バイオ技術産業における研究・技術の発展

Biotechnology Industry Impact Service

発行	Technical Insights, Inc.
出版日	2004年03月	商品コード	19982
ページ情報	英文 224 pages
価格	こちらの商品の販売は終了いたしました。

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原文目次
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当商品の販売は、2011年07月19日を持ちまして終了しました。

原文目次

Research Overview

Biochip Technology to Revolutionize the Pharmaceutical Industry

Growth in biotechnology blurs the lines of differentiation between different fields of science. For instance, biotechnology advancements are integrating with semiconductor technologies such as micro-electromechanical systems resulting in the evolution of biochips. Biochips provide pharma companies with sophisticated tools for understanding gene expressions, biological mechanisms, speedy development of drugs, and accurate diagnosis. DNA and protein biochips streamline drug development and significantly lower average drug screening costs from $2 to $0.0001. In addition, with the transition of the medical lab-on-chip (LOC) from a concept to a reality, the focus has been on developing high density and smaller-sized biochips wherein less than 300 wafers may accommodate the entire human genome. As opposed to conventional laboratory analysis, LOCs eliminate the need for trained personnel and expensive equipment to provide significant time and cost efficiencies.

This Frost & Sullivan research analyzes the biotechnology industry by providing a comprehensive view of emerging technologies and applications such as bioanalytics, biopharmaceuticals, glycobiology, nanobiotechnology, and industrial biotechnology. Analysis of the technological trends, drivers, challenges and recent developments will assist in creating effective marketing and production strategies. Participants can identify potential collaborators, stay ahead of the competition, and stay shoulder-to-shoulder with critical developments in their industries.

Developments in Protein-based Drugs Enrich Biopharmaceuticals Pipeline

The rapid evolution of glycomics as a natural extension of proteomics provides a better understanding of glycoproteins; thereby, helping the development of novel biodrugs. "Improved understanding of the structural and functional data in glycomics coupled with phenomenal developments in genetic engineering techniques drives the usage of recombinant glycoproteins as therapeutic agents and as an alternative to small molecules," says the analyst of the study.

Demand for therapeutic glycoproteins and monoclonal antibodies is expected to increase creating an urgent need for higher production capacity. Additionally, alternate manufacturing mediums such as transgenic animals, plants, and mammalian and fungal cell lines are also on the rise. Fungal cell lines, in fact, provide considerable time and cost benefits over mammalian cell lines. The latter is not only a lengthy process but may also alter the properties of the final therapeutic glycoprotein. Conversely, fungal cell lines such as engineered yeast expression systems facilitate production of humanly glycosylated protein, provide faster fermentation and generate higher product yield.

Nanobiotechnology and Extremophiles to Create Exciting Opportunities for Biotechnology

Small size, unique physical structures, and electronic properties have sparked an explosion of research in nanobiotechnology. "Carbon buckyballs and nanotubes are small enough to move inside the body serving as effective carriers of active ingredients," says the analyst. "For instance ABI 007 is a successfully tested nanocarrier that transports established anti-cancer drugs. Minute nanoparticles such as quantum dots may serve as imaging agents, revolutionizing conventional diagnostic imaging."

The application of extremophiles in industrial processes is set to usher in a new era in biotechnology. Ground breaking research into their unique ability to survive under harsh physical conditions creates numerous opportunities in bioprocessing and environmental biotechnology. Also, the potential of secondary metabolites derived from extremophiles in replacing certain industrial bioproducts is stimulating research in this area.

1 EXECUTIVE SUMMARY

Introduction: 1. Introduction; 2. Key Developments
Scope and Methodology: 1. Scope of This Study; 2. Methodology

2 BIOANALYTICAL APPLICATIONS

Introduction: 1. Introduction; 2. Key Developments
Research Trends - Companies: 1. Multiplexed DNA Biochip; 2. Customized Bioanalytical Arrays; 3. Benchtop Cell Analyzer System Increases Throughput; 4. Find Perfect Keys To Lock Desginer Proteins; 5. Electronic Canary
Research Trends - Universities: 1. Proteome Chip Licensed for Rapid Bio Studies; 2. Microchip Detects Proteins; 3. Invasive Procedure May Be a Thing of the Past; 4. Chip Detects Resistant Pathogens; 5. Detecting Mass of a Single Virus Particle; 6. Novel Chip Detects Influenza; 7. Biodegradable Chip Releases Drugs; 8. Chip Senses Narcotics Efficiently; 9. DNA for Nanopatterns; 10. DNA Analysis Made Simple; 11. Biosensors To Monitor Fruit Quality; 12. Move Free Drops on a Lab-on-Chip Surface; 13. Microarray and the Web Power
Technology Drivers and Restraints: 1. Technology Drivers; 2. Technology Restraints
Key Industry Participants: 1. North America; 2. Europe; 3. Asia Pacific

3 BIOPHARMACEUTICALS

Introduction: 1. Introduction; 2. Key Developments
Research Trends - Companies: 1. Fully Humanized Yeasts To Make Therapeutics; 2. GAG-Binding Proteins; 3. Reverse Genomics; 4. Proteosome Pathway in Tuberculosis and Stroke; 5. BioMarin Cuts Therapeutic Protein Immune Response; 6. AVI Antisense Drug; 7. PDL Gets License Fees for Humanized Antibodies; 8. Diversa Optimizes Antibodies
Research Trends - Universities: 1. Glycoproteins for Cancer Detection; 2. Create Customized Proteins To Perform Specific Tasks
Technology Drivers and Restraints: 1. Technology Drivers; 2. Technology Restraints
Key Industry Participants: 1. North America; 2. Europe; 3. Asia Pacific; 4 GLYCOBIOLOGY
Introduction: 1. Introduction; 2. Key Developments
Research Trends - Companies: 1. Glycoanalysis U-c Fingerprinting; 2. Neose Plans To Develop New G-CSF; 3. Rigel Finds Anti-Proliferative Random Peptides; 4. Thrombocytopenia Proteins at Bolder Biotechnology; 5. Avigenics Produces Human Proteins in Chicken Eggs; 6. Cubist Focuses on Lipopeptide Anti-Infectives
Research Trends - Universities: 1. Functional Glycomics; 2. Make and Manipulate Glycoproteins; 3. Other Notable Developments; 4. Potential Applications in Glycobiology
Technology Drivers and Restraints: 1. Technology Drivers; 2. Technology Restraints
Key Industry Participants: 1. North America; 2. Europe; 3. Asia Pacific

5 INDUSTRIAL BIOTECHNOLOGY

Introduction: 1. Introduction; 2. Key Developments
Research Trends - Companies: 1. Bio-Reaction Industry Takes Off; 2. Microbia Improves Fermentation Process at Teva; 3. Diatom Silica To Immobolize Enzymes; 4. Directed Evolution Improves Enzymes; 5. Phase Biosciences Develops Novel Enzyme Carriers
Research Trends - Universities: 1. Cryogels for Novel Industrial Biotech Applications; 2. Beta-Carotene Production by a Novel Two-Phase Fermenter Process; 3. Boost Cobalamin To Improve Fermentation Microbes; 4. Microbioreactor Speeds up Bioprocessing Development; 5. Producing Hydrogen by Fermentation; 6. Microbial Vanillin Process; 7. IBEA Sythesizes Bacteriophage Genome
Technology Drivers and Restraints: 1. Technology Drivers; 2. Technology Restraints
Key Industry Participants: 1. North America; 2. Europe; 3. Asia Pacific

6 NANOBIOTECHNOLOGY

Introduction: 1. Introduction; 2. Key Developments
Research Trends - Companies: 1. Novel Screening of Small Molecules; 2. Nanocrystals; Bioconjugates; Microspheres; and Encoded Cells; 3. Commercialization of Nano Drug Delivery Technology
Research Trends - Universities: 1. Use Quantum Dots as Flurescent Probes; 2. Molecular Profiling and UltraSensitive In-Vitro Diagnosis; 3. Generate High-Resolution Images of Living Organisms Using Quantum Dots; 4. Gold Nanoparticles To Detect Cancer; 5. Nanoparticles as Drug Carriers; 6. Nanoparticles Remove Toxins from Blood; 7. Transport Genetic Materials in Nanorods; 8. Use DNA as a Scaffold for Microelectronics; 9. DNA Wires Hook Up; 10. DNA; Nanotubes; and Transistors; 11. Increase Biocompatibility by Coating with Collagen; 12. Smart Dust To Detect Biological and Chemical Compounds; 13. Other Notable Developments
Technology Drivers and Restraints: 1. Technology Drivers; 2. Technology Restraints
Key Industry Participants: 1. North America; 2. Europe; 3. Asia Pacific

7 UNIQUE MICROBES AND THEIR APPLICATIONS

Introduction: 1. Introduction; 2. Key Developments
Research Trends - Companies: 1. Diversa Picks Best of Extremophiles; 2. Biodefense and Industrial Projects
Research Trends - Universities: 1. Applied Biocatalysis and Environmental Engineering; 2. Microbe Lives in Hottest Known Environment; 3. Bacteria that Degrade Oil in the Sea Water; 4. Arsenic-Eating Bacteria To Clean Drinking Water; 5. Bug Makes Chlorinated Pollutants Safe; 6. Enzyme Attacks Industrial Bleaching Waste; 7. Bug Makes Nano Photomask; 8. Bacterial Battery Power; 9. Electricity from Glucose in Microbial Fuel Cells; 10. Bacteria Found Deep in the Earth; 11. Recombinant Bacteria Prevents Corrosion
Technology Drivers and Restraints: 1. Technology Drivers; 2. Technology Restraints
Key Industry Participants: 1. North America; 2. Europe; 3. Asia Pacific

8 PATENTS; CONTACTS; AND DSD TABLES

Patents: 1. Patents Relating to Bioanalytical Applications; 2. Patents Relating to Biopharmaceuticals Applications; 3. Patents Relating to Glycobiology; 4. Patents Relating to Industrial Biotechnology; 5. Patents Relating to Nanobiotechnology; 6. Patents Relating to Extremophiles
Contacts: 1. Companies; 2. Universities
DSD Tables: 1. Number of Biotech Companies by Region; 1999-2005; 2. Number of Employees in Biotech Companies by Region; 1996-2004; 3. Government R&D Investment in Biotechnology (Million USD) by Region; 1996-2004; 4. Government R&D Investment in Biotechnology (in Percentage); 5. Private Investment in Biotechnology (Million USD) by Region; 1996-2004; 6. Private Investment in Biotechnology As a Percentage of Total Private Healthcare Expenditure; 7. Total Healthcare Expenditure (Billion USD); 8. Pharmaceuticals R&D Expenditure (Million USD); 9. Pharmaceuticals R&D Expenditure As a Percentage of Pharmaceuticals Market; 10. Total Number of Students Pursuing Graduation & Post-Graduation (Millions); 11. Number of Biotechnology Patents Filed at/ Granted by the European Patent Office (EPO) 1996-2000; 12. Number of Biotechnology Patents Filed at/ Granted by the US Patent and Trademark Office (USPTO) 1996-2000; 13. List of Proteomic Centers; 14. Number of Biological Manufacturing Establishment - US; 1999 - 2005