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セルベースアッセイ:技術および世界市場

Cell-based Assays: Technologies and Global Markets

発行 BCC Research 商品コード 196807
出版日 ページ情報 英文 199 Pages
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セルベースアッセイ:技術および世界市場 Cell-based Assays: Technologies and Global Markets
出版日: 2014年04月18日 ページ情報: 英文 199 Pages
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概要

セルベースアッセイの世界市場は今後5年間に12.4%のCAGRで成長し、2013年の121億米ドルから、2015年に152億米ドル、そして2018年までに216億米ドルに達すると予測されています。

当レポートでは、セルベースアッセイの概要と市場動向予測とともに、セルベースアッセイ技術プラットフォームの概要、市場の競合構造、地域市場、業界参入企業の包括的プロファイルと特許分析をまとめ、概略下記の構成でお届けいたします。

第1章 イントロダクション

第2章 サマリー

第3章 概要

  • イントロダクション
  • 創薬
  • 概要:セルベースアッセイ
  • 創薬向けツール
    • ハイコンテンツスクリーニング
    • セルベーススクリーニング

第4章 創薬のためのセルベースアッセイ

  • ADME/TOXスクリーニングのためのセルベースアプローチ
    • 市場機会
    • ADME・毒性スクリーニング
    • 多重アレイセルベースアッセイ
    • セルベースバイオロジカルアッセイ
    • セルベースアッセイ向けハイスループットイメージングベースプラットフォーム
    • ラベルフリーのセルラーアッセイ:創薬と関連ある将来
  • 結論

第5章 セルベースアッセイ:現在の技術

  • セルベースアッセイ開発における要因
  • レポーター遺伝子技術
  • タンパク質間相互作用研究のためのセルベースアッセイ
  • セルベースタンパク小片相補アッセイ
  • 自動化・小型化
  • セルパターニング
  • セルベースアッセイおよび生理的関連性
  • セルベースアッセイおよび多重化
  • ウルトラハイスループットスクリーニング
  • PATHHUNTER アッセイの開発
  • ハイコンテンツスクリーニング技術
  • 創薬における治験薬(IND)研究
  • プロドラッグ戦略
  • 分子モデリング
  • サマリー
  • 新技術
  • 結論

第6章 セルベースアッセイの商業化

  • セルベースアッセイの役割
  • 創薬・セルベースアッセイ
  • 市場導入の機会
  • 細胞増殖の測定
  • 細胞増殖アッセイ提供企業
  • 幹細胞・免疫細胞による治療に向かう動き
  • セルベーススクリーニングアッセイ
  • オーファン受容体
  • サマリー

第7章 世界のセルベースアッセイおよび計装市場

  • 現在の市場概要
  • セルベースアッセイの役割
  • セルベースアッセイ市場
  • 創薬技術市場
  • ADME・毒物学市場
  • ADME-毒物検査市場
  • 創薬向けセルベースアッセイ:世界市場
  • ハイコンテンツスクリーニング市場
  • ハイコンテンツスクリーニング計装市場
  • 研究目的のセルベースアッセイ
  • セルベースアッセイ:スクリーニングイオンチャネル
  • 結論

第8章 世界の地域市場

  • 世界のセルベースアッセイ市場
  • 新興経済諸国における創薬

第9章 主要企業

第10章 セルベースアッセイの法的状況

  • セルベースアッセイの知的財産情勢

第11章 参考資料

図表

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目次
Product Code: BIO080B

BCC Research estimates that the global market for cell-based assays will increase at a compound annual growth rate (CAGR) of 12.4% over the next five years to reach $15.2 billion in 2015 and $21.6 billion by 2018 from $12.1 billion in 2013.

This report provides:

  • An overview of the global market for cell-based assays available and currently used.
  • Analyses of global market trends, with data from 2012, estimates for 2013, and projections of compound annual growth rates (CAGRs) through 2018.
  • Examinations of major issues involved in the research and development (R&D) of more effective cell-based approaches, for drug discovery, and absorption, distribution, metabolism, and excretion (ADME)/ toxicity assays in development and in use.
  • Discussion of current issues and trends affecting the industry, and costs and other factors influencing demand.
  • Coverage of new technologies, trends, alliances, and mergers.

REPORT SCOPE

INTRODUCTION

STUDY GOALS AND OBJECTIVES

This BCC Research market report, Cell-Based Assays: Technologies and Global Markets, provides a detailed overview and thorough analysis of the present and future global market for cell-based techniques. This report analyzes in detail the cell-based assays available and currently used and their markets. This report includes current products in this market and detailed analyses of markets and competitive environments; market for cell assays in newly emerging regions, and instrumentation and robotics and their impact on the market.

The report includes information about significant products and assays, key players, issues and trends, current market status of cell-based assays, strengths, weaknesses, opportunities and threats facing various assays and developments already on the market, major issues involved in the research and development (R&D) of more effective cell-based approaches, for drug discovery, and absorption, distribution, metabolism and excretion (ADME)/toxicity assays in development and in use.

REASONS FOR DOING THE STUDY

Cell-based assays have emerged as a more relevant alternative to biochemical assays involving the use of purified proteins especially in the field of drug discovery. There has been growth in demand for cell-based assays. A number of cell culture and liquid-handling instruments are available on the market that allows cell-based screening. The majority of compound screening programs performed by the biopharmaceutical industry are dependent on cell-based assays for functional measures of target activation. Label-free cellular assays are also driving this market forward, with their sensitivity, robustness, ease of use and flexibility. These assays are now used routinely throughout early drug discovery from target identification and validation to primary screening, lead identification, lead optimization and into safety and toxicology. There is a need to understand the trends in this market, currently available assays and latest developments for drug discovery.

SCOPE AND FORMAT

This report is an update on Cell-Based Assays: Technologies and Global Markets. It will review global markets for cell-based assays and new developments and will forecast trends for use of these assays for drug discovery and safety and toxicology through 2018. Important assays, technologies and the latest developments, market share by assay type, products on the market and market share by company, and statistical information for types of cancers prevalent worldwide, with a special emphasis on the U.S. market.

The report also includes current issues and trends affecting the industry and costs, and factors influencing demand will be discussed. The report covers products in development, new technologies, trends, alliances and mergers. The report offers market data with respect to segments and geography. It also provides market trends with respect to drivers, restraints and opportunities.

INTENDED AUDIENCE

This report is an exhaustive study on the global market for cell-based assays, giving crucial statistics and analysis on existing technologies, latest trends, market structure, market size, key drug segments, important trends in technology development, major opportunities and market shares of key players and drugs. This report may prove crucial for the firms or investors seeking investments in the concerned sector. This report shows cell-based assays currently being used, new developments, spending trends and revenue prospects for cell-based assays in pharma. The report provides market data for 2012 to 2018 and also covers commercial prospects for cell assays in drug research and ADME/toxicity assays.

METHODOLOGY

Both primary and secondary research methodologies were used in preparing this report. Secondary sources include books, newspapers, trade journals, white papers, industry portals, government agencies, trade associations, monitoring industry news and developments and through access to paid databases. The base year of the report is 2012, with forecast data provided through 2018. Historical, base year and forecast data are provided for each market segment of this report. Growth rates are determined through a compilation of data, including past trends, future trends, demographics, incidence, mortality, products in R&D and current product growth.

ANALYST CREDENTIALS

Usha Nagavarapu is an experienced pharmaceutical professional with business development experience. She has preclinical, alliance management, discovery and technology development and marketing experience. Her strong focus areas include oncology and cardiovascular diseases, with expertise in molecular and cell biology and complex cell-based biological assays ranging from drug discovery, in vitro and in vivo screening, in vivo model development and pharmacokinetics. She has experience working with early start-ups.

Table of Contents

CHAPTER1 INTRODUCTION

  • STUDY GOALS AND OBJECTIVES
  • REASONS FOR DOING THE STUDY
  • SCOPE AND FORMAT
  • INTENDED AUDIENCE
  • METHODOLOGY
  • ANALYST CREDENTIALS
  • RELATED BCC RESEARCH REPORTS
  • BCC RESEARCH WEBSITE
  • DISCLAIMER

CHAPTER2 SUMMARY

  • SUMMARY TABLE GLOBAL MARKET FOR CELL-BASED ASSAYS, THROUGH 2018 ($ MILLIONS)
  • SUMMARY FIGURE GLOBAL MARKET FOR CELL-BASED ASSAYS, 2012-2018 ($ MILLIONS)

CHAPTER3 OVERVIEW

  • INTRODUCTION
  • DRUG DISCOVERY
  • FIGURE 1 DRUG DISCOVERY PROCESS AND STEPS
  • TABLE 1 CELL-BASED ASSAYS AND USES
    • HIGH-CONTENT SCREENING INSTRUMENTATION AND SOFTWARE
    • DATA ANALYSIS
  • OVERVIEW: CELL-BASED ASSAYS
  • TOOLS FOR DRUG DISCOVERY
    • HIGH-CONTENT SCREENING
      • History of High-Content Screening
    • CELL-BASED SCREENING
      • Types of Cell-Based Assays
      • TABLE 2 TYPES OF CELL-BASED ASSAYS
        • Proliferation Assays
          • WST Reagents
        • Fluorescence-Based Assays
        • Apoptosis Assays
        • TABLE 3 APOPTOTIC MARKERS
          • Caspase Assays
          • DNA Fragmentation Assays
          • Annexin V and Cell Permeability Assays
          • Mitochondrial Assays
        • Activation Assays
        • Assays to Measure Gene Expression
      • Proof of Concept for Cell-Based Assays
      • TABLE 4 PROOF OF CONCEPT FOR CELL-BASED ASSAYS
      • Cell-Based Assays and Technology Trends
        • Why Cell-Based Approaches?
        • In Vitro Homogeneous Assays
        • Cell-Based Reporter Assays
      • Cell-Based Assays and Future Growth
      • TABLE 5 GLOBAL MARKET AND FORECAST FOR CELL-BASED ASSAYS, THROUGH 2018 ($ MILLIONS)
      • FIGURE 2 GLOBAL MARKET AND FORECAST FOR CELL-BASED ASSAYS, 2012-2018 ($ MILLIONS)
        • Cell-Based Assays for GPCRs
        • Immortalized Cells
          • Why Immortalized Cells?
            • Future
        • Primary Cells
          • Stem Cells and Cell-Based Assays
            • Embryonic Stem Cells and Cell-Based Assays
        • New Developments: 3D Cell-Based Models

CHAPTER4 ASSAYS FOR DRUG DISCOVERY

  • CELL-BASED APPROACHES FOR ADME/TOX SCREENING
    • MARKET OPPORTUNITY
    • ADME AND TOXICITY SCREENING
      • Cytochrome P450
      • TABLE 6 BIOLOGICAL ASSAY SYSTEMS FOR THE EVALUATION OF CYTOCHROME P450 ENZYME ISOFORMS
      • TABLE 7 HEPATOCYTE ASSAY SYSTEMS
      • TABLE 8 ADME ASSAYS
      • TABLE 9 COMMON TOXICITY ASSAYS
      • Optical Oxygen Sensors
      • Characterized Cell Lines for Cell-Based ADME and Toxicity Screening
      • TABLE 10 TRADITIONAL METHODS OF ADME/TOX TESTING
      • TABLE 11 CONVENTIONAL IN VITRO ADME/TOX SCREENING METHODS
      • Predictive ADME/Tox Screening
    • MULTIPLEXED CELL-BASED ASSAYS
      • Compound Effects on Cells
    • CELL-BASED BIOLOGICAL ASSAYS
      • General Bioassay Guidance
    • HIGH-THROUGHPUT IMAGING-BASED PLATFORM FOR CELL-BASED ASSAYS
    • CELL ASSAYS IN TODAY'S DRUG DISCOVERY PROCESS
    • LABEL-FREE CELLULAR ASSAYS: THE RELEVANT FUTURE OF DRUG DISCOVERY
      • Label-Free Assays and Applications 6
      • Benefits of Label-Free Assays 6
      • TABLE 12 LABEL-FREE ASSAYS AND APPLICATIONS
      • Advantages
      • Major Challenges for Adoption of Label-Free Technology
  • CONCLUSIONS

CHAPTER5 CELL BASED ASSAYS: CURRENT TECHNOLOGIES

  • FACTORS IN CELL-BASED ASSAY DEVELOPMENT
  • TABLE 13 FACTORS FOR CELL-BASED ASSAY DEVELOPMENT
  • REPORTER GENE TECHNOLOGY
  • TABLE 14 DIFFERENT APPROACHES TO CELL-BASED SYSTEMS FOR DRUG SCREENING
  • CELL-BASED ASSAYS FOR STUDYING PROTEIN-PROTEIN INTERACTIONS
  • CELL-BASED PROTEIN-FRAGMENT COMPLEMENTATION ASSAYS
  • MEASURING CALCIUM SIGNALING
  • CELL-BASED LABEL-FREE APPROACHES
  • AUTOMATION AND MINIATURIZATION
  • CELL PATTERNING
  • CELL-BASED ASSAYS AND PHYSIOLOGICAL RELEVANCE
  • CELL-BASED ASSAYS AND MULTIPLEXING
    • DEVELOPING REPORTER ASSAYS
    • REPORTER ASSAYS AND MULTIPLEXING
  • ULTRAHIGH-THROUGHPUT SCREENING
  • DEVELOPMENT OF PATHHUNTER ASSAY
  • HIGH-CONTENT SCREENING TECHNOLOGY
  • TABLE 15 CURRENT CONFOCAL HCS PLATFORMS
  • TABLE 16 WIDEFIELD HCS PLATFORMS
    • IMAGING CELLS FOR CELL-BASED ASSAYS
    • MICROSCOPIC VISUALIZATION OF CELLS
    • QUANTUM DOTS
    • LABEL-FREE IMAGING
  • INVESTIGATIONAL NEW DRUG (IND) STUDIES IN DRUG DEVELOPMENT
  • TABLE 17 STUDIES FOR FILING AN IND
  • TABLE 18 STUDIES FOR CLINICAL FILINGS
    • ROLE OF ADME IN DRUG DESIGN
  • PRODRUG STRATEGIES
  • MOLECULAR MODELING
  • SUMMARY
    • LIMITATIONS OF THE USE OF CELL-BASED ASSAYS IN THE PROCESS OF RISK ASSESSMENT
    • BOTTLENECKS IN CELL-BASED SCREENING
    • METHODS TO IMPROVE THROUGHPUT IN CELL-BASED ASSAYS
  • NEW TECHNOLOGIES
    • DATACHIP
    • BIND TECHNOLOGY
    • SIMUGEN
    • MINIATURIZATION OF BIOLOGICAL ASSAYS
    • MICROFLUIDIC CELL-CULTURE SYSTEMS FOR DRUG RESEARCH
  • CONCLUSION

CHAPTER6 COMMERCIALIZATION OF CELL-BASED ASSAYS

  • ROLE OF CELL-BASED ASSAYS
  • DRUG DISCOVERY AND CELL-BASED ASSAYS
  • OPPORTUNITIES FOR MARKET ADOPTION
  • TABLE 19 BIOLOGICAL APPLICATIONS FOR HCA
  • MEASURING CELL PROLIFERATION
  • COMPANIES OFFERING CELL PROLIFERATION ASSAYS
    • Roche Applied Science
    • BioVision
    • Promega
    • EMD Millipore
  • MOVE TOWARD THERAPIES WITH STEM AND IMMUNE CELLS
  • CELL-BASED SCREENING ASSAYS
    • COMPANIES
      • Euroscreen
      • Arena Pharmaceuticals
    • GPCR
  • ORPHAN RECEPTORS
  • SUMMARY

CHAPTER7 GLOBAL CELL-BASED ASSAY AND INSTRUMENTATION MARKET

  • CURRENT MARKET OVERVIEW
  • ROLE OF CELL-BASED ASSAYS
  • CELL-BASED ASSAY MARKET
    • MARKET DYNAMICS
    • CELL-BASED ASSAYS AND PRECLINICAL DEVELOPMENT
    • HIGH-THROUGHPUT SCREENING
    • TABLE 20 GLOBAL HTS MARKET, THROUGH 2018 ($ MILLIONS)
      • Advantages of HTS Assays
      • Major Drivers
      • TABLE 21 HTS TECHNOLOGIES: KEY COMPANIES
  • DRUG DISCOVERY TECHNOLOGY MARKET
  • TABLE 22 GLOBAL MARKET FOR DRUG DISCOVERY TECHNOLOGIES, THROUGH 2018 ($ MILLIONS)
  • FIGURE 3 GLOBAL MARKET FOR DRUG DISCOVERY TECHNOLOGIES 2012-2018 ($ MILLIONS)
    • CELL-BASED ASSAYS: MARKET DRIVERS
    • CELLULAR BIOLOGY
      • RNA and DNA Reagents Market
      • TABLE 23 GLOBAL MARKET FOR REAGENTS AND TOOLS USED IN DNA AND RNA RESEARCH, THROUGH 2018 ($ MILLIONS)
      • FIGURE 4 GLOBAL MARKET FOR REAGENTS AND TOOLS USED IN DNA AND RNA RESEARCH, 2012-2018 ($ MILLIONS)
      • Life Science Tools Market
      • TABLE 24 GLOBAL MARKET FOR LIFE SCIENCE TOOLS, THROUGH 2018 ($ MILLIONS)
      • FIGURE 5 GLOBAL MARKET FOR LIFE SCIENCE TOOLS, 2012-2018 ($ MILLIONS)
      • Cell Biology Reagents
      • TABLE 25 GLOBAL MARKET FOR CELL BIOLOGY REAGENTS AND TOOLS, THROUGH 2018 ($ MILLIONS)
      • FIGURE 6 GLOBAL MARKET FOR CELL BIOLOGY REAGENTS AND TOOLS, 2012-2018 ($ MILLIONS)
      • Reagent Development
    • CELL CULTURE MARKET
    • TABLE 26 GLOBAL MARKET FOR CELL CULTURE TOOLS, THROUGH 2018 ($ MILLIONS)
    • FIGURE 7 GLOBAL MARKET FOR CELL CULTURE TOOLS, 2012-2018 ($ MILLIONS)
      • Cell Culture Reagent Market
      • TABLE 27 GLOBAL MARKET FOR CELL CULTURE REAGENTS, THROUGH 2018 ($ MILLIONS)
      • FIGURE 8 GLOBAL MARKET FOR CELL CULTURE REAGENTS, 2012-2018 ($ MILLIONS)
      • TABLE 28 U.S. MARKET FOR CELL CULTURE REAGENTS, THROUGH 2018 ($ MILLIONS)
      • FIGURE 9 U.S. MARKET FOR CELL CULTURE REAGENTS, 2012-2018 ($ MILLIONS)
      • Three-Dimensional Cell Culture Market
      • TABLE 29 GLOBAL MARKET FOR 3D CELL CULTURE REAGENTS, THROUGH 2018 ($ MILLIONS)
      • FIGURE 10 GLOBAL MARKET FOR 3D CELL CULTURE REAGENTS, 2012-2018 ($ MILLIONS)
    • CELL-BASED ASSAYS MARKET GROWTH
      • CELL-BASED ASSAYS: KEY GROWTH FACTORS
      • TABLE 30 CELL-BASED ASSAY COMPANIES
      • TABLE 31 GLOBAL MARKET FOR CELL-BASED ASSAYS, THROUGH 2018 ($ MILLIONS)
      • FIGURE 11 GLOBAL MARKET FOR CELL-BASED ASSAYS, 2012-2018 ($ MILLIONS)
      • MARKET DEMAND
      • TABLE 32 LIMITATIONS OF CELL-BASED ASSAYS
      • CELL-BASED ASSAYS: BASIC RESEARCH
      • TABLE 33 GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN BASIC RESEARCH, THROUGH 2018 ($ MILLIONS)
      • FIGURE 12 GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN BASIC RESEARCH, 2012-2018 ($ MILLIONS)
      • STEM CELLS AND TOXICITY TESTING
        • Market Drivers
  • ADME AND TOXICOLOGY MARKET
    • CYPROTEX
    • IN VITRO PREDICTIVE TOXICOLOGY
    • TABLE 34 GLOBAL MARKET FOR IN VITRO TOXICITY TESTS, THROUGH 2017 ($ MILLIONS)
    • FIGURE 13 GLOBAL MARKET FOR IN VITRO TOXICITY TESTS, 2012-2017 ($ MILLIONS)
  • ADME-TOXICOLOGY TESTING MARKET
    • SPECIALIZED CELL-BASED ASSAYS
    • TABLE 35 GLOBAL MARKET FOR SPECIALIZED CELL-BASED ASSAYS USED IN DRUG DISCOVERY, THROUGH 2018 ($ MILLIONS)
    • FIGURE 14 GLOBAL MARKET FOR SPECIALIZED CELL-BASED ASSAYS USED IN DRUG DISCOVERY, 2012-2018 ($ MILLIONS)
    • TABLE 36 IN VITRO PREDICTIVE TOXICOLOGY ASSAYS
    • ADME: TOOLS AND TECHNOLOGIES
    • ADME STUDIES FOR FDA SUBMISSIONS
    • MARKET PLAYERS
    • TABLE 37 GLOBAL MARKET FOR ADME ASSAYS, THROUGH 2018 ($ MILLIONS)
    • FIGURE 15 GLOBAL MARKET FOR ADME ASSAYS, 2012-2018 ($ MILLIONS)
  • CELL-BASED ASSAYS FOR DRUG DISCOVERY: GLOBAL MARKET
  • TABLE 38 GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN DRUG DISCOVERY BY SEGMENT, THROUGH 2018 ($ MILLIONS)
  • FIGURE 16 GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN DRUG DISCOVERY BY SEGMENT, 2012-2018 ($ MILLIONS)
    • CELL-BASED ASSAYS: KEY HISTORICAL FACTS
    • TABLE 39 KEY COMPANIES
    • CELL MIGRATION ASSAYS
  • HIGH-CONTENT SCREENING MARKET
  • TABLE 40 GLOBAL MARKET FOR HIGH-CONTENT SCREENING ASSAYS AND INSTRUMENTATION, THROUGH 2018 ($ MILLIONS)
  • FIGURE 17 GLOBAL MARKET FOR HIGH-CONTENT SCREENING ASSAYS AND INSTRUMENTATION, 2012-2018 ($ MILLIONS)
  • TABLE 41 HCS MARKET: MAJOR COMPANIES
    • HCS MARKET DRIVERS
    • COMPANIES
      • Thermo Fisher Scientific
      • Molecular Devices
      • TABLE 42 MOLECULAR DEVICES: PRODUCTS
        • Instruments for High-Content Screening
        • TABLE 43 HCS SYSTEM PLATFORMS
      • HIGH-CONTENT SCREENING KITS
        • Companies
          • EMD Millipore
          • TABLE 44 MILLIPORE PRODUCTS: APPLICATIONS
  • HIGH-CONTENT SCREENING INSTRUMENTATION MARKET
  • TABLE 45 GLOBAL MARKET FOR HIGH-CONTENT SCREENING INSTRUMENTS, THROUGH 2018 ($ MILLIONS)
  • FIGURE 18 GLOBAL MARKET FOR HIGH-CONTENT SCREENING INSTRUMENTS, 2012-2018 ($ MILLIONS)
    • FLOW CYTOMETERS
    • TABLE 46 KEY COMPANIES
    • LABEL-FREE DETECTION MARKET
    • MICROPLATE INSTRUMENTATION AND SUPPLIES
    • CHALLENGES WITH CELL-BASED ASSAYS
    • FUTURE OF CELL-BASED ASSAYS
    • IN VITRO INFLAMMATION MODELS
    • 3D CULTURE
    • NEW DEVELOPMENTS
      • Multiplex Assays for GPCR Signaling
  • CELL-BASED ASSAYS FOR RESEARCH PURPOSES
    • G PROTEIN-COUPLED RECEPTORS
      • GPCR Drugs
      • TABLE 47 GPCR-TARGETING KEY DRUGS
      • TABLE 48 KEY COMPANIES WITH GPCR PRODUCTS
      • Companies and Technologies
        • Multispan
        • DiscoveRx
        • Omeros
        • TABLE 49 OMEROS: GPCRS AND INDICATIONS
          • Patent Position
        • AB Vector
        • Cisbio
        • PerkinElmer
        • Codex Biosolutions
        • ChanTest
        • Corning Life Sciences
      • GPCRs: A Potent Class of Drug Targets
      • TABLE 50 ASSAY METHODS TO STUDY GPCRS (%)
      • TABLE 51 GPCR PRIMARY SCREENING ASSAYS
      • TABLE 52 GLOBAL MARKET FOR GPCR SCREENING AND PROFILING, 2010 ($ MILLIONS)
    • KEY FACTS
  • CELL-BASED ASSAYS: SCREENING ION CHANNELS
    • LABEL-FREE DETECTION
    • COMPANIES
      • Life Technologies (Invitrogen Corp.)
      • TABLE 53 LIFE TECHNOLOGIES PRODUCTS
      • TABLE 54 INVITROGEN'S CELL-BASED TECHNOLOGIES
        • CellSensor Assays
        • LanthaScreen Assays
        • TABLE 55 COMPARISON OF YEARS ENDED DEC. 31, 2011 AND 2010 ($ MILLIONS/%)
      • Molecular Devices
      • Roche Applied Science
        • Thermo Fisher Scientific
        • TABLE 56 THERMO FISHER SCIENTIFIC'S ANALYTICAL TECHNOLOGIES SEGMENT REVENUE, 2012 AND 2013 ($ MILLIONS)
  • CONCLUSION

CHAPTER8 GLOBAL REGIONAL MARKETS

  • GLOBAL MARKET FOR CELL-BASED ASSAYS
    • CELL-BASED ASSAYS IN THE LEADING EMERGING MARKETS
      • China
      • Summary
      • TABLE 57 GLOBAL MARKET FOR CELL-BASED ASSAYS BY REGION, THROUGH 2018 ($ MILLIONS)
      • FIGURE 19 GLOBAL MARKET FOR CELL-BASED ASSAYS BY REGION, 2012-2018 ($ MILLIONS)
      • Emerging Economies
    • U.S. MARKET
    • TABLE 58 U.S. MARKET FOR CELL-BASED ASSAYS, THROUGH 2018 ($ MILLIONS) 76
    • FIGURE 20 U.S. MARKET FOR CELL-BASED ASSAYS, 2012-2018 ($ MILLIONS)
      • Market Overview
      • TABLE 59 KEY GROWTH DRIVERS OF THE MARKET FOR CELL-BASED ASSAYS
      • What are Cell-Based Assays and Why the Hype?
      • EUROPEAN MARKET
      • TABLE 60 EUROPEAN CELL-BASED ASSAY MARKET, THROUGH 2018 ($ MILLIONS)
      • FIGURE 21 EUROPEAN CELL-BASED ASSAY MARKET, 2012-2018 ($ MILLIONS)
  • DRUG DISCOVERY IN THE EMERGING ECONOMIES
    • DRUG DISCOVERY IN INDIA AND CHINA
      • China
      • TABLE 61 CHINA'S DRUG DISCOVERY OUTSOURCING MARKET, THROUGH 2018 ($ MILLIONS)
      • FIGURE 22 CHINA DRUG DISCOVERY OUTSOURCING MARKET, 2012-2018 ($ MILLIONS)
        • Challenges
      • India
      • TABLE 62 INDIAN DRUG DISCOVERY MARKET, 2009 AND 2010 ($ MILLIONS)
      • FIGURE 23 INDIAN DRUG DISCOVERY MARKET, 2009-2010 ($ MILLIONS)
    • ADVANCES IN CELL-BASED ASSAYS
    • CONTRACT RESEARCH ORGANIZATIONS AND CELL-BASED ASSAYS
    • OUTLOOK

CHAPTER9 KEY COMPANIES

  • ACEA BIOSCIENCES
  • BD BIOSCIENCES
  • BECKMAN COULTER
  • CELLULAR DYNAMICS INTERNATIONAL
  • CALIPER LIFE SCIENCES
  • CELSIS IVT
  • CISBIO BIOASSAYS
  • DISCOVERX CORP.
  • EMD MILLIPORE
  • ENZO LIFE SCIENCES
  • EVOTEC AG
  • GE HEALTHCARE
  • HEMOGENIX
  • LIFE TECHNOLOGIES
  • LONZA
  • MOLECULAR DEVICES (DANAHER)
  • ONCOIMMUNIN
  • ORIGENE TECHNOLOGIES
  • PERKINELMER
  • PROMEGA CORP.
  • ROCHE
  • STEMCELLS INC.
  • THERMO FISHER SCIENTIFIC
  • TTP LABTECH
  • VIVO BIOSCIENCES
  • VITRO BIOPHARMA

CHAPTER10 LEGAL ASPECTS OF CELL-BASED ASSAYS

  • INTELLECTUAL PROPERTY LANDSCAPE OF CELL-BASED ASSAYS
    • LATEST NEWS, ALLIANCES AND MERGERS
      • Thermo Fisher Scientific to Sell Cell Culture Business
      • 3D Cell Culture Start-up
      • Vivo Biosciences, ACEA Biosciences and Roche to Develop New xCELLigence System Assays for Stem Cell and Cancer Research
      • DiscoveRx Corp. Acquires KINOMEscan
      • Promega and Celsis In Vitro Technologies Introduced More Reliable Solutions for ADME/Tox Testing in Primary Hepatocytes
      • Vitro Expands HemoGenix Alliance to Include Cell-Based Testing for Liver Toxicity
      • Platypus Licenses Cell Exclusion Zone Technology to Cell Biolabs
      • Ion Channel and GPCR Screening Services and Products
    • LABEL-FREE TECHNOLOGIES
      • PerkinElmer Launches the EnSpire Multimode Plate Reader
    • SUMMARY AND OUTLOOK

CHAPTER11 BIBLIOGRAPHY

LIST OF TABLES

  • SUMMARY TABLE GLOBAL MARKET FOR CELL-BASED ASSAYS, THROUGH 2018 ($ MILLIONS)
  • TABLE 1 CELL-BASED ASSAYS AND USES
  • TABLE 2 TYPES OF CELL-BASED ASSAYS
  • TABLE 3 APOPTOTIC MARKERS
  • TABLE 4 PROOF OF CONCEPT FOR CELL-BASED ASSAYS
  • TABLE 5 GLOBAL MARKET AND FORECAST FOR CELL-BASED ASSAYS, THROUGH 2018 ($ MILLIONS)
  • TABLE 6 BIOLOGICAL ASSAY SYSTEMS FOR THE EVALUATION OF CYTOCHROME P450 ENZYME ISOFORMS
  • TABLE 7 HEPATOCYTE ASSAY SYSTEMS
  • TABLE 8 ADME ASSAYS
  • TABLE 9 COMMON TOXICITY ASSAYS
  • TABLE 10 TRADITIONAL METHODS OF ADME/TOX TESTING
  • TABLE 11 CONVENTIONAL IN VITRO ADME/TOX SCREENING METHODS
  • TABLE 12 LABEL-FREE ASSAYS AND APPLICATIONS
  • TABLE 13 FACTORS FOR CELL-BASED ASSAY DEVELOPMENT
  • TABLE 14 DIFFERENT APPROACHES TO CELL-BASED SYSTEMS FOR DRUG SCREENING
  • TABLE 15 CURRENT CONFOCAL HCS PLATFORMS
  • TABLE 16 WIDEFIELD HCS PLATFORMS
  • TABLE 17 STUDIES FOR FILING AN IND
  • TABLE 18 STUDIES FOR CLINICAL FILINGS
  • TABLE 19 BIOLOGICAL APPLICATIONS FOR HCA
  • TABLE 20 GLOBAL HTS MARKET, THROUGH 2018 ($ MILLIONS)
  • TABLE 21 HTS TECHNOLOGIES: KEY COMPANIES
  • TABLE 22 GLOBAL MARKET FOR DRUG DISCOVERY TECHNOLOGIES, THROUGH 2018 ($ MILLIONS)
  • TABLE 23 GLOBAL MARKET FOR REAGENTS AND TOOLS USED IN DNA AND RNA RESEARCH, THROUGH 2018 ($ MILLIONS)
  • TABLE 24 GLOBAL MARKET FOR LIFE SCIENCE TOOLS, THROUGH 2018 ($ MILLIONS)
  • TABLE 25 GLOBAL MARKET FOR CELL BIOLOGY REAGENTS AND TOOLS, THROUGH 2018 ($ MILLIONS)
  • TABLE 26 GLOBAL MARKET FOR CELL CULTURE TOOLS, THROUGH 2018 ($ MILLIONS)
  • TABLE 27 GLOBAL MARKET FOR CELL CULTURE REAGENTS, THROUGH 2018 ($ MILLIONS)
  • TABLE 28 U.S. MARKET FOR CELL CULTURE REAGENTS, THROUGH 2018 ($ MILLIONS)
  • TABLE 29 GLOBAL MARKET FOR 3D CELL CULTURE REAGENTS, THROUGH 2018 ($ MILLIONS)
  • TABLE 30 CELL-BASED ASSAY COMPANIES
  • TABLE 31 GLOBAL MARKET FOR CELL-BASED ASSAYS, THROUGH 2018 ($ MILLIONS)
  • TABLE 32 LIMITATIONS OF CELL-BASED ASSAYS
  • TABLE 33 GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN BASIC RESEARCH, THROUGH 2018 ($ MILLIONS)
  • TABLE 34 GLOBAL MARKET FOR IN VITRO TOXICITY TESTS, THROUGH 2017 ($ MILLIONS)
  • TABLE 35 GLOBAL MARKET FOR SPECIALIZED CELL-BASED ASSAYS USED IN DRUG DISCOVERY, THROUGH 2018 ($ MILLIONS)
  • TABLE 36 IN VITRO PREDICTIVE TOXICOLOGY ASSAYS 1
  • TABLE 37 GLOBAL MARKET FOR ADME ASSAYS, THROUGH 2018 ($ MILLIONS)
  • TABLE 38 GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN DRUG DISCOVERY BY SEGMENT, THROUGH 2018 ($ MILLIONS)
  • TABLE 39 KEY COMPANIES
  • TABLE 40 GLOBAL MARKET FOR HIGH-CONTENT SCREENING ASSAYS AND INSTRUMENTATION, THROUGH 2018 ($ MILLIONS)
  • TABLE 41 HCS MARKET: MAJOR COMPANIES
  • TABLE 42 MOLECULAR DEVICES: PRODUCTS
  • TABLE 43 HCS SYSTEM PLATFORMS
  • TABLE 44 MILLIPORE PRODUCTS: APPLICATIONS
  • TABLE 45 GLOBAL MARKET FOR HIGH-CONTENT SCREENING INSTRUMENTS, THROUGH 2018 ($ MILLIONS)
  • TABLE 46 KEY COMPANIES
  • TABLE 47 GPCR-TARGETING KEY DRUGS
  • TABLE 48 KEY COMPANIES WITH GPCR PRODUCTS
  • TABLE 49 OMEROS: GPCRS AND INDICATIONS
  • TABLE 50 ASSAY METHODS TO STUDY GPCRS (%)
  • TABLE 51 GPCR PRIMARY SCREENING ASSAYS
  • TABLE 52 GLOBAL MARKET FOR GPCR SCREENING AND PROFILING, 2010 ($ MILLIONS)
  • TABLE 53 LIFE TECHNOLOGIES PRODUCTS
  • TABLE 54 INVITROGEN'S CELL-BASED TECHNOLOGIES
  • TABLE 55 COMPARISON OF YEARS ENDED DEC. 31, 2011 AND 2010 ($ MILLIONS/%)
  • TABLE 56 THERMO FISHER SCIENTIFIC'S ANALYTICAL TECHNOLOGIES SEGMENT REVENUE, 2012 AND 2013 ($ MILLIONS)
  • TABLE 57 GLOBAL MARKET FOR CELL-BASED ASSAYS BY REGION, THROUGH 2018 ($ MILLIONS)
  • TABLE 58 U.S. MARKET FOR CELL-BASED ASSAYS, THROUGH 2018 ($ MILLIONS)
  • TABLE 59 KEY GROWTH DRIVERS OF THE MARKET FOR CELL-BASED ASSAYS
  • TABLE 60 EUROPEAN CELL-BASED ASSAY MARKET, THROUGH 2018 ($ MILLIONS)
  • TABLE 61 CHINA'S DRUG DISCOVERY OUTSOURCING MARKET, THROUGH 2018 ($ MILLIONS)
  • TABLE 62 INDIAN DRUG DISCOVERY MARKET, 2009 AND 2010 ($ MILLIONS)

LIST OF FIGURES

  • SUMMARY FIGURE GLOBAL MARKET FOR CELL-BASED ASSAYS, 2012-2018 ($ MILLIONS)
  • FIGURE 1 DRUG DISCOVERY PROCESS AND STEPS
  • FIGURE 2 GLOBAL MARKET AND FORECAST FOR CELL-BASED ASSAYS, 2012-2018 ($ MILLIONS)
  • FIGURE 3 GLOBAL MARKET FOR DRUG DISCOVERY TECHNOLOGIES 2012-2018 ($ MILLIONS)
  • FIGURE 4 GLOBAL MARKET FOR REAGENTS AND TOOLS USED IN DNA AND RNA RESEARCH, 2012-2018 ($ MILLIONS)
  • FIGURE 5 GLOBAL MARKET FOR LIFE SCIENCE TOOLS, 2012-2018 ($ MILLIONS)
  • FIGURE 6 GLOBAL MARKET FOR CELL BIOLOGY REAGENTS AND TOOLS, 2012-2018 ($ MILLIONS)
  • FIGURE 7 GLOBAL MARKET FOR CELL CULTURE TOOLS, 2012-2018 ($ MILLIONS)
  • FIGURE 8 GLOBAL MARKET FOR CELL CULTURE REAGENTS, 2012-2018 ($ MILLIONS)
  • FIGURE 9 U.S. MARKET FOR CELL CULTURE REAGENTS, 2012-2018 ($ MILLIONS)
  • FIGURE 10 GLOBAL MARKET FOR 3D CELL CULTURE REAGENTS, 2012-2018 ($ MILLIONS)
  • FIGURE 11 GLOBAL MARKET FOR CELL-BASED ASSAYS, 2012-2018 ($ MILLIONS)
  • FIGURE 12 GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN BASIC RESEARCH, 2012-2018 ($ MILLIONS)
  • FIGURE 13 GLOBAL MARKET FOR IN VITRO TOXICITY TESTS, 2012-2017 ($ MILLIONS)
  • FIGURE 14 GLOBAL MARKET FOR SPECIALIZED CELL-BASED ASSAYS USED IN DRUG DISCOVERY, 2012-2018 ($ MILLIONS)
  • FIGURE 15 GLOBAL MARKET FOR ADME ASSAYS, 2012-2018 ($ MILLIONS)
  • FIGURE 16 GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN DRUG DISCOVERY BY SEGMENT, 2012-2018 ($ MILLIONS)
  • FIGURE 17 GLOBAL MARKET FOR HIGH-CONTENT SCREENING ASSAYS AND INSTRUMENTATION, 2012-2018 ($ MILLIONS)
  • FIGURE 18 GLOBAL MARKET FOR HIGH-CONTENT SCREENING INSTRUMENTS, 2012-2018 ($ MILLIONS)
  • FIGURE 19 GLOBAL MARKET FOR CELL-BASED ASSAYS BY REGION, 2012-2018 ($ MILLIONS)
  • FIGURE 20 U.S. MARKET FOR CELL-BASED ASSAYS, 2012-2018 ($ MILLIONS)
  • FIGURE 21 EUROPEAN CELL-BASED ASSAY MARKET, 2012-2018 ($ MILLIONS)
  • FIGURE 22 CHINA DRUG DISCOVERY OUTSOURCING MARKET, 2012-2018 ($ MILLIONS)
  • FIGURE 23 INDIAN DRUG DISCOVERY MARKET, 2009-2010 ($ MILLIONS)
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