Abstract
Biophotonics describes the use of photonics in biomedical applications. There
are several key areas that are associated with biophotonics. All of these
center on microscopy and related technology. The reason that this is so is
that biophotonics look at biological functions at the cellular level, or even
smaller. The only way that these processes can be observed is via one or
another form of microscopy.
Among the different types of microscopy and associated technologies essential to the applications of biophotonics are:
- Optical Sectioning Microscopy
- Differential Interference Contrasting Imaging (Nomarski Imaging)
- Laser Scanning Confocal Imaging
- Parallel Beam Confocal Imaging Systems
- Multiple-Photon Excitation Fluorescence Microscopy
- Computational Optical Sectioning Microscopy
- Photon Limited Microscopy
- Charge Coupled Detectors (CCDs)
- Avalanche photodiodes (APDs)
- Photomultipliers (PMTs)
- Fluorescent Probes
- Fluorescent Lifetime Imaging
- Caged Bioactive Probes
- Several Non-Imaging Optical Techniques
Photonics has been a reality in non-life-sciences (e.g., electronics,
materials sciences, weaponry, etc.) field for a long time now. It has been of
great value in many industrial applications and even to the point of use in
strategic surveillance. Now that it has been pointed toward the life-sciences
fields is had found a new, rapidly growing area of development.
Newer applications and associated technologies include:
- Microgenomics
- Maldi-ToF Mass Spectrometry
- Solid-State Lasers
- Raman Spectroscopy
- Cytometry
- Plasmon Resonance
- CARS Microscopy
- Quantum Dots
- Microwave Technology
- Föster Resonance Energy Transfer (FRET)
- Protein Microarrays
- Microlenses
- Atomic Force Microscopy
- Whirling Fiber Endoscopy
- Adaptive Optics
- Nanowires
- Aptamers
Scope and Methodology
This report, now in its 2nd edition, focuses on the technology of
biophotonics, its applications to biomedical research, its potential for
clinical applications, and the progress that is being made in these fields.
The major market effects of new biophotonics technology, with the potential of
a breakthrough finding always a possibility, are expected to be seen over the
next ten years in the biomedical research field - including pharmaceutical
development. The technology trends selected in conjunction with the growing
interest in biophotonics present the most informative picture of advances in
this technology and in the markets that result.
This report covers biophotonics in a broad sense. It does not go into the
detail of the individual products in the marketplace, either systems or
components. The ability to do so is limited by several factors, including
cross-applications of components, among which it is not possible to
discriminate in the marketplace, and the mix of systems and components needed
to provide complete biophotonic instruments - many of which are designed and
constructed in individual laboratories. It does discuss, however, the impacts
that various advanced technologies are having on biophotonics markets as a
whole. In general it is the growth of related technologies used in the
marketplace that have advanced the concept of photonics and, as we are
concerned, biophotonics to the level of achievement it has reached today.
Indeed, advanced biophotonics technology and applications will replace many of
the existing products used in biomedical research, clinical diagnostics and
imaging today. In an era of cost-containment and managed care, however, the
market value may be limited somewhat by existing standards.
Market analysis in this report, with regard to projections, considers the
biophotonics markets globally and in the United States. By way of comparison,
the global markets for all optoelectronics products and for optoelectronic
sensors (some of which are used in biophotonics) are provided. This report
does not consider individual products or product groups within biophotonics
because there simply is not enough definition in the market to do so. Again,
some mention is made of the global markets for overall optoelectronics
(photonics) and its related optoelectronic sensors, but the specific market
dynamics of those markets are not considered in detail. The focus of this
report is on the biophotonics technologies and those technologies with the
potential to provide first-line market entrants.
The analysis presented in this report is based on data from a combination of
company, government, industry, institutional and private sources. It includes
information from extensive literature reviews and discussions with experts in
the field, including electronics engineers, researchers, experts in materials
science, and business development managers and marketing managers.
Table of Contents
CHAPTER One: Executive Summary
- Scope and Methodology
- Market Analysis Summary
- Trends and Considerations
CHAPTER Two: The Basics of Biophotonics
- Optical Sectioning Microscopy
- Differential Interference Contrasting Imaging (Nomarski Imaging)
- Laser Scanning Confocal Imaging
- Parallel Beam Confocal Imaging System
- Multiple-Photon Excitation Fluorescence Microscopy
- Computational Optical Sectioning Microscopy
- Photon Limited Microscopy
- Charge Coupled Detectors (CCDs)
- Avalanche Photodiodes (APDs)
- Photomultipliers (PMTs)
- Fluorescent Probes in Biological Research
- Fluorescence Lifetime Imaging
- Caged Bioactive Probes
- Non-Imaging Optical Techniques
- Laser microsurgery
- Fluorescent Recovery after Photobleaching
- Photoactivation of Caged Compounds
- Optical Trapping
CHAPTER Three: Applications of Biophotonics
- Biophotonics and Microgenomics
- MALDI-TOF and Protein Analysis
- Diode-Pumped Solid State Lasers
- MicroFlow Cytometry
- Raman Spectroscopy and Surgery
- Plasmon Resonance and Protein Analysis
- Raman Spectra in HIV and Disease Diagnosis
- CARS Microscopy
- Fluorescent Probes and Quantum Dots
- Microwaves and Fluorescent Assays
- FRET
- Three-Color Large-Area Sensors
- Identification of RNA-Protein Interactions
- Protein Microarrays without Labels
- Microlenses
- Atomic Force Microscopy
- Miniature Lenses for Microarray Spots
- Whirling Fiber Endoscopy
- Adaptive Optics
- Self-Illuminating Quantum Dots
- Diamond Biosensors
- Nanowires
- Aptamers and Atomic Force Microscopy
CHAPTER Four: Market Analysis
CHAPTER Five: Company Profiles
- Affymetrix
- ANDOR Technology PLC
- 4/5D Microscopy
- Bioluminescent Imaging
- Cell Motility
- Chemiluminescent Imaging
- Single Cell Gel Electrophoresis - Comet Assay
- Fluorescence Resonance Energy Transfer (FRET)
- Fluorescent In-Situ Hybridization (FISH)
- Immunofluorescence Microscopy
- Ion Signaling Microscopy
- Live Cell Confocal Microscopy
- Single-Molecule Detection
- Total Internal Reflectance (TIRF) Microscopy
- BD Biosciences
- Biomedical Photometrics, Inc.
- Bio-Tek Instruments
- Caliper Life Sciences
- Cambridge Technology
- Carl Zeiss Microimaging, Inc.
- Life Sciences and Medical Systems
- Optical Consumer Goods
- Industrial Systems
- Cellomics, Inc.
- ArrayScan®
- Certified ArrayScanR HCS Reader
- Core BioApplications
- KineticScanR HCS Reader
- cellWoRx
- Hamamatsu Photonic Systems
- Horiba
- Engine Measurement Instruments and Systems
- Analytical Instrumentation and Systems
- Semiconductor Instruments and Systems
- Medical/Diagnostics Instruments and Systems
- Invitrogen Corporation
- Ludl Electronic Products, Ltd.
- Filter Wheels
- Focus Control System
- Microscope Power Supplies
- MDS Analytical Technologies
- Ocean Optics, Inc.
- Olympus America, Inc.
- Perkin Elmer Optoelectronics
- PicoQuant GmbH
- Spectra-Physics (A Division of Newport Corporation)
CHAPTER Six: Conclusions and Strategic Implications
- First Conclusion
- Second Conclusion
- Third Conclusion
- Fourth Conclusion
- Fifth Conclusion
- Sixth Conclusion
- Seventh Conclusion
APPENDIX A: Glossary
APPENDIX B: Market Participants Directory
List of Exhibits
CHAPTER One: Executive Summary
- Figure 1-1: Market Summary: Global and United States Markets for
Biophotonics and Related Products 2008-2018
CHAPTER Four: Market Analysis
- Table 4-1: Global and U.S. Markets for Biophotonics and Related Products
2008-2018
- Table 4-2: The World Market for Optoelectronics and Optoelectronic Sensors
2008-2018
- Figure 4-1: Trending in the Global and United States Markets for
Biophotonics Products: 2008-2018
- Figure 4-2: Trending in the Global Optoelectronics Products and Sensors
Markets: 2008-2018
