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市場調査レポート - 167147

癌治療薬パイプラインにおけるα6β4インテグリンシグナル伝達経路

Alpha6 Beta4 Integrin Signaling Pathway in Oncology Drug Pipeline Update 2014

発行 BioSeeker Group AB
出版日 ページ情報 英文
価格
癌治療薬パイプラインにおけるα6β4インテグリンシグナル伝達経路 Alpha6 Beta4 Integrin Signaling Pathway in Oncology Drug Pipeline Update 2014
出版日: 2014年10月27日 ページ情報: 英文
概要

現在、210の企業およびパートナーが癌に関する938の開発プロジェクトの中の315のα6β4インテグリンを標的とした薬剤開発に取り組んでいます。さらに、これまでに中止された薬剤の累積数は111に上っています。

当レポートでは、これらの開発中の薬剤のひとつひとつを分析し、標的、開発段階などに分類し、機序、適応などのそれぞれの薬剤プロファイルをまとめ、概略下記の構成でお届けいたします。

治験責任医師

薬剤名および異名

  • 商標名
  • ジェネリック薬
  • コードネーム

開発段階

  • 938の開発プロジェクトにおける開発中の315の薬剤最新動向
    • 上市済み
    • 登録前
    • 第3相
    • 第2相
    • 第1相
    • 前臨床
    • データなし
    • 中断
    • 中止

適応

標的

  • 101の標的を29に分類

標的発現プロファイル

経路

機序

化合物

薬剤プロファイル

  • 薬剤名
  • 治験担当医師およびパートナー
  • 標的および標的の分子機能
  • 標的の部位
  • 標的経路
  • 機序
  • 開発プロジェクト
  • 薬剤解説
  • 化合物データ
  • 特許データ
  • ビジネスおよび市場
  • 第3相データ
  • 第2相データ
  • 第1相データ
  • 臨床前データ
  • ライセンシング情報

応用特性

システム要件

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次

The Alpha6 Beta4 Integrin signaling pathway activates the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules.

There are today 245 companies plus partners developing 395 Alpha6Beta4 integrin pathway targeting drugs in 1391 developmental projects in cancer. In addition, there are 2 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 177 drugs. Alpha6 Beta4 Integrin Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 165 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 162 out of the 163 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 36 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
  • Find competitors, collaborations partners, M&A candidates etc.
  • Jump start competitive drug intelligence operations
  • Excellent starting point for world wide benchmarking
  • Compare portfolio and therapy focus with your peers
  • Speed up pro-active in-/out licensing strategy work
  • Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 245 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.

Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

This Drug Pipeline Update contains 395 Alpha6Beta4 integrin pathway targeting drugs in development, which have a total of 1391 developmental projects in cancer. In addition there are suspended and ceased drugs.

  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 33
  • Registered# 1
  • Pre-registration# 4
  • Phase III# 38
  • Phase II# 128
  • Phase I# 175
  • Preclinical# 193
  • No Data# 10
  • Suspended# 2
  • Ceased# 177

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

Included Alpha6Beta4 integrin pathway targeting drugs are also in development for 168 other indications, where of 127 are different cancer indications.

Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

Mutations

All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 162 out of the 163 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.

Biological Structures

The identity of available biological structures on 131 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 2451 structures available today among drug targets.

Identified drugs are linked to more than 165 different targets, divided into 36 classifications of molecular function:

  • Antigen binding
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Deacetylase activity
  • DNA binding
  • G-protein coupled receptor activity
  • Growth factor activity
  • GTPase activity
  • Isomerase activity
  • Kinase activity
  • Kinase binding
  • Ligand-dependent nuclear receptor activity
  • Lipid kinase activity
  • Lipid phosphatase activity
  • Molecular function unknown
  • Peroxidase activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein tyrosine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein tyrosine phosphatase activity
  • Structural constituent of cytoskeleton
  • Structural molecule activity
  • Superoxide dismutase activity
  • T cell receptor binding
  • Transcription factor activity
  • Transcription regulator activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity

Sub-Cellular Localization

Identified targets are categorized into 33 different primary and alternate sub-cellular localizations:

  • Cell projection
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Early endosome
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Focal adhesion
  • Golgi apparatus
  • Integral to membrane
  • Kinetochore
  • Late endosome
  • Lysosome
  • Microtubule
  • Mitochondrial membrane
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleoplasm
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisome
  • Plasma membrane
  • Ribosome
  • Sarcoplasmic reticulum
  • Secreted
  • Vesicle

Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

Direct links are provided from inside the application to 257 protein expression profiles of 152 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.

  • BioCarta# 209 Pathways
  • KEGG# 149 Pathways
  • NCI-Nature# 246 Pathways
  • NetPath# 32 Pathways

Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

In total there are different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile: Progress analysis and review of drug development

A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms

Presentation of drug name and synonyms

Principal Company & Partners

Presentation of principal company and partners

Target and Molecular Function of Target

Described target(s) is/are presented with:

  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles

Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:

  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.

Biological Structures

The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

Drug mechanism of action

Developmental Projects

Summary field of developmental projects for the drug, including indication, developmental stage and status.

Example:

  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

Short introduction to drug

Compound Data

Compound type, Chemical name, CAS Number and molecular weight

Patent Data

Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments

Deals & Licensing

  • Collaborations and deals
  • Availability for licensing

Phase IV Data

Available Phase IV development data, developmental history and scientific data.

Phase III Data

Available Phase III development data, developmental history and scientific data.

Phase II Data

Available Phase II development data, developmental history and scientific data.

Phase I Data

Available Phase I development data, developmental history and scientific data.

Phase 0 Data

Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

Available preclinical development data, developmental history and scientific data.

Discovery Data

Available discovery development data, developmental history and scientific data.

Application Features

Search, Find and Filter Panel with Initial Result Presentation

With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.

The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.

Direct linkage from inside the application to related internet resources

  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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