“Microtechnologies for chemical process intensification”
Market and technology trends for components, modules and systems dedicated to flow chemistry.
OBJECTIVES OF THE REPORT
The market of MicroReaction Technologies (MRT) dedicated to flow chemistry
sharply increased over the last five years. Recent and growing involvement of
the fine chemical and pharmaceutical industry clearly signals the
transformation of this technology from academic settings towards applied
research and production. How have micro-technologies impacted the
pharmaceutical and the fine chemicals industries?
Looking back on the last 5 years with an analysis of the most relevant changes
is essential to understand the market dynamics observed today.
This report provides a comprehensive view on the flow chemistry market,
- Consolidated MRT market data (2005-2011)
- Market forecasts (2012-2017) for modules, systems and production units.
- Main trends and challenges
- Modules, systems and production units supply chain.
- The main business models
R&D System Market Data
Yole Développement © March 2012
HIGHLY SEGMENTED MARKET DEPENDING ON THE ADDED VALUE OF MRT
Large chemical and pharmaceutical companies are increasingly considering MRT
as a process intensification solution to solve some of their current
processing problems for lab research and to debottleneck production.
Nevertheless, the motivations for implementation are multiple and vary form
one case to another. On the technical side, user requirements will be
different if the principal goal is to precisely control the reaction kinetics,
avoid hazardous situations or develop new syntheses. Likewise, drivers differ
depending on the molecule life cycle.
This leads to a market segmentation of the Flow Chemistry market. For each
segment the following elements are described: applications, technical and
economic requirements, key technology suppliers and some examples of
technologies and users. The ability to understand to which segment a prospect
belongs is essential as it determines the most appropriate offer and
Yole Développement © March 2012
STRCOONNTGE NETV OOLFU TTHIEO NAN FARLOYSMI SM RT MODULES TO INTEGRATED SYSTEMS
New players entered the field recently and previous ones have broadened their
product portfolio. Therefore, the range of MRT products available on the
market became wider in terms of both performance and price.
Some systems have evolved dramatically towards the high end market, with more
and more functionalities. Meanwhile low cost systems have been introduced
recently to respond to research and educational needs.
These significant changes show that the Flow Chemistry market is structuring
with different strategic positioning occupied by MRT supplier.
Yole Développement © March 2012
MRT SUPPLY CHAIN
The report describes the MRT supply chain, from R&D to commercialization and
distribution. It also shows several collaboration examples between key players
of the field and their market share.
In addition, the report provides company profiles for the main players.
MRT VALUE CHAIN
Analysis of the value chain provides an understanding of the price evolution
from microreaction components sold as stand-alone modules to a complete
systems installed in Production. MRT modules represent only approximately 20%
of the total system cost, while the instrumentation price share can exceed
60%. This explains how leading companies improved their market positioning and
increased their revenue by extending their offer from modules to complete
systems. Moreover, it explains as well why numbering-up modules can become
Business case analysis of MRT used for production shows that Flow Chemistry
hardware is more expensive than batch chemistry (CAPEX is higher).
Nevertheless, MRT appear to be cost effective solution for the exploitation by
decreasing the operational costs (strong decrease of OPEX).
KEY FEATURES OF THE REPORT
- Analysis of the last 5 years market evolution and key events
- 2011-2017 modules and systems forecasts from a foundry or a system
- Market segmentation with key success factors by segment in order to
succeed in MRT market.
- Business cases: comparison of investment and operational costs between
flow chemistry and traditional
- methods for different applications at a production level.
- Strategic maps: representation of several MRT suppliers' products
portfolio according to two main
- criterions: the price and the performance for each product.
- Production scale-up: comparison between numbering-up and sizing-up
WHO SHOULD BUY THIS REPORT?
- Executives of companies active in the development of microreaction
products or assessing their entry in this field
- Executives of engineering companies, that could broaden their process
intensification offer with microreaction
- R&D managers or production leaders of chemical and pharmaceutical
companies, that want to learn about flow chemistry technology (products,
players, market, costs...)
SOME COMPANIES CITED IN THE REPORT
Accendo, Aetdev, Alfa Laval, Atotech, Cetoni, Chemtrix, Corning, Dai Nippon
Screen, DSM, Ehrfeld Mikrotechnik BTS, ESK Ceramics, Future Chemistry,
Heatric, IMM, Institute for Microchemical Technology IMT, LioniX, Little
Things Factory, Lonza, Merck, Microinnova, Micronit, Mikroglas Chemtech GmbH,
Modular Block, Siemens, Sigma-Aldrich, Spec Corporation, Syntics, Syrris,
ThalesNano, ThinXXS, Velocys, YMC...
BIO OF THE AUTHORS
Frédéric Breussin is expert in Microfluidics for diagnostics and life
sciences. He has supported many companies in their innovation and product
development strategy in making the bridge between micro systems technologies
and their applications in Life sciences, diagnostics and medical device
industries. He holds an Engineering diploma from INSA Rouen and a DEA in fluid
mechanics from University of Rouen.
Benjamin Roussel is a Market Analyst at Yole Développement involved in
Microfluidic and Medical Technologies fields. He holds a pharmacy diploma from
the University Claude Bernard Lyon I, complemented by a master degree in
Technology and Innovation Management from EMLyon Business School.
Table of Contents
1 - EXECUTIVE SUMMARY
2 - INTRODUCTION
3 - WHAT HAPPENED SINCE 2007?
- Business News
- Learning curve and S-curve
- Market in Asia
- Involvement of Pharmaceutical companies
- Continuous reactors scaling
- MRT suppliers (news players, news activities, geographical distribution)
and portfolio evolutions
4 - MICROREACTION TECHNOLOGIES MARKET 2011-2017
- Individual modules market data
- R&D system market data
- Production system market data
5 - MARKET SEGMENTATION
- MRT Technologies for research applications
- MRT Technologies for process development
- MRT Technologies for production applications
6 - INDUSTRIAL STATUS OF DEVELOPMENT
- MRT equipment design
- MRT materials
7 - ADVANTAGES & CHALLENGES FOR MRT
- SWOT analysis
- Business Cases for different production applications
8 - FOCUS ON PHARMACEUTICAL INDUSTRY
- A changing environment
- MRT technologies in drug discovery
9 - INDUSTRY ORGANIZATION & TRENDS
- Green Chemistry
- Supply chain
- Value chain
- Strategic maps
- Case study: R&D system cost breakdown
10 - SUMMARY AND CONCLUSION
APPENDIX I: COMPANIES PROFILE APPENDIX
II: YOLE DÉVELOPPEMENT PRESENTATION