
    • GS FLX+ SYSTEM FROM ROCHE
    • MISEQ SYSTEMS FROM ILLUMINA
    • TABLE 57 COMPARISONS OF MISEQ SYSTEMS FROM ILLUMINA
    • HISEQ 2000 FROM ILLUMINA
    • ION TORRENT TECHNOLOGY FROM LIFE TECHNOLOGIES
    • GS JUNIOR FROM ROCHE
    • MARKET LEADING MICRORNA PROFILING TECHNOLOGIES
    • FIGURE 13 MARKET SHARES OF LEADING MICRORNA PROFILING TECHNOLOGIES, 2013 (%)
    • PREDOMINANTLY USED MICRORNA PROFILING TECHNOLOGIES
      • miRNA Isolation Tools
      • TABLE 58 MICRORNA ISOLATION KITS AND VENDORS
      • Most Commonly Used RNA Extraction Kits
      • TABLE 59 MOST COMMONLY USED RNA EXTRACTION KITS
      • Specimen-Specific RNA Kits
      • TABLE 60 COMMONLY USED RNA KITS BY TYPE OF SPECIMEN
    • MICRORNA EXTRACTION PRODUCTS
      • mirVana Kit Family
      • TABLE 61 MIRVANA MICRORNA ISOLATION KIT FAMILY
      • mirPremier miRNA Isolation Kit
      • miRCURY RNA Isolation Kit
      • TABLE 62 EXIQON'S MIRCURY RNA ISOLATION KITS
      • High Pure miRNA Isolation Kit from Roche
      • Favorgen miRNA Isolation Kit
      • RNeasy Mini Kit from Qiagen
      • TABLE 63 RNEASY MINI KIT FROM QIAGEN
      • Arcturus PicoPure RNA Isolation Kit from Life Technologies
      • Absolutely Total miRNA Purification Kits from Agilent Technologies
      • SV Total RNA Isolation Kit from Promega
      • TABLE 64 SV TOTAL RNA ISOLATION KIT FROM PROMEGA
      • RNAqueous Kit from Life Technologies
      • AllPrep DNA/RNA Micro Kit from Qiagen
    • NUCLEIC ACID ISOLATION AND PURIFICATION MARKET
    • FIGURE 14 GLOBAL MARKET FOR NUCLEIC ACID ISOLATION AND PURIFICATION, 2013-2019 ($ BILLIONS)
    • MICRORNA MICROARRAY TOOLS
    • TABLE 65 COMPARISON OF FOUR MICRORNA MICROARRAY PLATFORMS
      • Human miRNA V3 from Agilent
      • TABLE 66 HUMAN MICRORNA V3 MICROARRAYS FROM AGILENT
      • miRCURY LNA miRNA Array from Exiqon
      • TABLE 67 MIRCURY LNA MICRORNA ARRAYS FROM EXICON
      • Human miRNA V2 from Illumina
      • TABLE 68 HUMAN MICRORNA V2 FROM ILLUMINA
      • miRXplore Microarray V5 from Miltenyi
      • TABLE 69 MIRXPLORE MICROARRAYS FROM MILTENYI
      • Global Microarray Market
      • FIGURE 15 GLOBAL MICROARRAY DIAGNOSTIC ANALYSIS MARKET, 2013-2019 ($ BILLIONS)
        • Microarray Tools Market for miRNA Research
        • FIGURE 16 GLOBAL MARKET FOR MICROARRAY TOOLS USED IN MICRORNA RESEARCH, 2013-2019 ($ MILLIONS)
    • REAL-TIME PCR
    • FIGURE 17 STEPS INVOLVED IN PLANNING RT-QPCR ASSAY
      • RT-qPCR: The Preferred Choice of Researchers
      • Enhanced Features for Traditional PCR
      • Continued Demand for Higher Throughput
      • New Trends in PCR Enzymes
      • Popular qRT-PCR Systems in the Market
      • TABLE 70 SELECTED PCR SYSTEMS AND VENDORS
      • Selected Reagent Suppliers for PCR
      • TABLE 71 SELECTED REAGENT SUPPLIERS FOR PCR
      • Description of Selected Reagents
        • TRIzol Reagent
        • mirVana miRNA Isolation Kit
        • TABLE 72 REAGENTS PROVIDED WITH MIRVANA MIRNA ISOLATION KIT
        • mirVana qRT-PCR miRNA Detection Kit
        • TABLE 73 COMPONENTS OF MIRVANA QRT-PCR MICRORNA DETECTION KIT
        • PureLink miRNA Isolation Kit
        • TABLE 74 COMPONENTS OF PURELINK MICRORNA ISOLATION KIT
        • siPORT NeoFX Transfection Agent
        • miRNA-Specific Stem-Loop Primers
        • TaqMan miRNA Reverse Transcription Kit
        • Early Access TaqMan qRT-PCR miRNA panel
        • NCode miRNA First-Strand cDNA Synthesis Kit
      • Global PCR Market
      • FIGURE 18 GLOBAL MARKET FOR PCR PLATFORMS, 2013-2019 ($ BILLIONS)
        • Global Demand for PCR by End-Use Segment
        • FIGURE 19 GLOBAL DEMAND FOR PCR BY END-USE SEGMENT, 2013-2019 ($ BILLIONS)
        • Patenting Trends in PCR-Based Diagnostics in Cancer
        • TABLE 75 PATENTING TRENDS IN PCR-BASED DIAGNOSTICS FOR CANCER, 1991-2013 (NO. OF HITS)
        • PCR Instruments Market Shares
        • TABLE 76 REAL-TIME PCR MARKET SHARES IN LIFE SCIENCES RESEARCH, 2013 (%)
        • Global Market for qRT-PCR Tools and Reagents in miRNA Research
        • FIGURE 20 GLOBAL MARKET FOR QRT-PCR TOOLS AND REAGENTS FOR MICRORNA RESEARCH, 2013-2019 ($ MILLIONS)
    • NEXT-GENERATION SEQUENCING
    • TABLE 77 POPULAR NGS PLATFORMS CURRENTLY AVAILABLE IN THE MARKET 148
      • Choosing the Right NGS Instrument
      • TABLE 78 COMPARISON OF THE FOUR MAJOR NGS PLATFORMS
      • TABLE 79 COMPARISON OF ALL NGS SYSTEMS
      • Descriptions of Selected NGS Instruments
        • Illumina Platform (Illumina)
          • HiSeq X Ten
          • Next Seq 500
          • HiSeq 2500
          • HiScanSQ
          • GAIIx
          • MiSeq v3
          • MiSeq v2
        • Ion Platform (Life Technologies)
          • Ion Proton
          • Ion PGM 318
          • Ion PGM 316
          • Ion 314 Chip Kit v2
        • PacBio Platform (Pacific Biosciences)
          • PacBio RS II
        • Roche 454 Platform (Roche)
          • GS FLX+
          • GS Junior
        • SOLiD Platform (Life Technologies)
          • 5500 W Series
      • Number of NGS Systems and Facilities across the World
      • TABLE 80 NUMBER OF SEQUENCING CENTERS AND NUMBER OF NGS SYSTEMS BY COUNTRY, AS OF 2013 (NUMBER)
      • Number of NGS Systems by Geographical Region
      • TABLE 81 NUMBER OF NGS SYSTEMS BY REGION, 2013 (NUMBER)
      • NGS Platforms by Number of Centers and Machines
      • TABLE 82 NGS PLATFORMS BY NUMBER OF CENTERS AND MACHINES (NUMBER)
      • Number of NGS Systems in Top Genome Centers around the World
      • TABLE 83 NUMBER OF NGS SYSTEMS IN TOP GENOME CENTERS AROUND THE WORLD
      • NGS Systems in North American Facilities
      • TABLE 84 TYPES OF NGS SYSTEMS IN SELECTED NORTH AMERICAN FACILITIES
      • Most Cited Concerns in the Purchase of NGS Systems
      • TABLE 85 MOST CITED CONCERNS IN THE PURCHASE OF NGS SYSTEMS (%)
      • NGS Service Providers across the World
      • TABLE 86 LIST OF SELECTED NGS SERVICE PROVIDERS
      • NGS-Focused Publications
      • FIGURE 21 NGS-FOCUSED PUBLICATIONS, 2005-2013 (NUMBER)
      • Selected NGS-Based Tests with Clinical Application
      • TABLE 87 SELECTED NGS-BASED TESTS WITH CLINICAL APPLICATION
      • Utilization of NGS by Type of Research
      • FIGURE 22 APPLICATION SHARES OF NGS BY TYPE OF RESEARCH, 2013 (%)
      • Commercial Reagents and Kits for NGS-Based Research
      • TABLE 88 COMMERCIAL REAGENTS AND KITS FOR NGS-BASED RESEARCH 12
      • Most Popular NGS Methods
      • FIGURE 23 SHARES OF THE MOST POPULAR NGS METHODS, 2013 (%)
      • Utilization of NGS Platforms by Type of Instrument
      • FIGURE 24 UTILIZATION SHARES OF NGS PLATFORMS BY TYPE OF INSTRUMENT, 2013 (%)
      • Percentage of Utilization of NGS by Type of Study
      • FIGURE 25 SHARE OF PRIMARY SEQUENCING WORK PERFORMED IN LABORATORIES BY TYPE, 2013 (%)
      • Comparison of NGS with Microarray
        • NGS vs. Microarrays in ChIP Experiments
        • NGS vs. Microarrays in Gene Expression Experiments
        • NGS vs. Microarrays in Genotyping Studies
        • NGS vs. Microarrays in Methylation Projects
        • NGS vs. Microarrays in the Diagnostics Market
        • NGS vs. Microarrays in Cytogenetics
        • Global NGS Market
        • FIGURE 26 GLOBAL NGS MARKET, 2013-2019 ($ BILLIONS)
        • Global NGS Informatics Market
        • FIGURE 27 GLOBAL NGS INFORMATICS MARKET, 2013-2019 ($ MILLIONS)
        • NGS Market Shares by Region
        • FIGURE 28 GLOBAL NGS MARKET SHARES BY GEOGRAPHY, 2013-2019 (%)
        • NGS Platform Market Shares by Company
        • FIGURE 29 NGS PLATFORM MARKET SHARES BY COMPANY, 2013 (%)
        • Breakdown of NGS Market by Area of Research
        • FIGURE 30 BREAKDOWN OF NGS MARKET BY AREA OF RESEARCH, 2013 (%)
        • Cost Comparison of NGS Sequencers
        • TABLE 89 COST COMPARISON OF NEXT-GENERATION SEQUENCERS
        • NGS Sequence Platform Market Outlook in Units
        • FIGURE 31 NGS SEQUENCING PLATFORM MARKET OUTLOOK IN UNITS, 2013-2019 (UNITS)
        • Global NGS Consumables Market
        • FIGURE 32 GLOBAL NGS CONSUMABLES MARKET, 2013-2019 ($ BILLIONS)
        • Global Market for NGS and Functional Assays in miRNA Research
        • FIGURE 33 GLOBAL MARKET FOR NGS AND FUNCTIONAL ASSAYS IN MICRORNA RESEARCH, 2013-2019 ($ MILLIONS)
    • FLUORESCENCE MICRORNA IN SITU HYBRIDIZATION (MIRNA FISH)
      • FISH Tool from Affymetrix
      • ViewRNA miRNA In Situ Hybridization
      • TABLE 90 VIEWRNA MICRORNA ISH CELL ASSAY PROFILE
      • miRCURY LNA miRNA Detection Probes for In Situ Hybridization from Exiqon
      • TABLE 91 MIRCURY LNA PRODUCT FAMILY FROM EXIQON
      • Global Market for In Situ Hybridization Assays
      • FIGURE 34 GLOBAL MARKET FOR IN SITU HYBRIDIZATION ASSAYS, 2013-2019 ($ BILLIONS)

CHAPTER 9 SUMMARY OF TOOLS AND REAGENTS MARKET IN MICRORNA RESEARCH

  • TABLE 92 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, THROUGH 2019 ($ MILLIONS)
  • FIGURE 35 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, 2013-2019 ($ MILLIONS)

CHAPTER 10 MARKET SUMMARY FOR MICRORNA RESEARCH TOOLS, SERVICES, DIAGNOSTICS AND DRUG DISCOVERY PRODUCT DEVELOPMENT

  • TABLE 93 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES, DIAGNOSTICS AND DRUG DISCOVERY, THROUGH 2019 ($ MILLIONS)
  • FIGURE 36 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES, DIAGNOSTICS AND DRUG DISCOVERY, 2013-2019 ($ MILLIONS)
  • SELECTED MICRORNA MARKET PARTICIPANTS
  • TABLE 94 SELECTED MICRORNA MARKET PARTICIPANTS

CHAPTER 11 SELECTED COMPANY PROFILES

  • AFFYMETRIX INC.
    • BRIEF HISTORY
    • PRODUCTS
  • AGILENT TECHNOLOGIES INC.
    • BRIEF HISTORY
    • PRODUCTS
      • Human miRNA Microarrays
      • TABLE 95 AGILENT'S HUMAN MICRORNA MICROARRAYS
      • Agilent's Custom miRNA Microarrays
      • TABLE 96 AGILENT'S CUSTOM MICRORNA MICROARRAYS
      • Agilent's Universal Reference RNAs
      • TABLE 97 AGILENT'S UNIVERSAL REFERENCE RNAS
      • Agilent's miRNA Complete Labeling and Hybridization Kit
      • TABLE 98 AGILENTS MICRORNA COMPLETE LABELING AND HYBRIDIZATION KIT
  • ALNYLAM PHARMACEUTICALS INC.
    • BRIEF HISTORY
    • PRODUCT PIPELINE
      • Alnylam 5x15
      • TABLE 99 ALNYLAM 5 X 15 DEVELOPMENT PIPELINE
  • AMBION INC. (LIFE TECHNOLOGIES)
    • BRIEF HISTORY
    • PRODUCTS
    • TABLE 100 MICRORNA FROM AMBION
  • APPLIED BIOLOGICAL MATERIALS (ABM) INC.
    • BRIEF HISTORY
    • PRODUCTS
  • ASURAGEN INC.
    • BRIEF HISTORY
    • PRODUCTS
      • miRNA Services
      • miRNA Sequencing
      • miRInform Thyroid
  • BIOFIRE DIAGNOSTICS INC.
    • BRIEF HISTORY
    • PRODUCTS
      • FilmArray Multiplex PCR
  • BIO-RAD LABORATORIES INC.
    • BRIEF HISTORY
    • PRODUCTS
      • QX 200 Droplet Digital PCR System
      • CFX96 Touch Real-Time PCR Detection System
      • CSF384 Touch Real-Time PCR Detection System
      • CFX Connect Real-Time PCR Detection System
      • CFX96 Touch Deep Well Real-Time PCR Detection System
  • CBC (COMPREHENSIVE BIOMARKER CENTER)
    • BRIEF HISTORY
    • PRODUCTS
      • RNA Extraction Services
      • miRNA Profiling Services
      • miRNA Microarray Profiling Services
  • EXIQON A/S
    • BRIEF HISTORY
    • PRODUCTS AND SERVICES
      • miRCURY RNA Isolation Kits
      • TABLE 101 MIRCURY RNA ISOLATION KITS FROM EXIQON
      • miRCURY LNA miRNA Power Labeling Kits
      • TABLE 102 MIRCURY LNA MICRORNA POWER LABELING KITS FROM EXIQON
      • miRCURY LNA miRNA Arrays
      • TABLE 103 MIRCURY LNA MICRORNA ARRAYS
      • miRCURY LNA Universal RT microRNA PCR
      • TABLE 104 MIRCURY LNA UNIVERSAL RT MICRORNA PCR FROM EXICON
      • miRCURY LNA microRNA Detection Probes for Northern Blotting
      • TABLE 105 MIRCURY LNA MICRORNA DETECTION PROBES FOR NORTHERN BLOTTING FROM EXICON
      • miRCURY LNA microRNA Detection Probes for In Situ Hybridization
      • TABLE 106 MIRCURY LNA MICRORNA DETECTION PROBES FOR IN SITU HYBRIDIZATION FROM EXIQON
      • miRCURY LNA miRNA Inhibitors and Power Inhibitors
      • TABLE 107 MIRCURY LNA MICRORNA INHIBITORS AND POWER INHIBITORS
      • miRCURY LNA miRNA Inhibitor Libraries
      • TABLE 108 MIRCURY LNA MICRORNA INHIBITOR LIBRARIES FROM EXIQON
      • EXIQON'S STRONG PIPELINE OF MIRNA DIAGNOSTICS
      • TABLE 109 EXIQON'S STRONG PIPELINE OF MICRORNA DIAGNOSTICS
    • EXIQON'S REVENUE HISTORY
    • TABLE 110 EXIQON'S REVENUES, 2009-2013 (DKK THOUSAND)
    • FIGURE 37 COMPARISON OF EXIQON'S SEGMENTAL REVENUE SHARES, 2012 AND 2013 (%)
  • FIREFLY BIOWORKS INC.
    • BRIEF HISTORY
    • PRODUCTS
      • Firefly MicroRNA Assay
      • Circulating miRNA Assay
  • FLUIDIGM CORP.
    • BRIEF HISTORY
    • PRODUCTS
      • New CyTOF 2 Instrument
      • BioMark HD System
      • C1 Single-Cell Auto Prep System
      • EP1 System
      • Access Array System
      • C1 Single-Cell Auto Prep IFC
  • GENECOPOEIA INC.
    • BRIEF HISTORY
    • PRODUCTS
      • miExpress Precursor miRNA Expression Clones
      • miArrest miRNA Inhibitors
      • TABLE 111 COMPARISON OF VECTOR-BASED INHIBITORS AND SYNTHESIZED MICRORNA INHIBITORS
      • Mechanism of Action
      • All-in-One miRNA qRT-PCR Reagent Kits and Validated Primers
      • miRNA Lentivirus
  • GENOSENSOR CORP.
    • BRIEF HISTORY
    • PRODUCTS
      • GenoExplorer miRNA Products and Kits
      • GenoExplorer microRNA Quantitative RT-PCR kit
  • GENSIGNIA LIFE SCIENCES INC.
    • BRIEF HISTORY
    • PRODUCTS
      • Gensignia's MSC Lung Cancer Test
  • GROOVE BIOPHARMA CORP.
    • BRIEF HISTORY
    • TECHNOLOGY
  • HTG MOLECULAR DIAGNOSTICS INC.
    • BRIEF HISTORY
    • PRODUCTS
      • HTG Edge System/RNA Expression Platform
      • HTG Edge Assays/Gene Expression
      • HTG Molecular EdgeSeq System
      • HTG EdgeSeq miRNA Whole Transcriptome Assay
      • HTG's Custom Probesets
  • ILLUMINA INC.
    • BRIEF HISTORY
    • PRODUCTS
      • MiSeq Desktop Sequencer
      • MiSeqDx Instrument
      • NextSeq 500 Desktop Sequencer
      • HiSeq 2500
      • HiSeq X Ten
      • NeoPrep Library Prep System
      • HiScan
      • iScan
    • ILLUMINA'S SERVICES
      • FastTrack Microarray Services
      • Long-Read Sequencing Services
  • INTEGRATED DNA TECHNOLOGIES INC.
    • BRIEF HISTORY
    • PRODUCTS
      • IDT miRNA Inhibitors
      • miRNA Cloning Products
      • StarFire miRNA Detection Kit
  • INTERNA TECHNOLOGIES BV
    • BRIEF HISTORY
    • PRODUCT PIPELINE
      • TABLE 112 INTERNA PIPELINE
  • ISIS PHARMACEUTICALS INC.
    • BRIEF HISTORY
    • PRODUCTS
      • Antisense Technology
      • TABLE 113 ISIS PHARMACEUTICALS' PIPELINE
      • RG-101
  • JSR MICRO N.V.
    • BRIEF HISTORY
    • PRODUCTS
      • Atmosphere JWT203
      • CIMmultus Disposable
  • LC SCIENCES LLC
    • BRIEF HISTORY
    • PRODUCTS
      • miRNA Sequencing Service
      • miRNA Microarray Service
      • miRNA qRT-PCR Service
      • Degradome Sequencing
      • Seq-Array for miRNA Discovery and Profiling
  • LIFE TECHNOLOGIES CORP.
    • BRIEF HISTORY
    • PRODUCTS
      • Ambion PureLink miRNA Isolation Kit
      • mirVana miRNA Isolation Kit
      • TaqMan miRNA ABC Purification Kit
      • MagMax-96 for Microarrays Total RNA Isolation Kit
      • TaqMan miRNA Cells-to-CT Kit
  • MILTENYI BIOTEC
    • BRIEF HISTORY
    • PRODUCTS
      • TABLE 114 MILTENYI'S MIRXPLORE MICROARRAY KITS AND SERVICES
  • MIRAGEN THERAPEUTICS INC.
    • BRIEF HISTORY
    • PIPELINE
      • TABLE 115 MIRAGEN'S PIPELINE PRODUCTS
      • miR-208
      • miR-15/195
      • miR-145
      • miR-451
      • miR-29
      • miR-92a
      • miR-378
      • miR-206
  • MIRNA THERAPEUTICS INC.
    • BRIEF HISTORY
    • MIRNA'S PIPELINE
      • TABLE 116 MIRNA'S PIPELINE
  • MIRUS BIO LLC
    • BRIEF HISTORY
    • PRODUCTS
      • Label IT miRNA Labeling Reagent
  • NANOSTRING TECHNOLOGIES INC.
    • BRIEF HISTORY
    • PRODUCTS
      • nCounter Analysis System
      • nCounter Gene Expression CodeSets
      • nCounter PanCancer Pathways Panel
      • nCounter Panel-Plus and CodeSet-Plus
      • nCounter Single Cell Gene Expression Assay
      • nCounter Plex Expression Assay
      • nCounter miRNA Expression Assays
      • nCounter miRGE CodeSets
      • nCounter lncRNA Expression Assay
      • nCounter ChIP-String Assay
      • nCounter Leukemia Fusion Gene Expression
      • nSolver Analysis Software
  • ORIGENE TECHNOLOGIES INC.
    • BRIEF HISTORY
    • PRODUCTS
      • miRNA Expression Plasmid
      • TABLE 117 ORIGENE'S MICRORNA EXPRESSION PLASMID SETS
  • PACIFIC BIOSCIENCES OF CALIFORNIA INC.
    • BRIEF HISTORY
    • PRODUCTS
      • PacBio RS II
      • SMRT Cells
      • Reagents
  • PHALANX BIOTECH GROUP INC.
    • BRIEF HISTORY
    • PRODUCTS
  • PROLIAS TECHNOLOGIES
    • BRIEF HISTORY
    • PRODUCTS
      • Thymira
      • Armira
  • QIAGEN NV
    • BRIEF HISTORY
    • PRODUCTS
  • REGULUS THERAPEUTICS INC.
    • BRIEF HISTORY
    • REGULUS' CLINICAL MAP INITIATIVE
      • TABLE 118 REGULUS' CLINICAL MAP INITIATIVE
      • REGULUS' THERAPEUTIC AREAS
      • TABLE 119 REGULUS' INITIAL MICRORNA DEVELOPMENT PROGRAMS
  • ROCHE HOLDING AG
    • BRIEF HISTORY
    • PRODUCTS
      • Genome Sequencer FLX System
      • GS Junior System
      • LightCycler 1536 System
      • LightCycler 480 System
      • Light Cycler Nano Instrument
      • MagNA Lyser Instrument
      • MagNA Pure Systems
  • ROSETTA GENOMICS LTD.
    • BRIEF HISTORY
    • PRODUCTS
      • Cancer Origin Test
      • Lung Cancer Test
      • Kidney Cancer Test
      • Mesothelioma Test
      • TABLE 120 ROSETTA'S PIPELINE: ROSETTA'S PROPRIETARY TESTS, 2013-2017
    • ROSETTA'S REVENUE HISTORY
    • FIGURE 38 ACTUAL AND PROJECTED REVENUES FOR ROSETTA, 2011-2020 ($ MILLIONS)
  • SANTARIS PHARMA A/S
    • BRIEF HISTORY
    • PRODUCTS
    • TABLE 121 PRODUCT PIPELINE FROM SANTARIS PHARMA
  • SAREPTA THERAPEUTICS INC.
    • BRIEF HISTORY
    • PRODUCTS
      • RNA Medicine
      • TABLE 122 SAREPTA THERAPEUTICS' PIPELINE
  • THERADIAG SA
    • BRIEF HISTORY
    • PRODUCTS
      • Prestizia: miRNA Platform
  • THERMO FISHER SCIENTIFIC INC.
    • BRIEF HISTORY
    • PRODUCTS
  • WAFERGEN BIOSYSTEMS INC.
    • BRIEF HISTORY
    • PRODUCTS
      • Apollo 324 NGS Library Prep System
      • SmartChip Targeted Resequencing
      • Seq-Ready TE BRCA 1/2 Panel
      • SmartChip TE Custom DNA Panels
      • SmartChip Real-Time PCR Cycler
      • SmartChip Multisample Nanodispenser
      • WaferGen Portal to IDT PrimeTime qPCR Primers
      • SmartChip Human lncRNA 1 Panel
      • The SmartChip Human miRNA Panel V3
      • The SmartChip Human Oncology Panel
  • WAKO PURE CHEMICAL INDUSTRIES LTD.
    • BRIEF HISTORY
    • PRODUCTS

CHAPTER 12 APPENDIX: ACRONYMS AND ABBREVIATIONS

  • TABLE 123 ACRONYMS AND ABBREVIATIONS

LIST OF TABLES

  • SUMMARY TABLE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES, DIAGNOSTICS AND DRUG DISCOVERY, THROUGH 2019 ($ MILLIONS)
  • TABLE 1 MICRORNA TIMELINE
  • TABLE 2 MICRORNA ASSOCIATED WITH HUMAN DISEASES
  • TABLE 3 EXIQON MICRORNA RESEARCH GRANT PROGRAMS, 2011-2014
  • TABLE 4 PERCENTAGE SHARE OF MICRORNA PATENTS BY TECHNOLOGICAL CATEGORY, 2013 (%)
  • TABLE 5 U.S. PATENT APPLICATIONS RELATED TO MICRORNA, 2014
  • TABLE 6 PERCENTAGE OF MICRORNA PATENTS BY DISEASE CATEGORY, 2013 (%)
  • TABLE 7 TOP 10 EMERGING TECHNOLOGIES IN 2014
  • TABLE 8 DISEASE CLASSES ADDRESSED BY MICRORNA THERAPEUTICS
  • TABLE 9 CURRENT CLINICAL APPLICATIONS TARGETING MICRORNA
  • TABLE 10 A SMALL SAMPLE OF PRECLINICAL IN VIVO EXPERIMENTS WITH MICRORNA
  • TABLE 11 SELECTED COMPANIES DEVELOPING MICRORNA THERAPEUTICS
  • TABLE 12 THERAPEUTIC TARGETING OF CARDIOVASCULAR MICRORNA
  • TABLE 13 SELECTED COMPANIES OFFERING MICRORNA PROFILING SERVICES
  • TABLE 14 PRICES OF RNA SEQUENCING SERVICES BY ABM ($)
  • TABLE 15 TAQMAN SERVICE PROVIDERS
  • TABLE 16 PREDESIGNED MICROARRAYS FROM OXFORD GENE TECHNOLOGY
  • TABLE 17 SERVICEXS' SOLUTIONS FOR RNA ANALYSIS
  • TABLE 18 AFFYMETRIX SERVICES PRICE LIST ($)
  • TABLE 19 LIST OF SELECTED NGS-SPECIFIC SERVICE PROVIDERS
  • TABLE 20 MAJOR APPLICATIONS OF MICRORNA AS BIOMARKERS
  • TABLE 21 COMPARISON OF VARIOUS MICRORNA DETECTION METHODS
  • TABLE 22 EXPRESSION PROFILE OF MICRORNA IN DIFFERENT TYPES OF CANCERS
  • TABLE 23 SELECTED CIRCULATING MICRORNA REPORTED TO BE BIOMARKERS FOR PROSTRATE CANCER
  • TABLE 24 SELECTED CIRCULATING MICRORNAS AS BIOMARKERS FOR BREAST CANCER
  • TABLE 25 CIRCULATING MICRORNA AS BIOMARKERS FOR LUNG CANCER
  • TABLE 26 PROFILE OF MIRANDA
  • TABLE 27 PROFILE OF MIRANDA-MIRSVR
  • TABLE 28 PROFILE OF TARGETSCAN
  • TABLE 29 PROFILE OF DIANA-MICRO T-CDS
  • TABLE 30 PROFILE OF MIRTARGET2
  • TABLE 31 PROFILE OF RNA-22-GUI
  • TABLE 32 PROFILE OF TARGETMINER
  • TABLE 33 PROFILE OF SVMICRO
  • TABLE 34 PROFILE OF PITA
  • TABLE 35 PROFILE OF RNAHYBRID
  • TABLE 36 IMPORTANT MICRORNA PROFILING TECHNOLOGIES AND VENDORS
  • TABLE 37 A SAMPLE MICRORNA PROFILING TECHNOLOGIES AND RELATED ASSAYS
  • TABLE 38 MIRCURY RNA ISOLATION KITS OFFERED BY EXIQON
  • TABLE 39 EXIQON'S MICRORNA MICROARRAY PRODUCTS
  • TABLE 40 EXIQON'S UNIVERSAL CDNA SYNTHESIS KIT II
  • TABLE 41 EXIQON'S MIRCURY LNA UNIVERSAL RT MICRORNA PCR STARTER KIT
  • TABLE 42 EXIQON'S EXILENT SYBR GREEN MASTER MIX 2.5 ML
  • TABLE 43 EXIQON'S EXILENT SYBR GREEN MASTER MIX 20 ML
  • TABLE 44 CONTENTS OF EXIQON'S HUMAN MIRNOME PANEL I AND II, V3
  • TABLE 45 CONTENTS OF EXIQON'S MOUSE, RAT MIRNOME PANEL I AND II, V3
  • TABLE 46 CONTENTS OF EXIQON'S SERUM/PLASMA FOCUS MICRORNA PCR PANEL V3
  • TABLE 47 CONTENTS OF EXIQON'S CANCER FOCUS MICRORNA PCR PANEL, V3
  • TABLE 48 CONTENTS OF EXIQON'S PICK-&-MIX MICRORNA PCR PANEL
  • TABLE 49 QIAGEN'S PRODUCTS FOR MICRORNA PROFILING
  • TABLE 50 AFFYMETRIX' GENECHIP MICRORNA ARRAY PRODUCTS
  • TABLE 51 AFFYMETRIX FLASHTAG BIOTIN HSR RNA LABELING KIT
  • TABLE 52 GENOSENSOR'S MICRORNA PROFILING TOOLS
  • TABLE 53 AGILENT TECHNOLOGIES' HUMAN MICRORNA MICROARRAYS
  • TABLE 54 NCODE HUMAN RNA MICROARRAYS FROM LIFE TECHNOLOGIES
  • TABLE 55 ONE ARRAY PRODUCTS FROM PHALANX BIOTECH
  • TABLE 56 PARAFLO BIOCHIP ARRAY SERVICES FROM LC BIOSCIENCES
  • TABLE 57 COMPARISONS OF MISEQ SYSTEMS FROM ILLUMINA
  • TABLE 58 MICRORNA ISOLATION KITS AND VENDORS
  • TABLE 59 MOST COMMONLY USED RNA EXTRACTION KITS
  • TABLE 60 COMMONLY USED RNA KITS BY TYPE OF SPECIMEN
  • TABLE 61 MIRVANA MICRORNA ISOLATION KIT FAMILY
  • TABLE 62 EXIQON'S MIRCURY RNA ISOLATION KITS
  • TABLE 63 RNEASY MINI KIT FROM QIAGEN
  • TABLE 64 SV TOTAL RNA ISOLATION KIT FROM PROMEGA
  • TABLE 65 COMPARISON OF FOUR MICRORNA MICROARRAY PLATFORMS
  • TABLE 66 HUMAN MICRORNA V3 MICROARRAYS FROM AGILENT
  • TABLE 67 MIRCURY LNA MICRORNA ARRAYS FROM EXICON
  • TABLE 68 HUMAN MICRORNA V2 FROM ILLUMINA
  • TABLE 69 MIRXPLORE MICROARRAYS FROM MILTENYI
  • TABLE 70 SELECTED PCR SYSTEMS AND VENDORS
  • TABLE 71 SELECTED REAGENT SUPPLIERS FOR PCR
  • TABLE 72 REAGENTS PROVIDED WITH MIRVANA MIRNA ISOLATION KIT
  • TABLE 73 COMPONENTS OF MIRVANA QRT-PCR MICRORNA DETECTION KIT
  • TABLE 74 COMPONENTS OF PURELINK MICRORNA ISOLATION KIT
  • TABLE 75 PATENTING TRENDS IN PCR-BASED DIAGNOSTICS FOR CANCER, 1991-2013 (NO. OF HITS)
  • TABLE 76 REAL-TIME PCR MARKET SHARES IN LIFE SCIENCES RESEARCH, 2013 (%)
  • TABLE 77 POPULAR NGS PLATFORMS CURRENTLY AVAILABLE IN THE MARKET
  • TABLE 78 COMPARISON OF THE FOUR MAJOR NGS PLATFORMS
  • TABLE 79 COMPARISON OF ALL NGS SYSTEMS
  • TABLE 80 NUMBER OF SEQUENCING CENTERS AND NUMBER OF NGS SYSTEMS BY COUNTRY, AS OF 2013 (NUMBER)
  • TABLE 81 NUMBER OF NGS SYSTEMS BY REGION, 2013 (NUMBER)
  • TABLE 82 NGS PLATFORMS BY NUMBER OF CENTERS AND MACHINES (NUMBER)
  • TABLE 83 NUMBER OF NGS SYSTEMS IN TOP GENOME CENTERS AROUND THE WORLD
  • TABLE 84 TYPES OF NGS SYSTEMS IN SELECTED NORTH AMERICAN FACILITIES
  • TABLE 85 MOST CITED CONCERNS IN THE PURCHASE OF NGS SYSTEMS (%)
  • TABLE 86 LIST OF SELECTED NGS SERVICE PROVIDERS
  • TABLE 87 SELECTED NGS-BASED TESTS WITH CLINICAL APPLICATION
  • TABLE 88 COMMERCIAL REAGENTS AND KITS FOR NGS-BASED RESEARCH
  • TABLE 89 COST COMPARISON OF NEXT-GENERATION SEQUENCERS
  • TABLE 90 VIEWRNA MICRORNA ISH CELL ASSAY PROFILE
  • TABLE 91 MIRCURY LNA PRODUCT FAMILY FROM EXIQON
  • TABLE 92 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, THROUGH 2019 ($ MILLIONS)
  • TABLE 93 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES, DIAGNOSTICS AND DRUG DISCOVERY, THROUGH 2019 ($ MILLIONS)
  • TABLE 94 SELECTED MICRORNA MARKET PARTICIPANTS
  • TABLE 95 AGILENT'S HUMAN MICRORNA MICROARRAYS
  • TABLE 96 AGILENT'S CUSTOM MICRORNA MICROARRAYS
  • TABLE 97 AGILENT'S UNIVERSAL REFERENCE RNAS
  • TABLE 98 AGILENTS MICRORNA COMPLETE LABELING AND HYBRIDIZATION KIT
  • TABLE 99 ALNYLAM 5 X 15 DEVELOPMENT PIPELINE
  • TABLE 100 MICRORNA FROM AMBION
  • TABLE 101 MIRCURY RNA ISOLATION KITS FROM EXIQON
  • TABLE 102 MIRCURY LNA MICRORNA POWER LABELING KITS FROM EXIQON
  • TABLE 103 MIRCURY LNA MICRORNA ARRAYS
  • TABLE 104 MIRCURY LNA UNIVERSAL RT MICRORNA PCR FROM EXICON
  • TABLE 105 MIRCURY LNA MICRORNA DETECTION PROBES FOR NORTHERN BLOTTING FROM EXICON
  • TABLE 106 MIRCURY LNA MICRORNA DETECTION PROBES FOR IN SITU HYBRIDIZATION FROM EXIQON
  • TABLE 107 MIRCURY LNA MICRORNA INHIBITORS AND POWER INHIBITORS
  • TABLE 108 MIRCURY LNA MICRORNA INHIBITOR LIBRARIES FROM EXIQON
  • TABLE 109 EXIQON'S STRONG PIPELINE OF MICRORNA DIAGNOSTICS
  • TABLE 110 EXIQON'S REVENUES, 2009-2013 (DKK THOUSAND)
  • TABLE 111 COMPARISON OF VECTOR-BASED INHIBITORS AND SYNTHESIZED MICRORNA INHIBITORS
  • TABLE 112 INTERNA PIPELINE
  • TABLE 113 ISIS PHARMACEUTICALS' PIPELINE
  • TABLE 114 MILTENYI'S MIRXPLORE MICROARRAY KITS AND SERVICES
  • TABLE 115 MIRAGEN'S PIPELINE PRODUCTS
  • TABLE 116 MIRNA'S PIPELINE
  • TABLE 117 ORIGENE'S MICRORNA EXPRESSION PLASMID SETS
  • TABLE 118 REGULUS' CLINICAL MAP INITIATIVE
  • TABLE 119 REGULUS' INITIAL MICRORNA DEVELOPMENT PROGRAMS
  • TABLE 120 ROSETTA'S PIPELINE: ROSETTA'S PROPRIETARY TESTS, 2013-2017
  • TABLE 121 PRODUCT PIPELINE FROM SANTARIS PHARMA
  • TABLE 122 SAREPTA THERAPEUTICS' PIPELINE
  • TABLE 123 ACRONYMS AND ABBREVIATIONS

LIST OF FIGURES

  • SUMMARY FIGURE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES, DIAGNOSTICS AND DRUG DISCOVERY, 2013-2019 ($ MILLIONS)
  • FIGURE 1 BIOGENESIS OF MICRORNA
  • FIGURE 2 MICRORNA RESEARCH SHARE BY ORGANISM, 2013 (%)
  • FIGURE 3 MICRORNA RESEARCH SHARES BY AREA, 2013 (%)
  • FIGURE 4 GROWTH OF MICRORNA DATABASE, 2002-2013 (NUMBER)
  • FIGURE 5 PEER-REVIEWED SCIENTIFIC PUBLICATIONS ON MICRORNA, 2003-2013 (NUMBER OF PUBLICATIONS)
  • FIGURE 6 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, 2013-2019 ($ MILLIONS)
  • FIGURE 7 GLOBAL MARKET SHARES OF MICRORNA RESEARCH PRODUCTS BY REGION, 2013 (%)
  • FIGURE 8 INHIBITION OF MIR-122 BY MIRAVIRSEN
  • FIGURE 9 GLOBAL MICRORNA DRUG DISCOVERY MARKET, 2013-2019 ($ MILLIONS)
  • FIGURE 10 GLOBAL MICRORNA SERVICES MARKET, 2013-2019 ($ MILLIONS)
  • FIGURE 11 GLOBAL MICRORNA DIAGNOSTICS MARKET, 2013-2019 ($ MILLIONS)
  • FIGURE 12 GLOBAL BIOINFORMATICS MARKET, 2013-2019 ($ BILLIONS)
  • FIGURE 13 MARKET SHARES OF LEADING MICRORNA PROFILING TECHNOLOGIES, 2013 (%)
  • FIGURE 14 GLOBAL MARKET FOR NUCLEIC ACID ISOLATION AND PURIFICATION, 2013-2019 ($ BILLIONS)
  • FIGURE 15 GLOBAL MICROARRAY DIAGNOSTIC ANALYSIS MARKET, 2013-2019 ($ BILLIONS)
  • FIGURE 16 GLOBAL MARKET FOR MICROARRAY TOOLS USED IN MICRORNA RESEARCH, 2013-2019 ($ MILLIONS)
  • FIGURE 17 STEPS INVOLVED IN PLANNING RT-QPCR ASSAY
  • FIGURE 18 GLOBAL MARKET FOR PCR PLATFORMS, 2013-2019 ($ BILLIONS)
  • FIGURE 19 GLOBAL DEMAND FOR PCR BY END-USE SEGMENT, 2013-2019 ($ BILLIONS)
  • FIGURE 20 GLOBAL MARKET FOR QRT-PCR TOOLS AND REAGENTS FOR MICRORNA RESEARCH, 2013-2019 ($ MILLIONS)
  • FIGURE 21 NGS-FOCUSED PUBLICATIONS, 2005-2013 (NUMBER)
  • FIGURE 22 APPLICATION SHARES OF NGS BY TYPE OF RESEARCH, 2013 (%)
  • FIGURE 23 SHARES OF THE MOST POPULAR NGS METHODS, 2013 (%)
  • FIGURE 24 UTILIZATION SHARES OF NGS PLATFORMS BY TYPE OF INSTRUMENT, 2013 (%)
  • FIGURE 25 SHARE OF PRIMARY SEQUENCING WORK PERFORMED IN LABORATORIES BY TYPE, 2013 (%)
  • FIGURE 26 GLOBAL NGS MARKET, 2013-2019 ($ BILLIONS)
  • FIGURE 27 GLOBAL NGS INFORMATICS MARKET, 2013-2019 ($ MILLIONS)
  • FIGURE 28 GLOBAL NGS MARKET SHARES BY GEOGRAPHY, 2013-2019 (%)
  • FIGURE 29 NGS PLATFORM MARKET SHARES BY COMPANY, 2013 (%)
  • FIGURE 30 BREAKDOWN OF NGS MARKET BY AREA OF RESEARCH, 2013 (%)
  • FIGURE 31 NGS SEQUENCING PLATFORM MARKET OUTLOOK IN UNITS, 2013-2019 (UNITS)
  • FIGURE 32 GLOBAL NGS CONSUMABLES MARKET, 2013-2019 ($ BILLIONS)
  • FIGURE 33 GLOBAL MARKET FOR NGS AND FUNCTIONAL ASSAYS IN MICRORNA RESEARCH, 2013-2019 ($ MILLIONS)
  • FIGURE 34 GLOBAL MARKET FOR IN SITU HYBRIDIZATION ASSAYS, 2013-2019 ($ BILLIONS)
  • FIGURE 35 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, 2013-2019 ($ MILLIONS)
  • FIGURE 36 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES, DIAGNOSTICS AND DRUG DISCOVERY, 2013-2019 ($ MILLIONS)
  • FIGURE 37 COMPARISON OF EXIQON'S SEGMENTAL REVENUE SHARES, 2012 AND 2013 (%)
  • FIGURE 38 ACTUAL AND PROJECTED REVENUES FOR ROSETTA, 2011-2020 ($ MILLIONS)
Back to Top