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DNAシークエンシング:新たな技術と用途

DNA Sequencing: Emerging Technologies and Applications

発行 BCC Research 商品コード 233598
出版日 ページ情報 英文 357 Pages
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DNAシークエンシング:新たな技術と用途 DNA Sequencing: Emerging Technologies and Applications
出版日: 2016年05月26日 ページ情報: 英文 357 Pages
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概要

世界のシークエンシング製品の市場は2015年から2020年にかけて18.7%のCAGR (年間複合成長率) で推移し、2014年の53億ドルから、2015年には59億ドル、2020年には138億ドルの規模に成長すると予測されています。

当レポートでは、世界のDNAシークエンシングの市場を調査し、市場および技術の定義と概要、各種シークエンシング製品および技術の動向、主要プロジェクト、エンドユーザー産業と各種用途、市場規模の推移と予測、関連特許のデータ、主要企業のプロファイルなどをまとめています。

第1章 イントロダクション

第2章 エグゼクティブサマリー

第3章 概要

  • イントロダクション
  • シークエンシング市場
  • シークエンシング製品
  • シークエンシング製品のライフサイクルの状況
  • 次世代シークエンシング産業

第4章 技術

  • DNAの重要性
  • 遺伝的変異・分析
  • 遺伝分析技術
  • 臨床用途でのシークエンシング
  • シークエンシング技術
    • サンガー法
    • 次世代シークエンシングプラットフォーム
    • ベンチトップシーククエンシング
  • インフォマティクス技術
  • 臨床シークエンシング技術の課題
  • 主要プロジェクト

第5章 DNAシークエンシングの各種用途

  • イントロダクション
  • 遺伝子解析
  • De Novo全ゲノムシークエンシング
  • リシークエンシング
  • SEQベースの手法
  • 構造多型の解析
  • 相補的シークエンシングとマイクロアレイプラットフォーム
  • エンドユーズ

第6章 臨床シークエンシングの各種用途

  • イントロダクション
  • メンデル遺伝病
  • 性と生殖に関する健康
  • 感染症
  • 複合的障害

第7章 シークエンシング産業

  • イントロダクション
  • 次世代シークエンシング機器産業
  • ドロップレットデジタルPCR産業
  • 標的濃縮・増幅産業
  • 専用DNAポリメラーゼ産業
  • 非侵襲的出生前診断産業
  • 着床前遺伝子診断・スクリーニング産業
  • 液体生検産業
  • 免疫システムプロファイリング産業
  • 次世代シークエンシング臨床インフォマティクス産業
  • HLAタイピング産業
  • 第3世代シークエンシング産業
  • DTC遺伝子検査産業
  • 買収・戦略的提携

第8章 シークエンシング市場

  • 成長推進因子
  • シークエンシング市場のサマリー
  • シークエンシング産業・消耗品市場
  • シークエンシングサンプル調製市場
  • シークエンシングインフォマティクス市場
  • シークエンシングサービス市場
  • 臨床シークエンシング市場
  • 癌の臨床シークエンシング市場
  • 性と生殖に関する健康の市場
  • 臓器移植の市場
  • 微生物学市場
  • インフォマティクス市場
  • 地域市場

第9章 関連特許

  • 臨床NGSの特許
  • 臨床NGSの特許:適応症別
  • 無細胞DNAの特許
  • シークエンシング関連特許の課題

第10章 企業プロファイル

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目次
Product Code: BIO045F

REPORT HIGHLIGHTS

The global market for sequencing products has grown to $5.9 billion in 2015 from $5.3 billion in 2014. The market is expected to grow at a five-year compound annual growth rate (CAGR) of 18.7% from 2015 to 2020, reaching nearly $13.8 billion by 2020.

This report provides:

  • An in-depth analysis of the sequencing industry, an important industry in life sciences with enormous market potential.
  • Analyses of global market trends, with data from 2014, estimates for 2015, and projections of compound annual growth rates (CAGRs) through 2020.
  • Quantification of the DNA sequencing markets by product type, platform, customer type, value chain position, analysis type and geography.
  • A look at substantial future growth opportunities for industry participants including consumer and diagnostic sequencing services, bioinformatics, sequence enrichment, benchtop NGS sequencers and consumables, and emerging sequencing instruments.
  • Comprehensive discussion covering sequencing technologies, market applications, industry structure, and important clinical sequencing initiatives.
  • A relevant patent analysis.
  • Profiles of major players in the sequencing industry.

SCOPE AND FORMAT OF REPORT

The scope of the report includes sequencing technologies, applications, industries, initiatives, markets, patents and companies. The markets for sequencing products and services are given for the years 2014, 2015 and 2020.

This report reviews the main sequencing platforms, and explains why genetic variation is important for many applications, including clinical testing. It then discusses some of the top research initiatives that are contributing to sequencing markets. Industry market driving forces are also discussed.

The report covers the sequencing markets by workflow, including sample preparation products; sequencing instruments and consumables; informatics; and sequencing services. It includes the sequencing instrument market by platform: Sanger and next-generation technologies, and by instrument class: low-throughput, high-throughput, benchtop and handheld.

The report covers the markets for the main sequencing end-use applications, including research (R&D, drug discovery and development, biotech); clinical; and applied (consumer, forensics, microbial genomics, agricultural genomics).

The report covers the sequencing clinical markets, including by test complexity, indication and test purpose. Test complexity refers to the multiplexing (e.g., the number of genes covered) and coverage (e.g., the extent to which the genome is covered) of the test. Examining the market by test complexity provides valuable insight into which products (e.g., sample preparation, sequencing instrument, informatics) will be in demand in the future.

The report provides market data and forecasts for sequencing-based diagnostics by specific applications, including those for cancer, rare diseases, common diseases, transplant and reproductive health.

The specific geographic markets discussed include North America, Europe, Asia-Pacific and the rest of the world.

Market data covers the years 2014, 2015 and 2020.

The report analyzes specific sequencing-related industries, including next-generation sequencing instruments (including market share data for the main instrument companies); droplet digital PCR; target enrichment and amplification; specialist DNA polymerase; noninvasive prenatal testing (including market share data for the leading companies); preimplantation genetic diagnosis and screening; liquid biopsy; immune sequencing; informatics industry; and human leukocyte antigen (HLA) typing industry.

More than 225 companies in the sequencing industry are profiled in this report.

BCC Research provides a summary of the main industry acquisitions and strategic alliances from 2014 through early 2016, including key alliance trends.

ANALYST'S CREDENTIALS

John Bergin is the author of previous BCC Research biotechnology reports titled Next Generation Sequencing: Emerging Clinical Applications and Global Markets; Epigenomics: Emerging Opportunities in Biomarkers, Diagnostics and Therapeutics; Global Biochip Markets: Microarrays and Lab-on-a-chip; RNA Interference in the Post-Genomics Era: Markets and Technologies; DNA Sequencing: Emerging Technologies and Applications; Biologic Imaging Reagents: Technologies and Global Markets; and Synthetic Biology: Emerging Global Markets.

Mr. Bergin has held business development, sales and marketing positions with a Fortune 500 advanced materials company, as well as executive management positions with an emerging nanotechnology company. Mr. Bergin holds a BS degree in Chemistry, an MS degree in Biotechnology and a Masters of Business Administration.

Table of Contents

CHAPTER 1 - INTRODUCTION

  • STUDY GOALS AND OBJECTIVES
  • REASONS FOR DOING THE STUDY
  • INTENDED AUDIENCE
  • SCOPE AND FORMAT OF REPORT
  • METHODOLOGY
  • INFORMATION SOURCES
  • RELATED BCC RESEARCH REPORTS
  • ANALYST'S CREDENTIALS
  • BCC RESEARCH WEBSITE
  • DISCLAIMER

CHAPTER 2 - EXECUTIVE SUMMARY

  • SUMMARY TABLE GLOBAL SEQUENCING MARKET BY PRODUCT TYPE, THROUGH 2020 ($ MILLIONS)
  • SUMMARY FIGURE GLOBAL SEQUENCING MARKET BY PRODUCT TYPE, 2014-2020 ($ MILLIONS)

CHAPTER 3 - OVERVIEW

  • INTRODUCTION
    • TABLE 1: ARRAY OF WORKFLOW PRODUCTS AND SERVICES
  • SEQUENCING MARKET
    • TABLE 2: GLOBAL SEQUENCING MARKET BY DELIVERED FORMAT, THROUGH 2020 ($ MILLIONS)
    • TABLE 3: KEY DRIVING FORCES FOR SEQUENCING INDUSTRY GROWTH
  • SEQUENCING PRODUCTS
    • SEQUENCING INSTRUMENTS AND CONSUMABLES
    • SAMPLE PREPARATION REAGENTS AND KITS
    • BIOINFORMATICS
    • SEQUENCING SERVICES
  • SEQUENCING PRODUCT LIFE CYCLE STATUS
    • TABLE 4: LIFE CYCLE OF DNA SEQUENCING TYPES
  • NEXT-GENERATION SEQUENCING INDUSTRY
    • TABLE 5: SUMMARY OF NEXT-GENERATION SEQUENCING INDUSTRY SECTORS

CHAPTER 4 - TECHNOLOGIES

  • IMPORTANCE OF DNA
    • TABLE 6: DNA CHEMICAL BUILDING BLOCKS
    • TABLE 7: PROCESS OF DNA TRANSLATION AND TRANSCRIPTION
    • TABLE 8: LONG-RANGE DNA STRUCTURE
  • GENETIC VARIATION AND ANALYSIS
    • TABLE 9: DIFFERENT TYPES OF GENETIC VARIANTS
  • GENETIC ANALYSIS TECHNOLOGIES
    • TABLE 10: IMPORTANT MOLECULAR DIAGNOSTIC PLATFORMS, BY COMPANY
  • SEQUENCING IN CLINICAL APPLICATIONS
    • TABLE 11: EVOLUTION OF GENETIC TESTING
    • TABLE 12: KEY NEAR- TO MID-TERM SEGMENTS FOR NEXT-GENERATION SEQUENCING DIAGNOSTICS
  • SEQUENCING TECHNOLOGIES
    • HISTORY OF DNA SEQUENCING
      • TABLE 13: HISTORICAL TIMELINE OF DNA SEQUENCING
      • TABLE 14: SEQUENCING TECHNOLOGY DEVELOPMENT, 1990-2020
      • TABLE 15: COST TO SEQUENCE A SINGLE HUMAN GENOME, 2001-2015 ($)
  • SANGER SEQUENCING TECHNOLOGY
    • TABLE 16: SANGER SEQUENCING SUMMARY
    • TABLE 17: SANGER SEQUENCING IMPROVEMENTS
  • NEXT-GENERATION SEQUENCING PLATFORMS
    • TABLE 18: NEXT-GENERATION SEQUENCING TECHNOLOGIES
    • TABLE 19: ROCHE NEXT-GENERATION SEQUENCING WORKFLOW STEPS
    • TABLE 20: ILLUMINA NEXT-GENERATION SEQUENCING WORKFLOW STEPS
    • TABLE 21: LIFE TECHNOLOGIES NEXT-GENERATION SEQUENCING WORKFLOW STEPS
  • BENCHTOP SEQUENCERS
    • TABLE 22: BENCHTOP AND HANDHELD SEQUENCER PLATFORMS, 2010-2015
  • INFORMATICS TECHNOLOGIES
    • TABLE 23: NEXT-GENERATION SEQUENCING BIOINFORMATICS WORKFLOW
  • BASE CALLING
    • MAPPING TO A REFERENCE SEQUENCE
      • TABLE 24: SEQUENCE ANNOTATION STEPS
  • VARIANT ANALYSIS
    • CLINICAL SEQUENCING TECHNOLOGY CHALLENGES
      • TABLE 25: FUTURE CHALLENGES FOR IMPLEMENTING CLINICAL NEXT-GENERATION SEQUENCING
    • CLINICAL NGS INITIATIVES
      • TABLE 26: KEY CLINICAL NGS PROJECTS
  • 100K GENOMES PROJECT
  • ACTIONABLE GENOME CONSORTIUM
  • BABYSEQ
  • CANCER MOON SHOTS PROGRAM
  • CLINGEN
  • CSER
  • DECIPHERING DEVELOPMENTAL DISORDERS PROJECT
  • EMERGE
  • GENOME KOREA
  • LUNG-MAP
  • MATCHMAKER EXCHANGE
  • MILLION VETERAN PROGRAM
  • MEDSEQ
  • PRECISION MEDICINE
  • PROMPT
  • UK10K

CHAPTER 5 - DNA SEQUENCING APPLICATIONS

  • INTRODUCTION
    • TABLE 27: GENOME SEQUENCING PROJECTS, 2005 AND 2015
  • GENETIC ANALYSIS
    • TABLE 28: COMPARISON OF GENETIC ANALYSIS FORMATS
    • TABLE 29: APPLICATIONS OF SEQUENCING ANALYSIS
    • TABLE 30: REQUIREMENTS FOR DE NOVO VS. RESEQUENCING
  • DE NOVO WHOLE GENOME SEQUENCING
  • RESEQUENCING
    • WHOLE GENOME RESEQUENCING
    • TARGETED RESEQUENCING
  • SEQ-BASED METHODS
    • TABLE 31: GENETIC ANALYSIS APPLICATIONS UTILIZING MICROARRAYS OR SEQUENCING PLATFORMS
  • CHIPSEQ
    • TABLE 32: COMPARISON OF SEQUENCING WITH MICROARRAYS FOR CHIP APPLICATIONS
  • DNASE-SEQ
    • RNA-SEQ
      • TABLE 33: COMPARISON OF SEQUENCING AND MICROARRAYS FOR GENE EXPRESSION ANALYSIS
    • METHYL-SEQ
  • STRUCTURAL VARIATION STUDIES
  • COMPLEMENTARY SEQUENCING AND MICROARRAY PLATFORMS
  • SEQUENCING END-USE APPLICATIONS
    • RESEARCH
    • CONSUMER SEQUENCING
      • TABLE 34: COMPARISON OF GENETIC ANALYSIS PLATFORMS
    • AGRICULTURAL SEQUENCING
      • TABLE 35: IMPACT OF SEQUENCING ON AGRICULTURAL PRODUCT CLASSES
    • MICROBIAL SEQUENCING
      • TABLE 36: KEY APPLICATIONS IN MICROBIAL SEQUENCING
    • FORENSICS SEQUENCING
      • TABLE 37: KEY APPLICATIONS IN FORENSICS/HUMAN IDENTITY SEQUENCING

CHAPTER 6 - CLINICAL SEQUENCING APPLICATIONS

  • INTRODUCTION
    • TABLE 38: CLINICAL NEXT-GENERATION SEQUENCING, NEAR-TO MID-TERM APPLICATIONS
  • CANCER APPLICATIONS
    • TABLE 39: MAJOR CANCER APPLICATIONS FOR NGS DIAGNOSTICS
  • MENDELIAN DISORDERS APPLICATION
    • TABLE 40: MENDELIAN DISORDERS APPLICATION
  • REPRODUCTIVE HEALTH APPLICATIONS
    • TABLE 41: SCREENING APPLICATIONS
    • TABLE 42: ETHICAL ISSUES ASSOCIATED WITH PRENATAL AND NEWBORN SCREENING
  • INFECTIOUS DISEASE APPLICATIONS
    • TABLE 43: INFECTIOUS DISEASE APPLICATIONS
  • COMPLEX DISORDERS APPLICATIONS
    • TABLE 44: COMPLEX DISORDERS APPLICATIONS

CHAPTER 7 - SEQUENCING INDUSTRY

  • INTRODUCTION
    • TABLE 45: KEY SEGMENTS AND TRENDS IN THE SEQUENCING INDUSTRY
  • NGS INSTRUMENT INDUSTRY
    • TABLE 46: NEXT-GENERATION SEQUENCING INSTRUMENT COMPANIES
  • DROPLET DIGITAL PCR INDUSTRY
    • TABLE 47: ADVANTAGES OF DROPLET DIGITAL PCR
    • TABLE 48: DROPLET DIGITAL PCR INDUSTRY
  • TARGET ENRICHMENT AND AMPLIFICATION INDUSTRY
    • TABLE 49: TARGET ENRICHMENT INDUSTRY
  • SPECIALIZED DNA POLYMERASE INDUSTRY
    • TABLE 50: SPECIALIZED DNA POLYMERASE INDUSTRY
  • NONINVASIVE PRENATAL TESTING INDUSTRY
    • TABLE 51: KEY COMPANIES IN THE NGS NIPT INDUSTRY
    • TABLE 52: GLOBAL NIPT MARKET BY REGION, COMPANY AND NUMBER OF TESTS, 2015
    • TABLE 53: GERMAN COMPANIES INVOLVED IN NGS-BASED NONINVASIVE PRENATAL DIAGNOSTICS
  • PREIMPLANTATION GENETICS DIAGNOSIS AND SCREENING INDUSTRY
    • TABLE 54: PREIMPLANTATION DIAGNOSTICS PLATFORMS
    • TABLE 55: PREIMPLANTATION GENETIC SCREENING AND DIAGNOSIS INDUSTRY
  • LIQUID BIOPSY INDUSTRY
    • TABLE 56: COMPANIES IN THE LIQUID BIOPSY INDUSTRY AND THEIR FOCUS
  • IMMUNE SYSTEM PROFILING INDUSTRY
    • TABLE 57: COMPANIES IN THE IMMUNE SYSTEM PROFILING INDUSTRY
  • NEXT-GENERATION SEQUENCING CLINICAL INFORMATICS INDUSTRY
    • TABLE 58: NEXT-GENERATION SEQUENCING CLINICAL INFORMATICS COMPANY POSITIONING
  • HLA TYPING INDUSTRY
    • TABLE 59: NGS-BASED HLA TYPING INDUSTRY COMPANIES
  • THIRD-GENERATION SEQUENCING INDUSTRY
    • TABLE 60: SUMMARY OF 3GS INDUSTRY
  • DIRECT-TO-CONSUMER GENETIC TESTING INDUSTRY
    • TABLE 61: KEY COMPANIES IN THE DIRECT-TO-CONSUMER GENETIC TESTING INDUSTRY
  • ACQUISITIONS AND STRATEGIC ALLIANCES
    • SEQUENCING INDUSTRY ACQUISITIONS
      • TABLE 62: SEQUENCING INDUSTRY ACQUISITIONS 2014-2015
    • SEQUENCING INDUSTRY STRATEGIC ALLIANCES
      • TABLE 63: SEQUENCING INDUSTRY STRATEGIC ALLIANCES 2014-2016

CHAPTER 8 - SEQUENCING MARKETS

  • FORCES DRIVING GROWTH
    • TABLE 64: KEY DRIVERS OF GROWTH FOR THE SEQUENCING INDUSTRY
  • SEQUENCING MARKET SUMMARY
    • TABLE 65: GLOBAL SEQUENCING MARKET BY DELIVERED FORMAT, THROUGH 2020 ($ MILLIONS)
  • SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET
    • TABLE 66: GLOBAL MARKET FOR SEQUENCING INSTRUMENTS AND CONSUMABLES BY PRODUCT TYPE, THROUGH 2020 ($ MILLIONS)
  • SEQUENCING INSTRUMENTS AND CONSUMABLES BY PLATFORM
    • TABLE 67: GLOBAL MARKET FOR SEQUENCING INSTRUMENTS AND CONSUMABLES BY PLATFORM, THROUGH 2020 ($ MILLIONS)
    • TABLE 68: COMPANIES MIGRATING TO NGS FOR HIV TESTING
  • NGS INSTRUMENTS AND CONSUMABLES BY PLATFORM
    • TABLE 69: GLOBAL MARKET FOR SEQUENCING INSTRUMENTS AND CONSUMABLES BY SEQUENCER PLATFORM, THROUGH 2020 ($ MILLIONS)
  • SEQUENCING SAMPLE PREP MARKET
    • TABLE 70: GLOBAL SEQUENCING SAMPLE PREP MARKET BY APPLICATION, THROUGH 2020 ($ MILLIONS)
  • SEQUENCING INFORMATICS MARKET
    • TABLE 71: GLOBAL SEQUENCING INFORMATICS MARKET BY SOFTWARE FUNCTION, THROUGH 2020 ($ MILLIONS)
  • SEQUENCING SERVICES MARKET
    • TABLE 72: GLOBAL SEQUENCING SERVICES MARKET BY END USER, THROUGH 2020 ($ MILLIONS)
  • SEQUENCING SERVICES MARKET BY GENOME TYPE
    • TABLE 73: GLOBAL SEQUENCING SERVICES MARKET BY GENOME TYPE, THROUGH 2020 ($ MILLIONS)
  • APPLIED SEQUENCING SERVICES MARKET
    • TABLE 74: GLOBAL MARKET FOR APPLIED SEQUENCING SERVICES BY APPLICATION, THROUGH 2020 ($ MILLIONS)
    • Agriculture Sequencing
    • Consumer Sequencing
    • Forensics Sequencing
    • Microbiology Sequencing
      • TABLE 75: GLOBAL AGRICULTURE SEQUENCING SERVICES MARKET BY APPLICATION, THROUGH 2020 ($ MILLIONS)
      • TABLE 76: SEQUENCING IMPACT ON AGRICULTURAL PRODUCT CLASSES
  • CLINICAL SEQUENCING MARKET
    • TABLE 77: GLOBAL CLINICAL SEQUENCING MARKET BY INDICATION, THROUGH 2020
    • TABLE 78: GLOBAL CLINICAL SEQUENCING MARKET BY TEST COMPLEXITY, THROUGH 2020 ($ MILLIONS)
    • TABLE 79: GLOBAL CLINICAL SEQUENCING MARKET BY TEST PURPOSE, THROUGH 2020 ($ MILLIONS)
  • CLINICAL SEQUENCING CANCER MARKET
    • TABLE 80: GLOBAL CLINICAL SEQUENCING CANCER MARKET BY INDICATION, THROUGH 2020 ($ MILLIONS)
    • TABLE 81: GLOBAL CLINICAL SEQUENCING CANCER MARKET BY TEST PURPOSE, THROUGH 2020 ($ MILLIONS)
    • TABLE 82: SCREENING METHODS FOR EARLY CANCER DETECTION
    • TABLE 83: GLOBAL CLINICAL SEQUENCING CANCER MARKET BY TEST COMPLEXITY, THROUGH 2020 ($ MILLIONS)
  • REPRODUCTIVE HEALTH MARKET
    • TABLE 84: GLOBAL MARKET FOR REPRODUCTIVE HEALTH SEQUENCING BY TEST APPLICATION, THROUGH 2020 ($ MILLIONS)
  • NIPT MARKET
    • TABLE 85: GLOBAL NIPT MARKET BY RISK TYPE, THROUGH 2020 ($ MILLIONS)
  • IVF MARKET
  • NEWBORN SCREENING MARKET
  • CARRIER SCREENING MARKET
    • TABLE 86: GLOBAL REPRODUCTIVE HEALTH SEQUENCING MARKET BY TEST COMPLEXITY, THROUGH 2020 ($ MILLIONS)
  • TRANSPLANT MARKET
    • TABLE 87: GLOBAL TRANSPLANT SEQUENCING MARKET BY TEST PURPOSE, THROUGH 2020 ($ MILLIONS)
    • TABLE 88: GLOBAL TRANSPLANT SEQUENCING MARKET BY TEST COMPLEXITY, THROUGH 2020 ($ MILLIONS)
    • TABLE 89: GLOBAL MARKET FOR SEQUENCING TRANSPLANT MONITORING BY ORGAN TYPE, THROUGH 2020 ($ MILLIONS)
    • TABLE 90: TRANSPLANT PROCEDURES PERFORMED IN THE U.S., 2015
  • MICROBIOLOGY MARKET
    • TABLE 91: GLOBAL MICROBIOLOGY SEQUENCING MARKET BY END USER, THROUGH 2020 ($ MILLIONS)
  • INFORMATICS MARKET
    • TABLE 92: GLOBAL INFORMATICS SEQUENCING MARKET BY SOFTWARE FUNCTION, THROUGH 2020 ($ MILLIONS)
  • REGIONAL MARKET
    • TABLE 93: GLOBAL SEQUENCING MARKET BY REGION, THROUGH 2020 ($ MILLIONS)
    • TABLE 94: GLOBAL CANCER DIAGNOSTICS MARKET BY REGION, THROUGH 2020 ($ MILLIONS)
    • TABLE 95: GLOBAL MARKET FOR REPRODUCTIVE HEALTH SEQUENCING BY REGION, THROUGH 2020 ($ MILLIONS)
    • TABLE 96: GLOBAL TRANSPLANT DIAGNOSTICS MARKET BY REGION, THROUGH 2020 ($ MILLIONS)

CHAPTER 9 - SEQUENCING PATENTS

  • CLINICAL NGS PATENTS
    • TABLE 97: CLINICAL NEXT-GENERATION SEQUENCING PATENTS, 2005-2015 (NO. OF PATENTS)
  • CLINICAL NGS PATENTS BY INDICATION
    • TABLE 98: CLINICAL NEXT-GENERATION SEQUENCING PATENTS BY INDICATION, 2005-2015
  • CELL-FREE DNA PATENTS
    • TABLE 99: CELL-FREE DNA PATENTS BY REGION, 2005-2015
  • SEQUENCING-RELATED PATENT ISSUES
    • TABLE 100: STATUS OF SEQUENCING-RELATED PATENT DISPUTES

CHAPTER 10 - COMPANY PROFILES

  • 10X GENOMICS
  • 23ANDME INC.
    • TABLE 101: 23ANDME DATA NEEDS
  • ACCURAGEN
  • ADAPTIVE BIOTECHNOLOGIES INC.
  • ADICON CLINICAL LABORATORIES
  • ADMERA HEALTH
  • AGILENT TECHNOLOGIES INC.
  • ALMAC GROUP LTD.
  • ALTHEA DX
  • AMARANTUS BIOSCIENCE HOLDINGS INC.
    • TABLE 102: MULTIPLE SCLEROSIS DIAGNOSTIC WORKFLOW
  • AMBRY GENETICS
  • ANNOROAD GENE TECHNOLOGY
  • APPISTRY INC.
  • ARCHERDX
  • ARUP LABORATORIES
  • ASTRIDBIO TECHNOLOGIES KFT.
  • ASSUREX HEALTH
  • ASURAGEN INC.
  • ATHENA DIAGNOSTICS INC.
  • ATRECA INC.
  • BASE4 INNOVATION LTD.
  • BAYLOR MIRACA GENETICS LABORATORIES INC.
  • BECTON, DICKINSON AND CO.
  • BECKMAN COULTER
  • BERRY GENOMICS CO. LTD.
  • BGI SHENZHEN
  • BIOCARTIS NV
  • BIOCEPT INC.
  • BIO.LOGIS GMBH
  • BIOINNOVATION SOLUTIONS
  • BIOMATTERS LTD.
  • BIO-RAD LABORATORIES INC.
  • BIOTHERANOSTICS INC.
  • BLUEPRINT GENETICS
  • BOREAL GENOMICS
  • CAMBRIDGE EPIGENETIX LTD.
    • TABLE 103: COMPANIES IN THE EPIGENETIC SEQUENCING INDUSTRY
  • CAREDX INC.
  • CARIS LIFE SCIENCES
  • CEGAT GMBH
  • CELL MICROSYSTEMS INC.
  • CELLULAR RESEARCH INC.
  • CELSEE DIAGNOSTICS
  • CENTOGENE AG
  • CERGENTIS BV
  • CHRONIX BIOMEDICAL
  • CIRCULOGENE THERANOSTICS
  • CLARITAS GENOMICS INC.
  • CLONTECH LABORATORIES INC.
  • COFACTOR GENOMICS INC.
  • COLOR GENOMICS
  • CORIELL LIFE SCIENCES INC.
  • CORRELAGEN DIAGNOSTICS INC.
  • COUNSYL INC.
  • COURTAGEN LIFE SCIENCES INC.
  • CYNVENIO BIOSYSTEMS INC.
  • DANAHER CORP.
  • DARUI BIOTECHNOLOGY CO. LTD.
  • DIAGNOMICS
  • DIAN DIAGNOSTICS
  • DIPLOID
  • DNA ELECTRONICS LTD.
  • DNA LINK INC.
  • DNANEXUS INC.
  • EAGLE GENOMICS LTD.
  • ELECTRONIC BIOSCIENCES
  • EPIC SCIENCES
  • ESPERITE NV
  • EUROFINS GENOMICS
  • EXIQON A/S
  • EXOSOME DIAGNOSTICS INC.
  • EXPRESSION ANALYSIS INC.
  • FOUNDATION MEDICINE
  • FLUXION BIOSCIENCES INC.
  • FULL GENOMES CORP.
  • FUSION GENOMICS CORP.
  • GATC BIOTECH AG
  • GE HEALTHCARE
  • GENAPSYS INC.
  • GENDX BV
  • GENE BY GENE LTD.
  • GENEDX INC.
  • GENEPEEKS INC.
  • GENEWIZ INC.
  • GENOMATIX SOFTWARE GMBH
  • GENOMEDX BIOSCIENCES
  • GENOMIC EXPRESSION
  • GENOMIC HEALTH INC.
  • GENOME PROFILING LLC
  • GENOMNIA SRL
  • GENOMONCOLOGY
  • GENOSPACE
  • GIGAGEN INC.
  • GOOD START GENETICS INC.
  • GOLDEN HELIX
  • GRAIL
  • GUARDANT HEALTH INC.
  • GUARDIOME
  • HELIX OPCO LLC
  • HISTOGENETICS LLC
  • HTG MOLECULAR DIAGNOSTICS INC.
  • HUMAN LONGEVITY INC.
  • ILLUMINA INC.
    • TABLE 104: NEW PLATFORMS INTRODUCED BY ILLUMINA, 2015
  • INTELLIMEDIX
  • INTERPACE DIAGNOSTICS LLC
    • TABLE 105: MOLECULAR THYROID NODULE CLASSIFIER TEST COMPANY POSITIONING
  • INVITAE
  • INVIVOSCRIBE TECHNOLOGIES INC.
  • IREPERTOIRE INC.
  • KAILOS GENETICS
  • KAPA BIOSYSTEMS INC.
  • KELLBENX INC.
  • KEW GROUP INC.
  • KINGMED DIAGNOSTICS CENTER CO. LTD.
  • LABORATORY CORP. OF AMERICA INC.
  • LABORATORY FOR MOLECULAR MEDICINE
  • LASERGEN INC.
  • LEUCINE RICH BIO
  • LUMENOGIX INC.
  • MACROGEN INC.
  • MAPMYGENOME
  • MAVERIX BIOMICS INC.
  • MAYO MEDICAL LABORATORIES
  • MDX HEALTH INC.
  • MEDGENOME LABS PVT. LTD.
  • MEDOMICS LLC
  • MERCK KGAA
  • MICROSYNTH AG
  • MIINOME INC.
  • MIRATI THERAPEUTICS
  • MOGENE DX
  • MOLECULAR HEALTH GMBH
  • MOLECULARMD CORP.
  • MRIGLOBAL RESEARCH INSTITUTE
  • MULTIPLICOM NV
  • MYRIAD GENETICS INC.
  • NATERA INC.
  • NEOGENOMICS INC.
  • NEW ENGLAND BIOLABS
  • NEWGENE LTD.
  • NEW ONCOLOGY AG
  • N-OF-ONE INC.
  • NOVARTIS AG
  • NOVOGENE BIOINFORMATICS TECHNOLOGY CO. LTD.
  • NUGEN TECHNOLOGIES INC.
  • NXT-DX
  • OMICIA INC.
  • OMIXON BIOCOMPUTING KFT
  • ONCODNA SA
  • ONCOSPIRE GENOMICS
  • ONEOME
  • OXFORD GENE TECHNOLOGY
  • OXFORD NANOPORE TECHNOLOGIES LTD.
  • PACIFIC BIOSCIENCES OF CALIFORNIA INC.
  • PAIRNOMIX INC.
  • PARABASE GENOMICS
  • PARSEQ LAB
  • PATHWAY GENOMICS CORP.
  • PERKINELMER INC.
  • PERSONAL GENOME DIAGNOSTICS INC.
  • PERSONAL GENOMICS INC.
  • PERSONALIS INC.
  • PICOSEQ
  • POPULATION GENETICS TECHNOLOGIES LTD.
    • TABLE 106: SENSITIVITY TO DETECT DRUG-RESISTANT MUTATIONS IN VIRUSES (%)
  • PORTABLE GENOMICS LLC
  • POSITIVE BIOSCIENCE
  • PREMAITHA HEALTH PLC
  • PRENETICS
  • PRESSURE BIOSCIENCES INC.
  • PREVENTIONGENETICS INC.
  • QIAGEN NV
  • QUANTAPORE INC.
  • QUANTUMDX
  • QUEST DIAGNOSTICS
  • RAINDANCE TECHNOLOGIES INC.
  • RARECELLS SAS
  • RARECYTE INC.
  • REAL TIME GENOMICS INC.
  • REPROGENETICS
  • RESOLUTION BIOSCIENCE INC.
  • ROCHE HOLDING AG
    • TABLE 107: COMMERCIAL SEQUENCER COMPETITIVE POSITIONING
  • RUBICON GENOMICS
  • SALVEO DX
  • SCREENCELL
  • SCIGENOM LABS
  • SELAH GENOMICS
  • SENGENICS INTERNATIONAL PTE LTD.
  • SEQUENOM INC.
  • SEVEN BRIDGES GENOMICS INC.
  • SILICON BIOSYSTEMS
  • SISTEMAS GENOMICOS SL
  • SOFTGENETICS LLC
  • SOPHIA GENETICS
  • SPIRAL GENETICS INC.
  • STATION X INC.
  • STRAND LIFE SCIENCES
  • STRATEC BIOMEDICAL AG
  • STRATOS GENOMICS INC.
  • SUNDANCE DIAGNOSTICS INC.
  • SURE GENOMICS INC.
  • SYAPSE INC.
  • SYGNIS AG
  • SYMBIODX
  • SYSMEX INOSTICS GMBH
  • TAI DIAGNOSTICS INC.
  • THERMO FISHER SCIENTIFIC INC.
  • THORNE DIAGNOSTICS INC.
  • TRANSGENOMIC INC.
  • TROVAGENE INC.
  • TUTE GENOMICS INC.
  • TWO PORE GUYS INC.
  • UBIQUITY GENOMICS INC.
  • VELA DIAGNOSTICS
  • WAFERGEN BIO-SYSTEMS INC.
    • TABLE 108: WAFERGEN STRATEGIC ALLIANCES
  • WARP DRIVE BIO LLC
  • XCELL BIOSCIENCES INC.
  • YIKON GENOMICS CO. LTD.
  • ZINXIN PHARMACEUTICAL INDUSTRIAL CO LTD.
  • ZS GENETICS INC.
  • ZYMO RESEARCH CORP.

LIST OFTABLES

  • SUMMARY TABLE: GLOBAL SEQUENCING MARKET BY PRODUCT TYPE, THROUGH 2020 ($ MILLIONS)
    • TABLE 1: ARRAY OF WORKFLOW PRODUCTS AND SERVICES
    • TABLE 2: GLOBAL SEQUENCING MARKET BY DELIVERED FORMAT, THROUGH 2020 ($ MILLIONS)
    • TABLE 3: KEY DRIVING FORCES FOR SEQUENCING INDUSTRY GROWTH
    • TABLE 4: LIFE CYCLE OF DNA SEQUENCING TYPES
    • TABLE 5: SUMMARY OF NEXT-GENERATION SEQUENCING INDUSTRY SECTORS
    • TABLE 6: DNA CHEMICAL BUILDING BLOCKS
    • TABLE 7: PROCESS OF DNA TRANSLATION AND TRANSCRIPTION
    • TABLE 8: LONG-RANGE DNA STRUCTURE
    • TABLE 9: DIFFERENT TYPES OF GENETIC VARIANTS
    • TABLE 10: IMPORTANT MOLECULAR DIAGNOSTIC PLATFORMS, BY COMPANY
    • TABLE 11: EVOLUTION OF GENETIC TESTING
    • TABLE 12: KEY NEAR- TO MID-TERM SEGMENTS FOR NEXT-GENERATION SEQUENCING DIAGNOSTICS
    • TABLE 13: HISTORICAL TIMELINE OF DNA SEQUENCING
    • TABLE 14: SEQUENCING TECHNOLOGY DEVELOPMENT, 1990-2020
    • TABLE 15: COST TO SEQUENCE A SINGLE HUMAN GENOME, 2001-2015 ($)
    • TABLE 16: SANGER SEQUENCING SUMMARY
    • TABLE 17: SANGER SEQUENCING IMPROVEMENTS
    • TABLE 18: NEXT-GENERATION SEQUENCING TECHNOLOGIES
    • TABLE 19: ROCHE NEXT-GENERATION SEQUENCING WORKFLOW STEPS
    • TABLE 20: ILLUMINA NEXT-GENERATION SEQUENCING WORKFLOW STEPS
    • TABLE 21: LIFE TECHNOLOGIES NEXT-GENERATION SEQUENCING WORKFLOW STEPS
    • TABLE 22: BENCHTOP AND HANDHELD SEQUENCER PLATFORMS, 2010-2015
    • TABLE 23: NEXT-GENERATION SEQUENCING BIOINFORMATICS WORKFLOW
    • TABLE 24: SEQUENCE ANNOTATION STEPS
    • TABLE 25: FUTURE CHALLENGES FOR IMPLEMENTING CLINICAL NEXT-GENERATION SEQUENCING
    • TABLE 26: KEY CLINICAL NGS PROJECTS
    • TABLE 27: GENOME SEQUENCING PROJECTS, 2005 AND 2015
    • TABLE 28: COMPARISON OF GENETIC ANALYSIS FORMATS
    • TABLE 29: APPLICATIONS OF SEQUENCING ANALYSIS
    • TABLE 30: REQUIREMENTS FOR DE NOVO VS. RESEQUENCING
    • TABLE 31: GENETIC ANALYSIS APPLICATIONS UTILIZING MICROARRAYS OR SEQUENCING PLATFORMS
    • TABLE 32: COMPARISON OF SEQUENCING WITH MICROARRAYS FOR CHIP APPLICATIONS
    • TABLE 33: COMPARISON OF SEQUENCING AND MICROARRAYS FOR GENE EXPRESSION ANALYSIS
    • TABLE 34: COMPARISON OF GENETIC ANALYSIS PLATFORMS
    • TABLE 35: IMPACT OF SEQUENCING ON AGRICULTURAL PRODUCT CLASSES
    • TABLE 36: KEY APPLICATIONS IN MICROBIAL SEQUENCING
    • TABLE 37: KEY APPLICATIONS IN FORENSICS/HUMAN IDENTITY SEQUENCING
    • TABLE 38: CLINICAL NEXT-GENERATION SEQUENCING, NEAR-TO MID-TERM APPLICATIONS
    • TABLE 39: MAJOR CANCER APPLICATIONS FOR NGS DIAGNOSTICS
    • TABLE 40: MENDELIAN DISORDERS APPLICATION
    • TABLE 41: SCREENING APPLICATIONS
    • TABLE 42: ETHICAL ISSUES ASSOCIATED WITH PRENATAL AND NEWBORN SCREENING
    • TABLE 43: INFECTIOUS DISEASE APPLICATIONS
    • TABLE 44: COMPLEX DISORDERS APPLICATIONS
    • TABLE 45: KEY SEGMENTS AND TRENDS IN THE SEQUENCING INDUSTRY
    • TABLE 46: NEXT-GENERATION SEQUENCING INSTRUMENT COMPANIES
    • TABLE 47: ADVANTAGES OF DROPLET DIGITAL PCR
    • TABLE 48: DROPLET DIGITAL PCR INDUSTRY
    • TABLE 49: TARGET ENRICHMENT INDUSTRY
    • TABLE 50: SPECIALIZED DNA POLYMERASE INDUSTRY
    • TABLE 51: KEY COMPANIES IN THE NGS NIPT INDUSTRY
    • TABLE 52: GLOBAL NIPT MARKET BY REGION, COMPANY AND NUMBER OF TESTS, 2015
    • TABLE 53: GERMAN COMPANIES INVOLVED IN NGS-BASED NONINVASIVE PRENATAL DIAGNOSTICS
    • TABLE 54: PREIMPLANTATION DIAGNOSTICS PLATFORMS
    • TABLE 55: PREIMPLANTATION GENETIC SCREENING AND DIAGNOSIS INDUSTRY
    • TABLE 56: COMPANIES IN THE LIQUID BIOPSY INDUSTRY AND THEIR FOCUS
    • TABLE 57: COMPANIES IN THE IMMUNE SYSTEM PROFILING INDUSTRY
    • TABLE 58: NEXT-GENERATION SEQUENCING CLINICAL INFORMATICS COMPANY POSITIONING
    • TABLE 59: NGS-BASED HLA TYPING INDUSTRY COMPANIES
    • TABLE 60: SUMMARY OF 3GS INDUSTRY
    • TABLE 61: KEY COMPANIES IN THE DIRECT-TO-CONSUMER GENETIC TESTING INDUSTRY
    • TABLE 62: SEQUENCING INDUSTRY ACQUISITIONS 2014-2015
    • TABLE 63: SEQUENCING INDUSTRY STRATEGIC ALLIANCES 2014-2016
    • TABLE 64: KEY DRIVERS OF GROWTH FOR THE SEQUENCING INDUSTRY
    • TABLE 65: GLOBAL SEQUENCING MARKET BY DELIVERED FORMAT, THROUGH 2020 ($ MILLIONS)
    • TABLE 66: GLOBAL MARKET FOR SEQUENCING INSTRUMENTS AND CONSUMABLES BY PRODUCT TYPE, THROUGH 2020 ($ MILLIONS)
    • TABLE 67: GLOBAL MARKET FOR SEQUENCING INSTRUMENTS AND CONSUMABLES BY PLATFORM, THROUGH 2020 ($ MILLIONS)
    • TABLE 68: COMPANIES MIGRATING TO NGS FOR HIV TESTING
    • TABLE 69: GLOBAL MARKET FOR SEQUENCING INSTRUMENTS AND CONSUMABLES BY SEQUENCER PLATFORM, THROUGH 2020 ($ MILLIONS)
    • TABLE 70: GLOBAL SEQUENCING SAMPLE PREP MARKET BY APPLICATION, THROUGH 2020 ($ MILLIONS)
    • TABLE 71: GLOBAL SEQUENCING INFORMATICS MARKET BY SOFTWARE FUNCTION, THROUGH 2020 ($ MILLIONS)
    • TABLE 72: GLOBAL SEQUENCING SERVICES MARKET BY END USER, THROUGH 2020 ($ MILLIONS)
    • TABLE 73: GLOBAL SEQUENCING SERVICES MARKET BY GENOME TYPE, THROUGH 2020 ($ MILLIONS)
    • TABLE 74: GLOBAL MARKET FOR APPLIED SEQUENCING SERVICES BY APPLICATION, THROUGH 2020 ($ MILLIONS)
    • TABLE 75: GLOBAL AGRICULTURE SEQUENCING SERVICES MARKET BY APPLICATION, THROUGH 2020 ($ MILLIONS)
    • TABLE 76: SEQUENCING IMPACT ON AGRICULTURAL PRODUCT CLASSES
    • TABLE 77: GLOBAL CLINICAL SEQUENCING MARKET BY INDICATION, THROUGH 2020
    • TABLE 78: GLOBAL CLINICAL SEQUENCING MARKET BY TEST COMPLEXITY, THROUGH 2020 ($ MILLIONS)
    • TABLE 79: GLOBAL CLINICAL SEQUENCING MARKET BY TEST PURPOSE, THROUGH 2020 ($ MILLIONS)
    • TABLE 80: GLOBAL CLINICAL SEQUENCING CANCER MARKET BY INDICATION, THROUGH 2020 ($ MILLIONS)
    • TABLE 81: GLOBAL CLINICAL SEQUENCING CANCER MARKET BY TEST PURPOSE, THROUGH 2020 ($ MILLIONS)
    • TABLE 82: SCREENING METHODS FOR EARLY CANCER DETECTION
    • TABLE 83: GLOBAL CLINICAL SEQUENCING CANCER MARKET BY TEST COMPLEXITY, THROUGH 2020 ($ MILLIONS)
    • TABLE 84: GLOBAL MARKET FOR REPRODUCTIVE HEALTH SEQUENCING BY TEST APPLICATION, THROUGH 2020 ($ MILLIONS)
    • TABLE 85: GLOBAL NIPT MARKET BY RISK TYPE, THROUGH 2020 ($ MILLIONS)
    • TABLE 86: GLOBAL REPRODUCTIVE HEALTH SEQUENCING MARKET BY TEST COMPLEXITY, THROUGH 2020 ($ MILLIONS)
    • TABLE 87: GLOBAL TRANSPLANT SEQUENCING MARKET BY TEST PURPOSE, THROUGH 2020 ($ MILLIONS)
    • TABLE 88: GLOBAL TRANSPLANT SEQUENCING MARKET BY TEST COMPLEXITY, THROUGH 2020 ($ MILLIONS)
    • TABLE 89: GLOBAL MARKET FOR SEQUENCING TRANSPLANT MONITORING BY ORGAN TYPE, THROUGH 2020 ($ MILLIONS)
    • TABLE 90: TRANSPLANT PROCEDURES PERFORMED IN THE U.S., 2015
    • TABLE 91: GLOBAL MICROBIOLOGY SEQUENCING MARKET BY END USER, THROUGH 2020 ($ MILLIONS)
    • TABLE 92: GLOBAL INFORMATICS SEQUENCING MARKET BY SOFTWARE FUNCTION, THROUGH 2020 ($ MILLIONS)
    • TABLE 93: GLOBAL SEQUENCING MARKET BY REGION, THROUGH 2020 ($ MILLIONS)
    • TABLE 94: GLOBAL CANCER DIAGNOSTICS MARKET BY REGION, THROUGH 2020 ($ MILLIONS)
    • TABLE 95: GLOBAL MARKET FOR REPRODUCTIVE HEALTH SEQUENCING BY REGION, THROUGH 2020 ($ MILLIONS)
    • TABLE 96: GLOBAL TRANSPLANT DIAGNOSTICS MARKET BY REGION, THROUGH 2020 ($ MILLIONS)
    • TABLE 97: CLINICAL NEXT-GENERATION SEQUENCING PATENTS, 2005-2015 (NO. OF PATENTS)
    • TABLE 98: CLINICAL NEXT-GENERATION SEQUENCING PATENTS BY INDICATION, 2005-2015
    • TABLE 99: CELL-FREE DNA PATENTS BY REGION, 2005-2015
    • TABLE 100: STATUS OF SEQUENCING-RELATED PATENT DISPUTES
    • TABLE 101: 23ANDME DATA NEEDS
    • TABLE 102: MULTIPLE SCLEROSIS DIAGNOSTIC WORKFLOW
    • TABLE 103: COMPANIES IN THE EPIGENETIC SEQUENCING INDUSTRY
    • TABLE 104: NEW PLATFORMS INTRODUCED BY ILLUMINA, 2015
    • TABLE 105: MOLECULAR THYROID NODULE CLASSIFIER TEST COMPANY POSITIONING
    • TABLE 106: SENSITIVITY TO DETECT DRUG-RESISTANT MUTATIONS IN VIRUSES (%)
    • TABLE 107: COMMERCIAL SEQUENCER COMPETITIVE POSITIONING
    • TABLE 108: WAFERGEN STRATEGIC ALLIANCES

LIST OF FIGURES

  • SUMMARY FIGURE: GLOBAL SEQUENCING MARKET BY PRODUCT TYPE, 2014-2020 ($ MILLIONS)
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