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RNAi

Agrow: RNAi

発行 AGROW 商品コード 527403
出版日 ページ情報 英文 87 Pages
納期: 即日から翌営業日
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RNAi Agrow: RNAi
出版日: 2017年04月01日 ページ情報: 英文 87 Pages
概要

当レポートでは、RNAiの技術とその作物品種改良、作物保護、および害虫管理向け新製品開発における利用について調査し、企業・製品プロファイル、RNAi技術に関連する専門企業・研究機関の活動とパイプライン、技術の主な安全検討事項のレビュー、および欧州・米国の規制当局の解説と位置づけなどについて、まとめています。

エグゼクティブサマリー

第1章 イントロダクション

第2章 昆虫およびその他の害虫の管理に向けたRNAi

  • サマリー
  • イントロダクション
  • 甲虫類
  • 鱗翅目
  • 双翅目
  • 半翅目
  • 線虫
  • その他の害虫
  • 特許アプリケーション
  • 参照・資料

第3章 その他の作物市場におけるRNAi

  • サマリー
  • イントロダクション
  • 病期の管理
  • 雑草の管理
  • 作物強化
  • 参照・資料

第4章 RNAi技術の処方・提供

  • サマリー
  • イントロダクション
  • 原理
  • 特許活動
  • 参照・資料

第5章 作物保護企業

  • サマリー
  • イントロダクション
  • BASF
  • Bayer CropScience
  • Dow AgroSciences
  • DuPont
  • Monsanto
  • Syngenta
  • 参照・資料

第6章 専門RNAi企業・機関

  • サマリー
  • イントロダクション
  • Alnylam Pharmaceuticals
  • Arbutus Biopharma
  • CSIRO
  • Evogene
  • Forage Genetics
  • Forrest Innovations
  • Fraunhofer Institute for Molecular Biology and Applied Ecology
  • Ghent University
  • Iden Biotechnology
  • Intrexon
  • J. R. Simplot
  • Okanagan Specialty Fruits
  • Nemgenix
  • Performance Plants
  • PhaseRx
  • Preceres
  • University of Cambridge
  • University of Nebraska
  • Tekmira
  • Venganza
  • References and resources

図表リスト

目次
Product Code: 86897

Employed as a research tool in entomology and as a means of crop protection and pest control, RNA interference (RNAi) technology is a natural process used to 'silence' genes - a way of reducing or switching off the activity (or expression) of individual genes.

With a major drive to tackle resistance to insecticides, RNAi technology has important defence and regulatory functions in animals, plants and fungi. Producing crop hybrids and varieties with enhanced yield and quality characteristics is also a major application of this technology, and superior traits brought to market include improved oil composition (high oleic acid), reduced lignin content (for greater digestibility of feed by livestock), the elimination of browning when slicing apples and potatoes, and reduced potential for acrylamide production when frying potatoes.

This report provides an overview of RNAi technology and its use in new product development for improved crop varieties, crop protection and pest control. It details company and product profiles, and activities and pipelines of specialist companies and research institutes engaged in RNAi technology. It also reviews key safety considerations for the technology, as well as commentary and positions of European and US regulatory authorities.

Other focus areas of this report include research undertaken and commentary about future sprayable RNAi technology, patent applications claiming the use of the technology for disease control, and newer commercial drivers for RNAi applications in crop protection as a possibility of overcoming herbicide resistance in weeds. Increasing crop production in responses to abiotic stress (such as drought) is also considered.

Table of Contents

Executive Summary

Chapter 1: Introduction

Chapter 2: RNAi for controlling insects and other pests

Chapter 3: RNAi in other crop sectors

Chapter 4: Formulation and delivery of RNAi technology

Chapter 5: Crop protection companies

Chapter 6: Specialist RNAi companies and institutes

Chapter 1: Introduction

  • 1.1. Summary
  • 1.2. Introduction
  • 1.3. Scope
  • 1.4. Technical background
    • 1.4.1. History
    • 1.4.2. Science of RNAi
      • 1.4.2.1. The flow of information in the cell: from DNA to protein via mRNA
      • 1.4.2.2. Discovery of RNA interference
      • 1.4.2.3. Role of RNAi in nature
      • 1.4.2.4. The RNAi process and machinery
  • 1.5. Safety and regulations
    • 1.5.1. Safety
      • 1.5.1.1. Environment
      • 1.5.1.2. Food and feed
      • 1.5.1.3. Non-target organisms
    • 1.5.2. Regulations
      • 1.5.2.1. Europe
      • 1.5.2.2. USA
  • 1.6. References and resources

Chapter 2: RNAi for controlling insects and other pests

  • 2.1. Summary
  • 2.2. Introduction
    • 2.2.1. Role of RNAi technology
    • 2.2.2. Progress in using RNAi technology
  • 2.3. Coleoptera
  • 2.4. Lepidoptera
  • 2.5. Diptera
  • 2.6. Hemiptera
  • 2.7. Nematodes
  • 2.8. Other pests
    • 2.8.1. Fire ants
    • 2.8.2. Spider mites
    • 2.8.3. Mites
    • 2.8.4. Locusts
    • 2.8.5. Termites
  • 2.9. Patent applications
    • 2.9.1. Insects
    • 2.9.2. Nematodes
  • 2.10. References and resources

Chapter 3: RNAi in other crop sectors

  • 3.1. Summary
  • 3.2. Introduction
  • 3.3. Control of diseases
    • 3.3.1. Viruses
    • 3.3.2. Progress with RNAi for disease control
    • 3.3.3. Disease control patent applications
  • 3.4. Control of weeds
    • 3.4.1. Overcoming herbicide resistance
    • 3.4.2. Control of parasitic weeds by RNAi
  • 3.5. Crop enhancement
    • 3.5.1. Modified oil composition
    • 3.5.2. Reduced lignin
    • 3.5.3. Abiotic stress
    • 3.5.4. Enzymatic browning
    • 3.5.5. Crop Enhancement patent applications
  • 3.6. References and resources

Chapter 4: Formulation and delivery of RNAi

  • 4.1. Summary
  • 4.2. Introduction
  • 4.3. Principles
    • 4.3.1. Knowledge base from human therapeutics
    • 4.3.2. Progress in crop protection and pest control
    • 4.3.3. Collaborations
  • 4.4. Patent activity
  • 4.5. References and resources

Chapter 5: Crop protection companies

  • 5.1. Summary
  • 5.2. Introduction
  • 5.3. BASF
    • 5.3.1. Modified starch potatoes
    • 5.3.2. Disease control
    • 5.3.3. Nematode control
    • 5.3.4. Weed control
  • 5.4. Bayer CropScience
    • 5.4.1. Collaborations
    • 5.4.2. Patent applications
  • 5.5. Dow AgroSciences
  • 5.6. DuPont
  • 5.7. Monsanto
    • 5.7.1. Low lignin alfalfa
    • 5.7.2. SmartStax Pro (MON87411)
    • 5.7.3. BioDirect
    • 5.7.4. Rosetta Green acquisition
    • 5.7.5. Preceres and RNAi delivery R&D
    • 5.7.6. Patent applications
  • 5.8. Syngenta
    • 5.8.1. Collaborations
    • 5.8.2. Patent applications
  • 5.9. References and resources

Chapter 6: Specialist RNAi technology companies and institutes

  • 6.1. Summary
  • 6.2. Introduction
  • 6.3. Alnylam Pharmaceuticals
  • 6.4. Arbutus Biopharma
  • 6.5. CSIRO
  • 6.6. Evogene
  • 6.7. Forage Genetics
  • 6.8. Forrest Innovations
  • 6.9. Fraunhofer Institute for Molecular Biology and Applied Ecology
  • 6.10. Ghent University
  • 6.11. Iden Biotechnology
  • 6.12. Intrexon
  • 6.13. J. R. Simplot
  • 6.14. Okanagan Specialty Fruits
  • 6.15. Nemgenix
  • 6.16. Performance Plants
  • 6.17. PhaseRx
  • 6.18. Preceres
  • 6.19. University of Cambridge
  • 6.20. University of Nebraska
  • 6.21. Tekmira
  • 6.22. Venganza
  • 6.23. References and resources

Appendix: Abbreviations and Glossary

List of Tables

  • Table 1: In planta RNAi products that have been reviewed and approved by at least one international regulatory agency
  • Table 2: Overview of recently published studies on the use of plant-RNAi against different insect pests
  • Table 3: Recent PCT and US patent applications covering the control of insects and other pests (excluding those of the crop protection majors)
  • Table 4: Recent PCT and US patent applications covering the control of nematodes (excluding the crop protection majors)
  • Table 5: Some recent PCT patent applications covering the control of diseases (excluding the crop protection majors)
  • Table 6: Recent patent applications covering crop enhancement (excluding the crop protection majors)
  • Table 7: Recent PCT and US patent applications claiming improved delivery of RNA
  • Table 8: Recent BASF PCT patents covering RNAi for disease control
  • Table 9: Recent BASF PCT patents covering RNAi for nematode control
  • Table 10: Bayer CropScience RNAi PCT patent applications
  • Table 11: Recent Dow AgroSciences patent applications covering RNAi: Non-collaborative patents
  • Table 12: Recent Dow AgroSciences patent applications covering RNAi: Patents with the University of Nebraska
  • Table 13: Recent Dow AgroSciences patent applications covering RNAi: Patents with the Fraunhofer Institute for Molecular Biology and Applied Ecology (Germany)
  • Table 14: Recent DuPont patent applications covering RNAi
  • Table 15: Recent Monsanto PCT and US patent applications: Insect and nematode control
  • Table 16: Recent Monsanto US patent applications: Disease control
  • Table 17: Recent Monsanto PCT and US patent applications: Crop enhancement
  • Table 18: Recent Monsanto PCT and US patent applications: Weed control
  • Table 19: Recent Monsanto PCT and US patent applications: General technology
  • Table 20: Recent Syngenta PCT patent applications covering RNAi
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