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診断、治療のための核酸アプタマー:世界市場

Nucleic Acid Aptamers for Diagnostics and Therapeutics: Global Markets

発行 BCC Research 商品コード 116974
出版日 ページ情報 英文 122 Pages
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2016年12月31日まで 年末キャンペーン割引: BCC Research社発行レポート
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診断、治療のための核酸アプタマー:世界市場 Nucleic Acid Aptamers for Diagnostics and Therapeutics: Global Markets
出版日: 2014年09月30日 ページ情報: 英文 122 Pages
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BCC Research社のレポートは、Reuter、Wall Street Journal、Fortuneなどで引用されることも多く、それぞれの業界の識者の意見として重きを置かれています。同社レポートを複数冊ご購入の場合年間パッケージのご契約がお得です。詳細は右の担当者のおすすめ商品よりご覧下さい。
概要

世界の核酸アプタマー市場は2014年に3億4,050万米ドルに達しました。同市場は2014年から2019年にかけて73.5%の年間複合成長率(CAGR)で拡大し、2015年には6億1030万米ドル、2019年には54億米ドルへ成長すると予測されています。

当レポートでは、治療および診断に用いられる世界の核酸アプタマー市場について調査し、世界市場の動向分析と予測、今後数年間のCAGR予測、、siRNAデリバリー・ワクチン・アンチセンス技術のアジュバントとしてのアプタマー利用における新興技術の成長機会の特定、産業において高成長・高い市場潜在性を持つセグメントの調査、主要企業のプロファイルなどをまとめ、お届けいたします。

第1章 イントロダクション

第2章 エグゼクティブサマリー

第3章 概要

  • イントロダクション
  • ナノ細孔センサーはアプタマー技術に向かう傾向
  • アプタマー分類
  • ポーターのファイブフォース分析
  • 市場力学、ほか

第4章 核酸アプタマー市場:技術別

  • イネーブリング技術
  • 診断用としてのアプタマー
  • アプタマーと感染症
  • 標的薬剤としてのアプタマー
  • アプタマー修正

第5章 核酸アプタマー市場:応用別

  • 診断としてのアプタマーの応用
  • 治療としてのアプタマーの応用
  • 研究におけるアプタマーの応用
  • バイオセンサーとしてのアプタマーの応用
  • バイオマーカー発見における応用

第6章 核酸アプタマー市場:地域別

  • 北米
  • 欧州
  • アジア太平洋地域
  • その他(ROW)

第7章 競合情勢

  • 治験
  • コラボレーション
  • 合意
  • 研究開発(R&D)

第8章 特許分析

  • 米国の特許分析:市場参入企業別
  • 日本の特許分析:市場参入企業別

第9章 企業プロファイル

第10章 付録

図表

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目次
Product Code: BIO071C

The global market for nucleic acid aptamers reached $340.5 million in 2014. This market should grow to about $610.3 million in 2015 and about $5.4 billion in 2019, with a compound annual growth rate (CAGR) of 73.5% from 2014 to 2019.

This report provides:

  • An overview of the specific applications for nucleic acid aptamers for therapeutic and diagnostic purposes, with a focus on applications judged to be commercially viable rather than enabling of basic research
  • Analyses of global market trends, with data from 2014, estimates for 2015, and projections of compound annual growth rates (CAGRs) through 2019
  • Identification of emerging technology growth opportunities in aptamer use as adjuvants for siRNA delivery, vaccines, and antisense technologies
  • Examination of high growth and market potential segments of the industry, and new and established companies in the arena
  • Comprehensive company profiles of major players in the industry.

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REPORT SCOPE

SCOPE OF THE REPORT

This research report presents an in-depth analysis of the global nucleic acid aptamer market by technologies, applications and geographic regional markets. It includes key technologies involved, analyzes the capabilities and characteristics of aptamers in comparison with antibodies and lists specific areas where aptamers could find application. The evolving trends and technological developments in the field of aptamers have been studied in detail.

Special emphasis will be given to collaborative efforts, research innovations and investment clinical trials conducted. Patents will be discussed as well. This study also analyzes the aptamer-based drugs that have been developed or are in the pipeline for the treatment of various diseases. Impact analysis of the key drivers and factors affecting or influencing the growth of this market is also included.

The market for aptamer technologies is further categorized into enabling technology, diagnostic sensors and therapeutics. Enabling technology consists of SELEX technology, modified oligonucleotides, next-generation sequencing, nanoparticles and quantum dot labels, surface plasmon resonance and biolayer interferometry and bioinformatics. In terms of application the market is classified into diagnostics, therapeutics, research, biosensors, biomarker discovery and others.

Furthermore, diagnostics-based aptamers are used in environmental monitoring and food and water safety. They are also used for developing aptasensors for sensing small molecules and pathogens. Aptamers also find application in human clinical diagnostic assays for diagnosing diseases such as cancer, infectious diseases and other immunological diseases.

Aptamers are used in therapeutics and research as drug delivery vehicles in cancer, as a modifier of surgical implants and in bioseparation processes. Research areas include flow cytometry, mass spectrometry and Western blotting; they are also used as reagents and assays and as biosensors and biomarker molecules.

The market is segmented by regions into North America, Europe, Asia-Pacific and ROW. Companies profiled in this report include Ophthotech Corp., Alimera Sciences, AM Biotechnologies LLC, Alnylam Pharmaceuticals, Noxxon, Rina Gmbh, Regado Biosciences, Base Pair Biotechnologies Inc., Aptamer Sciences Inc., Aptasol (Aptamer Solutions) Ltd, Isis Pharmaceuticals, Neoventures Biotechnology Inc., Mitsui & Co. (U.S.A.) Inc., Quest Diagnostics, SomaLogic Inc. and Sumitomo Bakelite Co. Ltd.

ANALYST'S CREDENTIALS

Yojana Jeevane has more than four years of experience in market intelligence and business research. She has experience in the healthcare domain with respect to medical devices, the life sciences market and the chemical domain. She has frequently delivered research services that include strategic recommendations and business strategies to assist market players in making beneficial strategies. Ms. Jeevane holds a B.Sc degree in biotechnology and an MBA in marketing.

Table of Contents

CHAPTER 1 INTRODUCTION

  • STUDY GOALS AND OBJECTIVE
  • SCOPE OF THE REPORT
  • INTENDED AUDIENCE
  • INFORMATION AND METHODOLOGY SOURCES
  • ANALYST'S CREDENTIALS
  • RELATED BCC RESEARCH REPORTS
  • BCC RESEARCH WEBSITE
  • DISCLAIMER

CHAPTER 2 EXECUTIVE SUMMARY

  • SUMMARY TABLE GLOBAL MARKET FOR NUCLEIC ACID APTAMERS BY TECHNOLOGY, THROUGH 2019 ($ MILLIONS)
  • SUMMARY FIGURE GLOBAL MARKET FOR NUCLEIC ACID APTAMERS BY TECHNOLOGY, 2013-2019 ($ MILLIONS)

CHAPTER 3 OVERVIEW

  • INTRODUCTION
  • FIGURE 1 SERVICE OFFERED UNDER APTAMER TECHNOLOGIES
  • INCLINATION OF NANOPORE SENSORS TOWARD APTAMER TECHNOLOGY
    • APPLICATIONS OF NANOPORES IN DNA SEQUENCING
    • APPLICATION OF NANOPORES AS GENERAL BIOSENSORS
    • CMOS APPLICATION IN NANOPORE AND APTAMER TECHNOLOGIES
  • POTENTIAL OF FYNOMER TECHNOLOGY
  • TENASCIN-C APTAMERS
  • SMART APTAMERS
  • BLOOD PROTEIN DETECTION METHOD BASED UPON APTAMER
  • IMPROVED AND EFFICIENT POTENTIAL OF NUCLEIC ACID-BASED APTAMER LIBRARIES PATTERNED TO FORM IMPROVED SECONDARY STRUCTURE
  • NUCLEIC ACID-BASED APTAMERS AGAINST PROTEASES
  • NUCLEIC ACID-BASED APTAMER SELECTION FOR MONITORING GENE EXPRESSION USING BETA-GLUCURONIDASE
  • NUCLEIC ACID-BASED APTAMER THAT BINDS TO BISPHENOL A SPECIFICALLY
  • APTAMERS VS. ANTIBODIES
  • TABLE 1 DIFFERENCE BETWEEN APTAMERS AND ANTIBODIES
  • APTAMER CLASSIFICATION
    • NUCLEIC ACID APTAMERS
    • PEPTIDE APTAMERS
    • FIGURE 2 APPLICATIONS OF PEPTIDE APTAMERS
  • APTAMERS AS AFFINITY REAGENTS
  • APTAMERS AS MOLECULAR PROBES
  • APTAMERS IN CYTOMICS ANALYSIS
  • APTAMERS AS DIAGNOSTIC AND THERAPEUTIC AGENTS FOR LYMPHOMA
  • APTAMER SYNTHESIS AND MODIFICATIONS
  • APPLICATION IN DIAGNOSTICS AND THERAPEUTICS
  • ADVANTAGES OF APTAMERS
    • HIGHER STABILITY OF APTAMERS
    • PRODUCTION OF APTAMERS (MODIFICATION/SYNTHESIS)
    • IMMUNOGENICITY OF APTAMERS
    • VARIETY OF TARGETS
  • PORTER'S FIVE FORCES ANALYSIS OF THE NUCLEIC ACID APTAMER MARKET
  • FIGURE 3 PORTER'S FIVE FORCE MODEL OF THE NUCLEIC ACID APTAMER TECHNOLOGY MARKET
    • BARGAINING POWER OF SUPPLIERS-LOW
    • BARGAINING POWER OF BUYERS-HIGH
    • INTENSITY OF COMPETITION-HIGH
    • THREAT OF SUBSTITUTE PRODUCTS-HIGH
    • THREAT OF NEW ENTRANTS-HIGH
    • GOVERNMENT REGULATIONS AND LEGISLATION
    • REGULATORY CHALLENGES IN THE UNITED STATES AND EUROPE
    • TABLE 2 ICH* GUIDELINES APPLICABLE TO THERAPEUTICS BASED UPON SYNTHETIC OLIGONUCLEOTIDES
      • Guidelines for Reimbursement
      • Documentation Requirements
      • TABLE 3 MACUGEN (PEGAPTANIB SODIUM) CODES FOR REIMBURSEMENT
      • FIGURE 4 HISTORICAL MILESTONE FOR MACUGEN (PEGAPTANIB SODIUM) REIMBURSEMENT PROGRAM
    • CLINICAL TRIALS COMPLETED
    • TABLE 4 CLINICAL TRIALS OF APTAMER RESEARCH (COMPLETED) 32
    • CLINICAL TRIALS TERMINATED
    • TABLE 5 CLINICAL TRIALS OF APTAMER RESEARCH (TERMINATED)
    • CLINICAL TRIALS IN PROGRESS
    • TABLE 6 CLINICAL TRIALS OF APTAMER RESEARCH (IN PROGRESS)
  • MARKET DYNAMICS
    • DRIVERS
      • Scope of Applications for Nucleic Acid-based Aptamer Technology
        • Therapeutics
        • Diagnostics
        • Research
      • Advantages of Aptamers Make Them a Novel Approach for Different Applications
      • Aptamer Significance over Antibodies
      • Increasing Number/Frequency of Clinical Trials
    • RESTRAINTS
    • OPPORTUNITIES

CHAPTER 4 NUCLEIC ACID APTAMERS MARKET BY TECHNOLOGIES

  • TABLE 7 GLOBAL MARKET FOR NUCLEIC ACID APTAMERS BY TECHNOLOGIES, THROUGH 2019 ($ MILLIONS)
  • ENABLING TECHNOLOGY
  • TABLE 8 GLOBAL MARKET FOR ENABLING TECHNOLOGY BY TYPE, THROUGH 2019 ($ MILLIONS)
    • SELEX TECHNOLOGY
    • TABLE 9 GLOBAL MARKET FOR SELEX TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
      • General SELEX Technology
      • FIGURE 5 PROCESS OF GENERAL SELEX TECHNOLOGY
      • SELEX Process Based upon Nitrocellulose Membrane Filtration
      • SELEX Process Based upon Magnetic Bead and Affinity Chromatography
      • FIGURE 6 SELEX PROCESS BASED UPON MAGNETIC BEAD AND AFFINITY CHROMATOGRAPHY
      • SELEX Based upon Capillary Electrophoresis
      • FIGURE 7 FUNDAMENTAL PRINCIPLE OF CAPILLARY ELECTROPHORESIS
      • SELEX Based upon Microfluidics
    • MODIFIED OLIGONUCLEOTIDES
    • TABLE 10 GLOBAL MARKET FOR MODIFIED OLIGONUCLEOTIDES TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
    • OLIGONUCLEOTIDES SYNTHESIS
    • TABLE 11 GLOBAL MARKET FOR OLIGONUCLEOTIDES SYNTHESIS TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
    • NEXT-GENERATION SEQUENCING
    • TABLE 12 GLOBAL MARKET FOR NEXT-GENERATION SEQUENCING TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
    • NANOPARTICLES AND QUANTUM DOT LABELS
    • TABLE 13 GLOBAL MARKET FOR NANOPARTICLES AND QUANTUM DOT LABELS TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
    • SURFACE PLASMON RESONANCE AND BIOLAYER INTERFEROMETRY
    • TABLE 14 GLOBAL MARKET FOR SURFACE PLASMON RESONANCE AND BIOLAYER INTERFEROMETRY TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
    • BIOINFORMATICS
    • TABLE 15 GLOBAL MARKET FOR BIOINFORMATICS TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
  • APTAMERS AS DIAGNOSTIC SENSORS
  • TABLE 16 GLOBAL MARKET FOR DIAGNOSTIC SENSORS TECHNOLOGY BY TYPE, THROUGH 2019 ($ MILLIONS)
  • TABLE 17 GLOBAL MARKET FOR DIAGNOSTIC SENSORS TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
    • SENSOR PLATFORM TECHNOLOGIES
    • TABLE 18 GLOBAL MARKET FOR SENSOR PLATFORM TECHNOLOGIES BY REGION, THROUGH 2019 ($ MILLIONS)
    • SELF-REPORTING SENSORS
    • TABLE 19 GLOBAL MARKET FOR SELF-REPORTING SENSORS BY REGION, THROUGH 2019 ($ MILLIONS)
    • TRENDS IN APTAMERS AS DIAGNOSTICS
  • APTAMERS AS THERAPEUTICS
  • APTAMERS AND INFECTIOUS DISEASE
  • APTAMERS AS TARGETING AGENTS
  • APTAMER MODIFICATIONS
    • CAPTAMERS
    • WHOLE CELL SELEX
    • VEGF APTAMERS

CHAPTER 5 NUCLEIC ACID APTAMERS MARKET BY APPLICATION

  • TABLE 20 GLOBAL MARKET FOR NUCLEIC ACID APTAMERS BY APPLICATION, THROUGH 2019 ($ MILLIONS)
  • FIGURE 8 APPLICATIONS OF NUCLEIC ACID APTAMERS
  • APPLICATION OF APTAMERS AS DIAGNOSTICS
  • TABLE 21 GLOBAL NUCLEIC ACID APTAMERS DIAGNOSTIC APPLICATIONS MARKET BY REGION, THROUGH 2019 ($ MILLIONS)
    • ENVIRONMENTAL MONITORING, FOOD AND WATER SAFETY
      • Aptasensors in Opposition to Small Molecules
        • Aptasensors against Antibiotics
          • Chloramphenicol (Cam)
          • Tetracycline
          • Aminoglycoside
        • Aptasensors against Toxins
        • Aptasensors against Contaminants Present in Food Packaging
        • Aptasensors against Heavy Metals
        • Aptasensors against Pesticides
      • Aptasensors in Opposition to Pathogens
        • Viruses
        • Bacteria
    • HUMAN CLINICAL DIAGNOSTIC ASSAYS
    • APTAMER-BASED DIAGNOSTICS FOR INFLUENZA VIRUSES IN HUMANS
    • APTAMER-BASED CLINICAL BIOMARKER ASSAYS
    • APTAMER-BASED COLORIMETRIC ASSAY FOR DETECTING CANCER CELLS
    • APPLICATION OF APTAMERS IN VETERINARY DIAGNOSTICS
  • APPLICATION OF APTAMERS AS THERAPEUTICS
  • TABLE 22 APTAMERS AS TARGETS OF THERAPEUTIC INTEREST
  • TABLE 23 GLOBAL NUCLEIC ACID APTAMERS THERAPEUTIC APPLICATIONS MARKET BY REGION, THROUGH 2019 ($ MILLIONS)
    • DRUG DELIVERY VEHICLES IN CANCER
    • NANOPARTICLE-BASED DRUG DELIVERY VEHICLES
    • PROSTATE CANCER TARGETING APTAMER
    • LEUKEMIA TARGETING APTAMER
    • NUCLEOLIN TARGETING APTAMER
    • OTHER TARGETING APTAMERS
    • DNA APTAMER-MICELLE-BASED DRUG DELIVERY VEHICLE
    • APTAMER-LIPOSOME BASED DRUG DELIVERY VEHICLE
    • DNA-APTAMER-BASED CARGOES AS DRUG DELIVERY VEHICLES IN CANCER
    • TABLE 24 APTAMERS WITH THEIR CARGOES AND INTERNALIZED TARGETS ON CANCER CELLS
      • Endocytic Pathway Driven by Aptamer-cargoes
    • MODIFIERS OF SURGICAL IMPLANTS
    • BIOSEPARATION PROCESSES
    • TABLE 25 APTAMER-BASED SEPARATION USED IN AFFINITY CHROMATOGRAPHY
  • APPLICATION OF APTAMERS IN RESEARCH
  • TABLE 26 GLOBAL NUCLEIC ACID APTAMERS RESEARCH APPLICATIONS MARKET BY REGION, THROUGH 2019 ($ MILLIONS)
    • FLOW CYTOMETRY
    • MASS SPECTROMETRY
    • WESTERN BLOTTING
    • REAGENTS AND ASSAYS
  • APPLICATION OF APTAMERS AS BIOSENSORS
  • TABLE 27 GLOBAL NUCLEIC ACID APTAMERS BIOSENSORAPPLICATIONS MARKET BY REGION, THROUGH 2019 ($ MILLIONS)
    • APTAMERS FOR SMALL MOLECULE TARGETS REGARDING FOOD SAFETY
    • TABLE 28 APTAMERS AND APTAMERS-BASED BIOSENSOR FOR TARGETS CONTAINING SMALL MOLECULES
      • Antibiotics
      • Mycotoxins
      • Heavy Metals
    • APTAMERS FOR FOOD PATHOGENS RELATED TO SAFETY
    • TABLE 29 APTAMER-BASED BIOSENSORS FOR MACROMOLECULAR TARGETS AND PATHOGENS
      • Bacteria
      • Viruses
      • Other Macromolecular Targets
  • APPLICATION IN BIOMARKERS DISCOVERY
  • TABLE 30 GLOBAL NUCLEIC ACID APTAMER BIOMARKERS DISCOVERY APPLICATIONS MARKET BY REGION, THROUGH 2019 ($ MILLIONS)

CHAPTER 6 NUCLEIC ACID APTAMER MARKET BY REGION

  • TABLE 31 GLOBAL MARKET FOR NUCLEIC ACID APTAMERS BY REGION, THROUGH 2019 ($ MILLIONS)
  • NORTH AMERICA
  • TABLE 32 NORTH AMERICA MARKET FOR NUCLEIC ACID APTAMERS BY APPLICATION, THROUGH 2019 ($ MILLIONS)
  • EUROPE
  • TABLE 33 EUROPE MARKET FOR NUCLEIC ACID APTAMERS BY APPLICATION, THROUGH 2019 ($ MILLIONS)
  • ASIA-PACIFIC
  • TABLE 34 ASIA-PACIFIC MARKET FOR NUCLEIC ACID APTAMERS BY APPLICATION, THROUGH 2019 ($ MILLIONS)
  • ROW
  • TABLE 35 ROW MARKET FOR NUCLEIC ACID APTAMERS BY APPLICATION, THROUGH 2019 ($ MILLIONS)

CHAPTER 7 COMPETITIVE LANDSCAPE

  • FIGURE 9 KEY COMPETITIVE STRATEGIES BY TYPE OF DEVELOPMENT, 2010-2014 (PERCENT)
  • CLINICAL TRIALS
  • FIGURE 10 CLINICAL TRIALS BY COMPANIES, 2010-2014 (NUMBER)
  • TABLE 36 CLINICAL TRIALS BETWEEN 2010 AND 2014
  • COLLABORATION
  • FIGURE 11 COLLABORATION STRATEGY BY APPLICATION, 2010-2014 (NUMBER)
  • TABLE 37 COLLABORATIONS BETWEEN 2010 AND 2014
  • AGREEMENTS
  • FIGURE 12 AGREEMENT STRATEGY BY COMPANIES, 2010-2014 (%)
  • TABLE 38 AGREEMENTS BETWEEN 2010 AND 2014
  • RESEARCH & DEVELOPMENT
  • FIGURE 13 RESEARCH AND DEVELOPMENT STRATEGY BY COMPANIES, 2010-2014 (NUMBER)
  • TABLE 39 RESEARCH AND DEVELOPMENT BETWEEN 2010 AND 2014

CHAPTER 8 PATENT ANALYSIS

  • FIGURE 14 PATENTS REGISTERED/APPROVED BY REGION, 2011-2014 (PERCENT)
  • U.S. PATENT ANALYSIS BY MARKET PARTICIPANT
  • FIGURE 15 U.S. PATENT ANALYSIS BY MARKET PARTICIPANT, 2011-2014 (%)
  • EUROPE PATENT ANALYSIS BY MARKET PARTICIPANT
  • FIGURE 16 EUROPE PATENT ANALYSIS BY MARKET PARTICIPANT, -2011-2014 (NUMBER/%)
  • JAPAN PATENT ANALYSIS BY MARKET PARTICIPANT
  • FIGURE 17 JAPAN PATENT ANALYSIS BY MARKET PARTICIPANT, 2011-2014 (%)

CHAPTER 9 COMPANY PROFILES

  • ALIMERA SCIENCES
  • TABLE 40 ALIMERA SCIENCES FINANCIALS, 2012 AND 2013 ($ MILLIONS)
  • ALNYLAM PHARMACEUTICALS
  • TABLE 41 ALNYLAM PHARMACEUTICALS FINANCIALS, 2011 AND 2012 ($ MILLIONS)
  • AM BIOTECHNOLOGIES LLC
    • APTAMER PRODUCT OVERVIEW
  • APTAGEN LLC
  • APTAMATRIX INC
  • APTAMER SCIENCES INC.
    • APTAMER PRODUCT OVERVIEW
    • TABLE 42 RECENT DEVELOPMENTS OF APTAMER SCIENCES INC.
  • APTARES AG
  • APTASOL (APTAMER SOLUTIONS) LTD
    • APTAMER PRODUCT AND SERVICES OVERVIEW
    • TABLE 43 RECENT DEVELOPMENTS OF APTASOL (APTAMER SOLUTIONS) LTD
  • APTUS BIOTECH SL
  • BASE PAIR BIOTECHNOLOGIES INC.
    • APTAMER PRODUCT OVERVIEW
    • TABLE 44 RECENT DEVELOPMENTS OF BASE PAIR BIOTECHNOLOGIES INC.
  • ISIS PHARMACEUTICALS
  • LUCERNA INC
  • MITSUI & CO. (U.S.A.) INC..
  • TABLE 45 MITSUI & CO. (U.S.A.) INC. FINANCIALS, 2013 AND 2014 ($ MILLIONS)
  • NEOVENTURES BIOTECHNOLOGY INC
    • APTAMERS PRODUCT AND APPLICATIONS OVERVIEW
    • TABLE 46 RECENT DEVELOPMENTS OF NEOVENTURES BIOTECHNOLOGY INC
  • NOXXON PHARMA AG
    • APTAMER PRODUCT OVERVIEW
    • TABLE 47 RECENT DEVELOPMENTS OF NOXXON
  • OPHTHOTECH CORP.
    • APTAMER PRODUCT OVERVIEW
    • TABLE 48 RECENT DEVELOPMENTS OF OPHTHOTECH CORP.
  • OTC BIOTECH
  • PFIZER
  • TABLE 49 PFIZER FINANCIALS, 201-2013 ($ MILLIONS)
  • QUEST DIAGNOSTICS
  • TABLE 50 QUEST DIAGNOSTICS FINANCIALS, 2011-2013 ($ MILLIONS)
  • REGADO BIOSCIENCES
  • TABLE 51 RECENT DEVELOPMENTS OF REGADO BIOSCIENCES
  • RINA GMBH 125
    • APTAMER PRODUCT OVERVIEW
    • TABLE 52 RECENT DEVELOPMENTS OF RINA GMBH
  • SOMALOGIC INC. 126
    • APTAMER PRODUCT OVERVIEW
    • TABLE 53 RECENT DEVELOPMENTS OF SOMALOGIC INC.
  • SUMITOMO BAKELITE CO. LTD.
  • TABLE 54 SUMITOMO BAKELITE CO LTD FINANCIALS, 2011-2014 ($ MILLIONS)

CHAPTER 10 APPENDIX

  • LIST OF PATENTS: NORTH AMERICA
  • TABLE 55 LIST OF PATENTS: NORTH AMERICA
  • LIST OF PATENTS: EUROPE
  • TABLE 56 LIST OF PATENTS: EUROPE
  • LIST OF PATENTS: JAPAN
  • TABLE 57 LIST OF PATENTS: JAPAN

LIST OF TABLES

  • SUMMARY TABLE GLOBAL MARKET FOR NUCLEIC ACID APTAMERS BY TECHNOLOGY, THROUGH 2019 ($ MILLIONS)
  • TABLE 1 DIFFERENCE BETWEEN APTAMERS AND ANTIBODIES
  • TABLE 2 ICH* GUIDELINES APPLICABLE TO THERAPEUTICS BASED UPON SYNTHETIC OLIGONUCLEOTIDES
  • TABLE 3 MACUGEN (PEGAPTANIB SODIUM) CODES FOR REIMBURSEMENT
  • TABLE 4 CLINICAL TRIALS OF APTAMER RESEARCH (COMPLETED)
  • TABLE 5 CLINICAL TRIALS OF APTAMER RESEARCH (TERMINATED)
  • TABLE 6 CLINICAL TRIALS OF APTAMER RESEARCH (IN PROGRESS)
  • TABLE 7 GLOBAL MARKET FOR NUCLEIC ACID APTAMERS BY TECHNOLOGIES, THROUGH 2019 ($ MILLIONS)
  • TABLE 8 GLOBAL MARKET FOR ENABLING TECHNOLOGY BY TYPE, THROUGH 2019 ($ MILLIONS)
  • TABLE 9 GLOBAL MARKET FOR SELEX TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 10 GLOBAL MARKET FOR MODIFIED OLIGONUCLEOTIDES TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 11 GLOBAL MARKET FOR OLIGONUCLEOTIDES SYNTHESIS TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 12 GLOBAL MARKET FOR NEXT-GENERATION SEQUENCING TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 13 GLOBAL MARKET FOR NANOPARTICLES AND QUANTUM DOT LABELS TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 14 GLOBAL MARKET FOR SURFACE PLASMON RESONANCE AND BIOLAYER INTERFEROMETRY TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 15 GLOBAL MARKET FOR BIOINFORMATICS TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 16 GLOBAL MARKET FOR DIAGNOSTIC SENSORS TECHNOLOGY BY TYPE, THROUGH 2019 ($ MILLIONS)
  • TABLE 17 GLOBAL MARKET FOR DIAGNOSTIC SENSORS TECHNOLOGY BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 18 GLOBAL MARKET FOR SENSOR PLATFORM TECHNOLOGIES BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 19 GLOBAL MARKET FOR SELF-REPORTING SENSORS BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 20 GLOBAL MARKET FOR NUCLEIC ACID APTAMERS BY APPLICATION, THROUGH 2019 ($ MILLIONS)
  • TABLE 21 GLOBAL NUCLEIC ACID APTAMERS DIAGNOSTIC APPLICATIONS MARKET BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 22 APTAMERS AS TARGETS OF THERAPEUTIC INTEREST
  • TABLE 23 GLOBAL NUCLEIC ACID APTAMERS THERAPEUTIC APPLICATIONS MARKET BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 24 APTAMERS WITH THEIR CARGOES AND INTERNALIZED TARGETS ON CANCER CELLS
  • TABLE 25 APTAMER-BASED SEPARATION USED IN AFFINITY CHROMATOGRAPHY
  • TABLE 26 GLOBAL NUCLEIC ACID APTAMERS RESEARCH APPLICATIONS MARKET BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 27 GLOBAL NUCLEIC ACID APTAMERS BIOSENSORAPPLICATIONS MARKET BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 28 APTAMERS AND APTAMERS-BASED BIOSENSOR FOR TARGETS CONTAINING SMALL MOLECULES
  • TABLE 29 APTAMER-BASED BIOSENSORS FOR MACROMOLECULAR TARGETS AND PATHOGENS
  • TABLE 30 GLOBAL NUCLEIC ACID APTAMER BIOMARKERS DISCOVERY APPLICATIONS MARKET BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 31 GLOBAL MARKET FOR NUCLEIC ACID APTAMERS BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 32 NORTH AMERICA MARKET FOR NUCLEIC ACID APTAMERS BY APPLICATION, THROUGH 2019 ($ MILLIONS)
  • TABLE 33 EUROPE MARKET FOR NUCLEIC ACID APTAMERS BY APPLICATION, THROUGH 2019 ($ MILLIONS)
  • TABLE 34 ASIA-PACIFIC MARKET FOR NUCLEIC ACID APTAMERS BY APPLICATION, THROUGH 2019 ($ MILLIONS)
  • TABLE 35 ROW MARKET FOR NUCLEIC ACID APTAMERS BY APPLICATION, THROUGH 2019 ($ MILLIONS)
  • TABLE 36 CLINICAL TRIALS BETWEEN 2010 AND 2014
  • TABLE 37 COLLABORATIONS BETWEEN 2010 AND 2014
  • TABLE 38 AGREEMENTS BETWEEN 2010 AND 2014
  • TABLE 39 RESEARCH AND DEVELOPMENT BETWEEN 2010 AND 2014
  • TABLE 40 ALIMERA SCIENCES FINANCIALS, 2012 AND 2013 ($ MILLIONS)
  • TABLE 41 ALNYLAM PHARMACEUTICALS FINANCIALS, 2011 AND 2012 ($ MILLIONS)
  • TABLE 42 RECENT DEVELOPMENTS OF APTAMER SCIENCES INC.
  • TABLE 43 RECENT DEVELOPMENTS OF APTASOL (APTAMER SOLUTIONS) LTD
  • TABLE 44 RECENT DEVELOPMENTS OF BASE PAIR BIOTECHNOLOGIES INC.
  • TABLE 45 MITSUI & CO. (U.S.A.) INC. FINANCIALS, 2013 AND 2014 ($ MILLIONS)
  • TABLE 46 RECENT DEVELOPMENTS OF NEOVENTURES BIOTECHNOLOGY INC
  • TABLE 47 RECENT DEVELOPMENTS OF NOXXON
  • TABLE 48 RECENT DEVELOPMENTS OF OPHTHOTECH CORP.
  • TABLE 49 PFIZER FINANCIALS, 201-2013 ($ MILLIONS)
  • TABLE 50 QUEST DIAGNOSTICS FINANCIALS, 2011-2013 ($ MILLIONS)
  • TABLE 51 RECENT DEVELOPMENTS OF REGADO BIOSCIENCES
  • TABLE 52 RECENT DEVELOPMENTS OF RINA GMBH
  • TABLE 53 RECENT DEVELOPMENTS OF SOMALOGIC INC.
  • TABLE 54 SUMITOMO BAKELITE CO LTD FINANCIALS, 2011-2014 ($ MILLIONS)
  • TABLE 55 LIST OF PATENTS: NORTH AMERICA
  • TABLE 56 LIST OF PATENTS: EUROPE
  • TABLE 57 LIST OF PATENTS: JAPAN

LIST OF FIGURES

  • SUMMARY FIGURE GLOBAL MARKET FOR NUCLEIC ACID APTAMERS BY TECHNOLOGY, 2013-2019 ($ MILLIONS)
  • FIGURE 1 SERVICE OFFERED UNDER APTAMER TECHNOLOGIES
  • FIGURE 2 APPLICATIONS OF PEPTIDE APTAMERS
  • FIGURE 3 PORTER'S FIVE FORCE MODEL OF THE NUCLEIC ACID APTAMER TECHNOLOGY MARKET
  • FIGURE 4 HISTORICAL MILESTONE FOR MACUGEN (PEGAPTANIB SODIUM) REIMBURSEMENT PROGRAM
  • FIGURE 5 PROCESS OF GENERAL SELEX TECHNOLOGY
  • FIGURE 6 SELEX PROCESS BASED UPON MAGNETIC BEAD AND AFFINITY CHROMATOGRAPHY
  • FIGURE 7 FUNDAMENTAL PRINCIPLE OF CAPILLARY ELECTROPHORESIS
  • FIGURE 8 APPLICATIONS OF NUCLEIC ACID APTAMERS
  • FIGURE 9 KEY COMPETITIVE STRATEGIES BY TYPE OF DEVELOPMENT, 2010-2014 (PERCENT)
  • FIGURE 10 CLINICAL TRIALS BY COMPANIES, 2010-2014 (NUMBER)
  • FIGURE 11 COLLABORATION STRATEGY BY APPLICATION, 2010-2014 (NUMBER)
  • FIGURE 12 AGREEMENT STRATEGY BY COMPANIES, 2010-2014 (%)
  • FIGURE 13 RESEARCH AND DEVELOPMENT STRATEGY BY COMPANIES, 2010-2014 (NUMBER)
  • FIGURE 14 PATENTS REGISTERED/APPROVED BY REGION, 2011-2014 (PERCENT)
  • FIGURE 15 U.S. PATENT ANALYSIS BY MARKET PARTICIPANT, 2011-2014 (%)
  • FIGURE 16 EUROPE PATENT ANALYSIS BY MARKET PARTICIPANT, -2011-2014 (NUMBER/%)
  • FIGURE 17 JAPAN PATENT ANALYSIS BY MARKET PARTICIPANT, 2011-2014 (%)
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