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市場調査レポート
合成RNAiの最適化：製薬業界およびバイオテクノロジー業界からの展望
Optimizing Synthetic RNAi: Perspectives from the Pharmaceutical and Biotech Industry
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Abstract
RNA interference (RNAi) has rapidly evolved into a powerful technique to
silence gene expression in cells allowing researchers to study the molecular
effects of modulating expression at the level of individual genes. The
diversity of its applications has made RNAi an indispensable tool for both
academic and industrial scientists interested in gene function
characterization, signaling pathway analysis, and target validation.
From the perspective of industrial scientists who use synthetic siRNA, this
report will:
- Identify the RNAi research objectives of pharmaceutical and biotech
scientists;
- Present siRNA customer purchasing preferences by key experimental design
parameters;
- Examine future research trends in nucleic acid-based gene silencing;
- Determine industrial throughput levels of synthetic siRNAs per target gene;
- Assess market growth potential for custom, pre-designed, and validated
synthetic siRNAs;
- Reveal preferred suppliers of synthetic siRNAs and their Net Promoter
Score rankings;
- Determine synthetic siRNA brand share by usage rates and relative
expenditure for the U.S. market and the rest of the world market;
- Understand the role of customer satisfaction and brand loyalty in the
purchasing decision;
- Provide insights into which product attributes contribute to customer
satisfaction and customer dissatisfaction; and
- Evaluate brand health of the top suppliers based upon key performance
metrics related to product promotion, product attractiveness, product price,
product placement and supplier customer service and technical support.
Table of Contents
Section 1. Analysis and Interpretation of Survey Results
- Executive Overview
- Study Objectives
- Customer Profile
- Research Objectives
- Experimental Design
- Product Requirements
- Market Potential
- Throughput and Market Growth
- Future Trends
- Supplier Performance
- Preferred Suppliers
- Customer Satisfaction
- Brand Share
- Brand Health
Section 2. Study Methodology and Demographics
- Methodology
- Definition of Terms
- Demographics
- Questionnaire
Section 3. Presentation of Survey Data
- Experimental Design
- Currently use synthetic siRNA
- Primary research objective of RNAi experiments
- Primary species studied in RNAi research
- Cell types primarily used
- Typical method of measuring the effectiveness of RNAiinduced gene
silencing
- Percent reduction in gene expression that is usually required
- siRNA Selection
- Percentage of total RNAi experiments for which each type of synthetic
siRNA is used
- Preferred type of siRNA
- Synthesis scale typically ordered for preferred type of siRNA
- Order turn-around time normally required for preferred type of siRNA
- Typical specifications for preferred type of siRNA
- Strandedness
- Quantity
- Format
- Level of purification usually ordered for preferred type of siRNA
- Most common modification ordered for preferred type of siRNA
- Preferred method for ordering pre-designed or validated siRNA
- Primary way of designing custom siRNA
- Experimental Throughput
- Typical number of unique synthetic siRNAs utilized per gene target
- Average number of gene targets analyzed per month
- Expected change in the number of gene targets analyzed
- Choosing the siRNA Supplier
- Brands of synthetic siRNA currently used
- Primary brand of synthetic siRNA
- Percentage of RNAi experiments for which each brand of siRNA is used
- Relative amount of money spent on each brand of siRNA
- Evaluating the Primary Supplier' s Performance
- Satisfaction with specific product features of synthetic siRNA from
primary supplier
- Formats available
- Modifications available
- Purification options
- Purity
- Reduction of target gene expression
- Specificity of gene suppression
- Stability in cells
- Time-to-results
- Transfectability
- Overall satisfaction with synthetic siRNA from primary supplier
- Happiness with the performance of synthetic siRNA from primary supplier
- Familiarity with other RNAi products from primary supplier
- Level of acceptability of synthetic siRNA prices from primary supplier
- Ease of obtaining synthetic siRNA from primary supplier
- Helpfulness of customer service from primary supplier
- Helpfulness of technical service from primary supplier
- Likelihood of recommending synthetic RNAi products from primary supplier
to a colleague
- Future Trends in Nucleic Acid-Based Gene Silencing
- Identifying which molecules would be the most useful in advancing
research goals in:
- Gene function analysis
- Genome-wide screening
- Therapeutic applications
- Improvement to siRNA that would most convince scientists to try a new
supplier' s siRNA
- Demographics
Section 4. Appendices
- Insights and Perspectives
- Cross-Tabulations of Survey Data
- Other Recent Publications
- About BioInformatics
- Our Valued Clients
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