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市場調査レポート - 167162

癌治療薬パイプラインにおけるB細胞受容体シグナル伝達経路

B Cell Receptor Signaling Pathway in Oncology Drug Pipeline Update 2014

発行 BioSeeker Group AB
出版日 ページ情報 英文
価格
癌治療薬パイプラインにおけるB細胞受容体シグナル伝達経路 B Cell Receptor Signaling Pathway in Oncology Drug Pipeline Update 2014
出版日: 2014年07月15日 ページ情報: 英文
概要

現在、145の企業およびパートナーが癌に関する540の開発プロジェクトの中の190のB細胞受容体経路を標的とした薬剤開発に取り組んでいます。さらに、これまでに中止された薬剤の累積数は66に上っています。

当レポートでは、これらの開発中の薬剤のひとつひとつを分析し、標的、開発段階などに分類し、機序、適応などのそれぞれの薬剤プロファイルをまとめ、概略下記の構成でお届けいたします。

治験責任医師

薬剤名および異名

  • 商標名
  • ジェネリック薬
  • コードネーム

開発段階

  • 540の開発プロジェクトにおける開発中の190の薬剤最新動向
    • 上市済み
    • 登録前
    • 第3相
    • 第2相
    • 第1相
    • 前臨床
    • データなし
    • 中断
    • 中止

適応

標的

  • 120の標的を36に分類

標的発現プロファイル

経路

機序

化合物

薬剤プロファイル

  • 薬剤名
  • 治験担当医師およびパートナー
  • 標的および標的の分子機能
  • 標的の部位
  • 標的経路
  • 機序
  • 開発プロジェクト
  • 薬剤解説
  • 化合物データ
  • 特許データ
  • ビジネスおよび市場
  • 第3相データ
  • 第2相データ
  • 第1相データ
  • 臨床前データ
  • ライセンシング情報

応用特性

システム要件

  • AMD-Athlon/Pentium II PC
  • Windows 98/NT4/2000/ME/XP/VISTA/Windows 7
  • 8x-speed CD Rom drive
  • SVGA 16 bit display. (32 bit recommended)
  • 32 MB of available RAM (128 MB recommended)
  • Browser Application (Internet Explorer, Firefox)
  • Internet access (for related internet resources)

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目次

Activation of the B cell receptor involves phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present in Ig alpha and beta. This leads to activation of several non-receptor tyrosine kinases including those of the Src, Tec and Syk family of kinases. Downstream messengers include DAG, IP3, MAPK/ERK and JNK signaling modules.

There are today 215 companies plus partners developing 315 B cell receptor pathway targeting drugs in 1195 developmental projects in cancer. In addition, there are 4 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 131 drugs. B Cell Receptor Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 182 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 178 out of the 181 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 41 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 215 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 315 B cell receptor pathway targeting drugs in development, which have a total of 1195 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 26
  • Registered# 1
  • Pre-registration# 3
  • Phase III# 34
  • Phase II# 109
  • Phase I# 149
  • Preclinical# 164
  • No Data# 7
  • Suspended# 4
  • Ceased# 131
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included B cell receptor pathway targeting drugs are also in development for 168 other indications, where of 109 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 178 out of the 181 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 146 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 2762 structures available today among drug targets.
  • Identified drugs are linked to more than 182 different targets, divided into 41 classifications of molecular function:
  • ATPase activity
  • B cell receptor activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Deacetylase activity
  • DNA binding
  • DNA repair protein
  • DNA topoisomerase activity
  • G-protein coupled receptor activity
  • Growth factor activity
  • GTPase activity
  • Heat shock protein activity
  • Kinase activity
  • Kinase binding
  • Kinase regulator activity
  • Lipid kinase activity
  • Lipid phosphatase activity
  • Molecular function unknown
  • Oxidoreductase activity
  • Peroxidase activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein threonine/tyrosine kinase activity
  • Protein tyrosine phosphatase activity
  • Protein tyrosine/serine/threonine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein serine/threonine kinase activity
  • Serine-type peptidase activity
  • Structural constituent of cytoskeleton
  • Superoxide dismutase activity
  • Transcription factor activity
  • Transcription regulator activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 30 different primary and alternate sub-cellular localizations:
  • Basolateral membrane
  • Cell junction
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Extracellular matrix
  • Focal adhesion
  • Golgi apparatus
  • Kinetochore
  • Lysosome
  • Microtubule
  • Mitochondrial membrane
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleoplasm
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisome
  • Plasma membrane
  • Secreted
  • Vesicle
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 296 protein expression profiles of 169 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 228 Pathways
  • KEGG# 154 Pathways
  • NCI-Nature# 246 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

Dynamic Report Generator

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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