Abstract
Executive Summary
BioSeeker Group have identified 217 companies plus partners who are today
developing 244 cancer vaccine drugs in 509 developmental projects in cancer
across 112 different targets. In addition, there are 6 suspended drugs and
another 174 drugs where development has been ceased.
For busy executives within Pharma, Biotech and Investment companies who know
they need to stay on top of the developmental environment in their field, we
offer the Drug Pipeline update series.
You get detailed, world-wide drug pipeline information, delivered in an
unbiased and independent pipeline progress analysis for each identified drug.
Buying the Cancer Vaccines Drug Pipeline Update 2012 will mean you have this
important data at your fingertips and ensure that you can:
- Show investors/board/management that you are right on top of drug
development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc. and track
them by their products.
- Jump start competitive drug intelligence operations
- Benchmark your own development against world wide data
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/outlicensing strategy work
Some facts about Cancer Vaccines Drug Pipeline Update 2012
Cancer vaccines offer an attractive therapeutic addition, delivering treatment
of high specificity, low toxicity and prolonged activity. However, despite
years of R&D, a reproducible survival benefit has proved elusive, leaving the
market wide open.
There are today 217 companies plus partners developing 244 cancer vaccine
drugs in 509 developmental projects in cancer. In addition, there are 6
suspended drugs and the accumulated number of ceased drugs over the last years
amount to another 174 drugs. Cancer Vaccines Drug Pipeline Update lists all
drugs and gives you a progress analysis on each one of them. Identified drugs
are linked to 112 different targets. These targets are further categorized on
in the software application by 40 classifications of molecular function and
with pathway referrals to BioCarta, KEGG and NetPath.
Table of Contents
Details from Cancer Vaccines Drug Pipeline Update 2012 at a glance
This short overview shows actual findings from the Cancer Vaccines Drug
Pipeline Update 2012 report.
Investigators
Includes more than 217 principal investigators plus their collaborators. There
is direct access from inside the application to web pages of all principal
investigators.
Note: You are able to sort and find drugs according to investigators and
partners from drop-down menus in the application. You may also sort and find
drugs according to country of investigator.
Drug name & Synonyms
Lists commercial, generic and code names for drugs.
Developmental stage
This Drug Pipeline Update contains 244 cancer vaccine drugs in development,
which have a total of 509 developmental projects in cancer. In addition there
are suspended and ceased drugs.
Pipeline Breakdown According to Number of Drugs
- Marketed# 11
- Registered# 1
- Pre-registration# 2
- Phase III# 24
- Phase II# 81
- Phase I# 69
- Preclinical# 141
- No Data# 2
- Suspended# 6
- Ceased# 174
Note: You are able to sort and find drugs according to developmental stage
from drop-down menu in the application.
Indications
Included cancer vaccine drugs are also in development for 84 other
indications, where of 60 are different cancer indications.
Note: You are able to find and sort drugs according to type of indication from
drop-down menu in the application.
Targets
Identified drugs are linked to more than 112 different targets, divided into
40 classifications of molecular function:
- Acid phosphatase activity
- Carboxypeptidase activity
- Catalytic activity
- Cell adhesion molecule activity
- Chaperone activity
- Cofactor binding
- Complement activity
- Cytokine activity
- DNA binding
- DNA topoisomerase activity
- DNA-directed DNA polymerase activity
- Growth factor activity
- Heat shock protein activity
- Hormone activity
- Hydrolase activity
- Isomerase activity
- Kinase binding
- Kinase regulator activity
- Metallopeptidase activity
- MHC class I receptor activity
- Molecular function unknown
- Oxidoreductase activity
- Peptidase activity
- Peptide hormone
- Protein binding
- Protein serine/threonine kinase activity
- Protein-tyrosine kinase activity
- Receptor activity
- Receptor binding
- Receptor signaling complex scaffold activity
- Receptor signaling protein serine/threonine kinase activity
- RNA-directed DNA polymerase activity
- Serine-type peptidase activity
- T cell receptor activity
- Transcription factor activity
- Transcription regulator activity
- Transmembrane receptor activity
- Transmembrane receptor protein tyrosine kinase activity
- Transporter activity
- Unknown
Identified targets are categorized into 21 different primary and alternate
sub-cellular localizations:
- Apical membrane
- Centrosome
- Clathrin-coated vesicle
- Cytoplasm
- Cytoskeleton
- Endoplasmic reticulum
- Endosome
- Extracellular
- Extracellular matrix
- Golgi apparatus
- Integral to membrane
- Lysosome
- Mitochondrial matrix
- Mitochondrion
- Nucleolus
- Nucleus
- Peroxisomal matrix
- Plasma membrane
- Sarcoplasmic reticulum
- Secreted
- Secretory granule
Note: You are able to find and sort drugs according to target gene name,
molecular function of target, and target localization from drop-down menus in
the application.
Target Expression
Profile
Direct links are provided from inside the application to 143 protein
expression profiles of 89 drug targets in various human tissues and cancer
types, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Pathway Referals
Identified targets have been cross referenced against their involvement in
different cellular pathways, according to BioCarta, KEGG and NetPath.
- BioCarta# 117 Pathways
- KEGG# 113 Pathways
- NetPath# 21 Signaling Pathways
Note: You are able to find and sort drugs according to targeted pathways from
drop-down menus in the application.
Mechanism
In total there are different drug mechanism of action represented in this Drug
Pipeline Update.
Note: You are able to find and sort drugs according to mechanism of action
from drop-down menu in the application.
Compound
Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight
Note: You are able to sort and find drugs according to compound type from
drop-down menu in the application.
The Drug Profiles: Progress analysis and review of drug development.
Cancer Vaccines Drug Pipeline Update 2012 provides you with a profile for each
identified drug. A typical drug profile reports on, depending on stage of
development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms.
Principal Investigator & Partners
Presentation of principal investigator and partners.
Target and Molecular Function of Target
Described target(s) is/are presented with:
- Official Gene Symbol
- Official Gene Name [Species/Homo Sapiens]
- Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues,
cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways
according to BioCarta, KEGG, and NetPath.
Mechanism
Drug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication,
developmental stage and status.
Example:
- Cancer, myeloma - Phase II Clinical Trial - Active
- Cancer, prostate - Phase III Clinical Trial - Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight.
Patent Data
Available patent information related to the drug is presented here.
Analysis
- Business & Markets
- Collaborations and deals
- Approvals and submissions
- Analyst comments
Phase III Data
Available Phase III development data, developmental history and scientific
data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific
data.
Licensing Information
Availability for licensing.
About the unique Drug Pipeline Update Software Application
After purchase, the Drug Pipeline Update is delivered to you via electronic
download in a powerful yet easy to use desktop application which requires no
installation.
Find and sort drugs by twelve different parameters plus free text search
field. Our dynamic report generator lets you easily and quickly generate HTML
drug profile reports directly in your web browser, whether it is a single drug
profile or your own report selection of drugs that match your criteria.
Application Features
Use 13 different parameters, available in drop-down menus, to find and sort
among drugs
- Drug status
- Clinical Trial Status
- Principle Investigator
- Partners
- Indication
- Developmental Stage
- Compound Type
- Mechanism
- Target
- Molecular Function of Target
- Target Localization
- Targeted Pathways
- Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Drug target data is linked directly to BioCarta, Human Protein Atlas,
KEGG, and NetPath
- Direct links to company web pages of principal investigators
Dynamic Report Generator
Our dynamic report generator lets you with ease and speed generate html
reports directly in your web browser (Internet Explorer), whether it is a
single drug profile or an entire search you want have a report of.
System Requirements
Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard)
and OS X 10.7 (Lion)
Browser Application (Internet Explorer)
Internet access (to access related internet resources)
