US demand for pharmaceutical excipients is expected to approach $2 billion in
2015, driven by growing production of pharmaceuticals in the US and the
increasing importance of improved excipients in drug formulations.
Pharmaceutical companies are emphasizing the use and development of new and/or
improved inactive ingredients in response to the growing problems of patent
expirations for key products, increasing competition from foreign suppliers
and downward pricing pressure from end users. Of particular interest to
pharmaceutical companies is the development of new, patentable proprietary
formulations that can be used to compete with generic products. Excipients can
be used to provide more convenient dosage formats and are important to
maintaining the efficacy, stability, safety and longevity of medicines.
New, patentable applications for excipients to spur growth
Pharmaceutical companies are increasingly interested in developing new,
patentable proprietary drugs that can be used to compete with generic
formulations. Once only fillers and conduits for active ingredients,
excipients are now used to provide more convenient dosage forms, to deliver
drugs effectively, to control the timing of release (delayed, immediate), and
to provide immediate disintegration in special circumstances. Their importance
in drug delivery, safety, stability, efficacy and convenience can be crucial
to patient compliance. Growth opportunities will extend to a wide range of
compounds and applications. Cellulosic materials will remain the dominant
materials for excipient fillers, but will expand sales through specialty
combination of excipients to improve and reduce the costs of tableting.
Gelatin will remain the leading compound for encapsulation based on continued
solid performance and safety, withstanding challenges from more expensive
cellulosic and vegetable oil derivative alternatives, but will be used
increasingly to encapsulate granules of active ingredients and to improve
coatings. Lactose, used most often as a filler, is now being developed as an
inhalant for drug delivery. Other products are under development that can
deliver active ingredients to specific places in the body, or improve the
release of newly developed medicines that do not break down in water.
Combined materials improve quality and reduce costs
Excipient producers are marketing combination materials that, together,
improve overall performance in producing finished tablets of higher quality at
reduced cost. Cellulosic excipients will experience significant growth through
2015 due to the development of co-processed materials that combine properties
of compressibility and flowability. Composites of microcrystalline cellulose
(MCC), hydroxypropyl methylcellulose (HPMC) and Corpovidone (CPVD) are
engineered for binding, filling and disintegrating capabilities that exceed
the quality of action in individual excipients, and ensure product
consistency. MCC will see particularly strong growth because of its capacity
for use in direct compression in tableting -- a process that is substantially
less expensive than the more standard wet granulation process for the same
purpose. Multifunctional synthetic polymers such as polyethylene glycol (PEG)
and povidone will continue to experience strong growth because of their broad
application for high value-added oral medicines, including their use for
controlled release and disintegration.
Study coverage
This new Freedonia US industry study, “Excipients”, presents
historical demand data (2000, 2005 and 2010) plus forecasts for 2015 and 2020
by excipient product and application. The study also considers key market
environment factors, assesses industry structure, evaluates company market
share and profiles 60 industry competitors.
This study can help you:
Determine your market & sales potential
Learn more about industry competitors
Assess new products & technologies
Identify firms to merge with or acquire
Complement your research & planning
Gather data for presentations
Confirm your own internal data
Make better business decisions
Freedonia's methods involve:
Establishing consistent economic and market forecasts
Using input/output ratios, flow charts and other economic methods to
quantify data
Employing in-house analysts who meet stringent quality standards
Interviewing key industry participants, experts and end users
Researching a proprietary database that includes trade publications,
government reports and corporate literature
Table of Contents
INTRODUCTION
I. EXECUTIVE SUMMARY
II. MARKET ENVIRONMENT
General
Economic Factors
Demographic Patterns
Health Care Trends
National Health Expenditures
Medical Conditions
Chronic Conditions
Acute Conditions
Pharmaceuticals
Therapeutic Class
Dosage Formulations
Distribution Classifications
Historical Market Trends
Foreign Trade
International Markets
III. PRODUCTS
General
Polymers
Cellulose Derivatives
Microcrystalline Cellulose (MCC)
Hydroxypropyl Methylcellulose (HPMC)
Ethyl Cellulose
Methyl Cellulose
Carboxymethylcellulose (CMC)
Croscarmellose Sodium
Other Cellulose Excipients
Povidone
Starch Compounds
Pregelatinized Starch
Sodium Starch Glycolate
Other Starch Excipients
Polyethylene Glycol
Acrylic Polymers
Other Polymers
Natural Gums from Seaweeds
Other Plant-Based Natural Gums
Synthetic Polymers
Alcohols
Glycerin
Propylene Glycol
Sorbitol
Other Alcohols
Mannitol
Other Polyol Excipients
All Other Alcohols
Minerals
Calcium Phosphate
Calcium Carbonate
Mineral Hydrocarbons
Clay
Silicon Dioxide
Titanium Dioxide
Other Minerals
Gelatin
Sugars
Lactose
Sucrose
Other Sugar Excipients
Other Pharmaceutical Excipients
Dyes & Pigments
Flavors
Surfactants
Acidulants
Antioxidants
Stearate Compounds
All Other Compounds
Electrolytes & Related Compounds
Chemical Plasticizers
High Intensity Sweeteners
Natural Fats, Oils & Waxes
IV. APPLICATIONS
General
Fillers & Diluents
Binders
Suspension & Viscosity Agents
Coatings
Solvents
Flavoring Agents
Capsules
Disintegrants
Colorants
Lubricants & Glidants
Preservatives
Other Applications
V. INDUSTRY STRUCTURE
General
Market Share
Competitive Strategies
Selected Mergers & Acquisitions
Selected Licensing & Related Agreements
Marketing & Distribution
Research & Development
Manufacturing
Company Profiles
ABITEC, see Associated British Foods
Akzo Nobel NV
Archer-Daniels-Midland Company
Ashland Incorporated
Associated British Foods plc
AVANTOR Performance Materials
BASF SE
Berwind Corporation
Cabot Corporation
Cargill Incorporated
Celanese Corporation
Cognis Holding, see BASF
Colorcon, see Berwind
Corn Products International Incorporated
Covidien plc
CP Kelco, see Huber (JM)
Croda International plc
CyDex Pharmaceuticals, see Ligand Pharmaceuticals
Danisco A/S
Dow Chemical Company
Eastman Chemical Company
EMD Chemicals, see Merck
Evonik Industries AG
Ferro Corporation
FibroGen Incorporated
Flavorx Incorporated
FMC Corporation
GELITA AG
Generichem Corporation
Huber (JM) Corporation
Huntsman Corporation
Innophos Incorporated
International Specialty Products Incorporated
JRS Pharma, see Rettenmaier (J.) & Sohne
Kraft Foods Incorporated
Kuraray Company Limited
Ligand Pharmaceuticals Incorporated
Lubrizol Corporation
LyondellBasell Industries NV
Mallinckrodt Baker, see AVANTOR Performance Materials
Merck KGaA
Mutchler Incorporated
National Starch, see Corn Products International
Nitta Gelatin Incorporated
NutraSweet Company
Nutrinova Nutrition Specialties & Food Ingredients, see Celanese
P&G Chemicals, see Procter & Gamble
PB Gelatins, see Tessenderlo Group
Procter & Gamble Company
Rettenmaier (J.) & Sohne GmbH & Company KG
Roquette Freres SA
Royal Dutch Shell plc
Sasol Limited
Shin-Etsu Chemical Company Limited
Solvay SA
SPI Pharma, see Associated British Foods
Stepan Company
Tate & Lyle plc
Tessenderlo Group NV
USG Corporation
Wacker Chemie AG
Other Companies Involved in the US Excipients Industry
LIST OF TABLES
SECTION I -- EXECUTIVE SUMMARY
Summary Table
SECTION II -- MARKET ENVIRONMENT
Macroeconomic Indicators
Population & Households
National Health Expenditures
Chronic Conditions by Type
Acute Conditions by Type
Pharmaceutical Supply & Demand
Pharmaceutical Shipments by Therapeutic Class
Pharmaceutical Shipments by Dosage Formulation
Pharmaceutical Shipments by Distribution Classification
Excipient Market, 2000-2010
SECTION III -- PRODUCTS
Pharmaceutical Excipient Demand by Product Group
Polymer Excipient Demand by Type
Cellulose Excipient Demand by Type
Microcrystalline Cellulose Excipient Demand by Application
Hydroxypropyl Methylcellulose Excipient Demand by Application
Ethyl Cellulose Excipient Demand by Application
Methyl Cellulose Excipient Demand by Application
Carboxymethylcellulose Excipient Demand by Application
Croscarmellose Sodium Excipient Demand by Application
Other Cellulose Excipient Demand by Application
Povidone Excipient Demand by Application
Starch Excipient Demand by Type
Pregelatinized Starch Excipient Demand by Application
Sodium Starch Excipient Demand
Other Starch Excipient Demand by Application
Polyethylene Glycol Excipient Demand by Application
Acrylic Polymer Excipient Demand by Application
Other Polymer Excipients by Application
Alcohol Excipient Demand by Type
Glycerin Excipient Demand by Application
Propylene Glycol Excipient Demand by Application
Sorbitol Excipient Demand by Application
Other Alcohol Excipient Demand by Type & Application
Mineral Excipient Demand by Type
Calcium Phosphate Excipient Demand
Calcium Carbonate Excipient Demand
Mineral Hydrocarbon Excipient Demand by Application
Clay Excipient Demand by Application
Silicon Dioxide Excipient Demand by Application
Titanium Dioxide Excipient Demand
Other Mineral Excipient Demand by Application
Gelatin Excipient Demand by Application
Sugar Excipient Demand by Type
Lactose Excipient Demand by Application
Sucrose Excipient Demand by Application
Other Sugar Excipient Demand
Other Pharmaceutical Excipients Demand by Type & Application
SECTION IV -- APPLICATIONS
Pharmaceutical Excipient Demand by Application
Filler & Diluent Excipient Demand by Type
Binder Excipient Demand by Type
Suspension & Viscosity Excipient Demand by Type
Coating Excipient Demand by Type
Solvent Excipient Demand by Type
Flavoring Agent Excipient Demand by Type
Capsule Excipient Demand by Type
Disintegrant Excipient Demand by Type
Colorant Excipient Demand by Type
Lubricant & Glidant Excipient Demand by Type
Preservative Excipient Demand by Type
Other Applications for Excipients by Type
SECTION V -- INDUSTRY STRUCTURE
US Excipient Sales by Company, 2010
Selected Acquisitions & Divestitures
Selected Cooperative Agreements
LIST OF CHARTS
SECTION III -- PRODUCTS
Pharmaceutical Excipient Demand by Product Group, 2010
Polymer Excipient Demand by Type, 2010
SECTION IV -- APPLICATIONS
Pharmaceutical Excipient Demand by Application, 2010
